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Search Results: 1 - 10 of 1996 matches for " Chiara Panetta "
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Epithelioma of Malherbe: new ultrasound patterns
Francesco M Solivetti, Fulvia Elia, Alessandra Drusco, Chiara Panetta, Ada Amantea, Aldo Di Carlo
Journal of Experimental & Clinical Cancer Research , 2010, DOI: 10.1186/1756-9966-29-42
Abstract: We retrieved 124 histologically Pilomatricoma cases: 28 patients with 32 lesions were preoperatively evaluated with ultrasound.22/32 have shown a solid formation, hypoechoic, with a sharp outline. Of these 22, 10 lesions were completely calcifying and 12 partially calcified. In 3/32 lesions with uncertain diagnosis, ultrasounds showed a complex/mixed pattern with pseudo-fluid areas and microspots. 7/32 lesions with US different diagnosis included 3 complex lesions, 2 cystic lesions and 2 solid nodular lesions.In addition to well-known ultrasound patterns (completely calcified and partially calcified) we identified three new, not yet described, patterns that constitute the 31% of the cases: complex, pseudocistyc and pseudotumoral.Calcifying Epithelioma of Malherbe - or Trichomatricoma, Pilomatricoma, Pilomatrixoma (PM) - is an uncommon tumour [1], with an incidence of 1/800-1000 cutaneous tumours and about 20 new reports per year [2,3], affecting predominantly women. It is more common at a young age, especially in the first two decades of life, with an onset below 10 years in 40% of cases [4,5]. Although multiple localizations have been described in literature [6,7], PM occurs as a solitary lesion on the face (47% of cases), neck [8] and upper trunk and can be associated to other diseases, e.g. Steinert's Myotonic Dystrophy and Gardner Syndrome [4,7,9,10].Recent studies have shown that recurrent activating mutations in the ss-catenina gene (CTNNB1), induce PM tumourigenesis through activation of the WNT signalling pathway [11,12]. Despite the benign biological behaviour of the majority of cases, the treatment is still surgical. However, in recent years, aggressive cases with local post-surgery recurrences or metastasis have been described [2,3,13,14], accounting for variable percentage rates in literature, with 6 cases out of 228 in the Forbis series [6]. According to some authors [13], local recurrences are related to tumour aggressiveness, while for others, these c
Evoluzione del sistema bancario e finanziamento dell’economia nel Mezzogiorno (Developments in the Banking Market and Company Financing in the Italian Mezzogiorno)
Fabio Panetta
Moneta e Credito , 2003,
Abstract: In the 1990s the banks established in the Italian South have reduced their cost-income ratios and improved their ability to screen customers, increasing profitability. The spread between the loan rates in the South and North has narrowed substantially. Taking into account differences in the size and industry composition of firms in the two areas, the spread is currently equal to 0.90 percent. The growth of loans in the North has outpaced that in the South, but this divergence is merely a reflection of the greater proportion of new bad loans in relation to total lending in the South. Since the mid-1990s in the South the ratio of loans to local firms to funds raised locally has increased from 75 to 85%. The lower value of the ratio in the South reflects structural features of the Southern economy and the way in which loans are allocated geographically in financial statistics.
Prospective randomized clinical trial evaluating the impact of vinegar on lipids in non-diabetics  [PDF]
Carmelo J. Panetta, Yvonne C. Jonk, Alice C. Shapiro
World Journal of Cardiovascular Diseases (WJCD) , 2013, DOI: 10.4236/wjcd.2013.32027

Background: Heart disease is now considered an inflammatory process targeted primarily by medical therapy on lipid levels. Complementary and alternative medicine searches for novel non-pharmacologic therapy, including pursuing various diets. Animal studies and consumer literature suggest benefits of vinegar on lipid levels and diabetes mellitus. Our nonrandomized pilot study from our group suggested a benefit in raising high-density lipoprotein cholesterol (HDL-C). Based on this data, we conducted a randomized placebo controlled clinical trial to determine the effects of apple cider vinegar intake in those without diabetes mellitus on total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides, HDL-C, Hemoglobin A1C(Hgb-A1C) and measurement of inflammation with high sensitivity CRP levels (HS-CRP). Methods: A prospective randomized, double blind, placebo-controlled clinical trial consisting of 114 participants was conducted. Participants consumed 30 mL of either apple cider vinegar or placebo for two months. Measurements were collected at baseline, eight and sixteen weeks. The primary endpoint was the change in HDL-C from baseline to eight weeks between the vinegar and placebo groups. Secondary endpoints were change from baseline to eight weeks in TC, LDL-C, triglycerides, Hgb-A1cand HS-CRP. Results: Change in serum HDL-C concentration was not significantly different between the vinegar and control groups after eight weeks of supplementation. Secondary endpoints including TC, LDL-C, Hgb-A1cand HS-CRP were not statistically different at the Bonferroni corrected significance level of 0.01. No significant difference was found regardless of baseline HDL-C levels. Conclusions: We found no significant difference in HDL-C, LDL-C, triglycerides, total cholesterol, or HS-CRP levels with use of vinegar but a trend down of Hgb-A1cin this group of non-diabetic participants. Further investigation is required to define the impact of vinegar in those with diabetes mellitus.

Crohn’s Disease and Urinary Manifestations: A Crohn’s Intestinal Disease Mimicking a Bladder Mass  [PDF]
Bronislava Papadatou, Lidia Monti, Giuliano Torre, Fabio Panetta, Antonella Diamanti
Health (Health) , 2014, DOI: 10.4236/health.2014.612182
Abstract: We report a rare mode of presentation of Crohn’s Disease (CD) in a 17-year-old boy, who was admitted at our hospital due to abdominal pain, dysuria, polyuria and fever. The ultrasound showed an increased wall thickness of the small bowel and cecum and a vegetating lesion adjoined into the bladder. The histology was not suggestive of CD and it excluded the bladder neoplasm. Based on the biochemical assessment and the imaging, we started the treatment specific for CD (nutritional therapy by Modulen, short courses of steroids, azathioprine and mesalazine during the follow up), These treatments improved the gastrointestinal symptoms and the nutritional status of our patient but also induced the disappearance of the mass adjoined into the bladder. In spite of the severe onset, in this patient, the clinical course of CD was mild and responder to conventional therapy.
Comparative strengths of a pseudo-spectral time domain method in numerical simulation of single particle optical scattering
R. L. Panetta,>C. Liu,>P. Yang
Atti della Accademia Peloritana dei Pericolanti : Classe di Scienze Fisiche, Matematiche e Naturali , 2011, DOI: 10.1478/c1v89s1p074
Abstract: We present some results on the relative performance of the pseudo-spectral time domain, finite difference time domain, and DDA methods in calculating single-particle optical scattering properties. Our interest is in particles with size parameters in excess of 10. Using as test case a homogeneous spherical particle we have found that the pseudospectral time domain method is generally more efficient (uses less cpu time for a given accuracy) than the finite-difference time domain method. The DDA method appears to be superior to the pseudo-spectral method for indices of refraction less than 1.5, but as the index of refraction increases, the pseudo-spectral method becomes superior. We present here some results for particles with size parameters 10 and 30, and indices of refraction 1.3117 and 1.7.
Time Competition. The New Strategic Frontier  [PDF]
Chiara Demartini, Piero Mella
iBusiness (IB) , 2011, DOI: 10.4236/ib.2011.32020
Abstract: The acceleration of change necessitates strategies to control time, considered not only as a variable that influences the temporal evolution of phenomena but as one that directly influences phenomena itself. This study tries to present the logic of time compression and time to market, as well as the main instruments for the formulation of time-based strategies, not only by observing how the value of time is perceived as a contraction of production and distribution lead times but also by considering the choice of the most opportune moment to start a business and introduce (or withdraw) a new product. Starting from a discussion of time-based competition managerial approaches, this study develops a theoretical framework showing different time-based methodologies (JIT, MRP, OPT, FMS, PERT, HSM) that help management to adopt time-based strategies. It also puts forward a taxonomy of time-based strategies as well as a logical strategic path to time value.
Reducing seismic risk by understanding its cultural roots: Inference from an Italian case history  [PDF]
Francesco Stoppa, Chiara Berti
Natural Science (NS) , 2013, DOI: 10.4236/ns.2013.58A1010

The paper discusses how to approach the problem of the social mitigation of seismic risk, in order to reduce damage and grief consequent to earthquakes. An alert protocol, intended as a working hypothesis, is proposed based on the experience gained from analysis of the behaviour and social response to the threat before and after the great disaster of the L’Aquila earthquake on 6th April 2009. Authors propose a protocol addressing four levels of increasing alert based on signs of earthquake preparation and social concerns. In this sense, it works as an intensity scale and does not strictly relate to earthquake size (magnitude) or seismic hazard. The proposed alert protocol provides sensible measures for reducing vulnerability, which is the only factor that can be more or less efficiently controlled, based on structural and behavioural adjustments. Factors indicating the difficult relationship between politicians, scientific community and citizens are considered: 1) a serious gap between researchers and citizens; 2) measures adopted by local administrators and the National Civil Protection Service not agreed by the population; 3) misunderstanding originated from a lack of clarity of communication about scientific terminology; and 4) the lack of an alert procedure protocol. In the current situation, all these problems are crucial and contribute to the unpreparedness to face a seismic event, and thus greatly increase the risk. The adoption and implementation of an alert procedure protocol requires a preliminary assessment of the context and should be adapted to the local sensibility and culture. The application of a protocol may reduce the contrasts between preventive measures and individual responsibilities, making mitigation measures more feasible and socially acceptable. In this paper, risk evaluation is not strictly related to probabilistic or deterministic predictions. In fact, this is a result of a project that comes from the general analysis of risk and is not intended to give an alternative hazard estimate method. This paper proposes an alert protocol addressing four levels of increasing alert based on signs of earthquake generating preparation and social concerns. Finally, there is a suggestion on how to gradually communicate the threat and get citizens involved in the risk mitigation process.

Mental health literacy and the anxiety disorders  [PDF]
Adrian Furnham, Chiara Lousley
Health (Health) , 2013, DOI: 10.4236/health.2013.53A071

Context: This study set out to investigate the mental health literacy (MHL) about eight anxiety disorders (ADs), using vignette methodology. Methods: In all 317 British Adult participants completed a questionnaire with vignettes describing eight anxiety disorders including OCD, PTSD, Agoraphobia, Specific Phobias, Social Phobia, Separation Anxiety Disorder, GAD and Panic Disorder. Recognition, beliefs about treatments and perceived life adjustment (happiness, success at work) of specific people with these disorders were assessed. Results: Literacy levels varied across anxiety disorders, with high recognition of OCD (64.67%), but very poor for panic disorder (1.26%), GAD (2.84%) and separation anxiety disorder (5.99%). There were few significant effects of vignette gender on literacy levels. MHL for most anxiety disorders was relatively low; particularly panic disorder, GAD and separation anxiety disorder. Social Phobics were judged as least happy and adjusted and agoraphobics least successful at work and would benefit most from psychological help. Conclusions: Overall recognition of the anxiety disorders was poor. Beliefs about adjustment and treatment varied widely as a function of each disorder. Implications of the research for education of the public and limitations of this research are considered.

Ulcerative Colitis and Acute Thrombocytopenia in a Pediatric Patient: A Case Report and Review of the Literature  [PDF]
Bronislava Papadatou, Fiammetta Bracci, Daniela Knafelz, Antonella Diamanti, Maria Sole Basso, Fabio Panetta, Filippo Torroni, Valerio Nobili, Giuliano Torre
Health (Health) , 2014, DOI: 10.4236/health.2014.612184
Abstract: We report the case of a 14-year-old boy affected by ulcerative colitis (UC) and acute thrombocytopenic purpura (ITP) with simultaneous onset. UC diagnosis was based on symptoms, endoscopy and histology findings. ITP diagnosis was based on the normal bone marrow megakaryocyte count, the presence of platelet associated IgG and the absence of splenomegaly. Medical treatments including high doses of steroids, intravenous immunoglobulins were ineffective on ITP course, while UC course was mild for several months after the onset. When colonic inflammation became untractable not responsive at steroids and immunosuppressive agents, colectomy resolved both pathologies.
Modelling the Effects of Paclitaxel and Cisplatin on Breast and Ovarian Cancer
John Carl Panetta,Mark A. J. Chaplain,David Cameron
Computational and Mathematical Methods in Medicine , 2000, DOI: 10.1080/10273660008833061
Abstract: The two drugs, Paclitaxel and Cisplatin, have important roles in the treatment of breast and ovarian cancer, with the combination currently considered the optimum first line chemotherapy of epithelial ovarian cancer. There has been a variety of experimental and clinical studies to try to determine the most effective method to deliver these drugs. These studies consistently show that giving Paclitaxel prior to Cisplatin is the more effective regimen. However, the reasons why are not fully understood. Therefore, we have developed a mathematical model to describe and predict the effects of these two drugs. This model takes into account the cytotoxic effects of the drugs on the cell-cycle and the pharmacodynamic and pharmacokinetic effects of the drugs on each other. The model agrees with the experimental and clinical studies which show that Paclitaxel given prior to Cisplatin is the better combination and, in addition, the model also predicts more effective treatment regimens. These include conditions on the time between doses and the dosing of each of the drugs.
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