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Search Results: 1 - 10 of 44908 matches for " Chang-Min Choi3 "
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The inhibitory effects of Nardostachys jatamansi on alcoholic chronic pancreatitis
Gi-Sang Bae1, Kyoung-Chel Park2, Bon Soon Koo2, Sun Bok Choi2, Il-Joo Jo2, Chang-Min Choi3, Ho-Joon Song2 & Sung-Joo Park1,2,*
BMB Reports , 2012,
Abstract: Nardostachys jatamansi (NJ) belonging to the Valerianaceae familyhas been used as a remedy for gastrointestinal inflammatory diseasesfor decades. However, the potential for NJ to ameliorate alcoholicchronic pancreatitis (ACP) is unknown. The aim of thisstudy was to examine the inhibitory effects of NJ on ACP.C57black/6 mice received ethanol injections intraperitoneally for 3weeks against a background of cerulein-induced acute pancreatitis.During ACP, NJ was ad libitum administrated orally with water.After 3 weeks of treatment, the pancreas was harvested for histologicalexamination. NJ treatment increased the pancreatic acinarcell survival (confirmed by amylase level testing) and reduced collagendeposition and pancreatic stellate cell (PSC) activation. In addition,NJ treatment reduced the activation but not death of PSC. Inconclusion, our results suggest that NJ attenuated ACP through theinhibition of PSC activation.
Role of IGF-Binding Protein 3 in the Resistance of EGFR Mutant Lung Cancer Cells to EGFR-Tyrosine Kinase Inhibitors
Yun Jung Choi, Gun Min Park, Jin Kyung Rho, Sun Ye Kim, Gwang Sup So, Hyeong Ryul Kim, Chang-Min Choi, Jae Cheol Lee
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0081393
Abstract: Most patients treated with EGFR-tyrosine kinase inhibitors (EGFR-TKIs) eventually develop acquired resistance. Loss of expression of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) has been suggested as a possible mechanism of resistance to EGFR-TKIs in the A431 and HN11 cell lines. Here, we investigated IGFBP-3 expression in two EGFR mutant lung cancer cell lines with resistance to EGFR-TKIs and examined the value of serum IGFBP-3 level as a marker of resistance. The effect of the induction or suppression of IGFBP-3 expression on resistance was also evaluated. HCC827 sublines with resistance to gefitinib (HCC827/GR) and erlotinib (HCC827/ER) were established. Loss of IGFBP-3 expression was detected by Western blotting in both cell lines without changes in transcriptional activity, and ELISA showed significantly lower amounts of secreted IGFBP-3 in the culture media of the mutant cell lines than in that of the parental line. Despite the loss of IGFBP-3 expression, IGFR signalling activity remained unchanged. Forced expression of IGFBP-3 by adenovirus-mediated transfection or recombinant IGFBP-3 slightly increased the growth-inhibitory and apoptotic effects of EGFR-TKIs, whereas suppression of IGFBP-3 did not affect sensitivity to EGFR-TKI. Serum IGFBP-3 levels measured by ELISA before and after the development of EGFR-TKI resistance in 20 patients showed no significant changes (1815.3±94.6 ng/mL before treatment vs. 1778.9±87.8 ng/mL after EGFR-TKI resistance). In summary, although IGFBP-3 downregulation is associated with the acquisition of resistance to EGFR-TKIs regardless of the mechanism, its effect on resistance was not significant, indicating that IGFBP-3 may not play an important role in resistance to EGFR-TKIs and serum IGFBP-3 level is not a reliable indicator of resistance.
Effects of Interfacial Charge Depletion in Organic Thin-Film Transistors with Polymeric Dielectrics on Electrical Stability
Jaehoon Park,Jin-Hyuk Bae,Won-Ho Kim,Min-Hoi Kim,Chang-Min Keum,Sin-Doo Lee,Jong Sun Choi
Materials , 2010, DOI: 10.3390/ma3063614
Abstract: We investigated the electrical stabilities of two types of pentacene-based organic thin-film transistors (OTFTs) with two different polymeric dielectrics: polystyrene (PS) and poly(4-vinyl phenol) (PVP), in terms of the interfacial charge depletion. Under a short-term bias stress condition, the OTFT with the PVP layer showed a substantial increase in the drain current and a positive shift of the threshold voltage, while the PS layer case exhibited no change. Furthermore, a significant increase in the off-state current was observed in the OTFT with the PVP layer which has a hydroxyl group. In the presence of the interfacial hydroxyl group in PVP, the holes are not fully depleted during repetitive operation of the OTFT with the PVP layer and a large positive gate voltage in the off-state regime is needed to effectively refresh the electrical characteristics. It is suggested that the depletion-limited holes at the interface, i.e., interfacial charge depletion, between the PVP layer and the pentacene layer play a critical role on the electrical stability during operation of the OTFT.
Differential expression of cell surface markers in response to 2,4-dinitrofluorobenzene in RAW 264.7 and primary immune cells
Dongbum Kim1, Min Chul Park1, Byoung Kwon Park1, Sanghoon Kwon2, Joon-Ho Choi3, Hyun-Jong Kim4, Soo-Young Choi5, Jinseu Park5, Younghee Lee6 & Hyung-Joo Kwon1,2,*
BMB Reports , 2012,
Abstract: We evaluated the expression of the costimulatory moleculesCD80 and CD83 and major histocompatibility (MHC) class IIinduced by 2,4-dinitrofluorobenzene (DNFB) in the RAW264.7 macrophage cell line. In contrast to the previously reportedeffect of DNFB on dendritic cells, CD86 expression didnot change. Furthermore, we observed that the CD83 expressionlevel transiently increased and then decreased.Induction of CD80 and MHC class II molecule expression anda decrease in CD83 expression by DNFB in vitro were alsoconfirmed in splenocytes of BALB/c and NC/Nga mice.However, DNFB did not influence CD83 expression in peritonealCD11b+ cells from BALB/c or NC/Nga mice. Detailedin vivo experiments and further studies on the possible contributionof CD11b+ cells to induce atopic dermatitis (AD)would be helpful to attain a better understanding of ADpathogenesis.
Implementation of RANSAC Algorithm for Feature-Based Image Registration  [PDF]
Lan-Rong Dung, Chang-Min Huang, Yin-Yi Wu
Journal of Computer and Communications (JCC) , 2013, DOI: 10.4236/jcc.2013.16009

This paper describes the hardware implementation of the RANdom Sample Consensus (RANSAC) algorithm for featured-based image registration applications. The Multiple-Input Signature Register (MISR) and the index register are used to achieve the random sampling effect. The systolic array architecture is adopted to implement the forward elimination step in the Gaussian elimination. The computational complexity in the forward elimination is reduced by sharing the coefficient matrix. As a result, the area of the hardware cost is reduced by more than 50%. The proposed architecture is realized using Verilog and achieves real-time calculation on 30 fps 1024 * 1024 video stream on 100 MHz clock.

Parameter Optimization and Development of Prediction Model for Second Generation Magnetic Abrasive Polishing of AZ31B Plate
Jae-Seob Kwak,Chang-Min Shin
Lecture Notes in Engineering and Computer Science , 2011,
Comparison of Directional Coronary Atherectomy-Based Intervention and Stenting Alone in Ostial Lesions of the Left Anterior Descending Artery
Chang-Min Chung,Shigeru Nakamura,Osamu Katoh
Chang Gung Medical Journal , 2005,
Abstract: Background: Balloon angioplasty yields suboptimal results and increases the rate ofrestenosis in the ostium of the left anterior descending coronary artery(LAD). Several non-balloon devices have been used to improve the outcomeof dilatation of such lesions.Methods: This investigation retrospectively compared the results of a directionalatherectomy (DCA)-based intervention and stenting alone on the ostiallesions of the LAD, and the effect on the left circumflex artery (LCX)ostium. Sixty-five patients with a successful angioplasty of LAD ostiallesions were studied. Patients were divided into 2 groups: group I (DCA, n =34) and group II (stenting, n = 31).Results: After intervention and at the 3-month follow-up, group I exhibited a largerminimal lumen diameter (MLD), smaller-diameter stenosis, and a lower lossindex than group II. At 6 months, group I showed a lower cumulativerestenosis rate of 32% as compared to 48% for group II (p = 0.04). In groupI, the MLD of the LCX ostium had not changed after DCA or at follow-up.In contrast, the MLD of the LCX was significantly reduced with stentingalone and during follow-up (p < 0.01). The strategy of optimal debulkingplus stenting exhibited a restenosis rate of 9%, in contrast to 33% in the optimaldebulking alone strategy (p = 0.05) after 3 months.Conclusions: During the intervention for LAD ostial lesions, the DCA-based strategyseemed to be superior compared to stenting alone both in terms of acute andlate target lesion revascularization and in terms of the risk of plaque shifting.The best results however were obtained when optimal DCA was combinedwith stenting.
Inhibition of glutamate dehydrogenase and insulin secretion by KHG26377 does not involve ADP-ribosylation by SIRT4 or deacetylation by SIRT3
Eun-A Kim1,#, Seung-Ju Yang2,#, Soo Young Choi3, Woo Je Lee4,* & Sung-Woo Cho1,*
BMB Reports , 2012,
Abstract: We investigated the mechanisms involved in KHG26377 regulationof glutamate dehydrogenase (GDH) activity, focusing onthe roles of SIRT4 and SIRT3. Intraperitoneal injection of micewith KHG26377 reduced GDH activity with concomitant repressionof glucose-induced insulin secretion. Consistent withtheir known functions, SIRT4 ribosylated GDH and reduced itsactivity, and SIRT3 deacetylated GDH, increasing its activity.However, KHG26377 did not affect SIRT4-mediated ADP-ribosylation/inhibition or SIRT3-mediated deacetylation/activationof GDH. KHG26377 had no effect on SIRT4 protein levels,and did not alter total GDH, acetylated GDH, or SIRT3 proteinlevels in pancreatic mitochondrial lysates. These results suggestthat the mechanism by which KHG26377 inhibits GDHactivity and insulin secretion does not involve ADP-ribosylationof GDH by SIRT4 or deacetylation of GDH by SIRT3.
An Essential Regulatory Role of Downstream of Kinase-1 in the Ovalbumin-Induced Murine Model of Asthma
Chang-Min Lee, In Duk Jung, Kyung Tae Noh, Jun Sik Lee, Jin Wook Park, Deok Rim Heo, Jun Ho Park, Jeong Hyun Chang, Il-Whan Choi, Jong-Suk Kim, Yong Kyoo Shin, Sung-Joo Park, Myung-Kwan Han, Chun Geun Lee, Won-Kyung Cho, Yeong-Min Park
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0034554
Abstract: The downstream of kinase (DOK)-1 is involved in the protein tyrosine kinase (PTK) pathway in mast cells, but the role of DOK-1 in the pathogenesis of asthma has not been defined. In this study, we have demonstrated a novel regulatory role of DOK-1 in airway inflammation and physiologic responses in a murine model of asthma using lentiviral vector containing DOK-1 cDNA or DOK-1-specific ShRNA. The OVA-induced inflammatory cells, airway hyperresponsiveness, Th2 cytokine expression, and mucus response were significantly reduced in DOK-1 overexpressing mice compared to OVA-challenged control mice. The transgenic introduction of DOK-1 significantly stimulated the activation and expression of STAT-4 and T-bet, while impressively inhibiting the activation and expression of STAT-6 and GATA-3 in airway epithelial cells. On the other hand, DOK-1 knockdown mice enhanced STAT-6 expression and its nuclear translocation compared to OVA-challenged control mice. When viewed in combination, our studies demonstrate DOK-1 regulates allergen-induced Th2 immune responses by selective stimulation and inhibition of STAT-4 and STAT-6 signaling pathways, respectively. These studies provide a novel insight on the regulatory role of DOK-1 in allergen-induced Th2 inflammation and airway responses, which has therapeutic potential for asthma and other allergic diseases.
Transglutaminase 2 as an independent prognostic marker for survival of patients with non-adenocarcinoma subtype of non-small cell lung cancer
Chang-Min Choi, Se-Jin Jang, Seong-Yeol Park, Yong-Bock Choi, Jae-Heon Jeong, Dae-Seok Kim, Hyun-Kyoung Kim, Kang-Seo Park, Byung-Ho Nam, Hyeong-Ryul Kim, Korean Thoracic Oncology Research Group (KTORG), Soo-Youl Kim, Kyeong-Man Hong
Molecular Cancer , 2011, DOI: 10.1186/1476-4598-10-119
Abstract: The significance of TGase 2 expression as an invasive/migratory factor was addressed by in vitro assays employing down-regulation of TGase 2. TGase 2 expression as a prognostic indicator was assessed in 429 Korean patients with early-stage non-small cell lung cancer (NSCLC) by immunohistochemical staining.TGase 2 expression increased the invasive and migratory properties of NSCLC cells in vitro, which might be related to the induction of MMP-9. In the analysis of the immunohistochemical staining, TGase 2 expression in tumors was significantly correlated with recurrence in NSCLC (p = 0.005) or in the non-adenocarcinoma subtype (p = 0.031). Additionally, a multivariate analysis also showed a significant correlation between strong TGase 2 expression and shorter disease-free survival (DFS) in NSCLC (p = 0.029 and HR = 1.554) and in the non-adenocarcinoma subtype (p = 0.030 and HR = 2.184). However, the correlation in the adenocarcinoma subtype was not significant.TGase 2 expression was significantly correlated with recurrence and shorter DFS in NSCLC, especially in the non-adenocarcinoma subtype including squamous cell carcinoma.Lung cancer is the leading cause of cancer-related death, accounting for approximately 29% of all cases (Cancer Stat Fact Sheets, http://www.seer.cancer.gov webcite); approximately 85% of lung cancer cases are non-small cell lung cancer (NSCLC). There are several different subtypes of NSCLC, among which are adenocarcinoma and squamous cell cancer. Currently, the NSCLC subtypes are regarded as a single disease, however, the adenocarcinoma and non-adenocarcinoma subtypes are regarded as being separate entities, owing to their different responses to recently developed agents such as pemetrexed, gefitinib, bevaciuzumab, and crizotinib, which are more effective in adenocarcinoma [1-3]. Accordingly, identification of the molecular differences between these tumor types will have a significant impact on the design of novel therapies that can improve tre
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