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Successful treatment of infundibulofolliculitis with topical tretinoin. Report of a case
Seema Srinivasa,Metikurke Vijayashankar
Our Dermatology Online , 2012,
Abstract: First described in 1968 by Hitch and Lund. Disseminated and Recurrent infundibulofolliculitis (DRIF) is an uncommon eruption characterized by recurrent, pruritic follicular papules commonly seen on the trunk and proximal extremities. Rarely limited to the neck. It is much more common in black population but has also been reported in other ethnicities including Caucasians. Its etiology has constantly been debated with a few authors describing it as a variant of atopic dermatitis while others have refuted the same as a family history of atopy is not present. Various others have classified DRIF as variants of follicular eczema, along with lichen spinulosus and juxtaclavicular beaded lines. Its treatment also varies with different authors claiming response to steroids, isotretinoin, UVA therapy, keratolytics and tetracyclines. We describe a case of localized infundibulofolliculitis of the neck diagnosed in a 21 year old female who was successfully treated with a course of topical tretinoin 0.025%. The presenting history, clinical findings, biopsy results and available literature are reviewed.
Participation and Activity Rates: Monitoring Exposure Potential for Native Americans and Others in the United States  [PDF]
Joanna Burger
Journal of Environmental Protection (JEP) , 2011, DOI: 10.4236/jep.2011.28116
Abstract: Managers and regulators are concerned about potential human health effects from exposure on lands contaminated by chemicals and radionuclides. Determining target cleanup levels is partly dependent upon future land use, and potential exposure from human use. This paper provides data from surveys of activity patterns of people attending festivals in four states, located in the vicinity of Department of Energy facilities. There were significant differences in both participation rates, and activity rates as a function of both location and ethnicity that can be used by managers to track exposure, land use, and preferred activities on natural lands. In general, 1) a higher percent of Native Americans engaged in consumptive activities than others, 2) a higher percent of Caucasians engaged in some non-consumptive activities than Native Americans, 3) a higher percentage of Native Americans engaged in activities on sacred grounds, 4) activity rates were generally higher for Native Americans for consumptive activities and religious/cultural than for Caucasians, 5) fishing rates were higher than other consumptive activities, and camping/hiking were higher than other non-con- sumptive activities, and 6) hunting rates were higher in subjects from Idaho than elsewhere. Baseline human use is critical for monitoring potential exposure, and provides the basis for monitoring, risk assessment and future land use, and these data can be used by managers for assessment and management. Tracking changes over time will reflect changing recreational, subsistence, and cultural/religious trends that relate to land use, public perceptions, and exposure.
Physiological Differences between Ethiopian and Caucasian Distance Runners and Their Effects on 10 km Running Performance  [PDF]
R. Rafael Wishnizer, Omri Inbar, Eliezer Klinman, Gershon Fink
Advances in Physical Education (APE) , 2013, DOI: 10.4236/ape.2013.33023

Objective: Ethiopian athletes currently dominate long distance running events in Israel. In an attempt to explain the apparently superior running ability of Israeli Ethiopian athletes at distances >5 km, we compared anatomical and physiological measurements in the fastest 21 Israeli Caucasian (CA) and 22 Israeli Ethiopian (ET) long distance runners with similar mean age, years of training, and weekly volume of training. Methods: Two to six months prior to or following official 10 km track race, subjects underwent an incremental maximal and sub-maximal exercise testing in an attempt to identify which of the measured anatomical and/or physiological variable/s explain best the success of the of Israeli Ethiopian long distance runners. Results: The ET runners were significantly shorter and lighter and possessed a lower BMI than the CA runners. Whereas mean  VO2peak (ml/kg/min) was 10.3% lower in the Ethiopian runners (p = 0.007), their mean 10,000 m run time was 6.2% faster than their Caucasian counterparts (p < 0.001). Although anaerobic threshold-related variables were similar in the two ethnic groups, the Ethiopians’ running economy (cost) was significantly higher than that of the CA ( VO2sub = 40.3 vs. 45.5 ml/kg/min in the ET and CA respectively) (p > 0.001). Conclusion: The results suggest that factors associated with running cost, independent of body size, play a crucial role in the performance of 10 km running. The results also suggest, though indirectly, that genetic and early life phenotypic factors are more dominant than later-life environmental factors (including training) at the 10 km performance level.

Tumor Necrosis Factor-α +489G/A gene polymorphism is associated with chronic obstructive pulmonary disease
Mehmet Kü?ükaycan, Michiel Van Krugten, Herman-Jan Pennings, Tom WJ Huizinga, Wim A Buurman, Mieke A Dentener, Emiel FM Wouters
Respiratory Research , 2002, DOI: 10.1186/rr194
Abstract: TNF-α gene polymorphisms at positions -376G/A, -308G/A, -238G/A, and +489G/A were examined in 169 Dutch COPD patients, who had a mean forced expiratory volume in one second (FEV1) of 37 ± 13%, and compared with a Dutch population control group of 358 subjects.The data showed that the TNF-α +489G/A genotype frequency tended to be different in COPD patients as compared to population controls, which was due to an enhanced frequency of the GA genotype. In line herewith, carriership of the minor allele was associated with enhanced risk of development of COPD (odds ratio = 1.9, p = 0.009). The other TNF-α gene polymorphisms studied revealed no discrimination between patients and controls. No differences in the examined four TNF-α polymorphisms were found between subtypes of COPD, which were stratified for the presence of radiological emphysema. However, comparison of the COPD subtypes with controls showed a significant difference in the TNF-α +489G/A genotype in patients without radiological emphysema (χ2-test: p < 0.025 [Bonferroni adjusted]), while no differences between COPD patients with radiological emphysema and controls were observed.Based on the reported data, it is concluded that COPD, and especially a subgroup of COPD patients without radiological emphysema, is associated with TNF-α +489G/A gene polymorphism.The pro-inflammatory cytokine Tumor Necrosis Factor (TNF)-α plays an important role in inflammatory processes. The gene coding for this cytokine is located on chromosome six in the class III region of the major histocompatibility complex. Several biallelic polymorphisms of this gene are known, including the TNF-α -308G/A gene polymorphism, which is the first discovered TNF-α gene polymorphism, the TNF-α -376G/A and the -238G/A gene polymorphisms. The latter gene polymorphisms are located in the promoter region of the gene, whereas another gene polymorphism found at position +489G/A, is located in the first intron of the gene [1-3].Several studies have analyz
Racial differences of colorectal cancer in a single institution in Northeast Louisiana primarily serving the underserved population
B Devkota,ES Arnbrecht
Health Renaissance , 2012, DOI: 10.3126/hren.v10i1.5998
Abstract: Background: Colorectal cancer (CRC) screening has helped decrease the incidence of CRC in the last two decades. Still African Americans share a higher burden of CRC disease in the United States in comparison to Caucasians. Objective: To study racial differences of colorectal cancer in low income patients. Methods: Retrospective chart review of all admitted patients with a diagnosis of CRC was done by the lead author over a period of eight months. Results: This study, drawn from a poor, diverse population of Louisiana residents suggests socioeconomic factors may explain observed differences in CRC rates between African Americans and Caucasians. Conclusion: Large scale surveillance studies that address social determinants of CRC are needed to further explore this association. DOI: http://dx.doi.org/10.3126/hren.v10i1.5998 HREN 2012; 10(1): 5-7
Interethnic diversity of the CD209 (rs4804803) gene promoter polymorphisms in African but not American sickle cell disease
Jenelle A Noble,Kimberley C Duru,Aldiouma Guindo,Li Yi,Dapa A Diallo,Bolaji Thomas
PeerJ , 2015, DOI: 10.7287/peerj.preprints.597v1
Abstract: Elucidating the genomic diversity of CD209 gene promoter polymorphisms could assist in clarifying disease pathophysiology as well as contribution to co-morbidities. CD209 gene promoter polymorphisms have been shown to be associated with susceptibility to infection. We hypothesize that CD209 mutant variants occur at a higher frequency among Africans and in sickle cell disease. We analyzed the frequency of the CD209 gene (rs4804803) in healthy control and sickle cell disease (SCD) populations and determined association with disease. We obtained genomic DNA from 145 SCD and 244 control Africans (from Mali), 331 SCD and 379 control African Americans and 159 Caucasians. Comparative analysis among and between groups was carried out by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Per ethnic diversification, we found significant disparity in genotypic (23.4% versus 16.9% versus 3.2%) and allelic frequencies (36.1% versus 25.1% versus 11.6%) of the mutant variant of the CD209 (snp 309A/G) gene promoter between Africans, African Americans and Caucasians respectively. Surprisingly, there was a wide disparity in the genotypic and allelic frequencies among African SCD versus healthy controls (10.4% versus 23.4% (genotypes) and 25.2% versus 36.1% (alleles), which is completely absent among African Americans. Comparing SCD groups, there was no difference between Africans and Americans, implying a lack of association between CD209 polymorphisms and sickle cell disease in either population. The higher frequency of CD209 mutant variants in the non-SCD group reveals an impaired capacity to mount an immune response to infectious diseases. We conclude that CD209 polymorphism play a major role in susceptibility to infectious pathogens and could potentially delineate susceptibility to and severity of co-morbidities.
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