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Search Results: 1 - 10 of 43468 matches for " Chang-Joong Lee "
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Valproic Acid Decreases Cell Proliferation and Color Preference in the Zebrafish Larvae  [PDF]
Bongkyu Lee, Sujeong Lee, Miyoung Choi, Chang-Joong Lee
Journal of Biosciences and Medicines (JBM) , 2017, DOI: 10.4236/jbm.2017.512007
Abstract: Valproic acid (VPA) is widely used as an antiepileptic drug or mood stabilizer. In this study, we evaluated the effects of treatment with 2 mM VPA for 3 h on cell proliferation in the telencephalic area of zebrafish larvae using bromodeoxyuridine (BRDU) to label dividing cells. It was demonstrated that 2 mM VPA exposure for 3 h at 2 and 3 days post-fertilization (dpf) larvae decreased cell proliferation in the telencephalic area of 5 dpf larvae. The reduced cell proliferation was not restored at 10 dpf larvae. The quantitative real-time PCR (qRT-PCR) data indicated that mRNA expression levels of WNT signaling pathway-related factors such as β-catenin, LEF1, and gsk3β were altered in the zebrafish larvae treated with 2 mM VPA at 2 and 3 pdf. It was also demonstrated that 2 mM VPA exposure affected color preference of the zebrafish larvae, reducing blue color preference at 5 dpf larvae. The altered color preference was restored at 10 dpf larvae. These results suggest that VPA exposure may cause molecular, cellular, and behavioral alterations in early developmental stage of the zebrafish.
Effect of Count Estimation in Finding Frequent Itemsets over Online Transactional Data Streams
Joong Hyuk Chang,Won Suk Lee,

计算机科学技术学报 , 2005,
Abstract: A data stream is a massive unbounded sequence of data elements continuously generated at a rapid rate. Due to this reason, most algorithms for data streams sacrifice the correctness of their results for fast processing time. The processing time is greatly influenced by the amount of information that should be maintained. This issue becomes more serious in finding frequent itemsets or frequency counting over an online transactional data stream since there can be a large number of itemsets to be monitored. We have proposed a method called the estDec method for finding frequent itemsets over an online data stream. In order to reduce the number of monitored itemsets in this method, monitoring the count of an itemset is delayed until its support is large enough to become a frequent itemset in the near future. For this purpose, the count of an itemset should be estimated. Consequently, how to estimate the count of an itemset is a critical issue in minimizing memory usage as well as processing time. In this paper, the effects of various count estimation methods for finding frequent itemsets are analyzed in terms of mining accuracy, memory usage and processing time.
Elevated Serum Ferritin Level Is Associated with the Incident Type 2 Diabetes in Healthy Korean Men: A 4 Year Longitudinal Study
Chang Hee Jung, Min Jung Lee, Jenie Yoonoo Hwang, Jung Eun Jang, Jaechan Leem, Joong-Yeol Park, JungBok Lee, Hong-Kyu Kim, Woo Je Lee
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0075250
Abstract: Background Elevated ferritin concentration has been implicated in the etiology of type 2 diabetes. Accumulating evidence, mostly from studies conducted on western populations, has demonstrated a strong association between the elevated ferritin concentrations and incident type 2 diabetes. In Asian populations, however, the longitudinal studies investigating the association of elevated serum ferritin levels and type 2 diabetes are lacking. In present study, we aimed to determine whether elevated serum ferritin levels are related to the incident type 2 diabetes in healthy Korean men. Methodology/Principal Findings This 4 year longitudinal observational study was conducted at the Asan Medical Center, Seoul, Republic of Korea. The study population consisted of 2,029 men without type 2 diabetes who underwent routine health examination in 2007 (baseline) and 2011 (follow-up). Baseline serum ferritin concentrations were measured by chemiluminescent two-site sandwich immunoassay. In multiple-adjusted model, the relative risk (RR) for incident type 2 diabetes was significantly higher in highest compared with the lowest ferritin quartile category, even after adjusting for confounding variables including homeostasis model assessment of insulin resistance (RR = 2.17, 95% confidence interval 1.27–3.72, P for trend = 0.013). Conclusions/Significance These results demonstrated that elevated level of serum ferritin at baseline was associated with incident type 2 diabetes in an Asian population.
Trends in the Rates of Peripartum Hysterectomy and Uterine Artery Embolization
Geum Joon Cho, Log Young Kim, Hye-Ri Hong, Chang Eun Lee, Soon-Cheol Hong, Min-Jeong Oh, Hai-Joong Kim
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0060512
Abstract: The objective of this study was to determine the trends in national rates of peripartum hysterectomy (PH) and uterine arterial embolization (UAE) in Korea. We used data collected by the Health Insurance Review & Assessment Service of Korea and analyzed data from patients who gave birth during the period from 2005 to 2008. There were 1785,178 deliveries during the study period, including 2636 cases of PH (1.48 per 1000 deliveries). The PH rate in 2005 was 1.57 per 1000 deliveries and in 2008 it was 1.33 per 1000 deliveries. UAE was performed in 161 women (incidence, 0.38 per 1000 deliveries) and 447 women (incidence, 0.98 per 1000 deliveries) in 2005 and 2008, respectively. In Korea, the rate of PH decreased slightly, while the rate of UAE rate increased dramatically during the period from 2005 to 2008. Further studies are needed to evaluate the effects of UAE on the rate of PH performed.
Vaspin Increases Nitric Oxide Bioavailability through the Reduction of Asymmetric Dimethylarginine in Vascular Endothelial Cells
Chang Hee Jung, Woo Je Lee, Jenie Yoonoo Hwang, Min Jung Lee, So Mi Seol, Yun Mi Kim, Yoo La Lee, Hyun Sik Kim, Min-Seon Kim, Joong-Yeol Park
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0052346
Abstract: Vaspin is an adipocytokine recently identified in the visceral adipose tissue of diabetic rats and having anti-diabetic effects. We have recently shown that vaspin has anti-atherogenic effect through Akt-mediated inhibition of endothelial cell apoptosis. Decreased activity of endothelial nitric oxide synthase (eNOS) plays an important role in the pathogenesis of atherosclerosis. Asymmetric dimethylarginine (ADMA) is a well-known endogenous competitive inhibitor of eNOS and risk factor of cardiovascular diseases. The aim of this study was to examine whether vaspin might protect against atherosclerosis through its beneficial effects on the ADMA-eNOS system. Treatment of vaspin significantly increased NO secretion from endothelial cells and isolated aorta from Sprague-Dawley (SD) rats. Furthermore, treatment of vaspin prevented fatty acid-induced decrease in endothelium-dependent vasorelaxation in isolated aorta of SD rat. For the mechanism of vaspin-induced NO biosynthesis, vaspin activated the STAT3 signaling pathway and stimulated eNOS phosphorylation (Ser 1177), a marker of eNOS activation, through STAT3-dependent mechanism. Furthermore, vaspin treatment increased the expression of dimethylarginine dimethylaminohydrolase (DDAH) II, the responsible enzyme for the degradation of ADMA, leading to a reduction in ADMA levels. Vaspin-induced increase in DDAH II gene expression was through STAT3-mediated stimulation of DDAH II promoter activity. These results suggest that vaspin increases eNOS activity by reducing ADMA level through STAT3-mediated regulation of DDAH II expression. Our findings provide a novel molecular mechanism of antiatherogenic actions of vaspin.
TTF-1 Action on the Transcriptional Regulation of Cyclooxygenase-2 Gene in the Rat Brain
Chang Ho Yun, Jae Geun Kim, Byong Seo Park, Hye Myeong Lee, Dong Hee Kim, Eun Ok Kim, Joong Jean Park, Jeong Woo Park, Giuseppe Damante, Young Il Kim, Byung Ju Lee
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0028959
Abstract: We have recently found that thyroid transcription factor-1 (TTF-1), a homeodomain-containing transcription factor, is postnatally expressed in discrete areas of the hypothalamus and closely involved in neuroendocrine functions. We now report that transcription of cyclooxygenase-2 (COX-2), the rate limiting enzyme in prostaglandin biosynthesis, was inhibited by TTF-1. Double immunohistochemistry demonstrated that TTF-1 was expressed in the astrocytes and endothelial cells of blood vessel in the hypothalamus. Promoter assays and electrophoretic mobility shift assays showed that TTF-1 inhibited COX-2 transcription by binding to specific binding domains in the COX-2 promoter. Furthermore, blocking TTF-1 synthesis by intracerebroventricular injection of an antisense oligomer induced an increase of COX-2 synthesis in non-neuronal cells of the rat hypothalamus, and resulted in animals' hyperthermia. These results suggest that TTF-1 is physiologically involved in the control of thermogenesis by regulating COX-2 transcription in the brain.
Immunization with a Thermostable Newcastle Disease Virus K148/08 Strain Originated from Wild Mallard Duck Confers Protection against Lethal Viscerotropic Velogenic Newcastle Disease Virus Infection in Chickens
Seung-Hwan Jeong, Dong-Hun Lee, Byoung-Yoon Kim, Soo-Won Choi, Joong-Bok Lee, Seung-Yong Park, In-Soo Choi, Chang-Seon Song
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0083161
Abstract: Newcastle disease (ND) is one of the most devastating poultry infections because of its worldwide distribution and accompanying economical threat. In the present study, we characterized the ND virus (NDV) K148/08 strain from wild mallard duck, with regard to safety, thermostability, immunogenicity, and protective efficacy against velogenic ND viral infection. The NDV K148/08 strain offered enhanced immunogenicity and safety relative to commercially available vaccine strains. The NDV K148/08 strain was safe in 1-day-old SPF chicks after vaccination using a coarse or cabinet-type fine sprayer. We demonstrated that the NDV K148/08 strain elicited high levels of antibody responses and provided protective efficacy against lethal NDV challenge. In addition, the thermostability of the NDV K148/08 strain was as high as that of the thermostable V4 strain. Therefore, the NDV K148/08 strain may be useful to ensure NDV vaccine performance and effectiveness in developing countries, especially in remote areas without cold chains.
Counter-Rotating Type Horizontal-Axis Bidirectional Propellers for Tidal Stream Power Unit  [PDF]
Yuki Funami, Yuji Nakanishi, Nak-Joong Lee, Bin Huang, Toshiaki Kanemoto
Journal of Power and Energy Engineering (JPEE) , 2017, DOI: 10.4236/jpee.2017.57003
Abstract: Tidal stream power units with horizontal-axis propellers are one of promising technologies for generating the renewable green energy. The ebb and flow require that the power unit must operate in bidirectional tidal streams. Hence a tidal stream power unit with counter-rotating type horizontal-axis bidirectional propellers is proposed in this paper. The blades with fully-symmetrical hydrofoils were optimized numerically. The output and flow conditions predicted by the computational fluid dynamics simulations are compared with the results of the wind tunnel experiments at the higher tip speed ratios, which are of expected usual operating conditions of this unit. The numerical and experimental results show good agreements. It is also confirmed that the flow discharged from the counter-rotating type propellers has no swirling component, though the single propeller generates the unacceptable swirling component.
Working Memory Impairment in Fibromyalgia Patients Associated with Altered Frontoparietal Memory Network
Jeehye Seo, Seong-Ho Kim, Yang-Tae Kim, Hui-jin Song, Jae-jun Lee, Sang-Hyon Kim, Seung Woo Han, Eon Jeong Nam, Seong-Kyu Kim, Hui Joong Lee, Seung-Jae Lee, Yongmin Chang
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0037808
Abstract: Background Fibromyalgia (FM) is a disorder characterized by chronic widespread pain and frequently associated with other symptoms. Patients with FM commonly report cognitive complaints, including memory problem. The objective of this study was to investigate the differences in neural correlates of working memory between FM patients and healthy subjects, using functional magnetic resonance imaging (MRI). Methodology/Principal Findings Nineteen FM patients and 22 healthy subjects performed an n-back memory task during MRI scan. Functional MRI data were analyzed using within- and between-group analysis. Both activated and deactivated brain regions during n-back task were evaluated. In addition, to investigate the possible effect of depression and anxiety, group analysis was also performed with depression and anxiety level in terms of Beck depression inventory (BDI) and Beck anxiety inventory (BAI) as a covariate. Between-group analyses, after controlling for depression and anxiety level, revealed that within the working memory network, inferior parietal cortex was strongly associated with the mild (r = 0.309, P = 0.049) and moderate (r = 0.331, P = 0.034) pain ratings. In addition, between-group comparison revealed that within the working memory network, the left DLPFC, right VLPFC, and right inferior parietal cortex were associated with the rating of depression and anxiety? Conclusions/Significance Our results suggest that the working memory deficit found in FM patients may be attributable to differences in neural activation of the frontoparietal memory network and may result from both pain itself and depression and anxiety associated with pain.
Sustainable Urban (re-)Development with Building Integrated Energy, Water and Waste Systems
Thorsten Schuetze,Joong-Won Lee,Tae-Goo Lee
Sustainability , 2013, DOI: 10.3390/su5031114
Abstract: The construction and service of urban infrastructure systems and buildings involves immense resource consumption. Cities are responsible for the largest component of global energy, water, and food consumption as well as related sewage and organic waste production. Due to ongoing global urbanization, in which the largest sector of the global population lives in cities which are already built, global level strategies need to be developed that facilitate both the sustainable construction of new cities and the re-development of existing urban environments. A very promising approach in this regard is the decentralization and building integration of environmentally sound infrastructure systems for integrated resource management. This paper discusses such new and innovative building services engineering systems, which could contribute to increased energy efficiency, resource productivity, and urban resilience. Applied research and development projects in Germany, which are based on integrated system approaches for the integrated and environmentally sound management of energy, water and organic waste, are used as examples. The findings are especially promising and can be used to stimulate further research and development, including economical aspects which are crucial for sustainable urban (re-)development.
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