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Search Results: 1 - 10 of 13191 matches for " Chadli El Bekkay "
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Chromosomal Abnormalities in 238 Couples with Recurrent Miscarriages in Morocco  [PDF]
Hanane Houmaid, Chadli El Bekkay, Sanaa Nassereddine, Hayat Talbi, Loubna Amehdare, Abderraouf Hilali
Open Journal of Genetics (OJGen) , 2018, DOI: 10.4236/ojgen.2018.82002
Abstract: Purpose: A proportion of cases with repeated abortion are caused by chromosomal abnormality in one of the parents. The purpose of this study was to assess the frequency and nature of chromosomal aberrations that contribute to the occurrence of recurrent miscarriages. Several studies have been done to determine the role of chromosomal abnormalities in couples with recurrent spontaneous abortion in various countries. None of these studies was done in Morocco. Material and Methods: Cytogenetic study was done for 238 Moroccan couples who presented with repeated abortion at the Institut Pasteur, Casablanca, Morocco. Results: We found that the frequency of chromosomal abnormalities was not significantly different from that reported worldwide. Chromosomal abnormalities were detected in 13 (6.1%) of 238 couples. twelve of chromosomal abnormalities were structural and one of them were numerical. Conclusion: This study highlights the importance of constitutional cytogenetic exploration of couples with a history of repeated spontaneous abortion. Cytogenetic findings could provide valuable information for genetic counseling and allow monitoring of future pregnancies by prenatal diagnosis in couples with a history of recurrent miscarriage.
Pulmonary epidermoid carcinoma in a patient with acromegaly: a rare entity
Siham El Aziz, Asma Chadli, Atika Obbiba, Hassan El Ghomari, Ahmed Farouqi
Pan African Medical Journal , 2012,
Abstract: A 56-years-old woman was referred to our unit for partially treated acromegaly. She had a high level of insulin growth factor. She did not complain of any pulmonary symptoms and was a non-smoker. Physical examination revealed clinical features of acromegaly. She had a 13 mm pituitary adenoma and was proposed for surgical intervention. Her chest X-ray showed a right paracardiac tumor. Computed tomography scan revealed a large right-sided fowler tumor. Pituitary surgery was cancelled and lobectomy after biopsy with lymph nodes excision was performed through thoracotomy. Histological study of the tumor revealed a medium differentiated epidermoid carcinoma with positive lymph nodes and extension to pleura. She was referred to chemotherapy protocol. Association between carcinoma and acromegaly has previously been reported. Most common tumors are colorectal and thyroid neoplasia. As we see in this case report, we need to consider other carcinomas in acromegalic patients like pulmonary carcinoma, despite their rarity in women. Pan African Medical Journal 2012; 12:27
Thyroid Hemiagenesis Associated with Hashimoto’s Thyroiditis
D. Nsame,A. Chadli,L. Hallab,S. El Aziz,H. El Ghomari,A. Farouqi
Case Reports in Endocrinology , 2013, DOI: 10.1155/2013/414506
Abstract: Thyroid hemiagenesis is a rare congenital anomaly resulting from failure of one thyroid lobe development. We report a 23-year-old female presented with Hashimoto’s thyroiditis in left lobe, associated with hemiagenesis of right lobe and isthmus which was previously diagnosed as Graves’ hyperthyroidism, but developed further into Hashimoto’s thyroiditis after being treated with antithyroid drugs. The symptoms of hyperthyroidism in the current case led to the diagnostic confirmation by scintiscanning of an absent lobe. The antithyroid pharmacotherapy by thiamazole was used. However, due to symptoms of hypothyroidism, it was discontinued two months later, so thyroid hormone substitution was reintroduced. Antithyroid antibody studies and ultrasonography documented the presence of Hashimoto’s thyroiditis. 1. Introduction Thyroid hemiagenesis is a rare congenital anomaly resulting from failure of one thyroid lobe development. The detection is often made by either clinical symptoms of thyroid dysfunction, by imaginological studies, or by anatomical abnormalities. A variety of pathological conditions occur in the remaining thyroid tissue in association with this rare anomaly such as adenoma, carcinoma, subacute thyroiditis, colloid nodule, Graves’ disease, simple goiter, and Hashimoto’s thyroiditis. Association of Hashimoto’s thyroiditis with thyroid hemiagenesis is quite rare and very few cases are reported in the literature. We report a case which is previously diagnosed as Graves’ hyperthyroidism but developed further into Hashimoto’s thyroiditis after being treated with antithyroid drugs. 2. Case Report We report a 23-year-old female who was seen in December 2011 complaining of clinical hyperthyroidism manifestation, that is, weight loss, excessive sweating, palpitation, and heat intolerance. The result of thyroid function revealed that FT4 was 19.49?pg/mL (normal = 9–17?pg/mL) and TSHs was <0.022 (normal = 0.27–4.2?μIU/mL). The scintiscanning documented the presence of Graves’ disease within the remaining lobe (Figure 1). The antithyroid pharmacotherapy by thiamazole was prescribed by a general practitioner. However, due to symptoms of hypothyroidism, it was discontinued, two months later, and referred to our outpatient clinic. On physical examination she had a heart rate of 75/minute, blood pressure of 130/70?mmHg, and a minimally palpable right thyroid lobe. There was no proptosis, extraocular eye movements were full, and there was no eyelid retraction in both eyes. The patient has been treated with thiamazole on ?mg/day for 2 months and the dose was
Hypoglycemia Controlled by Prednisone in an Occult Insulinoma or a Nesidioblastosis  [PDF]
Annelie Kérékou, Siham El Aziz, Alihonou Dédjan, Asma Chadli, Ahmed Farouqi
Open Journal of Endocrine and Metabolic Diseases (OJEMD) , 2019, DOI: 10.4236/ojemd.2019.96007
Abstract: Insulinoma is a pancreatic endocrine tumor lower in size than 20 mm in 80% of the cases and his treatment is chirurgical. However, in certain circumstances such as an occult location or circumstances of metastases, medical treatment is called for. Observation: A 29 years old patient with no specific pathological antecedents has presented severe hypoglycemia mainly in the morning. A patient was in a generally good condition. The fasting test revealed an inappropriate secretion of insulin at a venous glycemia of 0.35 g/l; which was corroborated by Turner index and altered glucose insulin index that we calculated. Moreover, the 8 h cortisolemia was normal at 90.13 ng/l, the TSH was normal at 1.44 μui/l, anti-insulin antibodies were negative at 6.7 U/l; the search of hypoglycemic sulfonamides was negative. Morphologically, she had three pancreatic tomodensitometry these were normal. She also had echo-endoscopy which showed a normal pancreas. The surgical exploration with preoperative echo is advised only after surgeon’s assessment when the technical conditions are not put together. The diagnosis of the occult insulinoma or of nesidioblastosis was retained. The medical treatment was retained. Due to the unavailability of diazoxide in our pharmacies and the high cost of analogs of somatostatine, she was provided with prednisone 0.5 mg/kg/24h which was 40 mg/day after common agreement. The evolution was favorable. Conclusion: It should be noticed that medical treatment can be suggested if insulinoma is not localized. This observation proves that the localization of the insulinoma can be unsuccessful. It should also be noticed that our experience is the fourth described in literature, where hypoglycemia in insulinomas is controlled by prednisone.
Mycotic Infections in Diabetic Patients in Casablanca  [PDF]
Annelie Kérékou, Siham El Aziz, Alihonou Dédjan, Asma Chadli, Ahmed Farouqi
Journal of Diabetes Mellitus (JDM) , 2019, DOI: 10.4236/jdm.2019.93014
Abstract: Introduction: The diabetes constitutes the factor risk of mycotic infections. The pathogenic agents depend on the climate, geography and the migration. The objective of this study is to evaluate the prevalence of the mycotic infections within the hospitalized diabetic patients, to describe their localization and identify the responsible germs. Patients and methods: It is about a descriptive and retrospective study conducted from November 2015 to March 2016 in endocrinology office at CHU Ibn Roch of Casablanca. It was included all diabetic patients hospitalized with whom mycotic infection has been suspected. Results: In total 350 diabetic patients have been hospitalized during the period of research. A mycotic infection has been suspected in 138 patients corresponding to the prevalence of 39.4 percent. The means localizations of mycotic infections were feet (intertrigos: 38.4%), onychomycosis (29%), vulvovaginal (21.7%) and mouth (oral candidiasis: 13.3%). The most frequent pathogenic agents were dermatophytes (Trichophyton rubrum: 61%, Trichophyton mentagrophytes: 6.3%) and Candida albicans (23.1%). The direct test and the culture were negative in 7.3%. Conclusion: One-third of the diabetic patients showed a mycotic infection. The feet, constitute the predilection localization of mycotic infections in the diabetic. The dermatophytes and Candida albicans constitute the most frequent pathogenic agents found in our study.
Le Texte et le Paratexte dans Les Jardins de Lumière et Les échelles du Levant d’Amin Maalouf
Djaouida Chadli
Synergies Algerie , 2011,
Abstract: Cet article aura pour objet l’étude paratextuelle de deux romans d’Amin Maalouf dont les titres respectifs sont : Les Jardins de Lumière et Les échelles du Levant. Cette analyse s’intéressera, en effet, aux différents éléments constituant le seuil de chaque roman. Elle est fondée essentiellement sur les travaux de Gérard Genette illustrés dans son ouvrage intitulé Seuils.
On a System of Generalized Mixed Equilibrium Problems Involving Variational-Like Inequalities in Banach Spaces: Existence and Algorithmic Aspects
H. Mahdioui,O. Chadli
Advances in Operations Research , 2012, DOI: 10.1155/2012/843486
Abstract: We study the existence and the algorithmic aspect of a System of Generalized Mixed Equilibrium Problems involving variational-like inequalities (SGMEPs) in the setting of Banach spaces. The approach adopted is based on the auxiliary principle technique and arguments from generalized convexity. A new existence theorem for the auxiliary problem is established; this leads us to generate an algorithm which converges strongly to a solution of (SGMEP) under weaker assumptions. When the study is reduced to the setting of reflexive Banach spaces, then it can be more relaxed by dropping the coercivity condition. The results obtained in this paper are new and improve some recent studies in this field. 1. Introduction and the Problem Statement Let be a nonempty closed convex subset of a Banach space , and let be a real-valued bifunction. By equilibrium problem, in short (EP), we mean the following problem: Equilibrium problems are suitable and common format for investigation of various applied problems arising in economics, mathematical physics, transportation, communication systems, engineering, and other fields. Moreover, equilibrium problems are closely related with other general problems in nonlinear analysis, such as fixed points, game theory, variational inequality, and optimization problems, see [1–4]. Various kinds of iterative algorithms to solve equilibrium problems and variational inequalities have been developed by many authors. There exists a vast literature on the approximation solvability of equilibrium problems and nonlinear variational inequalities using projection type methods, proximal-type methods, or resolvent operator type methods, see [5–11]. We observe that the projection method and its variant forms cannot be applied for constructing iterative algorithms of mixed variational-like inequalities or mixed equilibrium problems involving variational-like inequalities. This fact motivated many authors to develop the auxiliary principle technique to study the existence and algorithm of solutions for variational-like inequalities and its extensions to mixed equilibrium problems, see [12–15]. Kazmi and Khan [16] studied a system of generalized variational-like inequality problems in Hilbert spaces by using the auxiliary principle technique. Recently, Ding and Wang [17] and Ding [18] introduced new iterative algorithms for solving some class of system of generalized mixed variational-like inequalities and system of mixed equilibrium problems involving variational-like inequalities. In this paper, we study the existence and the algorithmic aspect of a
Epstein-Barr Virus Positive Inflammatory Pseudotumor of the Spleen: Case Report and Review of the Literature  [PDF]
Slim Jarboui, Abelwaheb Hlel, Med Ali Bekkay, Habib BelHaadj Khalifa, Moncef Mokni
Case Reports in Clinical Medicine (CRCM) , 2014, DOI: 10.4236/crcm.2014.38098

Inflammatory Pseudotumor (IPT) forms a group of etiologically, histologically, and biologically heterogeneous tumefactive lesions that are histologically characterized by prominent inflammatory infiltrates. It has been described in various organs including the lungs, bladder, liver, spleen, heart, and others. It may mimic a malignant tumor clinically and radiologically. Splenic IPT are most frequently detected incidentally. We report a case of 38-year-old women admitted for recurrent abdominal pain. Physical examination was unremarkable. Contrast enhanced CT showed a well hypodense, circumscribed lesion, measuring 5 × 3.5 cm. A differential diagnosis of lymphoma, teratomas, angioma or angiosarcoma was considered. The patient underwent splenectomy. Histologically, the tumor consisted of an inflammatory infiltrate composed predominantly of diffusely lymphoplasmocytic cells and stromal fibroblasts. Epstein-Barr virus was detected on in situ hybridization exclusively in the epitheloid and spindles cells. The optimal management of this tumor and eventually in asymptomatic patients is still controversial. IPT of the spleen should be remembered when evaluating single or multiple nodules in spleens. The clinical and pathological features of previously reported cases are reviewed in this paper.

Association of Spermatogenic Failure with the b2/b3 Partial AZFc Deletion
Abdelmajid Eloualid, Houria Rhaissi, Ahmed Reguig, Safaa Bounaceur, Brahim El houate, Omar Abidi, Majida Charif, Noureddine Louanjli, Elbakkay Chadli, Abdelhamid Barakat, Anu Bashamboo, Ken McElreavey, Hassan Rouba
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0034902
Abstract: Infertility affects around 1 in 10 men and in most cases the cause is unknown. The Y chromosome plays an important role in spermatogenesis and specific deletions of this chromosome, the AZF deletions, are associated with spermatogenic failure. Recently partial AZF deletions have been described but their association with spermatogenic failure is unclear. Here we screened a total of 339 men with idiopathic spermatogenic failure, and 256 normozoospermic ancestry-matched men for chromosome microdeletions including AZFa, AZFb, AZFc, and the AZFc partial deletions (gr/gr, b1/b3 and b2/b3). AZFa and AZFc deletions were identified in men with severe spermatogenic failure at similar frequencies to those reported elsewhere. Gr/gr deletions were identified in case and control populations at 5.83% and 6.25% respectively suggesting that these deletions are not associated with spermatogenic failure. However, b2/b3 deletions were detected only in men with spermatogenic failure and not in the normospermic individuals. Combined with our previous data this shows an association of the b2/b3 deletion (p = 0.0318) with spermatogenic failure in some populations. We recommend screening for this deletion in men with unexplained spermatogenic failure.
Association of the MTHFR A1298C Variant with Unexplained Severe Male Infertility
Abdelmajid Eloualid, Omar Abidi, Majida Charif, Brahim El houate, Houda Benrahma, Noureddine Louanjli, Elbakkay Chadli, Maria Ajjemami, Abdelhamid Barakat, Anu Bashamboo, Ken McElreavey, Houria Rhaissi, Hassan Rouba
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0034111
Abstract: The methylenetetrahydrofolate reductase (MTHFR) gene is one of the main regulatory enzymes involved in folate metabolism, DNA synthesis and remethylation reactions. The influence of MTHFR variants on male infertility is not completely understood. The objective of this study was to analyze the distribution of the MTHFR C677T and A1298C variants using PCR-Restriction Fragment Length Polymorphism (RFLP) in a case group consisting of 344 men with unexplained reduced sperm counts compared to 617 ancestry-matched fertile or normozoospermic controls. The Chi square test was used to analyze the genotype distributions of MTHFR polymorphisms. Our data indicated a lack of association of the C677T variant with infertility. However, the homozygous (C/C) A1298C polymorphism of the MTHFR gene was present at a statistically high significance in severe oligozoospermia group compared with controls (OR = 3.372, 95% confidence interval CI = 1.27–8.238; p = 0.01431). The genotype distribution of the A1298C variants showed significant deviation from the expected Hardy-Weinberg equilibrium, suggesting that purifying selection may be acting on the 1298CC genotype. Further studies are necessary to determine the influence of the environment, especially the consumption of diet folate on sperm counts of men with different MTHFR variants.
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