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Search Results: 1 - 10 of 112917 matches for " Chang-Wen Chen "
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MELD score can predict early mortality in patients with rebleeding after band ligation for variceal bleeding
Wei-Ting Chen,Chun-Yen Lin,I-shyan Sheen,Chang-Wen Huang
World Journal of Gastroenterology , 2011, DOI: 10.3748/wjg.v17.i16.2120
Abstract: AIM: To investigate the outcomes, as well as risk factors for 6-wk mortality, in patients with early rebleeding after endoscopic variceal band ligation (EVL) for esophageal variceal hemorrhage (EVH). METHODS: Among 817 EVL procedures performed for EVH between January 2007 and December 2008, 128 patients with early rebleeding, defined as rebleeding within 6 wk after EVL, were enrolled for analysis. RESULT: The rate of early rebleeding after EVL for acute EVH was 15.6% (128/817). The 5-d, 6-wk, 3-mo, and 6-mo mortality rates were 7.8%, 38.3%, 55.5%, and 58.6%, respectively, in these early rebleeding patients. The use of beta-blockers, occurrence of hypovolemic shock, and higher model for end-stage liver disease (MELD) score at the time of rebleeding were independent predictors for 6-wk mortality. A cut-off value of 21.5 for the MELD score was found with an area under ROC curve of 0.862 (P < 0.001). The sensitivity, specificity, positive predictive value, and negative predictive value were 77.6%, 81%, 71.7%, and 85.3%, respectively. As for the 6-mo survival rate, patients with a MELD score ≥ 21.5 had a significantly lower survival rate than patients with a MELD score < 21.5 (P < 0.001). CONCLUSION: This study demonstrated that the MELD score is an easy and powerful predictor for 6-wk mortality and outcomes of patients with early rebleeding after EVL for EVH.
None of the Six SNPs of IL28B Could Predict Treatment Responses in Genotype 2 Chronic HCV Infected Patients by Propensity Score Matching Analysis
Wen-Juei Jeng, Chun-Yen Lin, Ji-Yih Chen, Chang-Wen Huang, Chien-Hao Huang, I-Shyan Sheen
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0048217
Abstract: Background & Aims A combination of pegylated interferon-alpha and ribavirin (PR) is the standard therapy for patients with chronic hepatitis C. The impact of polymorphism of interleukin-28B (IL28B) on sustained virological response (SVR) to PR has been well documented in patients with CHC genotype-1 (GT1), but it is controversial in genotype-2 (GT2) CHC patients. This study investigated the predictability of six single nucleotide polymorphisms (SNP) of IL28B on the treatment responses of PR in patients with CHC GT2. Method 197 CHC GT2 consecutive patients who received PR treatment in our prospective cohort were enrolled. Hepatitis C virus (HCV) genotyping, quantification of HCV-RNA and genotyping of the ten SNPs of IL28B were performed. Six SNPs of IL28B were chosen for analysis. The propensity score matching (PSM) analysis was applied using patients with CHC GT1 in another prospective cohort as a positive comparison to avoid covariate bias. Results The distribution of the six SNPs was similar in GT1 and GT2 patients. Five of these SNPs had strong association with treatment responses in GT1 but not in GT2 patients. After PSM analysis, these five SNPs still showed strong association with rapid virological response (RVR), cEVR and SVR in GT1 and had no influence in GT2 patients. Furthermore, rs12979860 and baseline viral load were the predictors for both RVR and SVR in GT1 patients. However, only baseline viral load could predict RVR and SVR in GT2 patients. In addition, in patients without RVR, rs12979860 was the only predictor for SVR in GT1 but no predictor for SVR was found in GT2. Conclusions The genetic polymorphisms of IL28B had no impact on treatment responses in GT2 patients.
Application and comparison of scoring indices to predict outcomes in patients with healthcare-associated pneumonia
Wen-Feng Fang, Kuang-Yao Yang, Chieh-Liang Wu, Chong-Jen Yu, Chang-Wen Chen, Chih-Yen Tu, Meng-Chih Lin
Critical Care , 2011, DOI: 10.1186/cc9979
Abstract: We conducted a retrospective cohort study based on an inpatient database from six medical centers, recruiting a total of 444 patients with HCAP between 1 January 2007 and 31 December 2007. Pneumonia severity scoring indices including PSI (pneumonia severity index), CURB 65 (confusion, urea, respiratory rate, blood pressure, age 65), IDSA/ATS (Infectious Diseases Society of America/American Thoracic Society), modified ATS rule, SCAP (severe community acquired pneumonia), SMART-COP (systolic blood pressure, multilobar involvement, albumin, respiratory rate, tachycardia, confusion, oxygenation, pH), SMRT-CO (systolic blood pressure, multilobar involvement, respiratory rate, tachycardia, confusion, oxygenation), and SOAR (systolic blood pressure, oxygenation, age, respiratory rate) were calculated for each patient. Patient characteristics, co-morbidities, pneumonia pathogen culture results, length of hospital stay (LOS), and length of ICU stay were also recorded.PSI (>90) has the highest sensitivity in predicting mortality, followed by CURB-65 (≥2) and SCAP (>9) (SCAP score (area under the curve (AUC): 0.71), PSI (AUC: 0.70) and CURB-65 (AUC: 0.66)). Compared to PSI, modified ATS, IDSA/ATS, SCAP, and SMART-COP were easy to calculate. For predicting ICU admission (Day 3 and Day 14), modified ATS (AUC: 0.84, 0.82), SMART-COP (AUC: 0.84, 0.82), SCAP (AUC: 0.82, 0.80) and IDSA/ATS (AUC: 0.80, 0.79) performed better (statistically significant difference) than PSI, CURB-65, SOAR and SMRT-CO.The utility of the scoring indices for risk assessment in patients with healthcare-associated pneumonia shows that the scoring indices originally designed for CAP can be applied to HCAP.Healthcare-associated pneumonia (HCAP), a relatively new category of pneumonia, refers to infections that occur prior to hospital admission in patients with contact or exposure to a healthcare environment [1]. Compared to community-acquired pneumonia (CAP), HCAP is a distinct type of pneumonia with unique m
Plasma kallistatin levels in patients with severe community-acquired pneumonia
Wei-Chieh Lin, Shiou-Ling Lu, Chiou-Feng Lin, Chang-Wen Chen, Lee Chao, Julie Chao, Yee-Shin Lin
Critical Care , 2013, DOI: 10.1186/cc12507
Abstract: Plasma samples and clinical data were prospectively collected from 54 patients with severe CAP requiring ICU admission. Seventeen healthy control subjects were included for comparison. Plasma kallistatin, kallikrein, and other biomarkers of inflammation (tumor necrosis factor-alpha [TNF-alpha], interleukin [IL]-1beta, IL-6, IL-8, C-reactive protein [CRP]) and anti-coagulation (protein C, anti-thrombin III) were measured on days 1 and 4 of ICU admission. Comparison between survivors (n = 41) and non-survivors (n = 13) was performed.Plasma kallistatin was significantly consumed in severe CAP patients compared with healthy individuals. Lower day 1 kallistatin levels showed a strong trend toward increased mortality (P = 0.018) and higher day 1 CURB-65 scores (P = 0.004). Plasma kallistatin levels on day 1 of ICU admission were significantly decreased in patients who developed septic shock (P = 0.017) and who had acute respiratory distress syndrome (P = 0.044). In addition, kallistatin levels were positively correlated with anti-thrombin III and protein C and inversely correlated with IL-1beta, IL-6 and CRP levels. In a multivariate logistic regression analysis, higher day 1 CURB-65 scores were independent predictors of mortality (odds ratio = 29.9; P = 0.009). Also, higher day 1 kallistatin levels were independently associated with a decreased risk of death (odds ratio = 0.1) with a nearly significant statistical difference (P = 0.056). Furthermore, we found that a cutoff level of 6.5 mug/mL of day 1 kallistatin determined by receiver operating characteristic curves could be used to distinguish between patients who survived in 60 days and those who did not.These results suggest that kallistatin may serve as a novel marker for severe CAP prognosis, and may be involved in the pathogenesis of CAP through anti-inflammatory and anti-coagulation effects.
IL28B SNP rs12979860 Is a Critical Predictor for On-Treatment and Sustained Virologic Response in Patients with Hepatitis C Virus Genotype-1 Infection
Chun-Yen Lin,Ji-Yih Chen,Tsung-Nan Lin,Wen-Juei Jeng,Chien-Hao Huang,Chang-Wen Huang,Su-Wei Chang,I-Shyan Sheen
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0018322
Abstract: Single nucleotide polymorphisms (SNPs) of interleukin-28B (IL28B) have received considerable interest for their association with sustained virological response (SVR) when treating patients of genotype-1 hepatitis C virus (GT1-HCV) chronic infection with pegylated interferon and ribavirin (PegIFN/RBV). This study was to investigate the predictive power of IL28B SNPs for on-treatment responses and SVR in treatment-na?ve patients with GT1-HCV chronic infection.
Transformation and movement of potassium in ferti-sphere of paddy soil as affected by co-application of ammonium

SU Tong-qing,WANG Huo-yan,ZHOU Jian-min,CHEN Xiao-qin,DU Chang-wen,

土壤 , 2011,
Abstract: A soil column incubation experiment was conducted in this study to investigate the effect of NH4+ on transformation and movement of K+ in ferti-sphere of paddy soil. The results showed that movement of K+ increased with K dose. In presence of same amount of NH4+, as K dose increased by 2.4 times, the water-extractable K (WE-K), Exchangeable K (E-K) and non-exchangeable K (NE-K) in the nearest part of ferti-sphere significantly increased by 2.1, 1.7 and 0.3 times, respectively. While the K diffusion distance increased by 16.4% (12 mm) as K dose increased. The results indicated that fixation of K in ferti-sphere is somewhat limited; more portion of K remained in labile form as K dose increased. Co-application of NH4+ and K significantly increased both WE-K in the nearest part of ferti-sphere and the K diffusion distance as compared with K solely applied treatment. Co-application of NH4+ significantly increased E-K in the transition area from ferti-sphere to bulk soil and reduced NE-K in all the soil samples that NH4+ possibly reached. Co-application of NH4+ significantly restrained transformation of added K into NE-K in ferti-sphere, and the effect declined as the distance from ferti-sphere increased. Different models were compared to describe the change of K concentration from ferti-sphere to bulk soil, for both WE-K and E-K, the anti-S-shape curve y = a / 1 + b exp (c × x)] can be well fitted.
Comparing principles and efficiency of different methods for available potassium extraction

LIU Hong-ge,WANG Huo-yan,ZHOU Jian-min,DU Chang-wen,CHEN Xiao-qin,

土壤 , 2012,
Abstract: Principles and factors affecting the efficiency of different methods for extracting available K from six potassium-bearing minerals were investigated in current study.These methods included salt solutions,cation exchange resins and NaBPh4 methods.The results showed that the effectiveness of K extraction from minerals by salts was mainly dependent on the ion type, concentration and pH value of the solution.Different salts had different preferential effect on K release from various minerals.NH1+ saturation led to the collapse of the interlayer structure of the minerals and restrained non-exchangeable K(NEK) release remarkably.The effectiveness of K extraction by cation exchange resins method was mainly related to the ion type used to saturated resin beads and somewhat to the shaking speed used.Comparing with Ca2+,H+ and Na+ saturated resin had stronger K exchanging capacity from solution. For eliminating the effect of film mass transfer resistance on K exchange by resins,a shaking speed higher than 120 r/min was recommended.The solubility product constant of KBPh4 was 2.40×10-8(25℃) based on the data got in current study.Without NaCI, NaBPh4 concentration was the main factor affecting the effectiveness of K extraction from minerals.According to the mechanism and efficiency of different methods,ammonium salts are suitable for evaluating K availability in soils with high content of exchangeable K. However,non-ammonium salts which can extract a small portion of NEK under long time extraction procedure,is superior to ammonium acetate to evaluate K availability in soils containing NEK available to crop.Cation exchange resins which can also extract NEK are more suitable for in situ research of soil K movement,but the procedure is relatively tedious.Different portion of NEK could be efficiently extracted with the NaBPh4 method via modification of the K extracting power of the method.The NaBPh4 method is assumed to be a good method for evaluation of available K in various soils in future.
Application of allelopathy to weeds contro1

LI Shou-Tian,ZHU Jian-Min,WANG Huo-Yan,CHEN Xiao-Qin,DU Chang-Wen,

中国生态农业学报 , 2003,
Abstract: Weeds is very harmful to the growth of crops,and the utilization of herbicides will lead to environmental pollution and development of herbicide resistance in weeds.Allelopathy among plants is an effective way to control weeds.Weeds germination and growth are suppressed by allelochemicals released from smothering plants and environmental competition with smothering plants.In addition,the release of allelochemicals can be influenced by the measurements of rotation,tillage and other ways,which leads to different levels of weeds suppression.Breeding for smothering plants which possess allelo-pathic potentials is the most effective way to alleviate or eliminale adverse effects of weeds,which can incorporate allelo-pathte characteristics into plants to suppress weeds.
Effect of Monocalcium Phosphate and Potassium Chloride on Nitrogen Leaching in Paddy Soil

LI Shou-tian,ZHOU Jian-min,WANG Huo-yan,DU Chang-wen,CHEN Xiao-qin,

环境科学 , 2004,
Abstract: In this article, influence of monocalcium phosphate and potassium chloride application on nitrogen leaching in paddy soil of Taihu region was studied by soil column leaching. The results showed that nitrate nitrogen was the main component of nitrogen leaching without urea application which accounts for 93.39 percent of total nitrogen leaching(including urea, ammonium, and nitrate nitrogen). Amounts of urea, ammonium, and nitrate nitrogen in leachates increased significantly after urea application which account for 3.95, 15.25, and 80.80 percent of total nitrogen leaching respectively and for 0.26, 0.80, and 2.54 percent of applied nitrogen respectively. Amounts of urea, ammonium, and nitrate nitrogen in leachates were enhanced prominently by monocalcium phosphate or potassium chloride which are 4.54, 24.11, 71.34, and 3.45, 24.53, 72.02 percent of total nitrogen leaching respectively, and which are 0.39, 1.86, 3.34, and 0.32, 2.12, 4.06 percent of applied nitrogen separately. There is interactive influence on nitrogen leaching after application of monocalcium phosphate and potassium chloride together, and amounts of urea, ammonium, and nitrate nitrogen were 4.10, 27.35, and 68.55 percent of total nitrogen leaching, and 0.42, 2.60, and 4.26 percent of total applied nitrogen respectively. The leaching order of different form nitrogen followed as urea N>ammonium N>nitrate N, and leaching amounts of different form nitrogen followed as urea N
杂交鲟(Sturgeon cartilage)软骨中硫酸软骨素的提取方法及分析鉴定

CHEN Xiao-E,FANG Xu-Bo,YU Hui,SHI Jin-Yu,WU Chang-Wen,

海洋与湖沼 , 2008,
Abstract: 采用稀碱浸提、蛋白酶水解与三氯乙酸沉淀相结合脱蛋白的工艺,对杂交鲟软骨提取琉酸软骨素的方法进行了较系统的研究。综合考察各种影响因素,设计了正交试验对提取工艺参数进行了优化,并对产品的质量指标进行了检验。结果表明,最佳提取工艺参数为:碱提取时料液比为1:2.0,碱浓度为4%,碱提温度为40℃;胰蛋白酶的酶解温度为55℃,酶量为2%,酶解时间为10h,制备的硫酸软骨素为白色粉末,得率为28.9%,纯度为92.3%,蛋白质含量为2.59%,各项质量指标完全符合标准要求。与目前已报道的其他软骨素制备工艺相比较,该方法具有工艺简便,提取率高,产品纯度高的特点。光谱分析法结构鉴定结果表明它是一种软骨素肽,其主要成分为硫酸软骨素C。
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