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Search Results: 1 - 10 of 27861 matches for " Changhao Sun "
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Liuwei Dihuang Lowers Body Weight and Improves Insulin and Leptin Sensitivity in Obese Rats
Benjamin Perry,Junzeng Zhang,Changhao Sun,Tarek Saleh,Yanwen Wang
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/847167
Abstract: The present study was aimed at investigating the efficacy and mechanism(s) of action of a Chinese herbal formulation, Liuwei Dihuang (LWDH), as a prospective natural weight-lowering product. Following a 2-week acclimation period, 48 obesity-prone (OP-CD) rats were divided into 4 groups (=12 each). One group served as a positive control for obesity (OP), while the other 3 were challenged twice daily by oral gavage with total daily dosages of 500, 1500, or 3500 mg/kg BW LWDH, respectively, for 10 weeks. One group (=12) of obesity-resistant (OR-CD) rats served as the normal control group. All rats were fed the same AIN-93G diet modified to contain 60% energy from fat. The highest LWDH dose significantly reduced body weight during the last 4 weeks of treatment. Food intake was reduced beginning in week 2. The high LWDH dose lowered serum triglyceride (TG) and nonesterified fatty acid (NEFA) levels and body fat. Both the high and medium doses also lowered serum leptin and insulin levels. Liver function testing revealed no adverse side effects under the current experimental conditions. The results of the present study suggest that LWDH has potential as a preventive or therapeutic natural product against overweight and obesity.
Berberine Improves Glucose Homeostasis in Streptozotocin-Induced Diabetic Rats in Association with Multiple Factors of Insulin Resistance
Yanfeng Chen,Yanwen Wang,Junzeng Zhang,Changhao Sun
ISRN Endocrinology , 2011, DOI: 10.5402/2011/519371
Ursolic Acid Inhibits Adipogenesis in 3T3-L1 Adipocytes through LKB1/AMPK Pathway
Yonghan He, Ying Li, Tiantian Zhao, Yanwen Wang, Changhao Sun
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0070135
Abstract: Background Ursolic acid (UA) is a triterpenoid compound with multiple biological functions. This compound has recently been reported to possess an anti-obesity effect; however, the mechanisms are less understood. Objective As adipogenesis plays a critical role in obesity, the present study was conducted to investigate the effect of UA on adipogenesis and mechanisms of action in 3T3-L1 preadipocytes. Methods and Results The 3T3-L1 preadipocytes were induced to differentiate in the presence or absence of UA for 6 days. The cells were determined for proliferation, differentiation, fat accumulation as well as the protein expressions of molecular targets that regulate or are involved in fatty acid synthesis and oxidation. The results demonstrated that ursolic acid at concentrations ranging from 2.5 μM to 10 μM dose-dependently attenuated adipogenesis, accompanied by reduced protein expression of CCAAT element binding protein β (C/EBPβ), peroxisome proliferator-activated receptor γ (PPARγ), CCAAT element binding protein α (C/EBPα) and sterol regulatory element binding protein 1c (SREBP-1c), respectively. Ursolic acid increased the phosphorylation of acetyl-CoA carboxylase (ACC) and protein expression of carnitine palmitoyltransferase 1 (CPT1), but decreased protein expression of fatty acid synthase (FAS) and fatty acid-binding protein 4 (FABP4). Ursolic acid increased the phosphorylation of AMP-activated protein kinase (AMPK) and protein expression of (silent mating type information regulation 2, homolog) 1 (Sirt1). Further studies demonstrated that the anti-adipogenic effect of UA was reversed by the AMPK siRNA, but not by the Sirt1 inhibitor nicotinamide. Liver kinase B1 (LKB1), the upstream kinase of AMPK, was upregulated by UA. When LKB1 was silenced with siRNA or the inhibitor radicicol, the effect of UA on AMPK activation was diminished. Conclusions Ursolic acid inhibited 3T3-L1 preadipocyte differentiation and adipogenesis through the LKB1/AMPK pathway. There is potential to develop UA into a therapeutic agent for the prevention or treatment of obesity.
Nonperturbative QCD Contributions to the Semileptonic Decay Width of the B Meson
Changhao Jin
Physics , 1996, DOI: 10.1103/PhysRevD.56.2928
Abstract: Nonperturbative QCD contributions to the inclusive semileptonic decay of the B meson consist of the dynamic and kinematic components. We calculate the decay width in an approach based on the light-cone expansion and the heavy quark effective theory, which is able to include both components of nonperturbative QCD contributions. The kinematic component results in the phase-space extension and is shown to be quantitatively crucial, which could increase the decay width significantly. We find that the semileptonic decay width is enhanced by long-distance strong interactions by +(9\pm 6)%. This analysis is used to determine the CKM matrix element |V_{cb}| with a controlled theoretical error. Implications of the phase-space effects for the nonleptonic decay widths of b hadrons are briefly discussed. The experimental evidence for the phase-space effects is pointed out.
Determinations of |V_ub| and |V_cb| from measurements of B -> X_u,c\ellνdifferential decay rates
Changhao Jin
Physics , 1998, DOI: 10.1142/S0217732399001255
Abstract: Methods are described in the framework of light-cone expansion which allow one to determine the Cabibbo-Kobayashi-Maskawa matrix elements |V_ub| and |V_cb| from measurements of the differential decay rates as a function of the scaling variables in the inclusive semileptonic decays of B mesons. By these model-independent methods the dominant hadronic uncertainties can be avoided and the B -> X_u\ell\nu decay can be very efficiently differentiated from the B -> X_c\ell\nu decay, which may lead to precise determinations of |V_ub| and |V_cb|.
Calculation of the semileptonic decay width of the $Λ_b$ baryon
Changhao Jin
Physics , 1997, DOI: 10.1103/PhysRevD.56.7267
Abstract: We extend the approach based on the light-cone expansion and the heavy quark effective theory to the inclusive semileptonic decay of an unpolarized $b$-flavored hadron. It is applied to calculate the semileptonic decay width of the $\Lambda_b$ baryon and its ratio to that of the B meson. We obtain $\Gamma_{SL}(\Lambda_b)= 51\pm 9 |V_{cb}|^2{ps}^{-1}$ and $\Gamma_{SL}(\Lambda_b)/\Gamma_{SL}(B)= 1.052\pm 0.006$. From the latter, the semileptonic branching fraction for $\Lambda_b$ is predicted to be $(8.7\pm 0.7)%$.
Extracting |V_{ub}| from the inclusive charmless semileptonic branching ratio of b hadrons
Changhao Jin
Physics , 1998, DOI: 10.1016/S0370-2693(99)00034-9
Abstract: We calculate the inclusive charmless semileptonic decay width of the B meson using a QCD-based approach. This approach is able to account for both dynamic and kinematic effects of nonperturbative QCD. The charmless semileptonic decay width is found to be enhanced by long-distance strong interactions by +(7\pm 5)% with respect to the free quark decay width. Using the resulting theoretical value for the charmless semileptonic decay width, an extraction of $|V_{ub}|$ is made from the measured lifetime and inclusive charmless semileptonic branching ratio of b hadrons.
Inclusive Heavy Hadron Decays and Light-Cone Dynamics
Changhao Jin
Physics , 2000,
Abstract: The governing role of light-cone dynamics in inclusive heavy hadron decay processes is demonstrated. Nonperturbative QCD effects on the processes can be systematically calculated using light-cone expansion and heavy quark effective theory. The applications of the light-cone approach to studying electroweak and strong interactions and hadron structure with semileptonic and radiative decays of beauty hadrons are briefly reviewed.
Probing hadron structure and strong interactions with inclusive semileptonic decays of B mesons
Changhao Jin
Physics , 1998,
Abstract: The study of inclusive semileptonic decays of $B$ mesons is analyzed from the viewpoint of probing hadron structure and strong interactions. General formulas for the differential decay rates are given in terms of the structure functions in arbitrary frame of reference, taking into account the finite charged lepton mass. These formulas can be used for structure function measurements. The behavior of the structure functions is shown to contain information on the constitution of the $B$ meson and the dynamics of strong interactions. Measurements of the structure functions would reveal the existence of a point-like $b$ quark in the $B$ meson, establish the spin 1/2 nature of the $b$ quark, and identify the $b$ quantum number of the $B$ meson. These measurements would determine the $b$ quark distribution function, and allow new insight into the nature of confinement. The $b$ quark distribution function can also be extracted directly through the measurements of the decay distributions with respect to the scaling variable $\xi_+$.
Semi-inclusive nonleptonic decays B\to D_s^{(*)} X
Changhao Jin
Physics , 2002, DOI: 10.1103/PhysRevD.65.114009
Abstract: We calculate the total and differential decay rates for the semi-inclusive nonleptonic decays $B\to D_s^{(*)} X_q$ ($q=c$ or $u$) under the factorization hypothesis. The initial bound state effect is treated using the light-cone expansion and the heavy quark effective theory. We investigate the contribution of the penguin amplitude for the decay mode $B\to D_s^{(*)} X_c$ and find that it is small but non-negligible. The resulting decay rates for $B\to D_s^{(*)} X_c$ agree with the measurements. The use of the decay mode $B\to D_s^{(*)} X_u$ to determine $|V_{ub}|$ is discussed.
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