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Search Results: 1 - 10 of 14682 matches for " Chao Zou "
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Estrogen Receptor Alpha 36 Gene Knockdown Promote the Expression of NF-κB in PC12 Cells  [PDF]
Ping Zou, Chao Qu, Yihui Xu, Hongyan Li, Dannv Han, Dan Shi, Wei Zou
Open Journal of Endocrine and Metabolic Diseases (OJEMD) , 2013, DOI: 10.4236/ojemd.2013.34A2003
Abstract:

The nuclear transcription factors κB (NF-κB) is widely existing in various kinds of cell types in the nervous system and plays an important role in neuron apoptosis and neurodegenerative diseases. Estrogen receptor alpha 36 (ER-α36), is a novel variant of ERα (as known ER-α66) which can transduce both estrogenand antiestrogen-dependent activation of MAPK signal pathway and stimulate cell growth. Here, we aimed to detect the effect of ER-α36 gene silencing on the expression of NF-κB in normal cultured PC12 cells and to provide an experimental foundation for understanding the function of ER-α36 innerve cells. PC12 cells with ER-α36 expression knocked down by the shRNA method. Then Western blot and immunocytochemical staining were performed to detect the expression and translocation of NF-κB after transfection. The results showed that NF-κB expression was significantly higher comparing with the control group after transfection (P < 0.01). Also, NF-κB subunit entered nuclear after transfection; Immunofluorescence staining and immunocytochemical staining of PC12 cells demonstrated that ER-α36 was expressed mainly on the plasma membrane and on the cell nucleus membrane. These data indicate that ER-α36 gene silencing can increase the expression of NF-κB and promote its nuclear translocation in PC12 cells.

High sensitive and rapid responsive n-type Si: Au sensor for monitoring breath rate  [PDF]
Xuelan Hu, Jiachang Liang, Xing Li, Yue Chen, Chao Zou, Sheng Liu, Xin Chen
Natural Science (NS) , 2010, DOI: 10.4236/ns.2010.210130
Abstract: 125 μm-breath sensor with high sensitivity and rapid response was prepared by using n-type Si: Au material. Its sensitivity coefficient and time constant were 4 V.sec / L and 38 msec, respec-tively. Its working principle was based on ano- malous resistance effect, which not only increa- sed the sensitivity, but also reduced its time con-stant greatly. Its signal processing system can select the breath signals and work stably. Therefore, the small changes of breath system can be measured and, especially, patient’s breath rate can be monitored at a distance.
Anticancer Effect of Ginseng Leaves Crude Polysaccharides on Human Hepatoma Cell SMMC-7721  [PDF]
Xiaozhen Fu, Dan Shi, Chao Qu, Guangying Zhong, Wei Zou, Jing Liu
Chinese Medicine (CM) , 2014, DOI: 10.4236/cm.2014.52010
Abstract:
Background: Polysaccharides extracted from the medicinal herbs are known to possess antitumor effects. Although there is a significant number of evidences implicated on the beneficial effects of the ginseng leaves ginsenoside with diverse associated mechanisms, reports on the anticancer by the ginseng leaves crude polysaccharides (GLCP) are not sufficient. Experiments were carried out to unravel the anticancer effects of GLCP. Methods: Cells were treated with GLCP (0.5 - 2 mg/ml) for 48h. MTT method was used to detect the cell viability. Western blot and flow cytometry were used to detect apoptotic rate. Western blot and acridine orange staining were used to detect the cell autophagy. Results: Compared with the normal human liver cell (Chang liver), GLCP (1.5 - 2 mg/ml) significantly reduction cell viability, promote apoptosis-related proteins expression, promote cell apoptosis and autophagy in SMMC-7721 cells. But caveolin-1 gene silencing could inhibit the anticancer effect of GLCP. Conclusions: These data suggest that GLCP promote autophagy and apoptosis in human hepatoma cell SMMC-7721. We speculate that its mechanism may be associated with the caveolin-1 which is an essential structural molecule of caveolae. Although the effect of GLCP inhibited of liver cancer is not very strong, we are more interested in the GLCP which plays a tumor suppressor role in health care.
A cooperative fast annealing coevolutionary algorithm for protein motif extraction
Chao Chen,YuanXin Tian,XiaoYong Zou,PeiXiang Cai,JinYuan Mo
Chinese Science Bulletin , 2007, DOI: 10.1007/s11434-007-0047-x
Abstract: By integrating the cooperative approach with the fast annealing coevolutionary algorithm (FAEA), a so-called cooperative fast annealing coevolutionary algorithm (CFACA) is presented in this paper for the purpose of solving high-dimensional problems. After the partition of the search space in CFACA, each smaller one is then searched by a separate FAEA. The fitness function is evaluated by combining sub-solutions found by each of the FAEAs. It demonstrates that the CFACA outperforms the FAEA in the domain of function optimization, especially in terms of convergence rate. The current algorithm is also applied to a real optimization problem of protein motif extraction. And a satisfactory result has been obtained with the accuracy of prediction achieving 67.0%, which is in agreement with the result in the PROSITE database.
Reversible Cataract as the Presenting Sign of Diabetes Mellitus: Report of Two Cases and Literature Review
Yan Yan Jin,Ke Huang,Chao Chun Zou,Li Liang
Iranian Journal of Pediatrics , 2012,
Abstract: Background: Type 1 diabetes mellitus (T1DM) is the most common form of diabetes in young children.Serious optic complications, e.g. diabetic retinopathy and diabetic cataract involvement, are not usually detected in T1DM patients at the onset of the disease.Case Presentation: Two girls aged 11 years and 9 years were hospitalized in our unit in 2008 and 2009. They presented cataracts 1 and 6 months before the diagnosis of T1DM, respectively. After blood glucose level was controlled by insulin therapy, the cataract was resolved, totally in one and partly in the other girl. Meanwhile,visual acuity of both cases recovered, closely associated with fluctuation of plasma glucose level. In this study,we describe the symptoms, probable mechanism and treatment of diabetic cataract.Conclusion: Early antihyperglycemic therapy and maintenance of stable blood glucose level may reverse acute diabetic cataract or prevent it from getting worse.
Factors associated with fasting plasma ghrelin levels in children and adolescents
Chao-Chun Zou, Li Liang, Zheng-Yan Zhao
World Journal of Gastroenterology , 2008,
Abstract: AIM: To measure plasma ghrelin levels in children and adolescents, analyze the associated factors, and investigate the role of ghrelin in obesity, insulin resistance and reproductive physiology.METHODS: A total of 283 subjects aged 4.8-15.8 year were enrolled. Fasting blood samples were collected and plasma ghrelin levels were measured by radioimmunoassay. Fasting glucose (FG), fasting insulin (FI), baseline testosterone (T), estradiol (E2), prolactin (PRL), luteinizing hormone (LH), follicle-stimulating hormone (FSH), serum total cholesterol (TC), triglyceride (TG), alanine aminotransferase (ALT) and uric acid (UA) were measured. Body mass index (BMI), insulin resistance by homeostasis model (HOMA-IR) and beta cell function by homeostasis model (HOMA-β) were calculated.RESULTS: The median ghrelin level was 290 ng/L (15.0-1325.0 ng/L). Bivariate correlation analysis showed that ghrelin levels were inversely correlated with BMI, ALT, TG, UA, LH, FI and HOMA-IR (all P < 0.05). No other significant correlation was found between ghrelin levels and age, gender, TC, E2, FSH, PRL, FG and HOMA-β. Stepwise multiple regression analysis showed that only BMI and FI were independent determinants of plasma ghrelin levels in these children and adolescents (P = 0.018 and P = 0.046, respectively), which explained 25.4% of the variance.CONCLUSION: These data suggest that the lower ghrelin levels in obese subjects may be the result of obesity and hyperinsulinemia, which is very common in obese subjects. Moreover, ghrelin may regulate human reproductive physiology indirectly.
Experimental, Thermodynamic and Kinetic Studies for the Adsorption of Phenolic Compounds Derived from Oilfield Wastewater by the Corncob Hydrochar  [PDF]
Liangcheng Xie, Kangle Ding, Yan Liu, Mei Zou, Chao Han
Open Journal of Yangtze Oil and Gas (OJOGas) , 2019, DOI: 10.4236/ojogas.2019.44023
Abstract: The corncob hydrochar is prepared by using a stainless autoclave at 230°C for 8 h. The products are characterized by elemental analyzer, Fourier Transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and scanning electron microscope (SEM). The effects of hydrochar dosage, pH, adsorption time and phenol concentration on the adsorption performance of hydrochar are investigated by means of single-factor experimental analysis. Based on the experiments the adsorption thermodynamic and kinetics are tentatively discussed. The results show that abundant oxygen-containing functional groups are scattered on the surface of the corncob hydrochar. The adsorption kinetics of phenol on the hydrochar corresponds well with pseudo-second-order kinetic model. Thermodynamic studies indicate that Freundlich adsorption isotherm model is much better than Langmuir model in describing the adsorption of phenol on the corncob hydrochar at 25°C - 45°C. This study provides scientific basis for the development of cheap and efficient adsorbents for the removal of phenols derived from oilfield wastewater.
A cooperative fast annealing coevolutionary algorithm for protein motif extraction
CHEN Chao,TIAN YuanXin,ZOU XiaoYong,CAI PeiXiang,MO JinYuan,
CHEN
,Chao,TIAN,YuanXin,ZOU,XiaoYong,CAI,PeiXiang,MO,JinYuan

科学通报(英文版) , 2007,
Abstract: By integrating the cooperative approach with the fast annealing coevolutionary algorithm (FAEA), a so-called cooperative fast annealing coevolutionary algorithm (CFACA) is presented in this paper for the purpose of solving high-dimensional problems. After the partition of the search space in CFACA, each smaller one is then searched by a separate FAEA. The fitness function is evaluated by combining sub-solutions found by each of the FAEAs. It demonstrates that the CFACA outperforms the FAEA in the domain of function optimization, especially in terms of convergence rate. The current algorithm is also applied to a real optimization problem of protein motif extraction. And a satisfactory result has been obtained with the accuracy of prediction achieving 67.0%, which is in agreement with the result in the PROSITE database.
Preparation and Electrochemical Performance of Carbon nanotubes/Micro-expanded?Graphite Composite Anodes for Lithium-ion Batteries
GUO De-Chao, ZENG Xie-Rong, DENG Fei, ZOU Ji-Zhao, SHENG Hong-Chao
无机材料学报 , 2012, DOI: 10.3724/sp.j.1077.2012.11736
Abstract: Micro-expanded?flake?graphite (MEFG) and micro-expanded?spherical?graphite (MESG) were prepared from two kinds of natural graphite by intercalation reaction and rapid heating processes. Then carbon nanotubes/ micro-expanded?graphite (CNTs/MEG) composites were prepared by chemical vapor deposition (CVD) process, for which CNTs were grown in the pores of micro-expanded?graphite. Electrochemical test results?show that first discharge/ charge capacities of CNTs/MEFG and CNTs/MESG could respectively accommodate up to 443 and 477 mAh/g. Both of the prepared CNTs/MEG composites keep more than 95% capacities after 30 cycles at the rate of 0.2C and their capacities are stable at?259 and 195 mAh/g after 50 cycles at 1C rate, respectively. The nanoporous structure and the CNTs network can improve the discharge capacities and effectively?buffer the volumetric change of the composite electrode materials in the charge/discharge process. The diffusion path of Li+ can be reduced because of the electrolyte solution that filled in the nanopores, which significantly improves the rate capability of the electrodes. In addition, the growing ivy-like CNTs could improve the electric conductive property of the composites in the charge/discharge process.
The Power of Assumptions  [PDF]
Yongchen Zou
Modern Economy (ME) , 2011, DOI: 10.4236/me.2011.24056
Abstract: This paper examines computational merits provided by assumptions made in scientific modeling, especially regression, by trying to exhibit abstractly a model deprived of those assumptions. It shows that the principle of Occam’s Razor has been mistakenly used as model developers’ justification to keep scientific models “as simple as possible”, and that the cost of inflating computability is truncation of model robustness.
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