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Search Results: 1 - 10 of 25284 matches for " Chaeyoung Lee "
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HDAC6 Inhibitor Blocks Amyloid Beta-Induced Impairment of Mitochondrial Transport in Hippocampal Neurons
Chaeyoung Kim, Heesun Choi, Eun Sun Jung, Wonik Lee, Soojung Oh, Noo Li Jeon, Inhee Mook-Jung
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0042983
Abstract: Even though the disruption of axonal transport is an important pathophysiological factor in neurodegenerative diseases including Alzheimer's disease (AD), the relationship between disruption of axonal transport and pathogenesis of AD is poorly understood. Considering that α-tubulin acetylation is an important factor in axonal transport and that Aβ impairs mitochondrial axonal transport, we manipulated the level of α-tubulin acetylation in hippocampal neurons with Aβ cultured in a microfluidic system and examined its effect on mitochondrial axonal transport. We found that inhibiting histone deacetylase 6 (HDAC6), which deacetylates α-tubulin, significantly restored the velocity and motility of the mitochondria in both anterograde and retrograde axonal transports, which would be otherwise compromised by Aβ. The inhibition of HDAC6 also recovered the length of the mitochondria that had been shortened by Aβ to a normal level. These results suggest that the inhibition of HDAC6 significantly rescues hippocampal neurons from Aβ-induced impairment of mitochondrial axonal transport as well as mitochondrial length. The results presented in this paper identify HDAC6 as an important regulator of mitochondrial transport as well as elongation and, thus, a potential target whose pharmacological inhibition contributes to improving mitochondrial dynamics in Aβ treated neurons.
Cross-Family Translational Genomics of Abiotic Stress-Responsive Genes between Arabidopsis and Medicago truncatula
Daejin Hyung, Chaeyoung Lee, Jin-Hyun Kim, Dongwoon Yoo, Young-Su Seo, Soon-Chun Jeong, Jai-Heon Lee, Youngsoo Chung, Ki-Hong Jung, Douglas R. Cook, Hong-kyu Choi
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0091721
Abstract: Cross-species translation of genomic information may play a pivotal role in applying biological knowledge gained from relatively simple model system to other less studied, but related, genomes. The information of abiotic stress (ABS)-responsive genes in Arabidopsis was identified and translated into the legume model system, Medicago truncatula. Various data resources, such as TAIR/AtGI DB, expression profiles and literatures, were used to build a genome-wide list of ABS genes. tBlastX/BlastP similarity search tools and manual inspection of alignments were used to identify orthologous genes between the two genomes. A total of 1,377 genes were finally collected and classified into 18 functional criteria of gene ontology (GO). The data analysis according to the expression cues showed that there was substantial level of interaction among three major types (i.e., drought, salinity and cold stress) of abiotic stresses. In an attempt to translate the ABS genes between these two species, genomic locations for each gene were mapped using an in-house-developed comparative analysis platform. The comparative analysis revealed that fragmental colinearity, represented by only 37 synteny blocks, existed between Arabidopsis and M. truncatula. Based on the combination of E-value and alignment remarks, estimated translation rate was 60.2% for this cross-family translation. As a prelude of the functional comparative genomic approaches, in-silico gene network/interactome analyses were conducted to predict key components in the ABS responses, and one of the sub-networks was integrated with corresponding comparative map. The results demonstrated that core members of the sub-network were well aligned with previously reported ABS regulatory networks. Taken together, the results indicate that network-based integrative approaches of comparative and functional genomics are important to interpret and translate genomic information for complex traits such as abiotic stresses.
The Relationship between Visual Satisfaction and Water Clarity and Quality Management in Tourism Fishing Ports  [PDF]
Lee-Hsueh Lee
Journal of Water Resource and Protection (JWARP) , 2016, DOI: 10.4236/jwarp.2016.88064
Abstract: Visual satisfaction of the tourists with a water body is strongly influenced by water clarity, which is in turn influenced by a number of water quality parameters. Visual satisfaction thus stands to benefit from having a water quality management tool that results in better water clarity. A Clarity Suitability Index of Water Quality (CSIWQ), derived from clarity suitability curves of selected water quality parameters, can allow estimation of optimal values for these parameters, while ensuring high visual satisfaction among tourists. The present study used sampling and survey methodologies to investigate water clarity and quality at five tourism fishing ports; simultaneously, tourists’ visual satisfaction with a water body was assessed through a questionnaire based on their perceptions. The relationship between tourists’ visual satisfaction and water clarity was found to be positive and strong, with water clarity having predictive power of 74.2%. The study showed that DO, BOD, TP, and SS were the most critical parameters for water clarity. A continued product approach of CSIWQ was found to be most appropriate for describing the relationship between water clarity and these four parameters. This enabled a CSIWQ Index value to be calculated. With a CSIWQ value of 0.6, water clarity would be more than 2.08 m, and tourists would experience very high satisfaction. CSI curves showed that DO would preferably be 9.0 mg/L, and BOD, TP, and SS less than 0.5 mg/L, 0.12 mg/L, and 45.0 mg/L, respectively. The model thus produced valuable insights for assessing and improving water quality and ensuring high levels of visual satisfaction among tourists in tourism fishing ports. This model identified only four parameters but could be improved by ensuring that other water quality parameters were included, to encourage an increase in the number of tourists and to include monitoring of more pollutant sources.
Appearance’s Aesthetic Appreciation to Inform Water Quality Management of Waterscapes  [PDF]
Lee-Hsueh Lee
Journal of Water Resource and Protection (JWARP) , 2017, DOI: 10.4236/jwarp.2017.913103
The appearance of the water is just one aspect of a waterscape that can be appreciated aesthetically. Water appearance is affected by water clarity and water colour. Here, an aesthetic assessment model of waterscape was suggested. In the model, water clarity and colour have direct effects, whereas water quality and phytoplankton biomass have indirect effects, on tourists’ aesthetic assessment of water bodies. The preferred water colour is aquamarine to blue, regardless of depth of clarity. Water colour ranges from pastel yellow to yellow-green are not favoured by tourists. Four water-quality parameters were correlated with water clarity and phytoplankton biomass. The coefficient of indirect effect of river pollution index on tourists’ aesthetic valuation of aquamarine to blue water colour was -0.457, and for pastel yellow to yellowgreen, it was -0.209. The research results showed observation of water colour could not only reflect waterscape aesthetic value, but also serve as a guide of judging water quality, and the status of phytoplankton benefited to simplify the process of water-quality management for waterscape.
Abdominal Fat Reduction through Cryolipolysis  [PDF]
Doyeop Lee, Kyurae Lee
Journal of Biosciences and Medicines (JBM) , 2018, DOI: 10.4236/jbm.2018.69005
Abstract: Although several studies showed the efficacy and safety from this procedure, the comparative assessment of adipose tissue by cryolipolysis has not been studied until now. Therefore we investigated the quantitative change of cross sectional areas of abdominal SAT (subcutaneous adipose tissue) and VAT (visceral adipose tissue) following cryolipolysis. A prospective study for twelve subjects with a single session of cryolipolysis on abdomen was performed. We assessed for their height, weight, and waist circumferences, body contours by photographs, and the cross sectional areas of visceral and subcutaneous adipose tissues were measured at umbilicus level by computerized tomography for 2 months. The cross sectional areas in SAT reduced from 243.3 ± 24.7 to 238.5 ± 40.7 cm2 at 2 months post-treatment. Those of VAT reduced from 141.3 ± 46.4 to 125.1 ± 42.8 cm2 at 2 months post-treatment. Cross sectional areas of VAT, and waist circumferences were significantly reduced by 16.2 cm2, 4.1 cm respectively. Additionally visual improvement without unexpected adverse events was noted. In conclusion a single session cryolipolysis demonstrated to reduce visceral adipose tissue as well as waist circumferences tissue for 2 months. Further controlled study would be needed to evaluate for reduction of visceral adipose tissue by cryolipolysis.
Exponential Ergodicity and β-Mixing Property for Generalized Ornstein-Uhlenbeck Processes  [PDF]
Oesook Lee
Theoretical Economics Letters (TEL) , 2012, DOI: 10.4236/tel.2012.21004
Abstract: The generalized Ornstein-Uhlenbeck process is derived from a bivariate Lévy process and is suggested as a continuous time version of a stochastic recurrence equation [1]. In this paper we consider the generalized Ornstein-Uhlenbeck process and provide sufficient conditions under which the process is exponentially ergodic and hence holds the expo-nentially β-mixing property. Our results can cover a wide variety of areas by selecting suitable Lévy processes and be used as fundamental tools for statistical analysis concerning the processes. Well known stochastic volatility models in finance such as Lévy-driven Ornstein-Uhlenbeck process is examined as a special case.
Coastal Planning Strategies for Adaptation to Sea Level Rise: A Case Study of Mokpo, Korea  [PDF]
Yumi Lee
Journal of Building Construction and Planning Research (JBCPR) , 2014, DOI: 10.4236/jbcpr.2014.21007
Abstract: Climate change and sea level rise necessitate adaptation strategies for coastal areas. This paper showcases five strategies for sea level rise adaptation: hard protection, soft protection, accommodation, retreat, and attack. This study proposes adaptation measures and a phased development strategy for coastal areas of Mokpo, an old port city on the southwestern tip of the Korean Peninsula that has been expanded by land reclamation. Mokpo presently experiences frequent flooding during high-water and storm events; due to their low elevation and land subsidence, most of the reclaimed areas are susceptible to future inundation via sea level rise. The fundamental adaptation strategies for the impact areas are: hard protection of important infrastructures via multi-tiered terraces; the retreat of coastal developments accompanied by green buffer zones such as wetlands and parks to accommodate temporary inundation; and up-leveling the ground for new development and phased relocation of existing development. Through the case study of Mokpo, the paper emphasizes the importance of resilient planning strategies for urban development, and highlights both the challenges and opportunities for sea level rise adaptation.
Study on the Classification of Speech Anxiety Using Q-Methodology Analysis  [PDF]
SeoYoung Lee
Advances in Journalism and Communication (AJC) , 2014, DOI: 10.4236/ajc.2014.23008
Abstract: Public speaking is one of the cornerstones of mass communication, the influence of which has only been enhanced with the advent of the modern era. Yet despite its importance, up to 40% of the world’s population feels anxious when faced with the prospect of presenting in front of an audience (Wilbur, 1981). However, public speaking anxiety is human condition that can be understood and with effort, overcome by sufferers. Based on theoretical research, this study presents an empirical investigation of speech anxiety. The research uses Q-methodology to generate categories of speakers and then draws on the PQ-method program to suggest ways for speakers to improve their speaking confidence based on these categories. This research is of a value to those who are interested in speech anxiety for therapeutic or pedagogical practice.
Protecting the Coastline from the Effects of Climate Change: Adaptive Design for the Coastal Areas of Gangneung, Korea  [PDF]
Yumi Lee
Journal of Building Construction and Planning Research (JBCPR) , 2015, DOI: 10.4236/jbcpr.2015.32011
Abstract: The purpose of this research is to present design strategies to enable coastal areas to adapt to climate change and maintain the coastlines by addressing the environmental and urban issues. Gangneung is a tourist attraction situated on South Korea’s east coast, and there is an urgent need for integrated research on strategies to prevent the loss of sandy beaches and the damage caused by storm surges and high swell. This research has two objectives: The first is to offer an overview and describe the characteristics of exemplary projects carried out to manage the storm damage while maintaining the coastlines. The second is to propose a design model that can be applied to coastal areas susceptible to climate change by analyzing the design strategies and the current conditions of the Gangneung coastal area. In the case of Gangneung, the damage caused by the storm surges and high swells are more severe compared to inundation caused by sea level rise because of the steep slope and deep water. Therefore, adaptive design strategies are mainly focused on accommodation and retreat strategies that consider these characteristics by moving the coastal roads behind the pine forest and raising the coastal buildings to connect the coast to the forest and to prevent coastal erosion. This research has the potential to be used as an exemplary design adaptation for coastal erosion as well as a basis for regulating the land use policy in areas susceptible to flood by establishing guidelines for publicly funded developments, and preparing long-term relocation plans for the existing coastal developments to create a sustainable and resilient future for the coastal areas.
A Theoretical Solution for the Reynolds Stress: Validations in Canonical Flow Geometries  [PDF]
Taewoo Lee
Open Journal of Fluid Dynamics (OJFD) , 2016, DOI: 10.4236/ojfd.2016.64021
Abstract: A theoretical approach is developed for solving for the Reynolds stress in turbulent flows, and is validated for canonical flow geometries (flow over a flat plate, rectangular channel flow, and free turbulent jet). The theory is based on the turbulence momentum equation cast in a coordinate frame moving with the mean flow. The formulation leads to an ordinary differential equation for the Reynolds stress, which can either be integrated to provide parameterization in terms of turbulence parameters or can be solved numerically for closure in simple geometries. Results thus far indicate that the good agreement between the current theoretical and experimental/DNS (direct numerical simulation) data is not a fortuitous coincidence, and in the least it works quite well in sensible ways in canonical flow geometries. A closed-form solution for the Reynolds stress is found in terms of the root variables, such as the mean velocity, velocity gradient, turbulence kinetic energy and a viscous term. The form of the solution also provides radically new insight on how the Reynolds stress is generated and distributed.
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