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Search Results: 1 - 10 of 29804 matches for " Chia-Yi Kuan "
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The Study of Evaluation the Quality of the Mobile Experiential Learning Model  [PDF]
Ya-Chin Kang, Chia-Yi Chen
Creative Education (CE) , 2016, DOI: 10.4236/ce.2016.716236
Abstract: This study explores the learning behavior for the association of mobile learning and experiential learning. By performing on-site observation of the College Exploration Camp organized by the organization that is representative of youth experiential learning in Taiwan, a mobile experiential learning model is established. Suggestions for further research are also presented based on a survey of the camp leaders on the quality of their experience in order to evaluate the effectiveness of learning when combining mobile learning with experiential learning activities.
Synergy of Combined tPA-Edaravone Therapy in Experimental Thrombotic Stroke
Yu-Yo Sun, Yury M. Morozov, Dianer Yang, Yikun Li, R. Scott Dunn, Pasko Rakic, Pak H. Chan, Koji Abe, Diana M. Lindquist, Chia-Yi Kuan
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0098807
Abstract: Edaravone, a potent antioxidant, may improve thrombolytic therapy because it benefits ischemic stroke patients on its own and mitigates adverse effects of tissue plasminogen activator (tPA) in preclinical models. However, whether the combined tPA-edaravone therapy is more effective in reducing infarct size than singular treatment is uncertain. Here we investigated this issue using a transient hypoxia-ischemia (tHI)-induced thrombotic stroke model, in which adult C57BL/6 mice were subjected to reversible ligation of the unilateral common carotid artery plus inhalation of 7.5% oxygen for 30 min. While unilateral occlusion of the common carotid artery suppressed cerebral blood flow transiently, the addition of hypoxia triggered reperfusion deficits, endogenous thrombosis, and attenuated tPA activity, leading up to infarction. We compared the outcomes of vehicle-controls, edaravone treatment, tPA treatment at 0.5, 1, or 4 h post-tHI, and combined tPA-edaravone therapies with mortality rate and infarct size as the primary end-points. The best treatment was further compared with vehicle-controls in behavioral, biochemical, and diffusion tensor imaging (DTI) analyses. We found that application of tPA at 0.5 or 1 h – but not at 4 h post-tHI – significantly decreased infarct size and showed synergistic (p<0.05) or additive benefits with the adjuvant edaravone treatment, respectively. The acute tPA-edaravone treatment conferred >50% reduction of mortality, ~80% decline in infarct size, and strong white-matter protection. It also improved vascular reperfusion and decreased oxidative stress, inflammatory cytokines, and matrix metalloproteinase activities. In conclusion, edaravone synergizes with acute tPA treatment in experimental thrombotic stroke, suggesting that clinical application of the combined tPA-edaravone therapy merits investigation.
Creating high density ensembles of nitrogen-vacancy centers in nitrogen-rich type Ib nanodiamonds
Long-Jyun Su,Chia-Yi Fang,Yu-Tang Chang,Kuan-Ming Chen,Yueh-Chung Yu,Jui-Hung Hsu,Huan-Cheng Chang
Physics , 2013,
Abstract: This work explores the possibility of increasing the density of negatively charged nitrogen-vacancy centers [NV-] in nanodiamonds using nitrogen-rich type Ib diamond powders as the starting materials. The nanodiamonds (10 - 100 nm in diameters) were prepared by ball-milling of microdiamonds, in which the density of neutral and automatically dispersed nitrogen atoms [N0] was measured by diffuse reflectance infrared Fourier transform spectroscopy (DRIFT). A systematic measurement for the fluorescence intensities and lifetimes of the crushed monocrystalline diamonds as a function of [N0] indicated that the [NV-] increases nearly linearly with [N0] at 100 - 200 ppm. The trend, however, failed to continue for nanodiamonds with higher [N0] (up to 390 ppm) but poorer crystallinity. We attribute the result to a combined effect of fluorescence quenching as well as the lower conversion efficiency of vacancies to NV- due to the presence of more impurities and defects in these as-grown diamond crystallites. The principles and practice of fabricating brighter and smaller fluorescent nanodiamonds (FNDs) are discussed.
Cell Type-Specific Dependency on the PI3K/Akt Signaling Pathway for the Endogenous Epo and VEGF Induction by Baicalein in Neurons versus Astrocytes
Yu-Yo Sun, Shang-Hsuan Lin, Hung-Cheng Lin, Chia-Chi Hung, Chen-Yu Wang, Yen-Chu Lin, Kuo-Sheng Hung, Cheng-Chang Lien, Chia-Yi Kuan, Yi-Hsuan Lee
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0069019
Abstract: The neuroprotective effect of baicalein is generally attributed to inhibition of 12/15-lipoxygenase (12/15-LOX) and suppression of oxidative stress, but recent studies showed that baicalein also activates hypoxia-inducible factor-α (HIF1α) through inhibition of prolyl hydrolase 2 (PHD2) and activation of the phosphatidylinositide-3 kinase (PI3K)/Akt signaling pathway. Yet, the significance and regulation of prosurvival cytokines erythropoietin (Epo) and vascular endothelial growth factor (VEGF), two transcriptional targets of HIF1α, in baicalein-mediated neuroprotection in neurons and astrocytes remains unknown. Here we investigated the causal relationship between the PI3K/Akt signaling pathway and Epo/VEGF expression in baicalein-mediated neuroprotection in primary rat cortical neurons and astrocytes. Our results show that baicalein induced Epo and VEGF expression in a HIF1α- and PI3K/Akt-dependent manner in neurons. Baicalein also protected neurons against excitotoxicity in a PI3K- and Epo/VEGF-dependent manner without affecting neuronal excitability. In contrast, at least a 10-fold higher concentration of baicalein was needed to induce Epo/VEGF production and PI3K/Akt activity in astrocytes for protection of neurons. Moreover, only baicalein-induced astrocytic VEGF, but not Epo expression requires HIF1α, while PI3K/Akt signaling had little role in baicalein-induced astrocytic Epo/VEGF expression. These results suggest distinct mechanisms of baicalein-mediated Epo/VEGF production in neurons and astrocytes for neuroprotection, and provide new insights into the mechanisms and potential of baicalein in treating brain injury in vivo.
HOW TO ESTABLISH A SCALE THAT BEST FITS YOUR AGENDA: THE GUIDELINES TO BUILD AWEB SERVICE QUALITY SCALE
Chia-Chi Chang,Chia-Yi Chen,Yi-Hsuan Chiang
International Journal of Electronic Business Management , 2011,
Abstract: As the Web-based commerce booms rapidly, it is crucial for companies to develop comprehensive yet customized measurement of Website service quality in order to formulate their winning strategies. However, no single exiting scale can be globally effective to capture Websites service quality because service quality dimensions can differ according to the various characteristics of the websites. Therefore, managers and engineers need to cultivate their own abilities to develop a scale that can be more effectively evaluating service quality of their Websites. Accordingly, this article aims to provide guidelines for managers and/or engineers to adjust current measures or build new scales for Website service quality that best fits their agenda. This paper firstly discusses how to use literature review and focus group interview to identify possible dimensions of Website service quality. Next, item generation and selection techniques are introduced. Last, statistical methods for refining items and accessing reliability and validity of the scale are described. An example from previously published paper is also provided for readers’ reference.
Partnership disengagement from primary community care networks (PCCNs): A qualitative study for a national demonstration project
Chia-Yi Liau, Cheng-Chieh Lin, Yung-Kai Lin, Blossom Lin
BMC Health Services Research , 2010, DOI: 10.1186/1472-6963-10-87
Abstract: This study used a qualitative methodology with semi-structured questions for in-depth interviews. The semi-structured questions were pre-designed to explore the factors driving partnership disengagement. Thirty-seven clinic members who had withdrawn from their PCCNs were identified from the 2003-2005 Taiwan Primary Community Care Network Lists.Organization/participant factors (extra working time spend and facility competency), network factors (partner collaboration), and community factors (health policy design incompatibility, patient-physician relationship, and effectiveness) are reasons for clinic physicians to withdraw or change their partnerships within the PCCNs.To strengthen partnership relationships, several suggestions are made, including to establish clinic and hospital member relationships, and to reduce administrative work. In addition, both educating the public about the concept of family doctors and ensuring well-organized national health policies could help health care providers improve the integration processes.Regional or local health partnerships have been widely introduced around the world to improve health effectiveness from the perspectives of policy or provider strategy [1-6]. The presumed benefits of forming health networks are supporting expertise development, arranging referrals, coordinating programs, undertaking projects, sharing common interests, and providing mutual support for managing common conditions [7]. Many studies have explored how to run a health network more successfully. For example, it has been argued that sustainability is key to partnership success for community care network collaboration [8]. That includes sustaining the relationships, commitments, knowledge, capability, values, and trust, generated from partnerships, as well as sustaining funding, staff, programs, policy changes, and the partnership itself [9,10]. Human barriers have been identified as potential factors in network partnerships, among them user acceptance,
Aluminum overload increases oxidative stress in four functional brain areas of neonatal rats
Chia-Yi Yuan, Yih-Jing Lee, Guoo-Shyng Wang Hsu
Journal of Biomedical Science , 2012, DOI: 10.1186/1423-0127-19-51
Abstract: Postnatal day 3 (PND 3) rat pups (n =46) received intraperitoneal injection of aluminum chloride (AlCl3), at dosages of 0, 7, and 35 mg/kg body wt (control, low Al (LA), and high Al (HA), respectively), over 14 d.Aluminum concentrations were significantly higher in the hippocampus (751.0 ±?225.8 ng/g v.s. 294.9?± 180.8 ng/g; p < 0.05), diencephalon (79.6?± 20.7 ng/g v.s. 20.4?±?9.6 ng/g; p?<?0.05), and cerebellum (144.8?± 36.2 ng/g v.s. 83.1 ± 15.2 ng/g; p?<?0.05) in the HA group compared to the control. The hippocampus, diencephalon, cerebellum, and brain stem of HA animals displayed significantly higher levels of lipid peroxidative products (TBARS) than the same regions in the controls. However, the average superoxide dismutase (SOD) activities in the cerebral cortex, hippocampus, cerebellum, and brain stem were lower in the HA group compared to the control. The HA animals demonstrated increased catalase activity in the diencephalon, and increased glutathione peroxidase (GPx) activity in the cerebral cortex, hippocampus, cerebellum, and brain stem, compared to controls.Aluminum overload increases oxidative stress (H2O2) in the hippocampus, diencephalon, cerebellum, and brain stem in neonatal rats.
Aluminum alters NMDA receptor 1A and 2A/B expression on neonatal hippocampal neurons in rats
Chia-Yi Yuan, Guoo-Shyng Hsu, Yih-Jing Lee
Journal of Biomedical Science , 2011, DOI: 10.1186/1423-0127-18-81
Abstract: Utilizing a cultured neuron cells in vitro model, we have assessed Al influence on neuronal specific gene expression alteration by immunoblot and immunohistochemistry and neural proliferation rate changes by MTT assay.Microscopic images showed that the neurite outgrowth of hippocampal neurons increased along with the Al dosages (37, 74 μM Al (AlCl3)). MTT results also indicated that Al increased neural cell viability. On the other hand, the immunocytochemistry staining suggested that the protein expressions of NMDAR 1A and NMDAR 2A/B decreased with the Al dosages (p < 0.05).Treated hippocampal neurons with 37 and 74 μM of Al for 14 days increased neural cell viability, but hampered NMDAR 1A and NMDAR 2A/B expressions. It was suggested that Al exposure might alter the development of hippocampal neurons in neonatal rats.Aluminum (Al) is the second most abundant mineral in the soil, and it is also the major component of many legal food additives [1]. Al toxicities have been reported in renal disease patient with dialysis, due to high aluminum content in the dialysate and/or ingestion of Al-containing phosphate binder [2], resulting in microcytic hypochromic anemia, dialysis osteomalacia and dialysis encephalopathy [3]. The Al-content in the brain of person with Alzheimer's disease (AD) was reported to be higher than the age-matched non-AD elderly [4], although there are certain number of other reports disagreed with it [5,6]. Al over-loading has also been demonstrated in premature infants receiving intravenous fluid therapy [7]. These observations may imply that Al toxicity had a higher incidence in the population with kidney malfunction or immature kidney, such as nephropathy patients or in neonates. Although the absorption of Al in the gastrointestinal tract is less than 0.3%, and absorbed Al is mostly excreted through kidney in healthy individuals [8], the toxicity of dietary Al has raised concerns under certain patho-physiological, or even healthy conditions.The ne
Understanding Medical Physicians’ Knowledge Sharing: The Social Cognition Perspective
Feng-Yang Kuo,Fan-Chuan Tseng,Chia-Yi Liu
Journal of Library and Information Studies , 2006,
Abstract: The continuous progress in acquiring professional knowledge for medical professionals is considered as a critical successful factor in the health industry. Based on the Social Cognitive Theory, this study explores the reciprocal interactions of the environment, the medical physicians, and their practices to understand the factors that may impact the physicians’ knowledge sharing activities. Our findings reveal that physicians’ knowledge sharing may be impeded by the environmental factors such as the hospital’s incentive system, the requirement for research and publications, and the uncertaintyof medical practices. In addition, personal factors such as social efficacy and self-regulatory capability are critical to physicians’ level of willingness to share their expertise. We conclude that the complexity of medical environment requires various knowledge sharing channels for successful knowledge sharing among physicians. We further suggest that the design of information technology-basedknowledge management systems in the medical domain incorporate relevant personal, behavioral and environmental factors to facilitate effective knowledge sharing among physicians. [Article content in Chinese]
AKT/mTOR as Novel Targets of Polyphenol Piceatannol Possibly Contributing to Inhibition of Proliferation of Cultured Prostate Cancer Cells
Tze-Chen Hsieh,Chia-Yi Lin,Hung-Yun Lin,Joseph M. Wu
ISRN Urology , 2012, DOI: 10.5402/2012/272697
Abstract:
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