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Search Results: 1 - 10 of 39961 matches for " Cheng-xiong Gu "
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Off-pump coronary artery bypass grafting using a bilateral internal mammary artery Y graft
Cheng-Xiong Gu,Jun-Feng Yang,Hong-Chao Zhang,Hua Wei
老年心脏病学杂志(英文版) , 2012,
Abstract: ObjectiveTo evaluate the outcome of off-pump coronary artery bypass grafting (OPCABG) using a bilateral internal mammary artery (BIMA) Y configuration graft to achieve total arterial myocardial revascularization. Methods From October 2002 to December 2008, 208 patients (196 males and 12 females) underwent OPCABG using a BIMA Y configuration graft. The average age of the patients was 56.5 ± 11.3 years, with an age range of 33–78 years. A total of 167 (80.2%) cases had triple-vessel disease. Left main stem disease was found in 33 (15.9%) cases, and double-vessel disease was found in 8 (3.9%) cases. The semi-skeletonization technique was used to harvest the two internal mammary arteries (IMAs), and then the free right internal mammary artery was connected end-to-side to the left internal mammary artery (LIMA) in situ to complete the Y configuration graft. Off-pump and sequential anastomosis methods were used to perform coronary artery bypass surgery in all patients. Graft patency was assessed intra-operatively with the HT311 transit time flowmeter. Results A total of 728 distal anastomoses were performed in 208 patients, with the average being 3.5 ± 1.3 per person. No one died or experienced recurrent angina within 30 days after the operation. Conclusions OPCABG using the BIMA Y graft was safe and effective to achieve total arterial revascularization. This method avoids surgical operation on the ascending aorta and other incisions.
Outcomes of Middle Cardiac Vein Arterialization via Internal Mammary/Thoracic Artery Anastomosis
Yang Yu, Hai-tao Li, Ming-xin Gao, Fan Zhang, Cheng-xiong Gu
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0080963
Abstract: Objective Cardiac vein arterialization is seldom applied for treating right coronary artery disease. This study aimed to improve outcomes of cardiac vein arterialization in a porcine model using intramammary artery anastomosis. Methods A chronic, stenotic coronary artery model was established in 12 of 14 Chinese experimental miniature pigs of either sex, which were randomly divided into equal control (n = 6) and experimental (n = 6) groups. In experimental animals, blood flow was reconstructed in the right coronary artery using intramammary artery. Arterialization involved dissection of right internal mammary artery from bifurcation to apex of thorax followed by end-to-side anastomosis of internal mammary artery and middle cardiac vein plus posterior descending branch of right coronary artery. Intraoperative heart rate was maintained at 110 beats/min. Graft flow assessment and echocardiography were performed when blood pressure and heart rate normalized. Results The experimental group had significantly higher mean endocardial and epicardial blood flow postoperatively than control group (mean endocardial blood flow: 0.37 vs. 0.14 ml/(g*min), p<0.001; mean epicardial blood flow: 0.29 vs. 0.22, p = 0.014). Transmural blood flow was also higher in experimental group than in control group (0.33 vs. 0.19, p<0.001); ejection fraction increased from 0.46% at baseline to 0.51% (p = 0.0038) at 6 hours postoperatively, and mean blood flow of internal mammary artery was 44.50, perfusion index 0.73 at postoperative 6 months, 43.33 and 0.80 at 3 months. Conclusion Successful cardiac vein arterialization via intramammary artery in a porcine model suggests that this may be a viable method for reconstructing blood flow in chronic, severe coronary artery disease.
Off-pump coronary artery bypass grafting using a bilateral internal mammary artery Y graft

Cheng-Xiong Gu,Jun-Feng Yang,Hong-Chao Zhang,Hua Wei,Ling-Ke Li,

老年心脏病学杂志(英文版) , 2012,
Harmonic Propagation and Interaction Evaluation between Small-Scale Wind Farms and Nonlinear Loads
Guang-Long Xie,Bu-Han Zhang,Yan Li,Cheng-Xiong Mao
Energies , 2013, DOI: 10.3390/en6073297
Abstract: Distributed generation is a flexible and effective way to utilize renewable energy. The dispersed generators are quite close to the load, and pose some power quality problems such as harmonic current emissions. This paper focuses on the harmonic propagation and interaction between a small-scale wind farm and nonlinear loads in the distribution grid. Firstly, by setting the wind turbines as P – Q( V) nodes, the paper discusses the expanding Newton-Raphson power flow method for the wind farm. Then the generalized gamma mixture models are proposed to study the non-characteristic harmonic propagation of the wind farm, which are based on Gaussian mixture models, improved phasor clustering and generalized Gamma models. After the integration of the small-scale wind farm, harmonic emissions of nonlinear loads will become random and fluctuating due to the non-stationary wind power. Furthermore, in this paper the harmonic coupled admittance matrix model of nonlinear loads combined with a wind farm is deduced by rigorous formulas. Then the harmonic propagation and interaction between a real wind farm and nonlinear loads are analyzed by the harmonic coupled admittance matrix and generalized gamma mixture models. Finally, the proposed models and methods are verified through the corresponding simulation models in MATLAB/SIMULINK and PSCAD/EMTDC.
The Combination of RAD001 and NVP-BEZ235 Exerts Synergistic Anticancer Activity against Non-Small Cell Lung Cancer In Vitro and In Vivo
Cheng-Xiong Xu,Yikun Li,Ping Yue,Taofeek K. Owonikoko,Suresh S. Ramalingam,Fadlo R. Khuri,Shi-Yong Sun
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0020899
Abstract: The phosphoinositide 3-kinase (PI3K)-mammalian target of rapamycin (mTOR) signaling axis has emerged as a novel target for cancer therapy. Agents that inhibit PI3K, mTOR or both are currently under development. The mTOR allosteric inhibitor, RAD001, and the PI3K/mTOR dual kinase inhibitor, BEZ235, are examples of these agents. We were interested in developing strategies to enhance mTOR-targeted caner therapy. In this study, we found that BEZ235 alone effectively inhibited the growth of rapamycin-resistant cancer cells. Interestingly, the combination of sub-optimal concentrations of RAD001 and BEZ235 exerted synergistic inhibition of the growth of human lung cancer cells along with induction of apoptosis and G1 arrest. Furthermore, the combination was also more effective than either agent alone in inhibiting the growth of lung cancer xenografts in mice. The combination showed enhanced effects on inhibiting mTOR signaling and reducing the expression of c-Myc and cyclin D1. Taken together, our results suggest that the combination of RAD001 and BEZ235 is a novel strategy for cancer therapy.
Familial tumoral calcinosis in two Chinese patients: a case series
Che Zhang, Jiaowei Gu, Xiaoli Cheng, Kui Xiong
Journal of Medical Case Reports , 2011, DOI: 10.1186/1752-1947-5-394
Abstract: Familial tumoral calcinosis was present in two members of a Han Chinese family, namely, the son and daughter. The 14-year-old son had the first operation on his right sole of the foot at the age of six, and then experienced subsequent surgeries at a lesion in his right sole of the foot and left hip, respectively. The 16-year-old daughter underwent her first operation at the age of six in her left gluteal region, and subsequent surgeries were performed due to recurrence at the same lesion. Pathologic diagnoses of surgical specimens in both of the patients were reported as tumoral calcinosis. The laboratory results showed hyperphosphatemia with normal levels of serum calcium and alkaline phosphatase. Only surgical treatment was performed in both patients with satisfactory prognosis.This is the first report of Chinese familial tumoral calcinosis. The etiopathogenisis and treatment are discussed.Tumoral calcinosis (TC) was first described by Inclan [1] in 1943 as slow growing, progressive masses usually found adjacent to large joints such as hips, shoulders and elbows. The masses are hard and painless. Recurrence tends to be observed at the same location subsequent to inadequate resection. Further identification is based on the pathogenesis. We describe the first two cases of familial TC in Chinese siblings, and present their clinical and pathological features.A 14-year-old Han Chinese boy presented with an eight-year history of TC. He first noticed a painful mass on the bottom of his right foot at the age of six, and mass resection was performed. Then an operation was conducted for a mass that developed on the bottom of his left foot at the age of eight. A mass first occurred on his left hip at the age of 12. This mass excised and diagnosed on pathology as a tendon calcification tumor. After that, a recurrent mass on his lateral left hip was observed. On physical examination, the mass was firm, sessile, with a clear edge and normal skin temperature, and measured 4 × 5
Rhein Reduces Fat Weight in db/db Mouse and Prevents Diet-Induced Obesity in C57Bl/6 Mouse through the Inhibition of PPARγ Signaling
Yu Zhang,Shengjie Fan,Na Hu,Ming Gu,Chunxiao Chu,Yiming Li,Xiong Lu,Cheng Huang
PPAR Research , 2012, DOI: 10.1155/2012/374936
Abstract: Rheum palmatum has been used most frequently in the weight-reducing formulae in traditional Chinese medicine. However, the components of Rheum palmatum that play the antiobesity role are still uncertain. Here, we tested the weight-reducing effect of two major Rheum palmatum compounds on mouse. We found that rhein (100?mg kg?1?day?1), but not emodin, reduced the fat weight in mouse. Using diet-induced obese (DIO) C57BL/6 mice, we identified that rhein blocked high-fat diet-induced obesity, decreased fat mass and the size of white and brown adipocytes, and lowered serum cholesterol, LDL cholesterol, and fasting blood glucose levels in the mice. To elucidate the underlying mechanisms, we used reporter assay and gene expression analysis and found that rhein inhibited peroxisome proliferator-activated receptor γ (PPARγ) transactivity and the expression of its target genes, suggesting that rhein may act as a PPARγ antagonist. Our data indicate that rhein may be a promising choice for antiobesity therapy. 1. Introduction Obesity is one of the most serious public health problems of the 21st century [1, 2]. It increases the risk of various fetal diseases, particularly coronary artery disease, type II diabetes, hypertension, dyslipidemia, and certain types of cancer [3–5]. At present, there is only one drug, orlistat, approved by the Food and Drug Administration (FDA) for long-term use in the treatment of obesity. Thus, it is urgent to develop a new therapy for the prevention and treatment of obesity [5]. The development of novel antiobesity drugs has been proven difficult because of side-effects and lower efficiency [6–9]. Traditional medicine has various herbs for weight-reducing practice and may be a potential source for novel antiobesity drugs. Rheum palmatum is used most frequently in the weight-reducing formulae of traditional Chinese medicine. Recently, rhein, one of the major components of Rheum palmatum, has been shown to be an inhibitor of 3T3-L1 adipocyte differentiation [10]. Moreover, rhein has been reported to have pharmacological and biochemical effects on the inhibition of liver fibrosis and insulin sensitizing [11–13] and prevent hepatic steatosis through LXR inhibition in a high-fat diet-induced obese mouse model [14]. However, whether rhein plays the antiobesity role in vivo is still uncertain and the underlying mechanisms also need to be elucidated. In the present study, we compared the weight-reducing effect of two major compounds from Rheum palmatum. We found that rhein reduced fat weight in mouse. We also showed that rhein blocked weight
Carboxylation of Aromatics by CO2 under “Si/Al Based Frustrated Lewis Pairs” Catalytic System  [PDF]
Miaofei Gu, Zhenmin Cheng
Journal of Materials Science and Chemical Engineering (MSCE) , 2015, DOI: 10.4236/msce.2015.31015

Carboxylation of aromatics by CO2 to generate corresponding carboxylic acids is recently providing a novel approach to utilize the green gas CO2, in which the activation of CO2 is the key procedure. Among the many catalytic systems employed in the carboxylation, the concept of “Frustrated Lewis Pairs” (FLPs) was scarcely mentioned, which perform excellently in activating small molecules like CO2. The FLPs are combinations of Lewis acids and Lewis bases which failed to form adducts due to their bulky steric congestion. In this paper, we first attempted various Si/Al Based FLPs to catalyze the carboxylation of aromatics through the activation of CO2, and a good yield of 62% - 97% was obtained. The reaction mechanism was proposed, involving the activation of CO2 mainly contributed by AlCl3 in cooperation with organosilane, forming an intermediate consisting of CO2, AlCl3, and R4Si, as well as the subsequent electrophilic attack to aromatics, thus to promote the carboxylation reaction.

Association between RASSF1A Promoter Methylation and Ovarian Cancer: A Meta-Analysis
Hao Shi, Ya Li, Xiaozhong Wang, Cheng Lu, Lilan Yang, Changmei Gu, Jiaqiang Xiong, Yangxin Huang, Shixuan Wang, Meixia Lu
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0076787
Abstract: Background The RAS association domain family protein 1a gene (RASSF1A) is one of the tumor suppressor genes (TSG). Inactivation of RASSF1A is critical to the pathogenesis of cancer. Aberrant TSG methylation was considered an important epigenetic silencing mechanism in the progression of ovarian cancer. A number of studies have discussed association between RASSF1A promoter methylation and ovarian cancer. However, they were mostly based on a small number of samples and showed inconsist results, Therefore, we conducted a meta-analysis to better identify the association. Methods Eligible studies were identified by searching the PubMed, EMBASE, Web of Science, and CNKI databases using a systematic searching strategy. We pooled the odds ratio (ORs) from individual studies using a fixed-effects model. We performed heterogeneity and publication bias analysis simultaneously. Results Thirteen studies, with 763 ovarian cancer patients and 438 controls were included in the meta-analysis. The frequencies of RASSF1A promoter methylation ranged from 30% to 58% (median is 48%) in the cancer group and 0 to 21% (median is 0) in the control group. The frequencies of RASSF1A promoter methylation in the cancer group were significantly higher than those in the control group. The pooled odds ratio was 11.17 (95% CI = 7.51–16.61) in the cancer group versus the corresponding control group under the fixed-effects model. Conclusion The results suggested that RASSF1A promoter methylation had a strong association with ovarian cancer.
Effect of Unsaturated Hydroxyl-Fatty Acid Modified Nano-CaCO3 on the Morphology and Rheology of PP

GU Ju,XIONG Qiang,JIA Demin,LUO Yuanfang,CHENG Rongshi,

高分子学报 , 2008,
Abstract: 采用羟基不饱和脂肪酸,通过固相法对硬脂酸改性的工业纳米碳酸钙CCR进行表面改性制备了R-CCR,红外光谱(FTIR)显示改性剂已结合在碳酸钙表面.通过熔融共混法制备了聚丙烯(PP)/乙丙橡胶(EPDM)/纳米碳酸钙二元和三元复合材料.并利用扫描电子显微镜(SEM)和透射电子显微镜(TEM)观察复合材料的微观形态,发现R-CCR的加入,使PP复合材料的拉伸断面出现明显的拉丝状结构和大面积的屈服变形,与PP/EPDM/CCR相比,PP/EPDM/R-CCR冲击断面的空穴明显增加并细化,R-CCR在PP基体中分散均匀,且界面模糊,与基体的相容性明显优于CCR.复合材料流变行为的研究表明R-CCR的加入,体系储存模量G′和损耗模量G″随频率的增加而增加,对损耗因子和复数粘度的影响不大;但PP/EPDM/R-CCR复合材料的表观粘度,明显低于PP/EPDM/CCR和纯PP,同时,剪切速率的增加可有效降低体系的表观粘度.力学性能表明,R-CCR对PP同时起到增韧和增强的效果.且R-CCR和EPDM对PP具有协同增韧的效果.在保持聚丙烯的模量和强度基本不变的前提下,大幅度的改善聚丙烯的韧性,同时加工性能保持不变.
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