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Search Results: 1 - 10 of 28140 matches for " Cheng-Chieh Yen "
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Independent Component Analysis for Magnetic Resonance Image Analysis
Yen-Chieh Ouyang,Hsian-Min Chen,Jyh-Wen Chai,Cheng-Chieh Chen
EURASIP Journal on Advances in Signal Processing , 2008, DOI: 10.1155/2008/780656
Abstract: Independent component analysis (ICA) has recently received considerable interest in applications of magnetic resonance (MR) image analysis. However, unlike its applications to functional magnetic resonance imaging (fMRI) where the number of data samples is greater than the number of signal sources to be separated, a dilemma encountered in MR image analysis is that the number of MR images is usually less than the number of signal sources to be blindly separated. As a result, at least two or more brain tissue substances are forced into a single independent component (IC) in which none of these brain tissue substances can be discriminated from another. In addition, since the ICA is generally initialized by random initial conditions, the final generated ICs are different. In order to resolve this issue, this paper presents an approach which implements the over-complete ICA in conjunction with spatial domain-based classification so as to achieve better classification in each of ICA-demixed ICs. In order to demonstrate the proposed over-complete ICA, (OC-ICA) experiments are conducted for performance analysis and evaluation. Results show that the OC-ICA implemented with classification can be very effective, provided the training samples are judiciously selected.
THE SYNTAX OF BI-COMPARATIVES IN MANDARIN CHINESE
Cheng-Chieh Su
Taiwan Journal of Linguistics , 2012,
Abstract: The study attempts to propose a syntactic account of bi-comparatives in Mandarin Chinese under the generative framework. Bi plays a role reminiscent of a prepositional complementizer projecting a self-completed clause (Hsing 2003, Chung 2006), a preverbal adjunct in the wake of Liu (1996). Following Abney (1987), Kennedy (1997), Kennedy & Merchant (1997), it is suggested that a gradable adjective projects an extended functional structure DegP headed by a degree morpheme in the bi-comparative. The adjunction of the bi-clause onto the SpecDegP is triggered by the need to saturate and restrict the degree argument of the adjective (Liu 2007ab, 2010c). An adjective or verb phrase within the bi-clause is deleted. By studying bi-comparatives in depth, this study not only can shed light on the clausal analysis of bi-comparatives, but also provide useful data for future research on Comparative Deletion (Bresnan 1973, 1975).
The Association between Genetic Polymorphism and the Processing Efficiency of miR-149 Affects the Prognosis of Patients with Head and Neck Squamous Cell Carcinoma
Hsi-Feng Tu, Chung-Ji Liu, Che-Lun Chang, Pei-Wen Wang, Shou-Yen Kao, Cheng-Chieh Yang, En-Hao Yu, Shu-Chun Lin, Kuo-Wei Chang
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0051606
Abstract: MicroRNAs (miRNAs) play important roles in modulating the neoplastic process of cancers including head and neck squamous cell carcinoma (HNSCC). A genetic polymorphism (rs2292832, C>T) has been recently identified in the precursor of miR-149; nevertheless its clinicopathological implications remain obscure. In this study, we showed that miR-149 is down-regulated in HNSCC compared to normal mucosa and this is associated with a poorer patient survival. In addition, HNSCC patients with the T/T genotype have more advanced tumors and a worse prognosis. Multivariate analysis indicated that patients carried the T/T genotype have a 2.81-fold (95% CI: 1.58–4.97) increased risk of nodal metastasis and 1.66-fold (95% CI: 1.05–2.60) increased risk of mortality compared to other groups. T/T genotype also predicted the worse prognosis of buccal mucosa carcinoma subset of HNSCC. In vitro analysis indicated that exogenous miR-149 expression reduces the migration of HNSCC cells. Moreover, HNSCC cell subclones carrying the pri-mir-149 sequence containing the T variant show a low processing efficacy when converting the pre-mir-149 to mature miR-149. These findings suggest that miR-149 suppresses tumor cell mobility, and that the pre-mir-149 polymorphism may affect the processing of miR-149, resulting in a change in the abundance of the mature form miRNA, which, in turn, modulates tumor progression and patient survival.
miR-146a Enhances the Oncogenicity of Oral Carcinoma by Concomitant Targeting of the IRAK1, TRAF6 and NUMB Genes
Pei-Shi Hung, Chung-Ji Liu, Chung-Shan Chou, Shou-Yen Kao, Cheng-Chieh Yang, Kuo-Wei Chang, Ting-Hui Chiu, Shu-Chun Lin
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0079926
Abstract: MicroRNAs are short non-coding RNAs that regulate gene expression and are crucial to tumorigenesis. Oral squamous cell carcinoma (OSCC) is a prevalent malignancy worldwide. Up-regulation of miR-146 has been identified in OSCC tissues. However, the roles of miR-146 in carcinogenesis are controversial as it is suppressive in many other malignancies. The present study investigated the pathogenic implications of miR-146a in oral carcinogenesis. Microdissected OSCC exhibits higher levels of miR-146a expression than matched adjacent mucosal cells. The plasma miR-146a levels of patients are significantly higher than those of control subjects; these levels decrease drastically after tumor resection. miR-146a levels in tumors and in patients’ plasma can be used to classify OSCC and non-disease status (sensitivity: >0.72). Exogenous miR-146a expression is significantly increased in vitro oncogenic phenotypes as well as during xenograft tumorigenesis and OSCC metastasis. The plasma miR-146a levels of these mice parallel the xenograft tumor burdens of the mice. A miR-146a blocker abrogates the growth of xenograft tumors. miR-146a oncogenic activity is associated with down-regulation of IRAK1, TRAF6 and NUMB expression. Furthermore, miR-146a directly targets the 3′UTR of NUMB and a region within the NUMB coding sequence when suppressing NUMB expression. Exogenous NUMB expression attenuates OSCC oncogenicity. Double knockdown of IRAK1 and TRAF6, and of TRAF6 and NUMB, enhance the oncogenic phenotypes of OSCC cells. Oncogenic enhancement modulated by miR-146a expression is attenuated by exogenous IRAK1 or NUMB expression. This study shows that miR-146a expression contributes to oral carcinogenesis by targeting the IRAK1, TRAF6 and NUMB genes.
Mercuric Compounds Induce Pancreatic Islets Dysfunction and Apoptosis in Vivo
Kuo-Liang Chen,Shing-Hwa Liu,Chin-Chuan Su,Cheng-Chieh Yen,Ching-Yao Yang,Kuan-I Lee,Feng-Cheng Tang,Ya-Wen Chen,Tien-Hui Lu,Yi-Chang Su,Chun-Fa Huang
International Journal of Molecular Sciences , 2012, DOI: 10.3390/ijms131012349
Abstract: Mercury is a toxic heavy metal that is an environmental and industrial pollutant throughout the world. Mercury exposure leads to many physiopathological injuries in mammals. However, the precise toxicological effects of mercury on pancreatic islets in vivo are still unclear. Here, we investigated whether mercuric compounds can induce dysfunction and damage in the pancreatic islets of mice, as well as the possible mechanisms involved in this process. Mice were treated with methyl mercuric chloride (MeHgCl, 2 mg/kg) and mercuric chloride (HgCl 2, 5 mg/kg) for more than 2 consecutive weeks. Our results showed that the blood glucose levels increased and plasma insulin secretions decreased in the mice as a consequence of their exposure. A significant number of TUNEL-positive cells were revealed in the islets of mice that were treated with mercury for 2 consecutive weeks, which was accompanied by changes in the expression of the mRNA of anti-apoptotic ( Bcl-2, Mcl-1, and Mdm-2) and apoptotic ( p53, caspase-3, and caspase-7) genes. Moreover, plasma malondialdehyde (MDA) levels increased significantly in the mice after treatment with mercuric compounds for 2 consecutive weeks, and the generation of reactive oxygen species (ROS) in the pancreatic islets also markedly increased. In addition, the mRNA expression of genes related to antioxidation, including Nrf2, GPx, and NQO1, were also significantly reduced in these islets. These results indicate that oxidative stress injuries that are induced by mercuric compounds can cause pancreatic islets dysfunction and apoptosis in vivo.
Cadmium Induces Apoptosis in Pancreatic β-Cells through a Mitochondria-Dependent Pathway: The Role of Oxidative Stress-Mediated c-Jun N-Terminal Kinase Activation
Kai-Chih Chang, Ching-Cheng Hsu, Shing-Hwa Liu, Chin-Chuan Su, Cheng-Chieh Yen, Ming-Jye Lee, Kuo-Liang Chen, Tsung-Jung Ho, Dong-Zong Hung, Chin-Ching Wu, Tien-Hui Lu, Yi-Chang Su, Ya-Wen Chen, Chun-Fa Huang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0054374
Abstract: Cadmium (Cd), one of well-known highly toxic environmental and industrial pollutants, causes a number of adverse health effects and diseases in humans. The growing epidemiological studies have suggested a possible link between Cd exposure and diabetes mellitus (DM). However, the toxicological effects and underlying mechanisms of Cd-induced pancreatic β-cell injury are still unknown. In this study, we found that Cd significantly decreased cell viability, and increased sub-G1 hypodiploid cells and annexin V-Cy3 binding in pancreatic β-cell-derived RIN-m5F cells. Cd also increased intracellular reactive oxygen species (ROS) generation and malondialdehyde (MDA) production and induced mitochondrial dysfunction (the loss of mitochondrial membrane potential (MMP) and the increase of cytosolic cytochrome c release), the decreased Bcl-2 expression, increased p53 expression, poly (ADP-ribose) polymerase (PARP) cleavage, and caspase cascades, which accompanied with intracellular Cd accumulation. Pretreatment with the antioxidant N-acetylcysteine (NAC) effectively reversed these Cd-induced events. Furthermore, exposure to Cd induced the phosphorylations of c-jun N-terminal kinases (JNK), extracellular signal-regulated kinases (ERK)1/2, and p38-mitogen-activated protein kinase (MAPK), which was prevented by NAC. Additionally, the specific JNK inhibitor SP600125 or JNK-specific small interference RNA (si-RNA) transfection suppressed Cd-induced β-cell apoptosis and related signals, but not ERK1/2 and p38-MAPK inhibitors (PD98059 and SB203580) did not. However, the JNK inhibitor or JNK-specific si-RNA did not suppress ROS generation in Cd-treated cells. These results indicate that Cd induces pancreatic β-cell death via an oxidative stress downstream-mediated JNK activation-triggered mitochondria-regulated apoptotic pathway.
Partnership disengagement from primary community care networks (PCCNs): A qualitative study for a national demonstration project
Chia-Yi Liau, Cheng-Chieh Lin, Yung-Kai Lin, Blossom Lin
BMC Health Services Research , 2010, DOI: 10.1186/1472-6963-10-87
Abstract: This study used a qualitative methodology with semi-structured questions for in-depth interviews. The semi-structured questions were pre-designed to explore the factors driving partnership disengagement. Thirty-seven clinic members who had withdrawn from their PCCNs were identified from the 2003-2005 Taiwan Primary Community Care Network Lists.Organization/participant factors (extra working time spend and facility competency), network factors (partner collaboration), and community factors (health policy design incompatibility, patient-physician relationship, and effectiveness) are reasons for clinic physicians to withdraw or change their partnerships within the PCCNs.To strengthen partnership relationships, several suggestions are made, including to establish clinic and hospital member relationships, and to reduce administrative work. In addition, both educating the public about the concept of family doctors and ensuring well-organized national health policies could help health care providers improve the integration processes.Regional or local health partnerships have been widely introduced around the world to improve health effectiveness from the perspectives of policy or provider strategy [1-6]. The presumed benefits of forming health networks are supporting expertise development, arranging referrals, coordinating programs, undertaking projects, sharing common interests, and providing mutual support for managing common conditions [7]. Many studies have explored how to run a health network more successfully. For example, it has been argued that sustainability is key to partnership success for community care network collaboration [8]. That includes sustaining the relationships, commitments, knowledge, capability, values, and trust, generated from partnerships, as well as sustaining funding, staff, programs, policy changes, and the partnership itself [9,10]. Human barriers have been identified as potential factors in network partnerships, among them user acceptance,
THE IMPACTS OF ONLINE RETAILING SERVICE RECOVERY AND PERCEIVED JUSTICE
Yi-Wen Fan,Cheng-Chieh Wu,Wei-Ting Wu
International Journal of Electronic Business Management , 2010,
Abstract: Effective service failure recovery has been recognized as an important strategic tool for online retailers due to the dramatic growth of the online retail sector and the importance of service failures recovery in online environment. This study investigates the impacts of service failure recovery and perceived justice on consumer loyalty for online retailing service. By conducting a scenario-based experiment, it is found that perceived distributive justice positively affects recovery satisfaction and positive word-of-mouth; and that procedural justice has a positive impact on recovery satisfaction and repatronage intention. A comparison between researches on online service failure recovery and researches for offline setting is then presented. The research findings can provide valuable insights for online retailers to develop effective service recovery policies and procedures.
Utilization pattern of traditional Chinese medicine for liver cancer patients in Taiwan
Liao Yueh-Hsiang,Lin Cheng-Chieh,Li Tsai-Chung,Lin Jaung-Geng
BMC Complementary and Alternative Medicine , 2012, DOI: 10.1186/1472-6882-12-146
Abstract: Background Traditional Chinese Medicine (TCM) is one of the most popular complementary and alternative medicine modalities worldwide. In Chinese and East Asian societies, TCM plays an active role in the modern health care system and is even covered by the National Health Insurance Program of Taiwan. Liver cancer is the second most common cancer in Taiwan. This study aimed to analyze the TCM utilization patterns of patients with liver cancer from 1996–2007 using a population-based random sample of one million insured patients. Methods A cross-sectional study was conducted using registration and claim data sets from 1996 to 2007 obtained from the Longitudinal Health Insurance Database 2005 (LHID2005). The outpatient datasets contained the encounter form-based dates of visit, three items from the International Classification of Diseases (Ninth Revision, Clinical Modification codes), the primary procedure (e.g., drug or diagnostic procedure), type of copayment, billed amount, and paid amount. Only ambulatory care was analyzed. Results A total of 6358 liver cancer patients utilized ambulatory care during the study period. Among them, 1240 (19.50%) availed of TCM outpatient services. The prevalence of TCM use fluctuated during the study period, with a peak of 25.11% in 2001. After multivariable adjustment, the likelihood of TCM users was lower in participants aged 70 years and older (odds ratio, OR = 0.79, 95% confidence interval, CI: 0.64–0.97), males (OR = 0.60, 95% CI: 0.52–0.68), residents of Taipei (OR = 0.75, 95% CI: 0.58–0.96) as well as farmers and fishermen (OR = 0.71, 95% CI: 0.54–0.94), but was higher in residents of central Taiwan (OR = 1.99, 95% CI: 1.56–2.54. Most biomedicine and TCM outpatient services were provided by private clinics, followed by private hospitals. The two most frequently recorded coexisting diseases for both biomedicine and TCM outpatient visits specifically for liver cancer were (1) chronic liver disease and cirrhosis, and (2) malignant neoplasm of the liver and hepatic bile duct. The mean fee per visit for biomedicine was much higher than that for TCM, and the average expenditure was NT$429.73 (US$13.25) per biomedicine visit and NT$301.93 (US$9.32) per TCM visit (US$1 = NT$32.4 in 2007). For outpatient visits specifically for liver cancer, the mean fee per visit for biomedicine was much higher than that for TCM. The average cost per visit was NT$1457.31 (US$44.98) for biomedicine and NT$1080.76 (US$33.36) for TCM. Conclusion TCM was widely used by the patients with liver cancer, and the prevalence of TCM use remai
Betel nut chewing as a risk factor for hepatitis C infection in Taiwan-a community-based study
Lin Chih-Hsueh,Lin Cheng-Chieh,Liu Chiu-Shong
Annals of Saudi Medicine , 2011,
Abstract:
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