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Search Results: 1 - 10 of 176773 matches for " Charles E.;Lamien-Meda "
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Antiacetylcholinesterase and antioxidant activity of essential oils from six medicinal plants from Burkina Faso
Kiendrebeogo, Martin;Coulibaly, Ahmed Y.;Nebie, Roger C. H.;Zeba, Boukaré;Lamien, Charles E.;Lamien-Meda, Aline;Nacoulma, Odile G.;
Revista Brasileira de Farmacognosia , 2011, DOI: 10.1590/S0102-695X2011005000008
Abstract: in this investigation, we evaluated essential oils from six medicinal plants from burkina faso for their antiacetylcholinesterase and antioxidant abilities. the chemotype of most active were also determined. the best antiacetylcholinesterase activities were recorded for the essential oils of eucalyptus camaldulensis (ic50 18.98 μ g/ml) and ocimum canum (ic50 36.16 μ g/ml). their chemotype have been related to the 1,8-cineole one. both essential oils demonstrated a linear mixed non competitive inhibition. the essential oil of ocimum basilicum which belong to the linalool-eugenol chemotype exhibited the best radical scavenging activity (ic50 3.82 μ g/ml) and reducing power (531.75 mg aae/g). in comparison with gallic and ascorbic acids, o. basilicum essential oil evidenced interesting antioxidant activities. the antiacetylcholinesterase and antioxidant activities of essential oils were discussed in regard with their chemical composition.
In vitro Antioxidant, Xanthine Oxidase and Acetylcholinesterase Inhibitory Activities of Balanites aegyptiaca (L.) Del. (Balanitaceae)
N.T.R. Meda,A. Lamien-Meda,M. Kiendrebeogo,C.E. Lamien
Pakistan Journal of Biological Sciences , 2010,
Abstract: The present study aimed to test the validity of Balanites aegyptiaca remedies used for the treatment of rheumatisms and mental disorders by examining the antioxidant, xanthine oxidase and acetylcholinesterase inhibitory activities of galls and leaves extracts and fractions. The total phenolics and flavonoids were measured using Folin-Ciocalteu and AlCl3 reagents, respectively. Two methods i.e., FRAP and ABTS were used to estimate the total antioxidant capacity of the plant materials. The FRAP and ABTS antioxidant activities showed that among all extracts and fractions tested, the best antioxidant activities were found with the galls dichloromethane and the leaves ethyl acetate fractions. The antioxidant activities did correlated significantly with the total phenolic and flavonoid contents. The study also showed that B. aegyptiaca galls and leaves fractions exhibited a moderate xanthine oxidase inhibitory activity comparatively to the acetylcholinesterase which was weakly inhibited by the tested extracts and fractions.
Antioxidant and Antibacterial Activities of Combretum nioroense Aubrév. Ex Keay (Combretaceae)
T.H. Coulidiati,H. Millogo-Kone,A. Lamien-Meda,C.E. Lamien
Pakistan Journal of Biological Sciences , 2009,
Abstract: In this study, the antioxidant and antibacterial activities of acetone extract, ethyl acetate, n-butanol and n-hexane fractions of acetone extract from leaves of Combretum nioroense Aubrév. ex Keay were investigated. The total phenolics and total flavonoids contents in the fractions and acetone extract were determined by spectrophotometric methods using Folin-Ciocalteu and AlCl3, respectively. Two methods were adopted to assess the antioxidant activities: the Ferric Reducing Antioxidant Power (FRAP) and the radical scavenging activity of 2, 2’-azinobis (3-ethylbenzothiozoline-6-sulfonate) radical cation (ABTS). The Minimum Inhibitory Concentrations (MICs) of the extract and fractions against pathogenic bacteria (4) and serotyped bacteria (4) from American Type Culture Collection (ATCC) were also determined using the agar-well diffusion method. The results showed that the butanol fraction, with the highest phenolic content, exhibited the best antioxidant and antibacterial activities as compared to the ethyl acetate fraction which contains more flavonoids.
Polyphenol Contents and Antioxidant Activities of Five Indigofera Species (Fabaceae) from Burkina Faso
S. Bakasso,A. Lamien-Meda,C.E. Lamien,M. Kiendrebeogo
Pakistan Journal of Biological Sciences , 2008,
Abstract: Aqueous acetone extracts prepared from five Indigofera species of Burkina Faso, namely Indigofera colutea (Burm.) Murril., I. macrocalyx Guilld et Perr., I. nigritana Hook f., I. pulchra willd. and I. tinctoria L., were investigated for their phytochemical composition and their antioxidant activities. Standard methods and TLC were used to screen the phytochemical composition. The total phenolic and flavonoid content of extracts were assessed by Folin-Ciocalteu and AlCl3 methods, respectively. These extracts were also evaluated for their antioxidant potentials using ferric reducing antioxidant power (FRAP), 2,2-diphenyl-l-picrylhydrazyl (DPPH) and 2,2`-azinobis(3-ethylbenzothiazoline-6-sulphonate) (ABTS) assays. Flavonoids, saponins, quinones, sterols/triterpenes and tannins were present in all these species except for I. pulchra where quinones were not found. Gallic acid, caffeic acid, rutin and myricetin in I. colutea; gallic acid, quercitrin, myricetin in I. tinctoria; galangin and myricetin in I. macrocalyx were identified by thin layer chromatography. Among these, I. colutea, I. tinctoria, I. nigritana and I. macrocalyx, which had the highest phenolic content, were also found to possess the best antioxidant activities. The results indicated a good correlation between antioxidant activities and total phenolic content (p<0.05 for FRAP/DPPH and DPPH/ABTS and p<0.01 for FRAP/ABTS). These plants represent promising sources of natural antioxidants and these findings give scientific bases to their ethnopharmacological uses.
In vitro Inhibition of Acetyl Cholinesterase, Lipoxygenase, Xanthine Oxidase and Antibacterial Activities of Five Indigofera (Fabaceae) Aqueous Acetone Extracts from Burkina Faso
S. Bakasso,A. Lamien-meda,C.E. Lamien,M. Kiendrebeogo
Current Research Journal of Biological Sciences , 2013,
Abstract: The aim of this study is to evaluate the inhibition of oxidative stress related enzymes of aqueous acetone extracts, as well as antibacterial activity from five Indigofera species well-known medicinal plant from Burkina. Also are investigated in this study the potential contribution of tannins and of flavonol in these activities Particularly, aqueous acetone extracts were investigated for their Lipoxygenase (LOX), Xanthine Oxidase (XO) and Acetylcholinesterase (AChE) inhibitions that are implied in inflammation, gout and Alzheimer’s etiology diseases. Interestingly, I. macrocalyx which had the highest flavonol content (of all) showed more inhibition against LOX and XO (51.16 and 77.33% respectively). Our study showed a significant correlation between XO inhibition and total flavonol content (R2 = 0.9052). AChE was low sensible to all extracts. In contrast, the extracts were rich in tannin compounds especially in I. tinctoria extract. And results of the in vitro antibacterial activities of these extracts against five bacteria showed that all bacteria were sensible to all extracts particularly S. typhimurium and B. cereus. Our results suggest that the five studied species prove to be good sources of inhibition of the three enzymes involved in oxidative stress and also to have some antibacterial properties. That is what probably explains their uses in folk medicine, singularly, in the treatment of gout, dysentery and anti-inflammatory diseases.
Polyphenol Content and Antioxidant Activity of Fourteen Wild Edible Fruits from Burkina Faso
Aline Lamien-Meda,Charles Euloge Lamien,Moussa M.Y. Compaoré,Roland N.T. Meda,Martin Kiendrebeogo,Boukare Zeba,Jeanne F. Millogo,Odile G. Nacoulma
Molecules , 2008, DOI: 10.3390/molecules13030581
Abstract: A total of fourteen (14) species of wild edible fruits from Burkina Faso wereanalyzed for their phenolic and flavonoid contents, and their antioxidant activities usingthe DPPH, FRAP and ABTS methods. The data obtained show that the total phenolic andtotal flavonoid levels were significantly higher in the acetone than in the methanol extracts.Detarium microcarpum fruit had the highest phenolic and the highest flavonoid content,followed by that of Adansonia digitata, Ziziphus mauritiana, Ximenia americana andLannea microcarpa. Significant amounts of total phenolics were also detected in the otherfruit species in the following order of decreasing levels: Tamarindus indica > Sclerocaryabirrea > Dialium guineense > Gardenia erubescens > Diospyros mespiliformis > Parkiabiglobosa > Ficus sycomorus > Vitellaria paradoxa. Detarium microcarpum fruit alsoshowed the highest antioxidant activity using the three antioxidant assays. Fruits with highantioxidant activities were also found to possess high phenolic and flavonoid contents.There was a strong correlation between total phenolic and flavonoid levels and antioxidantactivities.
Composition and Antimicrobial Activities of Lippia multiflora Moldenke, Mentha x piperita L. and Ocimum basilicum L. Essential Oils and Their Major Monoterpene Alcohols Alone and in Combination
Ima?l Henri Nestor Bassolé,Aline Lamien-Meda,Balé Bayala,Souleymane Tirogo,Chlodwig Franz,Johannes Novak,Roger Charles Nebié,Mamoudou Hama Dicko
Molecules , 2010, DOI: 10.3390/molecules15117825
Abstract: Essential oils from leaves of Lippia multiflora, Mentha x piperita and Ocimum basilicum from Burkina Faso were analysed by GC–FID and GC–MS. Major components were p-cymene, thymol, b-caryophyllene, carvacrol and carvone for L. multiflora, menthol and iso-menthone for M. x piperita and, linalool and eugenol for O. basilicum. The essential oils and their major monoterpene alcohols were tested against nine bacterial strains using the disc diffusion and broth microdilution methods. The essential oils with high phenolic contents were the most effective antimicrobials. The checkerboard method was used to quantify the efficacy of paired combinations of essential oils and their major components. The best synergetic effects among essential oils and major components were obtained with combinations involving O. basilicum essential oil and eugenol, respectively. As phenolic components are characterized by a strong spicy aroma, this study suggests that the selection of certain combinations of EOs could help to reduce the amount of essential oils and consequently reduce any adverse sensory impact in food.
Phenolic Content and Antioxidant Activity of Six Acanthaceae from Burkina Faso
Wamtinga Richard Sawadogo,Aline Meda,Charles Euloge Lamien,Martin Kiendrebeogo
Journal of Biological Sciences , 2006,
Abstract: In this study the total phenolic and flavonoid content as well as the antioxidant activity of six Acanthaceae namely Blepharis lineariifolia PERS, Dicliptera verticillata (FORRSK.) C. CHRISTENS, Dyschoriste perrottetii (NEES) O. KTZE, Hygrophila auriculata (SCHUMACH.) HEINE, Lepidagathis anobrya NEES, Nelsonia canescens (LAM) SPRENG were evaluated. The total phenolic and flavonoid of their aqueous acetone extract were assessed by Folin-ciocalteu and AlCl3 method, respectively, whereas the antioxidant activities were determined by the DPPH method. Lepidagathis anobrya, Hygrophila auriculata and Nelsonia canescens which had the highest phenolic content, were found to possess the best antioxidant activities. The results suggest that these plants are good sources of antioxidants and support their use in cardiovascular and antiinflammatory diseases.
The phytochemical composition and in vitro antiviral activity of decoctions from galls of Guiera senegalensis J.F. Gmel. (Combretaceae) and their relative non-toxicity for chickens
C.E. Lamien,A. Meda,E. Couacy-Hymann,A.G. Ouedraogo
Onderstepoort Journal of Veterinary Research , 2010, DOI: 10.4102/ojvr.v72i2.206
Abstract: Aqueous decoctions obtained from the galls of Guiera senegalensis were screened to determine their phytochemical composition and in vitro antiviral activity against fowlpox virus. In addition, we wanted to investigate the toxic effects, if any, of crude extracts in chickens. Steroids as well as cardiac glycosides not previously reported, an alkaloid, polyphenols and saponins were detected in the various fractions of organic solvents used for extracting the decoctions. Antiviral activity was determined by cytopathic effect inhibition assay in primary chicken embryo skin cells. The 50 % inhibitory concentration (EC50) was shown to be 15.6 μg/ml. Toxicity for cells was established by determining the 50 % cytotoxic concentration (CCy50). A value of 90 μg/ml and a selectivity index (CCy50/EC50) of 5.8 were obtained. In vivo studies of toxicity were performed in chickens that were dosed orally with decoctions of several concentrations for 2 weeks and then monitored for 3 months. No significant changes in several blood chemical parameters were obtained, except for a significant decline in SGOT levels in birds dosed with 100 mg/kg. These levels were nevertheless within the accepted normal range. The findings suggest that aqueous decoctions of galls from G. senegalensis are non-toxic for chickens when administered orally, even at a daily dose of 100 mg/kg for 14 days.
Acute toxicity and antioxydant property of Striga hermonthica (Del.) Benth (Scrophulariaceae)
M Kiendrebeogo, M-G Dijoux-Franca, CE Lamien, A Meda, D Wouessidjewe
African Journal of Biotechnology , 2005,
Abstract: Plants containing flavonoids have been reported to possess strong antioxidant properties. The aqueous acetone extract of Striga hermonthica was further separated into aqueous and ethyl acetate fractions and assayed for their in vitro antioxidant properties using 2,2-diphenyl-1-picrylhydrazyl (DPPH). The crude extract exhibits a weak antioxidant activity (IC50 of 95.27±2.30 ìg/ml) and an insignificant acute toxicity on mice (LD50: 1753±44 mg/kg). Luteolin was isolated and identified by mean of its spectral data as the main DPPH radical scavenger of the ethyl acetate fraction, exhibiting an IC50 value of 6.80±1.46 ìg/ml. These results suggest an antioxidant potential for S. hermonthica.
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