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Studies on the in Vitro Dissolution of Insoluble Volatile Drug from Su-Anxin Nasal Inhalant and Its Correlation on the Nose Steady Self-Controllable Expiration and Inspiration at Night  [PDF]
Xiaodong Li, Guoxiang Xie, Suyun Li, Chao Hou
Pharmacology & Pharmacy (PP) , 2011, DOI: 10.4236/pp.2011.22008
Abstract: In the paper, the in vitro dissolution of borneol in 12 hours from 6 batches of optimized inhalant samples were investigated. As a new dosage form, the in vitro release apparatus of nasal inhalant was invented and a pushing bump was used according to the simulation of the nose expiration and inspiration. Based on the data of r2 in the profile and similar factor f2 from 6 linear release tendencies, a good controlled release and a zero order tendency were observed. It can be suggested that there is a good correlation between the in vitro controlled release and the nose steady self-controllable expiration and inspiration, which will contribute to the trend of insoluble volatile drug controlled release and the effect of quick absorption in nasal pulmonary delivery to cure severe or acute cardiovascular or lung diseases at patients' sleeping, such as angina or breathing obstruction. Also, it was concluded that the prescription composed of insoluble volatile drugs can be prepared to be nasal inhalant from which drugs can be absorbed through nose steady self-controllable inspiration to the lung then into the blood and have a great effectiveness improvement of bioavailability at night timing drug delivery system.
Aquabis(3′-hydroxy-2,2′-bipyridine-3-olato-κ2N,N′)zinc(II)
Shi Guo Zhang,Chao Hou
Acta Crystallographica Section E , 2008, DOI: 10.1107/s1600536808024495
Abstract: In the title complex, [Zn(C10H7N2O2)2(H2O)], the ZnII ion and water O atom are located on a crystallographic twofold rotation axis and the metal atom assumes a distorted trigonal-bipyramidal ZnN4O coordination geometry. An intramolecular O—H...O hydrogen bond occurs within the ligand and intermolecular O—H...O hydrogen bonds involving the water molecule result in a sheet structure in the crystal structure. In addition, a short C—O...π contact between the O atom of the deprotonated hydroxyl group and a nearby pyridine ring [O...Cg = 3.977 (2) , where Cg is the centroid of the pyridine ring] is observed.
Dichlorido(methanol-κO)[2-(2-pyridylmethoxy)-1,10-phenanthroline-κ3N,N′,N′′]manganese(II)
Hong Liang Li,Hou Chao
Acta Crystallographica Section E , 2008, DOI: 10.1107/s1600536808018631
Abstract: In the title mononuclear complex, [MnCl2(C18H13N3O)(CH4O)], the MnII ion assumes a distorted octahedral geometry. There is a π–π stacking interaction between the phenanthroline ligand and the pyridine ring of a neighboring complex [centroid-to-centroid distance 3.5518 (13) ]. The crystal structure also contains weak intermolecular O—H...Cl hydrogen bonds that link neighboring complex molecules into a one-dimensional chain along the b axis.
9-(2-Pyridylmethoxy)-1,10-phenanthrolin-1-ium perchlorate methanol solvate
Shi Guo Zhang,Chao Hou
Acta Crystallographica Section E , 2008, DOI: 10.1107/s1600536808020606
Abstract: In the title organic salt, C18H14N3O+·ClO4 ·CH4O, there is a π–π stacking interaction between neighbouring 1,10-phenanthroline rings and the relevant distances are 3.5453 (18) for the centroid–centroid distance and 3.354 for the perpendicular distance. There is also a relatively close contact between a C—H bond and a symmetry-related pyridine ring. There are classical N—H...O and O—H...N hydrogen bonds and non-classical C—H...O hydrogen bonds involving the cation, methanol solvent molecule and perchlorate anion.
Visual Saliency Based on Local and Global Features in the Spatial Domain
Chao Jia,Fang Hou,Liangiang Duan
International Journal of Computer Science Issues , 2013,
Abstract: The human visual system can quickly and efficiently capture the salient objects in a scene. Based on the biological mechanism, a new multi-scale saliency analysis method is proposed in this paper, in which the differences of region colors and spaces are calculated in different scale and their saliency map are fused together. First, we calculate the image saliency by using the color and space information of both local and global in single scale. Then by applying the multi-scale fusion, we can effectively inhibit outstanding but not salient region in each single scale, and different scale can also reflect salient region of the images from different aspects. The experiment results show that this algorithm can effectively predict the salient region attracting human attention. Our method has the state-of-the-art performance and achieves excellent results for salient objects of different sizes and salient region with complicated background in an image.
Convex Optimization Learning of Faithful Euclidean Distance Representations in Nonlinear Dimensionality Reduction
Chao Ding,Hou-Duo Qi
Mathematics , 2014,
Abstract: Classical multidimensional scaling only works well when the noisy distances observed in a high dimensional space can be faithfully represented by Euclidean distances in a low dimensional space. Advanced models such as Maximum Variance Unfolding (MVU) and Minimum Volume Embedding (MVE) use Semi-Definite Programming (SDP) to reconstruct such faithful representations. While those SDP models are capable of producing high quality configuration numerically, they suffer two major drawbacks. One is that there exist no theoretically guaranteed bounds on the quality of the configuration. The other is that they are slow in computation when the data points are beyond moderate size. In this paper, we propose a convex optimization model of Euclidean distance matrices. We establish a non-asymptotic error bound for the random graph model with sub-Gaussian noise, and prove that our model produces a matrix estimator of high accuracy when the order of the uniform sample size is roughly the degree of freedom of a low-rank matrix up to a logarithmic factor. Our results partially explain why MVU and MVE often work well. Moreover, we develop a fast inexact accelerated proximal gradient method. Numerical experiments show that the model can produce configurations of high quality on large data points that the SDP approach would struggle to cope with.
Ozone decomposition under the irradiation of 253.7 nm in the presence of methyl bromide
LI Chao-min,HOU Jian,YU Yong,HOU Hui-qi,
LI Chao-min
,HOU Jian,YU Yong,HOU Hui-qi

环境科学学报(英文版) , 2000,
Abstract: In this paper the mechanism and kinetic of ozone decomposition under the irradiation of 253.7 nm UV\|light were studied. The quantum yield of the ozone depletion in the presence of methyl bromide is further determined and a reaction model is provided to explain the experimental fact.
Carbon nanotubes prepared by anodic aluminum oxide template method
PengXiang Hou,Chang Liu,Chao Shi,HuiMing Cheng
Chinese Science Bulletin , 2012, DOI: 10.1007/s11434-011-4892-2
Abstract: One of the most unique structural characteristics of carbon nanotubes (CNTs) differentiating from other carbon materials is their hollow nanochannles, which can be utilized for encapsulating and loading foreign matters. The anodic aluminum oxide (AAO) template technique enables the diameter, length, and cap structure control of the replicated CNTs, and thus shows advantages in pore structure control over the traditional CNT growth approaches. This review details the synthesis of CNTs with tunable diameter, length, wall thickness, and crystalline by using the AAO template method. The doping of heteroatoms and filling of foreign matters into AAO-CNTs are also addressed. Moreover, the main challenges and developing trends of the AAO template method are discussed.
Simple diffusion delivery via brain interstitial route for the treatment of cerebral ischemia
HongBin Han,ZuoLi Xia,He Chen,Chao Hou,WeiBo Li
Science China Life Sciences , 2011, DOI: 10.1007/s11427-011-4141-6
Abstract: Delivering pharmacologic agents directly into the brain has been proposed as a means of bypassing the blood brain barrier. However, despite 16 years of research on a number of central nervous system disorders, an effective treatment using this strategy has only been observed in the brain tumor glioblastoma multiforme. Within this study we propose a novel system for delivering drugs into the brain named the simple diffusion (SDD) system. To validate this technique, rats were subjected to a single intracranial (at the caudate nucleus), or intraperitoneal injection, of the compound citicoline, followed two hours later by a permanent middle cerebral artery occlusion (pMCAO). Results showed that 12 h after pMCAO, with 0.0025 g kg 1 citicoline, an infarct volume 1/6 the size of the intraperitoneal group was achieved with a dose 1/800 of that required for the intraperitoneal group. These results suggest that given the appropriate injection point, through SDD a pharmacologically effective concentration of citicoline can be administered.
A Novel Dualband Frequency Selective Surface with Periodic Cell Perturbation
Chao Guo;Hou-Jun Sun;Xin Lv
PIER B , 2008, DOI: 10.2528/PIERB08071302
Abstract: A novel dualband frequency selective surface (FSS) with both a dielectric substrate and superstrate constructed by double-fourlegged loaded slots (DFLLSs) is investigated, in which each periodic cell consists of two neighboring DFLLSs with different dimensions, its resonant frequencies occur at 183 GHz and 220 GHz. Good selectivity performance can be easily achieved both in lower passband and higher passband by tuning the dimensions of the DFLLSs. Besides, the passbands are mainly determined by the neighboring perturb cells and can be designed independently. According to the explicit physical concept and some formulas, the design process become straightforward and simple. Its frequency performance is obtained by using numerical simulation software CST based on finite difference time domain method (FDTD). The simulated results show the good stability of the resonant frequencies and bandwidths at different polarization states and various incident angles.
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