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Search Results: 1 - 10 of 100809 matches for " Chiang-Yi Chen "
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Classification and regression tree analysis in acute coronary syndrome patients  [PDF]
Heng-Hsin Tung, Chiang-Yi Chen, Kuan-Chia Lin, Nai-Kuan Chou, Jyun-Yi Lee, Daniel L. Clinciu, Ru-Yu Lien
World Journal of Cardiovascular Diseases (WJCD) , 2012, DOI: 10.4236/wjcd.2012.23030
Abstract: Objectives: The objectives of this study are to use CART (Classification and regression tree) and step-wise regression to 1) define the predictors of quality of life in ACS (acute coronary syndrome) patients, using demographics, ACS symptoms, and anxiety as independent variables; and 2) discuss and compare the results of these two statistical approaches. Back- ground: In outcome studies of ACS, CART is a good alternative approach to linear regression; however, CART is rarely used. Methods: A descriptive survey design was used with 100 samples recruited. Result and Conclusions: Anxiety is the most significant predictor and also a stronger predictor than symptoms of ACS for the quality of life. The anxiety level patients experienced at the time heart attack occurred can be used to predict quality of life a month later. Furthermore, the majority of ACS patients experienced a moderate to high level of anxiety during a heart attack.
The Impact of a Pharmacist-Conducted Interactive Anti-Smoking Education Program on the Attitudes and Knowledge of High School Students  [PDF]
Man-Tzu Marcie Wu, Wan-Chen Shen, Juei-Chia Chang, Yi-Chun Chiang, Hsiang-Mei Chen, Hsiang-Yin Chen
Creative Education (CE) , 2013, DOI: 10.4236/ce.2013.47061

Introduction: Smoking among adolescents remains a major concern because of its long term health hazards. An effective adolescent-specific anti-smoking education is needed. Objectives: To measure the impact of a school-based tobacco prevention program provided by pharmacists on the attitudes and knowledge of senior high students. Methods: An anti-smoking program specifically aimed at high school students was developed by pharmacists and introduced to 354 students inTaiwan. It consisted of a role play and a lecture. The students were asked to complete a structural questionnaire right before and after the intervention. Results: After the intervention, the average of the total attitude scores increased from 41.7 to 43.2 (p = 0.001), and the total knowledge scores increased from 6.4 to 8.2 (p < 0.001). The average practice score was 31.2 (maximum score = 50) and the result suggested that the practice score was associated with attitude rather than knowledge. Conclusion: This pharmacist-conducted anti-smoking program for high school students resulted in positive changes regarding both attitude and knowledge. This suggests that further anti-smoking programs targeting students would be effective in helping to prevent youth smoking.

Cortex Moutan Inhibits Bladder Cancer Cell Proliferation and Expression of Angiogenic Factors  [PDF]
Mei-Yi Lin, Cheng-Huang Shen, Su-Yin Chiang, Syue-Yi Chen, Yu-Shih Lin, Cheng-Da Hsu
Pharmacology & Pharmacy (PP) , 2014, DOI: 10.4236/pp.2014.58095

Metastases are the main cause of death among patients with bladder cancer, which is the second most common malignancy of the genitourinary tract and is highly prevalent in the southwestern region of Taiwan. Angiogenesis plays a critical role in tumor growth and metastasis processes and has relevance in disease recurrence, pelvic lymph node metastasis and poor prognosis. Cancer cells can produce several angiogenesis-stimulating factors involved in vascular growth, including vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and inflammatory cytokines such as interleukin (IL)-8. Common chemotherapeutic drugs for intravesical instillations usually cause major side effects, including urinary frequency, urinary urgency, cystitis, and hematuria. In order to identify a less cytotoxic therapeutic agent that can inhibit tumor cell proliferation, we examined the traditional Chinese herbal medicine Cortex Moutan—reported to have antibacterial, antiviral, anti-inflammatory, antithrombotic, and antitumor properties—for its effects on bladder cancer cell proliferation and expression of angiogenic factors. Our results revealed that Cortex Moutan exhibited high selectivity in inhibiting the growth of bladder cancer cells and also reduced the expression of angiogenesis-stimulating factors in those cells. Thus, we suggest that Cortex Moutan might be used as a cancer therapy drug for bladder’s intravesical chemotherapy in the future.

Original Article: Prognostic Factors of Long-Term Outcome and Functional Status Following Spontaneous Cerebellar Hemorrhage  [PDF]
Chia-Hung Sun, Shin-Tsu Chang, Liang-Cheng Chen, Heng-Yi Chu, Shang-Lin Chiang, Tsung-Ying Li, Yung-Tsan Wu
World Journal of Cardiovascular Diseases (WJCD) , 2014, DOI: 10.4236/wjcd.2014.43014

Cerebellar hemorrhage (CH) has a higher early mortality rate compared with other types of intracranial hemorrhage and the survivors often suffer from momentous disability. Hence, the prognostic factors of long-term outcome beyond 6 months after CH are clinically valuable, however only three studies were reported in the literature. Sixty-one patients with CH were retrospectively analyzed at least 6 months after hemorrhage. The long-term outcome of all patients and long-term functional status of survivors beyond 6 months (the patients who died within 6 months after hemorrhage were excluded) were assessed using the modified Rankin Scale (mRS): favorable outcome (mRS 0 - 2) and unfavorable outcome (mRS 3 - 6). All of the prognostic factors were analyzed by univariate and multivariate Cox proportional hazards regression models. There were 16 (26.2%) patients in the favorable outcome group and 45 (73.8%) in the unfavorable outcome group with respect of long-term outcome in all patients. The radiological brainstem compression (HR = 3; p = 0.015) was shown to be an independent predictor. On the other hand, 46 out of 61 (75.4%) patients survived beyond 6 months. In total, 16 (34.7%) patients had a favorable functional status, and 65.3% (30/46) had a persistent unfavorable functional status. Moreover, only age 365 years (HR = 3; p = 0.019) was an independent predictor. Radiological brainstem compression and age 365 were respectively shown to be a strong prognostic factor for long-term outcome and functional status among survivors beyond 6 months after hemorrhage in patients with CH.

Chia-Chi Chang,Chia-Yi Chen,Yi-Hsuan Chiang
International Journal of Electronic Business Management , 2011,
Abstract: As the Web-based commerce booms rapidly, it is crucial for companies to develop comprehensive yet customized measurement of Website service quality in order to formulate their winning strategies. However, no single exiting scale can be globally effective to capture Websites service quality because service quality dimensions can differ according to the various characteristics of the websites. Therefore, managers and engineers need to cultivate their own abilities to develop a scale that can be more effectively evaluating service quality of their Websites. Accordingly, this article aims to provide guidelines for managers and/or engineers to adjust current measures or build new scales for Website service quality that best fits their agenda. This paper firstly discusses how to use literature review and focus group interview to identify possible dimensions of Website service quality. Next, item generation and selection techniques are introduced. Last, statistical methods for refining items and accessing reliability and validity of the scale are described. An example from previously published paper is also provided for readers’ reference.
Fabrication and Optoelectrical Properties of IZO/ Heterostructure Solar Cells by Thermal Oxidation
Cheng-Chiang Chen,Lung-Chien Chen,Yi-Hsuan Lee
Advances in Condensed Matter Physics , 2012, DOI: 10.1155/2012/129139
Abstract: Indium zinc oxide (IZO)/cupper oxide (Cu2O) is a nontoxic nature and an attractive all-oxide candidate for low-cost photovoltaic (PV) applications. The present paper reports on the fabrication of IZO/Cu2O heterostructure solar cells which the Cu2O layers were prepared by oxidation of Cu thin films deposited on glass substrate. The measured parameters of cells were the short-circuit current ( ), the open-circuit voltage ( ), the maximum output power ( ), the fill factor (FF), and the efficiency (η), which had values of 0.11?mA, 0.136?V, 5.05?μW, 0.338, and 0.56%, respectively, under AM 1.5 illumination. 1. Introduction Cu2O has long been considered an attractive to silicon, and there are other semiconductors being favored for the fabrication of cheaper solar cells for terrestrial applications [1–4]. The Cu2O is intrinsically P-type, has a band gap (Eg) of 2.17?eV [5], and is expected to have a maximum theoretical efficiency of 20% [6, 7]. Its advantages include: its nontoxic nature, abundance of the starting material (copper), and cheap production processing. Cuprous oxide is of particular interest in the field of solar energy, because of their low cost, abundance of the starting material (copper), and its nontoxic nature and the light-to-electricity conversion efficiency [8]. IZO/Cu2O is an attractive all-oxide candidate for low-cost photovoltaic (PV) applications. The indium zinc oxide (IZO) films have been attracting a lot of attention because of good conductivity [9], high optical transparency [10], low deposition temperature, and very smooth surface roughness [11] in comparison with ITO films. Therefore, Cu2O thin films can be prepared by various techniques, such as reactive sputtering [12], MOCVD [13], electrochemical deposition [14–17], solution chemical [18–20], and direct oxidation of Cu sheets [21], of which the magnetron sputtering presents many advantages as low-cost approach, large scale, and easy control. Some groups reported ZnO/Cu2O solar cells prepared [21, 22]. The efficiency was to be 1-2%. In this work, the effect of the conditions of deposition of the P-type Cu2O thin films by the radiofrequency magnetron sputtering method is studied; in particular, the effect of changing the temperature and time of annealing to obtain the different performances of P-type Cu2O thin layers on crystal quality was investigated. Finally, the fabrication and optoelectronic performance of an IZO/Cu2O solar cell is considered. 2. Experimental In the study, devices that had cupper (Cu) layers of one micron thick were deposited with a purity of 99.995% on a
The Effect of Postoperative Hyperbaric Oxygen Treatment on Intra-Abdominal Adhesions in Rats
Ming-Jenn Chen,Tzu-Yu Chen,Ya-Min Cheng,Yi-Chiang Hsu
International Journal of Molecular Sciences , 2012, DOI: 10.3390/ijms131012224
Abstract: Abdominal adhesions, whether caused by peritoneal trauma, radiation, infection, or a congenital condition, are associated with a wide range of complications. These complications include chronic abdominal or pelvic pain, infertility, and adhesive small bowel obstruction. Such adhesions render re-operation difficult, with attendant risks of inadvertent enterostomy and increased operation time. The purpose of this study was to investigate the potential of hyperbaric oxygen (HBO) therapy in the prevention of abdominal adhesions in an experimental animal study. A laparotomy was performed on Wistar rats to induce the formation of adhesions on the cecum and the intra-abdominal area (1 ′ 2 cm). A superficial layer of the underlying muscle from the right abdominal wall was also shaved and prepared for aseptic surgery. The rats were divided into four groups according to the duration of HBO therapy; five additional groups were designated according to the conditions of HBO therapy. When the rats were evaluated according to adhesion area and grade, a statistically significant difference was observed between the control and HBO treatment groups ( p < 0.005). Results from this study suggest that HBO treatment could reduce adhesion formation; and further suggest that HBO therapy may have therapeutic potential in the treatment of postoperative peritoneal adhesion.
ESR Study of Interfacial Hydration Layers of Polypeptides in Water-Filled Nanochannels and in Vitrified Bulk Solvents
Yei-Chen Lai, Yi-Fan Chen, Yun-Wei Chiang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0068264
Abstract: There is considerable evidence for the essential role of surface water in protein function and structure. However, it is unclear to what extent the hydration water and protein are coupled and interact with each other. Here, we show by ESR experiments (cw, DEER, ESEEM, and ESE techniques) with spin-labeling and nanoconfinement techniques that the vitrified hydration layers can be evidently recognized in the ESR spectra, providing nanoscale understanding for the biological interfacial water. Two peptides of different secondary structures and lengths are studied in vitrified bulk solvents and in water-filled nanochannels of different pore diameter (6.1~7.6 nm). The existence of surface hydration and bulk shells are demonstrated. Water in the immediate vicinity of the nitroxide label (within the van der Waals contacts, ~0.35 nm) at the water-peptide interface is verified to be non-crystalline at 50 K, and the water accessibility changes little with the nanochannel dimension. Nevertheless, this water accessibility for the nanochannel cases is only half the value for the bulk solvent, even though the peptide structures remain largely the same as those immersed in the bulk solvents. On the other hand, the hydration density in the range of ~2 nm from the nitroxide spin increases substantially with decreasing pore size, as the density for the largest pore size (7.6 nm) is comparable to that for the bulk solvent. The results demonstrate that while the peptides are confined but structurally unaltered in the nanochannels, their surrounding water exhibits density heterogeneity along the peptide surface normal. The causes and implications, especially those involving the interactions between the first hydration water and peptides, of these observations are discussed. Spin-label ESR techniques are proven useful for studying the structure and influences of interfacial hydration.
Predicting Rotator Cuff Tears Using Data Mining and Bayesian Likelihood Ratios
Hsueh-Yi Lu, Chen-Yuan Huang, Chwen-Tzeng Su, Chen-Chiang Lin
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0094917
Abstract: Objectives Rotator cuff tear is a common cause of shoulder diseases. Correct diagnosis of rotator cuff tears can save patients from further invasive, costly and painful tests. This study used predictive data mining and Bayesian theory to improve the accuracy of diagnosing rotator cuff tears by clinical examination alone. Methods In this retrospective study, 169 patients who had a preliminary diagnosis of rotator cuff tear on the basis of clinical evaluation followed by confirmatory MRI between 2007 and 2011 were identified. MRI was used as a reference standard to classify rotator cuff tears. The predictor variable was the clinical assessment results, which consisted of 16 attributes. This study employed 2 data mining methods (ANN and the decision tree) and a statistical method (logistic regression) to classify the rotator cuff diagnosis into “tear” and “no tear” groups. Likelihood ratio and Bayesian theory were applied to estimate the probability of rotator cuff tears based on the results of the prediction models. Results Our proposed data mining procedures outperformed the classic statistical method. The correction rate, sensitivity, specificity and area under the ROC curve of predicting a rotator cuff tear were statistical better in the ANN and decision tree models compared to logistic regression. Based on likelihood ratios derived from our prediction models, Fagan's nomogram could be constructed to assess the probability of a patient who has a rotator cuff tear using a pretest probability and a prediction result (tear or no tear). Conclusions Our predictive data mining models, combined with likelihood ratios and Bayesian theory, appear to be good tools to classify rotator cuff tears as well as determine the probability of the presence of the disease to enhance diagnostic decision making for rotator cuff tears.
4,4’-Methylenebis(2-chloroaniline) (MBOCA) May Be Highly Toxic and a Carcinogen Based on an Experimental Study with Mice  [PDF]
Hong-I Chen, Tzong-Cherng Chi, Shun-Yao Ko, Yi-Chiang Hsu, I-Hsuan Lin, Ann Chen, Saou-Hsing Liou, Chien-Feng Li
Advances in Biological Chemistry (ABC) , 2014, DOI: 10.4236/abc.2014.43025
Abstract: 4,4’-Methylenebis(2-chloroaniline) (MBOCA) is a probable human carcinogen. Few studies have been performed regarding the genotoxicity of MBCOA, and the MBOCA metabolic pathway is not fully understood. We treated four-week-old ICR male mice weighing 25 - 30 g with MBOCA and observed the effects of MBOCA on the internal organs. It can be concluded that MBOCA is a carcinogen and also affects gene regulation. Oral or topical administration of 50 mg/kg, 100 mg/kg or 200 mg/kg MBOCA resulted in 56% - 81% of mice showing unusual inflammation, degeneration, and dysplasia in kidney, liver, stomach, intestine and urinary bladder based on histology. Furthermore, we investigated the association between oxidative DNA damage and MBOCA exposure by measuring plasma level of 8-hydroxydeoxyguanosine (8-OHdG). The results showed that the MBOCA-treated mice had significantly higher 8-OHdG levels than the control mice. This study confirms that MBOCA is potentially carcinogenic and highly toxic to both animals and humans.
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