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Search Results: 1 - 10 of 43374 matches for " Chang-Seop Lee "
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Risk Factors Leading to Fatal Outcome in Scrub Typhus
Jeong-Hwan Hwang, Chang-Seop Lee*
JK Science : Journal of Medical Education & Research , 2010,
Abstract: Not Available
Clinical significance of hypoalbuminemia in outcome of patients with scrub typhus
Chang-Seop Lee, In-Suk Min, Jeong-Hwan Hwang, Keun-Sang Kwon, Heung-Bum Lee
BMC Infectious Diseases , 2010, DOI: 10.1186/1471-2334-10-216
Abstract: The patients with scrub typhus were divided into two groups based on the serum albumin levels; Group I (serum albumin <3.0 g/dL) and Group II (serum albumin ≥3.0 g/dL). The outcome of patients with hypoalbuminemia was compared with that of normoalbuminemia.Of the total 246 patients who underwent the study, 84 patients (34.1%) were categorized as Group I and 162 patients were (65.9%) as Group II. Group I showed significantly higher incidence of confusion (24.6% vs. 5.3%, p < 0.001), pulmonary edema (15.8% vs. 3.2%, p = 0.002), pleural effusion (22.8% vs. 11.1%, p = 0.03), arrhythmia (12.3% vs. 2.6%, p = 0.008) and non-oliguric acute renal failure (40.4% vs. 11.1%, p < 0.001) compared to group II. Hypoalbuminemic group had a higher APACHE II score (11.37 ± 5.0 vs. 6.94 ± 4.2, p < 0.001), longer hospital stay (19.9 ± 42.1 days vs 7.5 ± 13.8 days, p = 0.012), and higher hospital cost compared to Group II.This study showed hypoalbuminemia in scrub typhus was closely related to the frequency of various complication, longer hospital stay, consequently the higher medical cost, necessitating more efficient management of patients, including medical resources.Scrub typhus is an acute febrile illness with the characteristic findings of high fever, eschar, maculopapular rash, lymphadenopathy, headache, and myalgia [1-3]. Scrub typhus caused by infection with Orientia tsutsugamushi occurs over a wide area of Eastern Asia and the Western Pacific region [1]. Usually, the symptoms of this disease are mild and its clinical course is uneventful. However, some patients experience severe or fatal events such as acute renal failure, respiratory distress or multiorgan dysfunctions [1,4,5].Generally, hypoalbuminemia is known to be associated with complications and mortality in patients with acute infectious disease [6]. In scrub typhus, about 25%~69.2% of patients presented hypoalbuminemia [7,8]. For the mechanism of hypoalbuminemia, decreased synthesis of albumin due to hepatic dysfunctio
A placebo-controlled trial of Korean red ginseng extract for preventing Influenza-like illness in healthy adults
Ki-Chan Ha, Min-Gul Kim, Mi-Ra Oh, Eun-Kyung Choi, Hyang-Im Back, Sun-Young Kim, Eun-Ok Park, Dae-Young Kwon, Hye-Jeong Yang, Min-Jeong Kim, Hee-Joo Kang, Ju-Hyung Lee, Kyung-Min Choi, Soo-Wan Chae, Chang-Seop Lee
BMC Complementary and Alternative Medicine , 2012, DOI: 10.1186/1472-6882-12-10
Abstract: We will conduct a randomized, double-blind, placebo-controlled study at the onset of the influenza seasons. A total of 100 subjects 30-70 years of age will be recruited from the general populations. The subjects will be instructed to take 9 capsules per day of either the KRG extract or a placebo for a period of 3 months. The primary outcome measure is to assess the frequency of ILI onset in participated subjects. Secondary variable measures will be included severity and duration of ILI symptoms. The ILI symptoms will be scored by subjects using a 4-point scale.This study is a randomized placebo controlled trial to evaluate the efficacy of the KRG extract compared to placebo and will be provided valuable new information about the clinical and physiological effects of the KRG extract on reduction of ILI incidence including flu and upper respiratory tract infections. The study has been pragmatically designed to ensure that the study findings can be implemented into clinical practice if KRG extract can be shown to be an effective reduction strategy in ILI incidence.NCT01478009.Respiratory viruses are a major cause of influenza-like illness(ILI) symptoms in children and adults, leading to substantial morbidity and mortality each year [1-5]. The complications of ILI symptoms may occur in young children (< 1 year old) and elderly people (> 65 years old), even though ILI symptoms is most often self-limited and restrained to the upper respiratory tract [6-8]. The ILI symptoms is characterized by sudden onset of symptoms such as high fever (> 38°C) and cough in the absence of other diagnosis [9,10]. Other symptoms including myalgia, headache, chills and fatigue can only be used as optional inclusion criteria. Although it is known that rhinovirus infections cause 10% to 40% of the upper respiratory tract infection [11], with coronavirus, parainfluenza virus, adenovirus, echovirus, and coxsackievirus accounting for the remainder of cases [12,13], these viruses produce clinicall
中国电机工程学报 , 2010,
Abstract: 提出一种模拟电工钢片复杂磁特性的矢量磁滞模型。该模型考虑频率、磁化历史等因素对磁滞特性的影响,模型中磁滞系数与磁阻系数的确定是基于双激励二维磁特性测量实验获得的,在实验中通过对磁通密度变化轨迹的控制实现对磁场强度波形的测量。所提出的模型既避免了传统磁滞模型数学表达的复杂性,又提高了模拟的准确度,更适用于工程应用。通过与传统模型及实验测量结果的比较,证明了所提出的模型能更有效、更准确地模拟电工钢片的复杂磁特性。
中国电机工程学报 , 2010,
Abstract: 为了准确分析变压器、电机等电工设备的磁性能,在基于传统Chua-type模型的基础上,提出了一种直接描述电工钢片磁场强度H与磁通密度B数学关系的改进型矢量磁滞模型,其中模型参数由单片电工钢片磁特性测量系统获得;推导了不同轧制方向磁滞模型的数学表达式,讨论了耦合该磁滞模型的时步有限元计算的收敛性,并通过对单相变压器铁心模型磁场的实验测试,验证了耦合磁滞模型有限元分析的有效性。
Effect of the Weaving Density of Aramid Fabrics on Their Resistance to Ballistic Impacts  [PDF]
Jung Seop Lim, Bum Hoon Lee, Chang Bae Lee, In-Sik Han
Engineering (ENG) , 2012, DOI: 10.4236/eng.2012.412A119

Two Heracron? woven fabrics, HT600-1 and HT600-2, were fabricated with different weaving densities and their resistance to ballistic impact was investigated. While HT600-1 was inherently stronger along the weft than HT600-2, the latter exhibited a higher tensile strength along the warp. Crimp values indicate that HT600-1, which possesses a relatively larger weft weaving density, induces an excess in the warp crimp ratio, thereby weakening the fabric along the warp. The dimensionless fiber property U*, which is defined as the product of the specific fiber toughness and the strain wave velocity, was calculated for each fabric. The U* values of HT600-1 were lower than those of HT600-2; U* values along the warp of HT600-1 were extremely low. These analyses show that HT600-2 exhibited improved ballistic properties over those of HT600-1. These findings further indicate the existence of an optimal weave that would minimize damage to both yarn and fabric. Establishing these optimal conditions can be crucial in implementing better ballistic properties into fabrics.

Use of the Delta Neutrophil Index as a Prognostic Factor of Mortality in Patients with Spontaneous Bacterial Peritonitis: Implications of a Simple and Useful Marker
Tae Seop Lim, Beom Kyung Kim, Jong Wook Lee, Young Ki Lee, Sooyun Chang, Seung Up Kim, Do Young Kim, Sang Hoon Ahn, Kwang-Hyub Han, Chae Yoon Chon, Jun Yong Park
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0086884
Abstract: Background Spontaneous bacterial peritonitis (SBP) is a common and life-threatening infection in patients with advanced cirrhosis. The prognostic value of a novel marker, the delta neutrophil index (DNI), was investigated relative to mortality in patients with SBP. Materials & Methods Seventy-five patients with SBP were studied from April 2010 to May 2012. DNI at initial diagnosis of SBP was determined and compared with 30-day mortality rates. Results Of the patients, 87.7% were men, and the median age of all patients was 59.0 yrs. The area under the receiver-operating characteristic (ROC) curve of DNI for 30-day mortality was 0.701 (95% confidence interval [CI], 0.553–0.849; p = 0.009), which was higher than that of C-reactive protein (0.640, 95% CI, 0.494–0.786; p = 0.076) or the model for end-stage liver disease score (0.592, 95% CI, 0.436–0.748; p = 0.235). From the ROC curve, with the sum of sensitivity and specificity, the cutoff value of DNI was determined to be 5.7%. In the high-DNI group (DNI ≥5.7%), septic shock and 30-day mortality were more prevalent compared with the low-DNI group (84.2% vs. 48.2%, p = 0.007; 57.9% vs. 14.3%, p<0.001, respectively). Patients with an elevated DNI had a higher risk of 30-day mortality compared with those with a low DNI (4.225, 95% CI, 1.631–10.949; p = 0.003). Conclusion A higher DNI at the time of SBP diagnosis is an independent predictor of 30-day mortality in patients with SBP.
1′-Acetoxychavicol Acetate Isolated from Alpinia galanga Ameliorates Ovalbumin-Induced Asthma in Mice
Joung-Wook Seo, Soon-Chang Cho, Sang-Joon Park, Eun-Ji Lee, Jong-Hwa Lee, Sang-Seop Han, Byeong Sik Pyo, Dae-Hun Park, Bong-Hee Kim
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0056447
Abstract: The World Health Organization reports that 235 million people are currently affected by asthma. This disease is associated with an imbalance of Th1 and Th2 cells, which results in the upregulation of cytokines that promote chronic inflammation of the respiratory system. The inflammatory response causes airway obstruction and can ultimately result in death. In this study we evaluated the effect of 1′-acetoxychavicol acetate (ACA) isolated from Alpinia galanga rhizomes in a mouse model of ovalbumin (OVA)-induced asthma. To generate the mouse model, BALB/c mice were sensitized by intraperitoneal injection of OVA and then challenged with OVA inhalation for 5 days. Mice in the vehicle control group were sensitized with OVA but not challenged with OVA. Treatment groups received dexamethasone, 25 mg/kg/day ACA, or 50 mg/kg/day ACA for 5 days. Asthma-related inflammation was assessed by bronchoalveolar lavage fluid cell counts and histopathological and immunohistochemical analysis of lung tissues. Our results showed that ACA reduced the infiltration of white blood cells (especially eosinophils) and the level of IgE in the lungs of mice challenged with OVA and suppressed histopathological changes such as airway remodeling, goblet-cell hyperplasia, eosinophil infiltration, and glycoprotein secretion. In addition, ACA inhibited expression of the Th2 cytokines interleukin (IL)-4 and IL-13, and Th1 cytokines IL-12α and interferon-γ. Because asthmatic reactions are mediated by diverse immune and inflammatory pathways, ACA shows promise as an antiasthmatic drug candidate.
Pharmacogenetic Study of Deferasirox, an Iron Chelating Agent
Ji Won Lee, Hyoung Jin Kang, Ji-Yeob Choi, Nam Hee Kim, Mi Kyung Jang, Chang-Woo Yeo, Sang Seop Lee, Hyery Kim, June Dong Park, Kyung Duk Park, Hee Young Shin, Jae-Gook Shin, Hyo Seop Ahn
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0064114
Abstract: Transfusion-associated iron overload induces systemic toxicity. Deferasirox, a convenient long acting oral agent, has recently been introduced in clinical practice with a promising efficacy. But there are some patients who experience drug-related toxicities and cannot tolerate it. To investigate effect of genetic variations on the toxicities and find optimal target population, we analyzed the genetic polymorphisms of UDP-glucuronosyltransferase 1A (UGT1A) subfamily, multi-drug resistance-associated protein 2 (MRP2) and breast cancer resistance protein (BCRP). A total of 20 functional genetic polymorphisms were analyzed in 98 patients who received deferasirox to reduce transfusion-induced iron overload. We retrospectively reviewed the medical records to find out the drug-related toxicities. Fifteen (15.3%) patients developed hepatotoxicity. Patients without wild-type allele carrying two MRP2 haplotypes containing ?1774 del and/or ?24T were at increased risk of developing hepatotoxicity compared to patients with the wild-type allele on multivariate analysis (OR = 7.17, 95% CI = 1.79–28.67, P = 0.005). Creatinine elevation was observed in 9 patients (9.2%). Body weight ≥40 kg and homozygosity for UGT1A1*6 were risk factors of creatinine elevation (OR = 8.48, 95% CI = 1.7–43.57, P = 0.010 and OR = 14.17, 95% CI = 1.34–150.35, P = 0.028). Our results indicate that functional genetic variants of enzymes to metabolize and transport deferasirox are associated with drug-related toxicities. Further studies are warranted to confirm the results as the pharmacogenetic biomarkers of deferasirox.
Automatic Classification for Various Images Collections Using Two Stages Clustering Method  [PDF]
Wan Hyun Cho, In Seop Na, Jun Yong Choi, Tae Hoon Lee
Open Journal of Applied Sciences (OJAppS) , 2013, DOI: 10.4236/ojapps.2013.31B010
Abstract: In this paper, we propose an automatic classification for various images collections using two stage clustering method. Here, we have used global and local image features. First, we review about various types of feature vector that is suita-ble to represent local and global properties of images, and similarity measures that can be represented an affinity be-tween these images. Second, we consider a clustering method for image collection. Here, we first build a coarser clus-tering by partitioning various images into several clusters using the flexible Mean shift algorithm and K-mean cluster-ing algorithm. Second, we construct dense clustering of images collection by optimizing a Gaussian Dirichlet process mixture model taking initial clusters as given coarser clustering. Finally, we have conducted the comparative experi-ments between our method and existing methods on various images datasets. Our approach has significant advantage over existing techniques. Besides integrating temporal and image content information, our approach can cluster auto-matically photographs without some assumption about number of clusters or requiring a priori information about initial clusters and it can also generalize better to different image collections.
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