oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Any time

2019 ( 10 )

2018 ( 122 )

2017 ( 118 )

2016 ( 107 )

Custom range...

Search Results: 1 - 10 of 8838 matches for " Changmei Gu "
All listed articles are free for downloading (OA Articles)
Page 1 /8838
Display every page Item
Association between MGMT Promoter Methylation and Non-Small Cell Lung Cancer: A Meta-Analysis
Changmei Gu, Jiachun Lu, Tianpen Cui, Cheng Lu, Hao Shi, Wenmao Xu, Xueli Yuan, Xiaobo Yang, Yangxin Huang, Meixia Lu
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0072633
Abstract: Background O6-methylguanine-DNA methyltransferase (MGMT) is one of most important DNA repair enzyme against common carcinogens such as alkylate and tobacco. Aberrant promoter methylation of the gene is frequently observed in non-small cell lung cancer (NSCLC). However, the importance of epigenetic inactivation of the gene in NSCLC published in the literature showed inconsistence. We quantified the association between MGMT promoter methylation and NSCLC using a meta-analysis method. Methods We systematically reviewed studies of MGMT promoter methylation and NSCLC in PubMed, EMBASE, Ovid, ISI Web of Science, Elsevier and CNKI databases and quantified the association between MGMT promoter methylation and NSCLC using meta-analysis method. Odds ratio (OR) and corresponding 95% confidence interval (CI) were calculated to evaluate the strength of association. Potential sources of heterogeneity were assessed by subgroup analysis and meta-regression. Results A total of 18 studies from 2001 to 2011, with 1, 160 tumor tissues and 970 controls, were involved in the meta-analysis. The frequencies of MGMT promote methylation ranged from 1.5% to 70.0% (median, 26.1%) in NSCLC tissue and 0.0% to 55.0% (median, 2.4%) in non-cancerous control, respectively. The summary of OR was 4.43 (95% CI: 2.85, 6.89) in the random-effects model. With stratification by potential source of heterogeneity, the OR was 20.45 (95% CI: 5.83, 71.73) in heterogeneous control subgroup, while it was 4.16 (95% CI: 3.02, 5.72) in the autologous control subgroup. The OR was 5.31 (95% CI: 3.00, 9.41) in MSP subgroup and 3.06 (95% CI: 1.75, 5.33) in Q-MSP subgroup. Conclusion This meta-analysis identified a strong association between methylation of MGMT gene and NSCLC. Prospective studies should be required to confirm the results in the future.
Association between RASSF1A Promoter Methylation and Ovarian Cancer: A Meta-Analysis
Hao Shi, Ya Li, Xiaozhong Wang, Cheng Lu, Lilan Yang, Changmei Gu, Jiaqiang Xiong, Yangxin Huang, Shixuan Wang, Meixia Lu
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0076787
Abstract: Background The RAS association domain family protein 1a gene (RASSF1A) is one of the tumor suppressor genes (TSG). Inactivation of RASSF1A is critical to the pathogenesis of cancer. Aberrant TSG methylation was considered an important epigenetic silencing mechanism in the progression of ovarian cancer. A number of studies have discussed association between RASSF1A promoter methylation and ovarian cancer. However, they were mostly based on a small number of samples and showed inconsist results, Therefore, we conducted a meta-analysis to better identify the association. Methods Eligible studies were identified by searching the PubMed, EMBASE, Web of Science, and CNKI databases using a systematic searching strategy. We pooled the odds ratio (ORs) from individual studies using a fixed-effects model. We performed heterogeneity and publication bias analysis simultaneously. Results Thirteen studies, with 763 ovarian cancer patients and 438 controls were included in the meta-analysis. The frequencies of RASSF1A promoter methylation ranged from 30% to 58% (median is 48%) in the cancer group and 0 to 21% (median is 0) in the control group. The frequencies of RASSF1A promoter methylation in the cancer group were significantly higher than those in the control group. The pooled odds ratio was 11.17 (95% CI = 7.51–16.61) in the cancer group versus the corresponding control group under the fixed-effects model. Conclusion The results suggested that RASSF1A promoter methylation had a strong association with ovarian cancer.
Relative Infinite Determinacy for Map-Germs
Changmei Shi,Donghe Pei
Journal of Function Spaces , 2013, DOI: 10.1155/2013/549845
Abstract: The infinite determinacy for smooth map-germs with respect to two equivalence relations will be investigated. We treat the space of smooth map-germs with a constraint, and the constraint is that a fixed submanifold in the source space is mapped into another fixed submanifold in the target space. We study the infinite determinacy for such map-germs with respect to a subgroup of right-left equivalence group and finite and infinite determinacy with respect to a subgroup of contact group and give necessary and sufficient conditions for the corresponding determinacy. 1. Introduction This work is concerned with the singularity theory of differentiable maps. Singularity theory of differentiable maps is a wide-ranging generalization of the theory of the maxima and minima of functions of one variable, and it is now an essential part of nonlinear analysis. This theory has numerous applications in mathematics and the natural sciences; see, for example, [1, 2]. In differentiable analysis, the local behavior of a differentiable map can be determined by the derivatives of the map at a point. Hence we have the theories of finitely and infinitely determined map-germs. We know that every finitely determined map-germ is equivalent to its Taylor polynomial of some degree, and infinite determinacy is a way to express the stability of smooth map-germs under flat perturbations. The analysis of the conditions for a map-germ to be finitely or infinitely determined involves the most important local aspects of singularity theory. Therefore, the study of finite and infinite determinacy of smooth map-germs is a very important subject in singularity theory. Now there are several articles treating the question of infinite determinacy with respect to the most frequently encountered and naturally occurring equivalence groups, for instance, the right-equivalence group , left-equivalence group , group , contact group , and right-left-equivalence group . In [3, 4], Wilson characterized the infinite determinacy of smooth map-germs with respect to one of the groups , , , and and the infinite determinacy for finitely -determined map-germs with respect to . Besides, for the case of , Brodersen [5] showed that the results of [4] hold for map-germs without assuming -finiteness. We can see [6] for detailed survey of all of these results. Recently, there appeared the notion of relative infinite determinacy for smooth function-germs with nonisolated singularities. Sun and Wilson [7] treated the smooth function-germs with real isolated line singularities, and this work was later generalized and
catena-Poly[[tetrakis(hexamethylphosphoramide-κO)bis(nitrato-κ2O,O′)holmium(III)] [silver(I)-di-μ-sulfido-tungstate(VI)-di-μ-sulfido]]
Juxiang Zeng,Guodong Tang,Changmei Wei
Acta Crystallographica Section E , 2011, DOI: 10.1107/s1600536811046460
Abstract: In the title salt, {[Ho(NO3)2(C6H18N3OP)4][AgWS4]}n, the anion forms a W/S/Ag polymeric chain along the a axis. The holmium atom in the cation is coordinated by eight O atoms from two nitrate and four hexamethylphosphoramide ligands in a distorted square-antiprismatic geometry. Together with the two nitrate ligands, the complex cation in the title compound is univalent, which leads the anion to be univalent as well. The polymeric anionic chain with W—Ag—W and Ag—W—Ag angles of 161.429 (17) and 153.608 (10) °, respectively, presents a distorted linear configuration. The title complex is isotypic with the corresponding Y, Yb, Eu, Nd, La and Dy analogues.
A Factorial Validation of Knowledge-Sharing Motivation Construct  [PDF]
Qinxuan Gu, Yingting Gu
Journal of Service Science and Management (JSSM) , 2011, DOI: 10.4236/jssm.2011.41009
Abstract: While there is increasingly strategic importance in knowledge, it is facing new challenges to manage knowledge effectively. The paper studies the motivational construct model for knowledge sharing from the perspective of content theories and social motivation theories. The data collected by using the questionnaire survey from a variety of industries was analyzed on the basis of interviews and pretest. The results of exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) showed the motivational construct model for knowledge sharing was comprised of existence motivation, relatedness motivation, growth motivation and norm motivation. The results extended the perspectives for knowledge sharing motivation and provided theoretical evidences for facilitating knowledge sharing behavior.
Improved Synthesis of 5-Substituted 1H-Tetrazoles via the [3+2] Cycloaddition of Nitriles and Sodium Azide Catalyzed by Silica Sulfuric Acid
Zhenting Du,Changmei Si,Youqiang Li,Yin Wang,Jing Lu
International Journal of Molecular Sciences , 2012, DOI: 10.3390/ijms13044696
Abstract: A silica supported sulfuric acid catalyzed [3+2] cycloaddition of nitriles and sodium azide to form 5-substituted 1 H-tetrazoles is described. The protocol can provide a series of 5-substituted 1 H-tetrazoles using silica sulfuric acid from nitriles and sodium azide in DMF in 72%–95% yield.
Multi-objective Optimization of Multi-Agent Elevator Group Control System Based on Real-time Particle Swarm Optimization Algorithm  [PDF]
Yanwu Gu
Engineering (ENG) , 2012, DOI: 10.4236/eng.2012.47048
Abstract: In order to get a globally optimized solution for the Elevator Group Control System (EGCS) scheduling problem, an algorithm with an overall optimization function is needed. In this study, Real-time Particle Swarm Optimization (RPSO) is proposed to find an optimal solution to the EGCS scheduling problem. Different traffic patterns and controller mechanisms for EGCS are analyzed. This study focuses on up-peak traffic because of its critical importance to modern office buildings. Simulation results show that EGCS based on Multi-Agent Systems (MAS) using RPSO gives good results for up-peak EGCS scheduling problem. Besides, the elevator real-time scheduling and reallocation functions are realized based on RPSO in case new information is available or the elevator becomes busy because it is unavailable or full. This study contributes a new scheduling algorithm for EGCS, and expands the application of PSO.
Research on the Cultivation of “Managerial” Accounting Talents’ IT Quality  [PDF]
Lingyan Gu
Open Journal of Accounting (OJAcct) , 2012, DOI: 10.4236/ojacct.2012.11002
Abstract: The rapid development of information technology puts forward higher request on the accounting personnel’s IT quality. This paper begins with the analysis about the information technologies which impact on accounting personnel in order to discuss what IT quality should be possessed by accounting personnel. Then according to the target of “managerial” accounting talents cultivation mode, it proposes several suggestions for the university about how to cultivate the “managerial” accounting talents’ IT quality.
The Allocation of Family Guanxi-Oriented Control Rights
—Evidence from Family Listed Companies of Zhejiang China
 [PDF]

Lingyan Gu
American Journal of Industrial and Business Management (AJIBM) , 2014, DOI: 10.4236/ajibm.2014.42016
Abstract:

Different from the market-oriented control mechanism in British and American, the guanxi-oriented control mechanism is a significant feature in Chinese family business. This paper proposes the concept of family guanxi-oriented control rights allocation for the first time. Based on the analysis about the influencing factors of the family guanxi-oriented control rights allocation, we use the sample companies coming from Zhejiang province of China to do further discussion. We find that 1) the actual controllers of Zhejiang family listed companies mainly have blood relationship; 2) parts of companies allocate the control rights between the family members who have more than three kinds of guanxi; 3) the controlling families prefer to control the board of the listed companies; 4) the intergenerational succession of control rights in Zhejiang family listed companies has been highlighted.

The Theoretical Analysis of the Allocation of Family Control Rights Based on Guanxi in China  [PDF]
Lingyan Gu
Open Journal of Business and Management (OJBM) , 2014, DOI: 10.4236/ojbm.2014.24037
Abstract: With the development of the family businesses, family members are coming from diversified source. Under this circumstance, guanxi and potential conflicts between family members are becoming complicated. The allocation of control rights among the family members plays an important role. This paper proposes the allocation concept of the family guanxi-oriented control rights for the first time. On the basis of the review of classical theories about the control rights allocation, it builds a theoretical analysis framework of family control rights allocation embedding guanxi.
Page 1 /8838
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.