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Search Results: 1 - 10 of 80804 matches for " Chenxing Liu "
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MirSNP, a database of polymorphisms altering miRNA target sites, identifies miRNA-related SNPs in GWAS SNPs and eQTLs
Liu Chenxing,Zhang Fuquan,Li Tingting,Lu Ming
BMC Genomics , 2012, DOI: 10.1186/1471-2164-13-661
Abstract: Background Numerous single nucleotide polymorphisms (SNPs) associated with complex diseases have been identified by genome-wide association studies (GWAS) and expression quantitative trait loci (eQTLs) studies. However, few of these SNPs have explicit biological functions. Recent studies indicated that the SNPs within the 3’UTR regions of susceptibility genes could affect complex traits/diseases by affecting the function of miRNAs. These 3’UTR SNPs are functional candidates and therefore of interest to GWAS and eQTL researchers. Description We developed a publicly available online database, MirSNP (http://cmbi.bjmu.edu.cn/mirsnp), which is a collection of human SNPs in predicted miRNA-mRNA binding sites. We identified 414,510 SNPs that might affect miRNA-mRNA binding. Annotations were added to these SNPs to predict whether a SNP within the target site would decrease/break or enhance/create an miRNA-mRNA binding site. By applying MirSNP database to three brain eQTL data sets, we identified four unreported SNPs (rs3087822, rs13042, rs1058381, and rs1058398), which might affect miRNA binding and thus affect the expression of their host genes in the brain. We also applied the MirSNP database to our GWAS for schizophrenia: seven predicted miRNA-related SNPs (p < 0.0001) were found in the schizophrenia GWAS. Our findings identified the possible functions of these SNP loci, and provide the basis for subsequent functional research. Conclusion MirSNP could identify the putative miRNA-related SNPs from GWAS and eQTLs researches and provide the direction for subsequent functional researches.
Existence and uniqueness of positive solutions to higher-order nonlinear fractional differential equation with integral boundary conditions
Chenxing Zhou
Electronic Journal of Differential Equations , 2012,
Abstract: In this article, we consider the nonlinear fractional order three-point boundary-value problem $$displaylines{ D_{0+}^{alpha} u(t) + f(t,u(t))=0, quad 0 < t < 1,cr u(0) = u'(0) = dots = u^{(n-2)}(0)=0, quad u^{(n-2)}(1) = int_0^eta u(s)ds, }$$ where $D_{0+}^{alpha}$ is the standard Riemann-Liouville fractional derivative, $n-1 < alpha leq n$, $n geq 3$. By using a fixed-point theorem in partially ordered sets, we obtain sufficient conditions for the existence and uniqueness of positive and nondecreasing solutions to the above boundary value problem.
Sequencing ASMT Identifies Rare Mutations in Chinese Han Patients with Autism
Lifang Wang, Jun Li, Yanyan Ruan, Tianlan Lu, Chenxing Liu, Meixiang Jia, Weihua Yue, Jing Liu, Thomas Bourgeron, Dai Zhang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0053727
Abstract: Melatonin is involved in the regulation of circadian and seasonal rhythms and immune function. Prior research reported low melatonin levels in autism spectrum disorders (ASD). ASMT located in pseudo-autosomal region 1 encodes the last enzyme of the melatonin biosynthesis pathway. A previous study reported an association between ASD and single nucleotide polymorphisms (SNPs) rs4446909 and rs5989681 located in the promoter of ASMT. Furthermore, rare deleterious mutations were identified in a subset of patients. To investigate the association between ASMT and autism, we sequenced all ASMT exons and its neighboring region in 398 Chinese Han individuals with autism and 437 healthy controls. Although our study did not detect significant differences of genotypic distribution and allele frequencies of the common SNPs in ASMT between patients with autism and healthy controls, we identified new rare coding mutations of ASMT. Among these rare variants, 4 were exclusively detected in patients with autism including a stop mutation (p.R115W, p.V166I, p.V179G, and p.W257X). These four coding variants were observed in 6 of 398 (1.51%) patients with autism and none in 437 controls (Chi-Square test, Continuity Correction p = 0.032, two-sided). Functional prediction of impact of amino acid showed that p.R115W might affect protein function. These results indicate that ASMT might be a susceptibility gene for autism. Further studies in larger samples are needed to better understand the degree of variation in this gene as well as to understand the biochemical and clinical impacts of ASMT/melatonin deficiency.

WANG Zheng,REN Chenxing and WANG Suying
金属学报(英文版) , 1996,
A Two-Stage Association Study Suggests BRAP as a Susceptibility Gene for Schizophrenia
Fuquan Zhang, Chenxing Liu, Yong Xu, Guoyang Qi, Guozhen Yuan, Zaohuo Cheng, Jidong Wang, Guoqiang Wang, Zhiqiang Wang, Wei Zhu, Zhenhe Zhou, Xingfu Zhao, Lin Tian, Chunhui Jin, Janmin Yuan, Guofu Zhang, Yaguang Chen, Lifang Wang, Tianlan Lu, Hao Yan, Yanyan Ruan, Weihua Yue, Dai Zhang
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0086037
Abstract: Schizophrenia (SZ) is a neurodevelopmental disorder in which altered immune function typically plays an important role in mediating the effect of environmental insults and regulation of inflammation. The breast cancer suppressor protein associated protein (BRAP) is suggested to exert vital effects in neurodevelopment by modulating the mitogen-activated protein kinase cascade and inflammation signaling. To explore the possible role of BRAP in SZ, we conducted a two-stage study to examine the association of BRAP polymorphisms with SZ in the Han Chinese population. In stage one, we screened SNPs in BRAP from our GWAS data, which detected three associated SNPs, with rs3782886 being the most significant one (P = 2.31E-6, OR = 0.67). In stage two, we validated these three SNPs in an independently collected population including 1957 patients and 1509 controls, supporting the association of rs3782886 with SZ (P = 1.43E-6, OR = 0.73). Furthermore, cis-eQTL analysis indicates that rs3782886 genotypes are associated with mRNA levels of aldehyde dehydrogenase 2 family (ALDH2) (P = 0.0039) and myosin regulatory light chain 2 (MYL2) (P < 1.0E-4). Our data suggest that the BRAP gene may confer vulnerability for SZ in Han Chinese population, adding further evidence for the involvement of developmental and/or neuroinflammatory cascades in the illness.
Skin Friction Coefficients of Swimming Cloths

Li Chenxing,Yan Dachun Beijing University,

实验力学 , 1989,
Abstract: Local skin friction coefficients of several swimming cloths are measured by a two-component laser-Doppler velocimetric system in a comparative experiment.As the surface of cloths are very rough and flexiable,the skin friction has to be estimated from the layer with logarithmic velocity distribution.Results indicate that the differences between skin frictions of different cloths approach to 90% and the cloths made in Dalian with one-directional exansibility is the best for swimming dressing.
Study of Runoff Simulation Considering Effect of Human Activity on the Loess Plateau
黄土区人类活动影响下的 产汇流模拟研究

CHI Chenxing,Hao Zhenchun,WANG Ling,Hu Jianwei,
,郝振纯,王 玲,胡健伟

地理科学进展 , 2005,
Abstract: Human activity has great effect on runoff producing and conflux for basins and can not be neglected, especially for the day-scale hydrology modeling. Because of the special human activity on the Loess Plateau, the Yellow River's runoff has been decreasing from 1960's. Because of the complex land surface condition, the relationship of rain-off and runoff is very anomaly. Runoff is hard to be modeled by uniform experience formula. And what' s more, when the land surface condition changes, the experience formula loses its validity. Based on distributed hydrologic model, a grid-based lag-and-storage method, with consideration of the effect of human activity, is in detail shown, taking Chabagou (a typical watershed on the loess plateau) as an example. The digital terrain parameters are extracted from DEM(digital elevation model) with resolution of 950mx950m. The location of dams and reservoirs et al are distributed on the grids with their real location on the watershed in mind. The model also uses the mix-runoff-producing method, which considers the variation of runoff-producing area. The modeling results show the feasibility of this method. Model using the gird-based lag-and-storage method can consider the land change on grid-scale and reflect the condition of every periods, so it would make reasonable response to rain-off. With the effect of human activity on runoff brought into the distributed hydrologic model, the nature law of watershed and the effect of human activity on runoff can be deeply understood.
Study on immobilizing of lubricating oil-degradation strains FZ5 by magnetic carriers

She Chenxing,Wu Zhicheng,Ma Xiuling,Chen Sheng,

环境工程学报 , 2008,
Abstract: 利用聚乙烯醇-海藻酸钠-磁性竹炭复合制备磁性悬浮小球,该小球的磁矫顽力为28.6 mT,具有较强的磁场,可用于磁场引导分离。利用磁性悬浮小球作为载体对机油降解菌FZ5进行固定化,研究了固定化时间、降解时间、固定化小球投加量、初始pH值和初始机油浓度对机油降油率的影响。结果表明,在固定化挂膜3 d,固定化小球投加量为8%,初始pH值为7,初始机油浓度为400 mg/L,降解培养3 d后对机油的降解率可达91.21%。
The Model of Mobile Knowledge Services System in the Management of Complex Cluster Project  [PDF]
Yong Liu, Bingxin Liu
iBusiness (IB) , 2011, DOI: 10.4236/ib.2011.31006
Abstract: Cluster projects are projects of large-scale or with huge investment, such as Beijing 2008 Olympic Games and Shanghai 2010 Expo. A lot of on-site management works are involved in the process of cluster project management, especially the treatment of sudden accidents which would produce plenty of knowledge and experience. As cluster project on-site management spots change frequently, knowledge produced by mobile workers in the process of on-site management is hard to be saved into the knowledge repository on time. It may cause a knowledge distortion or even missing. On the other hand, in the process of cluster project management, a lot of knowledge is required by on-site workers to deal with on-site activities. However, due to lack of effective mechanisms for knowledge communion, they often face the risk of making wrong decisions. To solve the problems of knowledge management and acquisition in the process of cluster project on-site management, this paper presents a system model for mobile knowledge service.
The Collusion Deterrence with Prisoner’s Dilemma  [PDF]
Aidong Liu, Jinfang Liu
Journal of Service Science and Management (JSSM) , 2010, DOI: 10.4236/jssm.2010.34053
Abstract: I tried to present a new method to prevent collusion through employing two auditors at the same time and inspiring them provide true report by exploiting their prisoner’s dilemma. But I found this method cannot be put into practice because of the high cost. So I analyzed whether sending the second auditor in a probability, a low cost method, can deter the audit collusion. I find sending the second auditor in a probability, enforcing the rigidly lawful punishment and perfecting the reward mechanism can prevent audit collusion. I also find the auditor’s ethical constraint do good to prevent collusion and the charger of state assets management can play the same role as the real owner of the state-owned enterprise in deterring collusion. This finding provides theory support for the government to implement the publicly audit bidding and random double auditing system on state-owned enterprise. The supervision of PCAOB on auditors is also the operation of this theory.
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