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Search Results: 1 - 10 of 25626 matches for " Cheng XD "
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Enhanced oral absorption of 20(S)-protopanaxadiol by self-assembled liquid crystalline nanoparticles containing piperine: in vitro and in vivo studies
Jin X, Zhang ZH, Sun E, Tan XB, Li SL, Cheng XD, You M, Jia XB
International Journal of Nanomedicine , 2013, DOI: http://dx.doi.org/10.2147/IJN.S38203
Abstract: hanced oral absorption of 20(S)-protopanaxadiol by self-assembled liquid crystalline nanoparticles containing piperine: in vitro and in vivo studies Original Research (506) Total Article Views Authors: Jin X, Zhang ZH, Sun E, Tan XB, Li SL, Cheng XD, You M, Jia XB Published Date February 2013 Volume 2013:8 Pages 641 - 652 DOI: http://dx.doi.org/10.2147/IJN.S38203 Received: 17 September 2012 Accepted: 22 October 2012 Published: 13 February 2013 Xin Jin,1,2 Zhen-hai Zhang,1 E Sun,1 Xiao-bin Tan,1 Song-lin Li,3 Xu-dong Cheng,4 Ming You,4 Xiao-bin Jia1 1Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing, People's Republic of China; 2College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China; 3Department of Pharmaceutical Analysis and Metabolomics, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, People's Republic of China; 4ALG Bioscience Co, Ltd, Suzhou, People's Republic of China Background: 20(S)-protopanaxadiol (PPD), similar to several other anticancer agents, has low oral absorption and is extensively metabolized. These factors limit the use of PPD for treatment of human diseases. Methods: In this study, we used cubic nanoparticles containing piperine to improve the oral bioavailability of PPD and to enhance its absorption and inhibit its metabolism. Cubic nanoparticles loaded with PPD and piperine were prepared by fragmentation of glyceryl monoolein (GMO)/poloxamer 407 bulk cubic gel and verified using transmission electron microscopy and differential scanning calorimetry. We evaluated the in vitro release of PPD from these nanoparticles and its absorption across the Caco-2 cell monolayer model, and subsequently, we examined the bioavailability and metabolism of PPD and its nanoparticles in vivo. Results: The in vitro release of PPD from these nanoparticles was less than 5% at 12 hours. PPD-cubosome and PPD-cubosome loaded with piperine (molar ratio PPD/piperine, 1:3) increased the apical to basolateral permeability values of PPD across the Caco-2 cell monolayer from 53% to 64%, respectively. In addition, the results of a pharmacokinetic study in rats showed that the relative bioavailabilities of PPD-cubosome [area under concentration–time curve (AUC)0–∞ ] and PPD-cubosome containing piperine (AUC0–∞) compared to that of raw PPD (AUC0–∞) were 166% and 248%, respectively. Conclusion: The increased bioavailability of PPD-cubosome loaded with piperine is due to an increase in absorption and inhibition of metabolism of PPD by cubic nanoparticles containing piperine rather than because of improved release of PPD. The cubic nanoparticles containing piperine may be a promising oral carrier for anticancer drugs with poor oral absorption and that undergo extensive metabolism by cytochrome P450.
Formulation and pharmacokinetic evaluation of a paclitaxel nanosuspension for intravenous delivery
Wang YL, Li XM, Wang LY, Xu YL, Cheng XD, Wei P
International Journal of Nanomedicine , 2011, DOI: http://dx.doi.org/10.2147/IJN.S21097
Abstract: rmulation and pharmacokinetic evaluation of a paclitaxel nanosuspension for intravenous delivery Original Research (5866) Total Article Views Authors: Wang YL, Li XM, Wang LY, Xu YL, Cheng XD, Wei P Published Date July 2011 Volume 2011:6 Pages 1497 - 1507 DOI: http://dx.doi.org/10.2147/IJN.S21097 Yonglu Wang1,4, Xueming Li1,2*, Liyao Wang3, Yuanlong Xu1, Xiaodan Cheng1, Ping Wei4 1College of Pharmacy, Nanjing University of Technology, Nanjing; 2State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing University of Technology, Nanjing; 3College of Life Science, Anhui Agricultural University, Hefei; 4College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing, People’s Republic of China *These authors contributed equally to this work. Abstract: Paclitaxel is a diterpenoid isolated from Taxus brevifolia. It is effective for various cancers, especially ovarian and breast cancer. Due to its aqueous insolubility, it is administered dissolved in ethanol and Cremophor EL (BASF, Ludwigshafen, Germany), which can cause serious allergic reactions. In order to eliminate Cremophor EL, paclitaxel was formulated as a nanosuspension by high-pressure homogenization. The nanosuspension was lyophilized to obtain the dry paclitaxel nanoparticles (average size, 214.4 ± 15.03 nm), which enhanced both the physical and chemical stability of paclitaxel nanoparticles. Paclitaxel dissolution was also enhanced by the nanosuspension. Differential scanning calorimetry showed that the crystallinity of paclitaxel was preserved during the high-pressure homogenization process. The pharmacokinetics and tissue distribution of paclitaxel were compared after intravenous administration of paclitaxel nanosuspension and paclitaxel injection. In rat plasma, paclitaxel nanosuspension exhibited a significantly (P < 0.01) reduced area under the concentration curve (AUC)0–∞ (20.343 ± 9.119 μg · h · mL 1 vs 5.196 ± 1.426 μg · h · mL 1), greater clearance (2.050 ± 0.616 L · kg 1 · h 1 vs 0.556 ± 0.190 L · kg 1 · h 1), and shorter elimination half-life (5.646 ± 2.941 vs 3.774 ± 1.352 hours) compared with the paclitaxel solution. In contrast, the paclitaxel nanosuspension resulted in a significantly greater AUC0–∞ in liver, lung, and spleen (all P < 0.01), but not in heart or kidney.
Electrical Potential of Acupuncture Points: Use of a Noncontact Scanning Kelvin Probe
Brian J. Gow,Justine L. Cheng,Iain D. Baikie,Ørjan G. Martinsen
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/632838
Abstract:
Pulmonary injury after intestinal ischemia and reperfusion injury: effects of treatment with lexipafant, a PAF antagonist
A B?rjesson, XD Wang, R Andersson
Critical Care , 1998, DOI: 10.1186/cc146
Abstract:
Antibodies to ICAM-1 and PECAM-1 ameliorate pulmonary injury after intestinal ischemia-reperfusion in the rat
A B?rjesson, XD Wang, R Andersson
Critical Care , 1998, DOI: 10.1186/cc141
Abstract: In the present study, a significant increase in albumin leakage over the pulmonary capillaries, as well as increased pulmonary MPO (myeloperoxidase)-content was found in rats subjected to 30 min intestinal ischemia (by clamping the superior mesenteric artery) followed by 12 h reperfusion. Treatment with anti-ICAM-1 or anti-PECAM-1 monoclonal antibodies significantly reduced the otherwise occuring increase in both albumin leakage and pulmonary MPO-content in pancreatitis animals. There was also an increase in serum IL-1β levels after intestinal I/R, which could be prevented by use of antibodies to ICAM-1 and PECAM-1.In conclusion we found that the acute lung injury seen after intestinal I/R in the rat to a large extent could be prevented by blocking the adhesion/transmigration process of pulmonary leukocytes.
Corrosion Behaviour of AZ and ZA Magnesium Alloys in Alkaline Chloride Media
Mustafa Ö. Öteyaka,Edward Ghali,Réal Tremblay
International Journal of Corrosion , 2012, DOI: 10.1155/2012/452631
Abstract:
Isolation and characterization of Rhodococcus ruber CGMCC3090 that hydrolyzes aliphatic, aromatic and heterocyclic nitriles
J Zhang, M Wang, H Sun, XD Li, LP Zhong
African Journal of Biotechnology , 2009,
Abstract: A bacterial strain was isolated from soil samples that had been polluted by nitrile compounds. This strain converts acrylonitrile to acrylamide with high activity. The nitrile hydrolysis activity was tested using eight substrates, including aliphatic, aromatic and heterocyclic (di)nitriles. All of the nitrile compounds were hydrolyzed by the resting cells. The main (cyano-)amide products demonstrated that nitrile hydratase was abundantly produced in this strain and that it mediated monohydrolysis. The specific conversion rate decreased in the following order: acrylonitrile > 3-cyanopyridine > valeronitrile > adiponitrile > 2,3,4,5,6-pentafluorobenzonitrile > -hydroxyphenylacetonitrile > 3-indoleaceto-nitrile > phthalonitrile, suggesting a higher conversion capability towards aliphatic nitriles. The strain that had broad substrate spectra was identified and named Rhodococcus ruber CGMCC3090 based on the 16S rDNA sequence.
Improved biocompatibility of novel poly(L-lactic acid)/ -tricalcium phosphate scaffolds prepared by an organic solvent-free method
Zhao XF, Li XD, Kang YQ, Yuan Q
International Journal of Nanomedicine , 2011, DOI: http://dx.doi.org/10.2147/IJN.S20743
Abstract: oved biocompatibility of novel poly(L-lactic acid)/ -tricalcium phosphate scaffolds prepared by an organic solvent-free method Original Research (2895) Total Article Views Authors: Zhao XF, Li XD, Kang YQ, Yuan Q Published Date July 2011 Volume 2011:6 Pages 1385 - 1390 DOI: http://dx.doi.org/10.2147/IJN.S20743 Xue-Feng Zhao1,2, Xiao-Dong Li3, Yun-Qing Kang4, Quan Yuan1,2 1State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, People's Republic of China; 2West China School of Stomatology, Sichuan University, Chengdu, People's Republic of China; 3Affiliated Hospital of Stomatology and College of Stomatology, Chongqing Medical University, Chongqing, People's Republic of China; 4College of Materials Science and Engineering, Sichuan University, Chengdu, People's Republic of China Abstract: A porous poly(L-lactic acid)/ -tricalcium phosphate (PLLA/ -TCP) composite scaffold was fabricated using a novel technique comprising powder mixing, compression molding, low-temperature treatment, and particulate leaching without any organic solvent. The effect of this scaffold on osteoblast proliferation and differentiation was evaluated in vitro. The fabricated scaffold had a homogeneously interconnected porous structure with a porosity of 70% and compressive strength of 1.35 MPa. The methylthiazol tetrazolium values and alkaline phosphatase (ALP) activity of osteoblasts seeded on the solvent-free scaffold were significant higher than those of the control. Using real-time PCR, gene expressions of ALP, osteocalcin, and type 1 collagen were shown to be upregulated. As the method does not use any organic solvent, it eliminates problems associated with organic solvent residue and therefore improves the cell compatibility. It has a promising potential for the preparation of porous scaffold for bone tissue engineering.
Birth Defects Data from Surveillance Hospitals in Hubei Province, China, 200l - 2008
Lh Tu,H Li,Hp Zhang,Xd Li
Iranian Journal of Public Health , 2012,
Abstract: Background: To determine the prevalence and characteristics of birth defects in perinatal infants in Hubei Province during 200l-2008.Methods: The prevalence of birth defects in perinatal infants delivered after 28 weeks or more was analyzed in Hubei surveillance hospitals during 200l-2008.Results: The incidence of birth defects in perinatal infants from 200l to 2008 was 120.0 per 10,000 births, and was increased by about 41% from 81. 1 in 2001 to 138.5 per 10,000 births in 2008. The incidence in the first 4 years (2005-2008) was much higher than the latter four (2001-2004) (χ2=77.64 , P <0.05). The difference in prevalence between urban and rural was of no significance in 2008 (χ2=0.03,P >0.05), but that between male and female was significant (χ2=5.24 , P <0.05), as the former prevalence was much higher. The prevalence of birth defects was slightly higher among mothers over 35 years old than those under 35 years old, but with no significance (χ2=1.98, P >0.05). The two leading birth defects were cleft lip and/or palate and polydactyly, followed by congenital heart disease, hydrocephaly, external ear malformation and neural tube defects. The prevalence of congenital heart disease was rising.Conclusions: Eight years birth defects data indicate that the birth defect rate was on the rise and the birth defects prevalence in Hubei province should be valued.
The first case of cutaneous infection with Mycobacterium parascrofulaceum
Zong WK,Zhang XD,Wang HS,Xu XL
Therapeutics and Clinical Risk Management , 2012,
Abstract: Wenkai Zong,* Xiaodong Zhang,* Hongsheng Wang, Xiu Lian Xu, Qiuling Wang, Weiwei Tian, Ya LI Jin, Qinxue Wu, Meiyu Tang Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for STD and Leprosy Control, Chinese Center for Disease Control and Prevention, Nanjing, People’s Republic of China*These authors contributed equally to this workAbstract: The authors present the first, to the best of their knowledge, reported case of cutaneous infection caused by Mycobacterium parascrofulaceum. A 42-year-old woman presented with asymptomatic reddish papules, nodules, plaques, and patches on the right side of her face and on her forehead that had persisted for 5 years, with the lesions gradually increasing in size over that time. No previous intervening medical treatment had been applied. No history or evidence of immunosuppression was found. A skin biopsy was performed for routine histological examination. Samples of lesioned skin were inoculated on L wenstein–Jensen medium to determine the presence of acid-fast bacilli. Ziehl–Neelsen staining was used to confirm the presence of the organism. In vitro drug susceptibility testing was conducted using the microtiter plate method. Mycobacterium was identified by polymerase chain reaction–restriction fragment length polymorphism analysis and sequencing of the hsp65 and 16S rDNA genes. Cultures for aerobic and anaerobic bacteria, as well as fungus, were also conducted. Routine histopathology revealed granulomatous changes without caseation. Ziehl–Neelsen staining showed that the organisms in both the lesions and the cultures were acid-fast bacilli. The cultured colonies were grown in L wenstein–Jensen medium and incubated at two different temperatures (32°C and 37°C) for 2–3 weeks, developing pigmentation both in the dark and in the light. In vitro drug susceptibility tests showed that the organism was sensitive to clarithromycin and moxifloxacin. Polymerase chain reaction–restriction fragment length polymorphism analysis and sequencing of the hsp65 and 16S rDNA genes confirmed that the isolated organisms were M. parascrofulaceum. Fungal and other standard bacterial cultures were negative. In conclusion, identification and diagnosis of nontuberculous mycobacteria should be performed promptly to obtain better prognoses. Empirical treatments may be feasible, and drug susceptibility tests are important.Keywords: nontuberculous mycobacteria, skin infection, PCR-RFLP, laboratory diagnosis, therapy
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