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Search Results: 1 - 10 of 14165 matches for " Chi-Dug Kang "
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TRAIL sensitize MDR cells to MDR-related drugs by down-regulation of P-glycoprotein through inhibition of DNA-PKcs/Akt/GSK-3β pathway and activation of caspases
Suk-Bin Seo, Jung-Gu Hur, Mi-Ju Kim, Jae-Won Lee, Hak-Bong Kim, Jae-Ho Bae, Dong-Wan Kim, Chi-Dug Kang, Sun-Hee Kim
Molecular Cancer , 2010, DOI: 10.1186/1476-4598-9-199
Abstract: MDR variants, CEM/VLB10-2, CEM/VLB55-8 and CEM/VLB100 cells, with gradually increased levels of P-gp derived from human lymphoblastic leukemia CEM cells, were gradually more susceptible to TRAIL-induced apoptosis and cytotoxicity than parental CEM cells. The P-gp level of MDR variants was positively correlated with the levels of DNA-PKcs, pAkt, pGSK-3β and c-Myc as well as DR5 and negatively correlated with the level of c-FLIPs. Hypersensitivity of CEM/VLB100 cells to TRAIL was accompanied by the activation of mitochondrial apoptotic pathway as well as the activation of initiator caspases. In addition, TRAIL-induced down-regulation of DNA-PKcs/Akt/GSK-3β pathway and c-FLIP and up-regulation of cell surface expression of death receptors were associated with the increased susceptibility to TRAIL of MDR cells. Moreover, TRAIL inhibited P-gp efflux function via caspase-3-dependent degradation of P-gp as well as DNA-PKcs and subsequently sensitized MDR cells to MDR-related drugs such as vinblastine and doxorubicin. We also found that suppression of DNA-PKcs by siRNA enhanced the susceptibility of MDR cells to vincristine as well as TRAIL via down-regulation of c-FLIP and P-gp expression and up-regulation of DR5.This study showed for the first time that the MDR variant of CEM cells was hypersensitive to TRAIL due to up-regulation of DR5 and concomitant down-regulation of c-FLIP, and degradation of P-gp and DNA-PKcs by activation of caspase-3 might be important determinants of TRAIL-induced sensitization of MDR cells to MDR-related drugs. Therefore, combination of TRAIL and chemotherapeutic drugs may be a good strategy for treatment of cancer with multidrug resistance.Acquired resistance to chemotherapeutic agents remains a major obstacle for the effective treatment of many advanced and metastatic cancers. Several mechanisms are thought to be involved in the development of multidrug resistance (MDR), defined by simultaneous cross-resistance to a variety of anticancer drugs
High susceptibility of metastatic cells derived from human prostate and colon cancer cells to TRAIL and sensitization of TRAIL-insensitive primary cells to TRAIL by 4,5-dimethoxy-2-nitrobenzaldehyde
Hak-Bong Kim, Mi-Ju Kim, Dae-Young Kim, Jae-Won Lee, Jae-Ho Bae, Dong-Wan Kim, Chi-Dug Kang, Sun-Hee Kim
Molecular Cancer , 2011, DOI: 10.1186/1476-4598-10-46
Abstract: PC3-MM2 and KM12L4A cells with high level of c-Myc and DNA-PKcs were more susceptible to TRAIL than their poorly metastatic primary PC3 and KM12 cells, which was associated with down-regulation of c-FLIPL/S and Mcl-1 and up-regulation of the TRAIL receptor DR5 but not DR4 in both metastatic cells. Moreover, high susceptibility of these metastatic cells to TRAIL was resulted from TRAIL-induced potent activation of caspase-8, -9, and -3 in comparison with their primary cells, which led to cleavage and down-regulation of DNA-PKcs. Knockdown of c-Myc gene in TRAIL-treated PC3-MM2 cells prevented the increase of DR5 cell surface expression, caspase activation and DNA-PKcs cleavage and attenuated the apoptotic effects of TRAIL. Moreover, the suppression of DNA-PKcs level with siRNA in the cells induced the up-regulation of DR5 and active caspase-8, -9, and -3. We also found that 4,5-dimethoxy-2-nitrobenzaldehyde (DMNB), a specific inhibitor of DNA-PK, potentiated TRAIL-induced cytotoxicity and apoptosis in relatively TRAIL-insensitive PC3 and KM12 cells and therefore functioned as a TRAIL sensitizer.This study showed the positive relationship between c-Myc expression in highly metastatic human prostate and colon cancer cells and susceptibility to TRAIL-induced apoptosis and therefore indicated that TRAIL might be used as an effective therapeutic modality for advanced metastatic cancers overexpressing c-Myc and combination of TRAIL therapy with agent that inhibits the DNA-PKcs/Akt signaling pathway might be clinically useful for the treatment of relatively TRAIL-insensitive human cancers.Despite the improvement of therapeutic strategies against cancer, the acquisition of invasive/metastatic capabilities and the development of resistance to therapy in cancer cells are still critical problems for successful cancer therapy because recurrent or metastatic cancers that appear after the initial radiotherapy or chemotherapy are generally refractory to secondary therapies [1]. Som
Fabrication of Stable Cartilage Framework for Microtia in Incomplete Synchondrosis
Byung Chae Cho,Jung Hun Lee,Kang Young Choi,Jung Dug Yang
Archives of Plastic Surgery , 2012, DOI: http://dx.doi.org/10.5999/aps.2012.39.2.162
Abstract: The synchondrosis between the sixth and seventh costal cartilage is usually used for thebase frame in autogenous ear reconstruction. If the synchondrosis is loose, a variety ofmodifications can be devised. This report introduces new methods for these problems. Incases of incomplete synchondrosis, only the surface of the base block margin was smoothlytapered without carving for the removal of the conchal deepening. The secure fixation ofthe two segments (helix and antihelix) to the base block using fine wire sutures gave stabilityto the unstable basal frame. After confirming that all the segments were assembled in onestable piece, the remaining conchal deepening of the basal framework was removed, and theouter lower portion of the basal cartilage was trimmed along its whole length. A total of 10consecutive patients with microtia, ranging from 8 to 13 years old, were treated from 2008 to2009. The follow-up period was 6 months to 2 years. Despite incomplete synchondrosis, thestable frameworks were constructed using the authors’ method and aesthetically acceptableresults were achieved. The proposed method can provide an easy way to make a stablecartilage framework regardless of the variable conditions of synchondrosis.
Current Concepts in the Mandibular Condyle Fracture Management Part I: Overview of Condylar Fracture
Kang-Young Choi,Jung-Dug Yang,Ho-Yun Chung,Byung-Chae Cho
Archives of Plastic Surgery , 2012, DOI: http://dx.doi.org/10.5999/aps.2012.39.4.291
Abstract: The incidence of condylar fractures is high,but the management of fractures of the mandibularcondyle continues to be controversial. Historically, maxillomandibular fixation, externalfixation, and surgical splints with internal fixation systems were the techniques commonlyused in the treatment of the fractured mandible. Condylar fractures can be extracapsularor intracapsular, undisplaced, deviated, displaced, or dislocated. Treatment depends on theage of the patient, the co-existence of other mandibular or maxillary fractures, whether thecondylar fracture is unilateral or bilateral, the level and displacement of the fracture, thestate of dentition and dental occlusion, and the surgeonnds on the age of the patient, theco-existence of othefrom which it is difficult to recover aesthetically and functionally;anappropriate treatment is required to reconstruct the shape and achieve the function oftheuninjured status. To do this, accurate diagnosis, appropriate reduction and rigid fixation, andcomplication prevention are required. In particular, as mandibular condyle fracture may causelong-term complications such as malocclusion, particularly open bite, reduced posterior facialheight, and facial asymmetry in addition to chronic pain and mobility limitation, great cautionshould be taken. Accordingly, the authors review a general overview of condyle fracture.
Current Concepts in the Mandibular Condyle Fracture Management Part II: Open Reduction Versus Closed Reduction
Kang-Young Choi,Jung-Dug Yang,Ho-Yun Chung,Byung-Chae Cho
Archives of Plastic Surgery , 2012, DOI: http://dx.doi.org/10.5999/aps.2012.39.4.301
Abstract: In the treatment of mandibular condyle fracture, conservative treatment using closedreduction or surgical treatment using open reduction can be used. Management of mandibularcondylar fractures remains a source of ongoing controversy in oral and maxillofacial trauma.For each type of condylar fracture,the treatment method must be chosen taking intoconsideration the presence of teeth, fracture height, patient’sadaptation, patient’s masticatorysystem, disturbance of occlusal function, and deviation of the mandible. In the past, closedreduction with concomitant active physical therapy conducted after intermaxillary fixationduring the recovery period had been mainly used, but in recent years, open treatment ofcondylar fractures with rigid internal fixation has become more common. The objectiveof this review was to evaluate the main variables that determine the choice of an open orclosed method for treatment of condylar fractures, identifying their indications, advantages,and disadvantages, and to appraise the current evidence regarding the effectiveness ofinterventions that are used in the management of fractures of the mandibular condyle.
The Correction of a Secondary Bilateral Cleft Lip Nasal Deformity Using Refined Open Rhinoplasty with Reverse-U Incision, V-Y Plasty, and Selective Combination with Composite Grafting: Long-term Results
Byung Chae Cho,Kang Young Choi,Jung Hun Lee,Jung Dug Yang
Archives of Plastic Surgery , 2012, DOI: http://dx.doi.org/10.5999/aps.2012.39.3.190
Abstract: Background This article presents long-term outcomes after correcting secondary bilateralcleft lip nasal deformities using a refined reverse-U incision and V-Y plasty or in combinationwith a composite graft in order to elongate the short columella.Methods A total of forty-six patients underwent surgery between September 1996 andDecember 2008. The age of the patients ranged from 3 to 19 years of age. A bilateral reverse-Uincision and V-Y plasty were used in 24 patients. A composite graft from the helical rootwas combined with a bilateral reverse-U incision in the 22 patients who possessed a severelyshortened columella. The follow-up period ranged between 2 and 10 years.Results A total of 32 patients out of 46 were evaluated postoperatively. The average columellalength was significantly improved from an average of 3.7 mm preoperatively to 8.5 mmpostoperatively. The average ratio of the columella height to the alar base width was 0.18preoperatively and 0.29 postoperatively. The postoperative basal and lateral views revealed abetter shape of the nostrils and columella. The elongated columella, combined with a compositegraft, presented good maintenance of the corrected position with no growth disturbance. Acomposite graft showed color mismatching in several patients. Twenty-six patients demonstratedno alar-columella web deformity and satisfactory symmetry of the nostrils. Four patientsexperienced a drooping and overhanging of the corrected alar-columella web.Conclusions A bilateral reverse-U incision with V-Y plasty or in combination with acomposite graft was effective in correcting secondary bilateral cleft lip nasal deformity.
Iterative solutions of nonlinear equations with Φ-strongly accretive operators
Shin Min Kang, Chi Feng, Zeqing Liu
ACTA MATHEMATICA UNIVERSITATIS COMENIANAE , 2008,
Abstract: . Suppose that X, is an arbitrary real Banach space and T X X is a Lipschitz continuous
Iterative Solutions of Nonlinear Equations with Φ-strongly Accretive Operators
Shin Min Kang,Chi Feng,Zeqing Liu
ACTA MATHEMATICA UNIVERSITATIS COMENIANAE , 2008,
Abstract: Suppose that X, is an arbitrary real Banach space and T : X X is a Lipschitz continuous f-strongly accretive operator or uniformly continuous f-strongly accretive operator. We prove that under different conditions the three-step iteration methods with errors converge strongly to the solution ofthe equation Tx = f for a given f X.
Vector Map Management in the MicroStation CAD System
Dugá?ek Du?an
Acta Montanistica Slovaca , 1999,
Abstract: Due to needs for the management of digital vector maps was created the Vector Manager application. This application increases possibilities and utilization of the basic core of MicroStation CAD System. The article shortly describes that part of internal graphic envi-ronment of the MicroStation, which is closely connected to the vector data management. In this context are introduced practical reasons formed arising of the application. The paper explained a way, how the application manages maps in the S-JTSK coordinate system. Vector Manager can be used as a supporting application for small GIS tasks.
CAD and GIS in the graphic environment of MicroStation
Dugá?ek Du?an,Orlitová Erika
Acta Montanistica Slovaca , 1998,
Abstract: The article introduces the CAD and GIS systems and graphical environment MicroStation, as a software base. Some important systems moduls by Benley Corporation and complemen-tary moduls created in MDL language at our department are described.
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