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Search Results: 1 - 10 of 11379 matches for " Carolina Baraldi Araujo Restini "
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Antioxidant Protective Effects of the Resveratrol on the Cardiac and Vascular Tissues from Renal Hypertensive Rats  [PDF]
Joyce Cristina de Oliveira, Carla Renata Kitanish Antonietto, Angélica Cristina Scalabrini, Talita Sanches Marinho, Larissa Pernomian, José Wilson N. Corrêa, Carolina Baraldi Araujo Restini
Open Journal of Medicinal Chemistry (OJMC) , 2012, DOI: 10.4236/ojmc.2012.23008
Abstract: Background: Accumulating reactive oxygen species (ROS) is involved in cellular signaling and function disturbances due to the oxidative stress, which contributes to several diseases. The consequences of ROS activity represent an im-portant mechanism on the pathogenesis of vascular diseases, such as hypertension. Increased blood pressure observed in renal hypertension of the 2 kidneys-1 clip (2K-1C) model involves increased ROS levels in the cardiovascular system. Resveratrol, a polyphenolic compound primarily found in red wine, has many biological and pharmacological proper-ties. Considering the antioxidant properties of resveratrol, the present study was aimed to investigate the effects of the chronic treatment with resveratrol on cardiovascular system from renal hypertensive rats. Results: 2K-1C hypertension presented increased blood pressure, which was reduced at the end of the fifth week of resveratrol treatment. The cardiac hypertrophy index and the basal levels of ROS in rat aortic rings were also reduced by resveratrol treatment. Conclusions: The present findings clearly show the protective effects from resveratrol on the blood pressure, the car-diac growth and the vascular ROS generation in renal hypertension.
Role of endothelium on the abnormal Angiotensin-mediated vascular functions in epileptic rats  [PDF]
Carolina Restini, Rosana Reis, Claudio Costa-Neto, Norberto Garcia-Cairasco, José Cortes-de-Oliveira, Lusiane Bendhack
Journal of Biophysical Chemistry (JBPC) , 2012, DOI: 10.4236/jbpc.2012.32019
Abstract: Epidemiological studies have found that the risk for cardiovascular disease is increased in patients with epilepsy. The Renin Angiontensin System (RAS), an important player in vascular tone control, is also involved in many neurological disorders, including seizures and epilepsy. Although it has been reported that Angiotensin II (Ang II) release and Angiotensin receptors expression are altered in many cerebral areas in patients/animal models with neurological disorders, there are no data on the vascular function. We evaluated Ang I and Ang II-mediated vascular responses and to correlate their contractile responses to the pres- ence of endothelium and the protein levels of components of the RAS (AT1, AT2, Mas and ACE) in aorta isolated from genetically epileptic rats (WAR strain). The major finding was that the vascular contractile response induced by Ang I and Ang II is endothelium-dependent. Ang II induced contractions in aortas from Wistar rats either with intact endothelium (E+) (1.16 ± 0.04 g, n = 6) and endothelium-denuded (E-) (1.24 ± 0.04 g, n = 6). Maximum contractile response (ME) induced by Ang I was lower in Wistar E+ (0.45 ± 0.03 g, n = 6) compared with Wistar E- (1.13 ± 0.08 g, n = 6). Ang I and Ang II failed to induce contraction in WAR E+, whereas the ME induced by Ang I in WAR E- was lower (0.52 ± 0.04 g, n = 11) than in the Wistar. ME induced by Ang II in aortas from WAR was also lower (0.40 ± 0.03 g, n = 11) compared with Wistar. AT1 receptor expression in both E+ WAR and Wistar was lower than in both E- WAR and Wistar. AT2 and Mas receptor expression was higher in Wistar E- and E+ as compared to WAR E- and E+. ACE expression was higher in both E+ WAR and Wistar, but it was lower in both E- WAR and Wistar. Endothelium impairs the contractile response induced by Angiotensin in WAR, suggesting that endothelial relaxing factors play important role on the aorta contraction.
The cone of pseudo-effective divisors of log varieties after Batyrev
Carolina Araujo
Mathematics , 2005, DOI: 10.1007/s00209-008-0457-8
Abstract: In these notes we investigate the cone of nef curves of projective varieties, which is the dual cone to the cone of pseudo-effective divisors. We prove a structure theorem for the cone of nef curves of projective $\mathbb Q$-factorial klt pairs of arbitrary dimension from the point of view of the Minimal Model Program. This is a generalization of Batyrev's structure theorem for the cone of nef curves of projective terminal threefolds.
Identifying quadric bundle structures on complex projective varieties
Carolina Araujo
Mathematics , 2008,
Abstract: In this paper we characterize smooth complex projective varieties that admit a quadric bundle structure on some dense open subset in terms of the geometry of certain families of rational curves.
K?hler-Einstein Metrics for some quasi smooth log del Pezzo Surfaces
Carolina Araujo
Mathematics , 2001,
Abstract: Recently Johnson and Koll\'ar determined the complete list of anticanonically embedded quasi smooth log del Pezzo surfaces in weighted projective 3-spaces. They also proved that many of those surfaces admit a K\"ahler-Einstein metric, and that some of them do not have tigers. The aim of this paper is to settle the question of the existence of K\"ahler-Einstein metrics and tigers for those surfaces for which the question was still open. In order to do so, we will use techniques developed earlier by Nadel and Demailly and Koll\'ar.
Rationally connected varieties
Carolina Araujo
Mathematics , 2005,
Abstract: This is an expository paper on rationally connected varieties. The aim is to provide an introduction to the subject, as well as to discuss a recent result by T. Graber, J. Harris and J. Starr. The paper is based on the talk I gave at the 2004 Summer Research Conference on Algebraic Geometry at Snowbird.
Rational curves of minimal degree and characterizations of ${\mathbb P}^n$
Carolina Araujo
Mathematics , 2004,
Abstract: In this paper we investigate complex uniruled varieties $X$ whose rational curves of minimal degree satisfy a special property. Namely, we assume that the tangent directions to such curves at a general point $x\in X$ form a linear subspace of $T_xX$. As an application of our main result, we give a unified geometric proof of Mori's, Wahl's, Campana-Peternell's and Andreatta-Wi\'sniewski's characterizations of ${\mathbb P}^n$.
Explicit log Fano structures on blow-ups of projective spaces
Carolina Araujo,Alex Massarenti
Mathematics , 2015,
Abstract: In this paper we determine which blow-ups $X$ of $\mathbb{P}^n$ at general points are log Fano, that is, when there exists an effective $\mathbb{Q}$-divisor $\Delta$ such that $-(K_X+\Delta)$ is ample and the pair $(X,\Delta)$ is klt. For these blow-ups, we produce explicit boundary divisors $\Delta$ making $X$ log Fano.
The Effect of Extracellular pH Changes on Intracellular pH and Nitric Oxide Concentration in Endothelial and Smooth Muscle Cells from Rat Aorta
Verena K. Capellini, Carolina B. A. Restini, Lusiane M. Bendhack, Paulo R. B. Evora, Andréa C. Celotto
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0062887
Abstract: Aims It has been known for more than a century that pH changes can alter vascular tone. However, there is no consensus about the effects of pH changes on vascular response. In this study, we investigated the effects of extracellular pH (pHo) changes on intracellular pH (pHi) and intracellular nitric oxide concentration ([NO]i) in freshly isolated endothelial cells and cross sections from rat aorta. Main Methods The HCl was used to reduce the pHo from 7.4 to 7.0 and from 7.4 to 6.5; the NaOH was used to increase the pHo from 7.4 to 8.0 and from 7.4 to 8.5. The fluorescent dyes 5-(and-6)-carboxy SNARF-1, acetoxymethyl ester, acetate (SNARF-1) and diaminofluorescein-FM diacetate (DAF-FM DA) were employed to measure the pHi and [NO]i, respectively. The fluorescence intensity was measured in freshly isolated endothelial cells by flow cytometry and in freshly obtained aorta cross sections by confocal microscopy. Key Findings The endothelial and vascular smooth muscle pHi was increased at pHo 8.5. The extracellular acidification did not change the endothelial pHi, but the smooth muscle pHi was reduced at pHo 7.0. At pHo 8.5 and pHo 6.5, the endothelial [NO]i was increased. Both extracellular alkalinization and acidification increased the vascular smooth muscle [NO]i. Significance Not all changes in pHo did result in pHi changes, but disruption of acid-base balance in both directions induced NO synthesis in the endothelium and/or vascular smooth muscle.
Vascular Relaxation Induced by C-Type Natriuretic Peptide Involves the Ca2+/NO-Synthase/NO Pathway
Fernanda A. Andrade, Carolina B. A. Restini, Marcella D. Grando, Leandra N. Z. Ramalho, Lusiane M. Bendhack
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0095446
Abstract: Aims C-type natriuretic peptide (CNP) and nitric oxide (NO) are endothelium-derived factors that play important roles in the regulation of vascular tone and arterial blood pressure. We hypothesized that NO produced by the endothelial NO-synthase (NOS-3) contributes to the relaxation induced by CNP in isolated rat aorta via activation of endothelial NPR-C receptor. Therefore, the aim of this study was to investigate the putative contribution of NO through NPR-C activation in the CNP induced relaxation in isolated conductance artery. Main Methods Concentration-effect curves for CNP were constructed in aortic rings isolated from rats. Confocal microscopy was used to analyze the cytosolic calcium mobilization induced by CNP. The phosphorylation of the residue Ser1177 of NOS was analyzed by Western blot and the expression and localization of NPR-C receptors was analyzed by immunohistochemistry. Key Findings CNP was less potent in inducing relaxation in denuded endothelium aortic rings than in intact ones. L-NAME attenuated the potency of CNP and similar results were obtained in the presence of hydroxocobalamin, an intracellular NO0 scavenger. CNP did not change the phosphorylation of Ser1177, the activation site of NOS-3, when compared with control. The addition of CNP produced an increase in [Ca2+]c in endothelial cells and a decrease in [Ca2+]c in vascular smooth muscle cells. The NPR-C-receptors are expressed in endothelial and adventitial rat aortas. Significance These results suggest that CNP-induced relaxation in intact aorta isolated from rats involves NO production due to [Ca2+]c increase in endothelial cells possibly through NPR-C activation expressed in these cells. The present study provides a breakthrough in the understanding of the close relationship between the vascular actions of nitric oxide and CNP.
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