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Search Results: 1 - 10 of 10843 matches for " Chiaramoni Nadia Silvia "
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Effect of Risperidone and Fluoxetine on the Movement and Neurochemical Changes of Zebrafish  [PDF]
Maria Jimena Prieto, Hector Carreno Gutierrez, Rosario Arévalo Arévalo, Nadia S. Chiaramoni, Silvia del Valle Alonso
Open Journal of Medicinal Chemistry (OJMC) , 2012, DOI: 10.4236/ojmc.2012.24016
Abstract: Brain developmental disorders in humans, including Autism Spectrum Disorders (ASD) and Downs syndrome, have been linked to increased serotonin levels. This work was designed to study changes in serotonin levels in the early stages of development with two classes of antipsychotic drugs: Risperidone, a drug that blocks serotonin and dopamine receptors, and fluoxetine, a serotonin reuptake inhibitor. The use of antipsychotic drugs is a solid choice to study the decrease and increase of these neurotransmitters and their influence on development. The study of these parameters will give an idea of the effects of serotonin in early developmental stages. To this end, we examined the effects of risperidone and fluoxetine on the locomotor activity, heart rate and brain development of zebrafish larvae. Our results showed that in larvae exposed to fluoxetine alone, swimming was significantly increased at 9 dpf (days post-fertilization). Erratic and abnormal movements were observed suggesting a toxic effect of fluoxetine. No erratic swimming was observed in larvae treated with fluoxetine plus risperidone. Both drugs presented morphological changes in dopaminergic neurons and mononeurons. Exposure to fluoxetine plus risperidone indicated possible reversal effects. Studies in zebrafish allow obtaining new insights into the side effects of these drugs as well as into the brain control of locomotor activity. Testing several drug-induced changes in behavior and serotonin levels is one of the experimental approaches for screening a new therapeutically relevant compound, and thus, merits further research.
Lipid-Polymer Membranes as Carriers for L-Tryptophan: Molecular and Metabolic Properties  [PDF]
Fernández Ruocco María Julieta, Siri Macarena, Igartúa Daniela, Prieto María Jimena, Alonso Silvia Del Valle, Chiaramoni Nadia Silvia
Open Journal of Medicinal Chemistry (OJMC) , 2013, DOI: 10.4236/ojmc.2013.31005
Abstract: Polymerized liposomes encapsulating L-tryptophan were studied with the aim to characterize them as drug delivery systems for the treatment of several metabolic diseases that need an increased systemic L-tryptophan concentration. polymerized liposomes were obtained by UV irradiation of vesicles containing 1,2-bis(10,12-tricosadiynoyl)-sn-glycero-3-phosphocholine (DC8,9PC) and 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) in a 1:1 molar ratio, in the presence of 10 and 50 mol% of L-tryptophan (respect to total lipid concentration). Polymerization efficiency was studied spectrophotometrically. Also, bilayer packing at the polar head region was followed with the Merocyanine 540 (MC540) and specific interactions in the lipopolymers were studied by FTIR. High L-tryptophan concentrations (50 mol% respect to total lipid concentration) induced a higher amount of six- and nine-unit polymers. This phenomenon was induced because the L-tryptophan located outside the lipid membrane was included in it during the polymerization process and was thus responsible for the better accommodate of the polar head region. This was not possible with the lower amount of L-tryptophan (10 mol%). The stability of lipopolymers with different amounts of L-tryptophan was studied through release profiles. Polymerized liposomes with 50 mol% of L-tryptophan were able to retain around 80% of the amino acid after 24 hours, whereas those with 10 mol % of the amino acid were able to retain 20%. The metabolic activity of the Caco-2 cell line was also studied. Cytotoxic effects were low in the presence of polymerized liposomes, rendering a maximum percentage of cell death of 30%. In summary, this work stresses the relevance of nonspecific drug-polymerized membrane binding on L-tryptophan pharmacological interaction with possible pharmaceutical applications in liposomal drug delivery. Moreover, the absence of significant cytotoxic effects allows the system proposed to be applied in human health.
Optimization and In Vivo Toxicity Evaluation of G4.5 Pamam Dendrimer-Risperidone Complexes
Maria Jimena Prieto, Nahuel Eduardo del Rio Zabala, Cristian Hernán Marotta, Hector Carre?o Gutierrez, Rosario Arévalo Arévalo, Nadia Silvia Chiaramoni, Silvia del Valle Alonso
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0090393
Abstract: Risperidone is an approved antipsychotic drug belonging to the chemical class of benzisoxazole. This drug has low solubility in aqueous medium and poor bioavailability due to extensive first-pass metabolism and high protein binding (>90%). Since new strategies to improve efficient treatments are needed, we studied the efficiency of anionic G4.5 PAMAM dendrimers as nanocarriers for this therapeutic drug. To this end, we explored dendrimer-risperidone complexation dependence on solvent concentration, pH and molar relationship. The best dendrimer-risperidone incorporation (46 risperidone molecules per dendrimer) was achieved with a mixture of chloroform:methanol 50:50 v/v solution pH 3. In addition, to explore the possible effects of this complex, in vivo studies were carried out in the zebrafish model. Changes in the development of dopaminergic neurons and motoneurons were studied using tyrosine hydroxylase and calretinin, respectively. Physiological changes were studied through histological sections stained with hematoxylin-eosin to observe possible morphological brain changes. The most significant changes were observed when larvae were treated with free risperidone, and no changes were observed when larvae were treated with the complex.
Advocacy and Policy Change in the Multilevel System of the European Union: A Case Study within Health Policy  [PDF]
Nadia Carboni
Open Journal of Political Science (OJPS) , 2012, DOI: 10.4236/ojps.2012.23005
Abstract: Health policy is basically Member States’ competence. However, the European Union has recently raised a number of key questions facing both (pharmaceutical) industries and public health interests. By applying the Advocacy Coalition Framework, the paper sheds light on policy change within the European multilevel system. The analysis is based on a case-study strategy. Two processes in the pharmaceutical policy are taken into account: the “Pharma Forum” and the “Pharma Package”. They both concern “information to patient”—a controversial policy issue at the crossroad of competing pressures.
A gel-free approach in vascular smooth muscle cell proteome: perspectives for a better insight into activation
Silvia Rocchiccioli, Lorenzo Citti, Claudia Boccardi, Nadia Ucciferri, Lorena Tedeschi, Caterina Lande, Maria Trivella, Antonella Cecchettini
Proteome Science , 2010, DOI: 10.1186/1477-5956-8-15
Abstract: This paper describes a strategy for the study of the VSMC proteome. Our approach was based on pre-fractionation with ion exchange chromatography coupled with matrix assisted laser desorption-time of flight mass spectrometry analysis assisted by a liquid chromatography (LC-MALDI-TOF/TOF). Ion exchange chromatography resulted in a good strategy designed to simplify the complexity of the cellular extract and to identify a large number of proteins. Selectivity based on the ion-exchange chemical features was adequate if evaluated on the basis of protein pI. The LC-MALDI approach proved to be highly reproducible and sensitive since we were able to identify up to 815 proteins with a concentration dynamic range of 7 orders of magnitude.In our opinion, the large number of identified proteins and the promising quantitative reproducibility made this approach a powerful method to analyze complex protein mixtures in a high throughput way and to obtain statistical data for the discovery of key factors involved in VSMC activation and to analyze a label-free differential protein expression.The use of chromatography coupled with MS analysis is a powerful approach for the identification of proteins, owing to its capacity to fractionate molecules with different chemical features [1-4]. Furthermore, LC-MALDI-TOF/TOF analysis combined with preliminary fractionation of a total protein extract is a potential tool for biomarker discovery because of its high sensitivity and high throughput capacity [5].However, the use of LC-MALDI analysis still needs to be optimized and evaluated [6,7]. To obtain useful information for comparative analysis of samples and differential protein expression using a label-free approach in LC-MALDI techniques, the reproducibility in measuring m/z abundances (peak intensity) and a linear relation between intensity and marker concentration are essential [8-10]. Moreover, although LC-MALDI MS/MS analysis is a high mass precision technique, it is time consuming, espe
Eritrodermia secundaria a planta productora de látex (Synadenium grantii)
Docampo,Patricia C.; Cabrerizo,Silvia; Paladino,Nadia; Parre?o,María L.; Ruffolo,Virginia; Mutti,Olga;
Archivos argentinos de pediatr?-a , 2010,
Abstract: the euphorbiaceae family are plants that have in common latex production. there are over 8000 species. they have worldwide distribution. we can find trees, shrubs or herbs. many important species belong to this family and they are used in our country for industrial and medical purposes. there are also ornamental plants with attractive appearence that stimulate children curiosity, intake or manipulation. in the national poison center consultations for plants represent a small number (0.2%) of the total accidents in children, however they can be serious. we report the case of a 4 years old girl who manipulated and swallowed part of an euphorbiaceae family plant (synadenium grantii).
Reversible enhancement of the magnetism of ultrathin Co films by H adsorption
Silvia Gallego,Nadia Sanchez,Sofia Martin,Carmen Mu?oz,Laszlo Szunyogh
Physics , 2010, DOI: 10.1103/PhysRevB.82.085414
Abstract: By means of ab initio calculations, we have investigated the effect of H adsorption in the structural, electronic and magnetic properties of ultrathin Co films on Ru(0001). Our calculations predict that H occupies hollow sites preserving the two-dimensional 3-fold symmetry. The formation of a complete H overlayer leads to a very stable surface with strong H-Co bonds. H tends to suppress surface features, in particular, the enhancement of the magnetic moments of the bare film. The H-induced effects are mostly confined to the Co atoms bonded to H, independent of the H coverage or of the thickness and the structure of the Co film. However, for partial H coverages a significant increase occurs in the magnetic moment for the surface Co atoms not bonded to H, leading to a net enhancement of surface magnetism.
Life Cycle Assessment of Hydrogel Used in Hydroponics for the Impatiens New Guinea Production  [PDF]
Silvia Paola Venegas Segura, Martha Lilia Domínguez Pati?o, Miguel Aguilar Cortes, Jorge Avelino Domínguez Pati?o, Luz Elva Marín Vaca, Nadia Lara Ruiz, Rosa María Melgoza Alemán, Oscar Gabriel Villegas Torres
Open Journal of Applied Sciences (OJAppS) , 2016, DOI: 10.4236/ojapps.2016.65030
Abstract: The environmental impact on the planet leads to the search of new processes that are friendly with the environment and obtaining high quality products. In this sense, green chemistry is used in the generation of products through processes that do not affect the planet. In many of these processes and in general, the use of water has been depleted this resource of vital importance for the survival of living things. In Mexico, 77% of water is used in agriculture; 14% in the public supply; 5% in the thermoelectric plants and 4% in the industry. In research presented, hydroponics is essential in the process and is defined as a technique used to reduce excessive water consumption, by providing the necessary nutrients, in addition to preventing soil erosion by allowing the growth of plants without use of ground. The potassium polyacrylate is a super-absorbent polymer (Hydrogel) capable of absorbing water up to 500 times of its weight and has a life span of 10 years. When mixed with a substrate, the required nutrient solution potassium polyacrylate allows to lengthen the interval watering and thus reducing the consumption of water from plants. Morelos is the largest producer of ornamental plants in the country, due to its privileged climate and location. In the present work using the hydroponic methodology, we planted cuttings of Bethlehem New Guinea (Impatiens New Guinea) in a substrate made by 60% of coconut fiber, 20% tepojal, 20% ground sheet mixed with polymer of potassium (20 g per litre), 400 ml of Steiner nutrient solution in concentrations of 40%, 60%, 80% and 100%, varying the interval of 3-, 6-, 8- and 10-day watering. The variables considered are: concentration of chlorophyll, the plant height, leaf area, number of stems and weight dry total. The 12 principles of green chemistry applied to hydroponics using polyacrylate of potassium as part of the substrate in Bethlehem New Guinea (Impatiens New Guinea) to determine the analysis of life cycle (LCA), doing the balance of inputs and outputs of the system, and the stages of the LCA. Finally the SimaPro software was used to measure the environmental impact of the use of the polymer in hydroponics by varying the watering interval and the concentration of the Steiner solution, entering data for the concentration of Steiner, and the volume of water used. With the results obtained by measurement of weight dry total and concentration of Steiner solution and using the Software SimaPro, Steiner saw that the solution with the concentration of 60% using potassium polyacrylate as part of the
Synthesis of Some New Spiro β-Lactams and Thiazolidinones Compounds Containing Sulfur Incorporating Quinon Compounds  [PDF]
Nadia Ali Ahmed Elkanzi
International Journal of Organic Chemistry (IJOC) , 2012, DOI: 10.4236/ijoc.2012.24048
Abstract: A series of spiro, β-Lactams, and thiazolidinones incorporating compounds 4 have been synthesized by cycloaddition reaction of, chloroacetyl chloride and mercaptoacetic acid with the synthesized Shiff,s bases 5a-c to give new spiro β- Lactam 6a-c and spiro thiazolidinone 7a-c the cycloaddition were characterized by spectral data including HNMR, 13C-NMR, IR and elemental analysis.
Molecular Structure, Vibrational Assignments and Non-Linear Optical Properties of 4,4’ Dimethylaminocyanobiphenyl (DMACB) by DFT and ab Initio HF Calculations  [PDF]
Charef Tabti, Nadia Benhalima
Advances in Materials Physics and Chemistry (AMPC) , 2015, DOI: 10.4236/ampc.2015.57023
Abstract: In the present study, structural properties of 4,4’ dimethylaminocyanobiphenyl (DMACB) have been studied extensively by using ab initio Hartree Fock (HF) and density functional theory (DFT) employing B3LYP/B3PW91 exchange correlation levels of theory. The vibrational frequencies of DMACB in the ground state have been calculated by using Hartree Fock level and density functional method (B3LYP/B3PW91) with 6-31G(d, p), basis set. Nonlinear optical (NLO) behavior of the examined molecule is investigated by the determination of the electric dipole moment μ, the polarizability α, and the hyperpolarizability β by using the B3LYP/B3PW91 methods.
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