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[18F]-FDDNP was synthesized and
characterized as a positron-emitting probe to identify Alzheimer’s disease
(AD) in transgenic mouse models (Tg2576 and dE9) expressing the AD pathology.
We observed in in vitro, in vivo, and ex vivo studies that [18F]-FDDNP accumulated specifically in the Ab-overexpressing brain regions and that this accumulation was
significantly reduced by co-incubation with non-radioactive FDDNP. In ex vivo
and in vivo studies of brain sections, the retention of radioactivity was more
specific in Tg2576 mice than in dE9 mice. Using in vitro, ex vivo, in vivo, and
ELISA analyses, we characterized the utility of [18F]-FDDNP in mapping b-amyloid in the Tg2576 mouse brain, to assess its potential
application in imaging strategies.
In Qinjiagou watershed of Three-Gorge of
Yangtze River, 18 indices were selected from canopy layer, litter layer, soil
layer and topography to evaluate the soil and water conservation capacities of
four common plantation types by ideal point method. Results indicated that the
broadleaf plantation of robur (Lithocrpus glabra) and Chinese gugertree (Schima
superba) (LS) has the biggest soil and water conservation capacity. The rank of
three other plantation types from big to small is the mixed broadleaf
plantation of sweetgum (Liguidambar formosana), Chinese gugertree and camphor
tree (Cinnamomum camphora) (LSC), the mixed broadleaf-conifer plantation of
Chinese fir (Cunninghamia lanceolata), Masson pine (Pinus massoniana) and Chinese
gugertree (CPS), and the mixed Pine plantation of Chinese fir and Masson pine (CP).
Under the same climate and topographical condition, the broadleaf plantation
has better soil and water conservation capacity than the conifer plantation.
Sensitivity analysis showed that the three most sensitive indices are soil
non-capillary porosity, soil aggregation, and soil initial infiltration rate.
The litter amount and soil properties are the most important indicators of soil
and water conservation capacity of plantations. Therefore, suitable
measurements such as deep tillage should be taken to improve the properties of
soil under different plantations.