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Search Results: 1 - 10 of 461971 matches for " Carmino A.;Voltarelli "
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Estudo retrospectivo do tratamento de leucemia mielóide aguda com o transplante de medula óssea: a experiência brasileira
Hamerschlak, Nelson;Barton, Débora;Pasquini, Ricardo;Sarquis, Yana N.;Ferreira, Eurípedes;Moreira, Frederico R.;Colturato, Vergilio A. R.;Souza, Carmino A.;Voltarelli, Júlio;Piron-Ruiz, Lilian;Setúbal, Daniela C.;Zanichelli, Maria A.;Castro, Cláudio G. de;Bueno, Nadjanara D.;Seber, Adriana;Rotolo, Marco A.;Silla, Lucia M. R.;Bittencourt, Henrique;Souza, Mair P.;Vigorito, Afonso C.;Brandalise, Silvia R.;Maiolino, Angelo;Nucci, Márcio;Coelho, érika;Ostronoff, Maurício;Sim?es, Belinda;Ruiz, Milton A.;
Revista Brasileira de Hematologia e Hemoterapia , 2006, DOI: 10.1590/S1516-84842006000100005
Abstract: data from the international bone marrow transplant registry (ibmtr) contribute for the improvement of bone marrow transplant (bmt) worldwide. we studied the brazilian experience in bmt for aml to compare this with international data. we performed a retrospective study by sending questionnaires to 16 bmt centers regarding clinical and treatment variables. statistical analyses concerning autologous bmt (autobmt) and allogeneic bmt (allobmt) were performed using the kaplan-meier method and the log-rank test. all p-values were two-tailed. we collected data from 731 patients (205 autobmt and 526 allobmt). median overall survival (os) for autobmt patients was longer than allobmt patients (1035 vs. 466 days, p=0.0012). allobmt stem cell source (scs): 73% bone marrow stem cell (bmsc), 23% peripheral blood stem cells (pbsc) and 4% umbilical cord blood. among the autobmt patients, the scs was 63% pbsc, 22% bmsc and 15% both. the scs did not impact on os. there was no difference in os between different fab classifications in the allobmt group, but in the autobmt the m3 patients had longer survival. as expected, the main cause of mortality among autobmt patients was related to disease relapse (60%), while in the allobmt, to infection (38%). in both groups we found longer os in first complete remission (1cr) compared to second (2cr) and other (p<0.0001), and longer os in de novo aml than in secondary. in the allobmt group we found more patients with advanced disease (60%), while in the autobmt group, we found more m3 patients (24%), which could explain the difference in os. most of our results are in accordance with ibmtr data. one should consider the fact that this is a retrospective study and our findings should be analysed with caution.
“If We Only Knew How You Feel”—A Comparative Study of Automated vs. Manual Classification of Opinions of Customers on Digital Media  [PDF]
Huoston Rodrigues Batista, José Carmino Gomes Junior, Marcelo Drudi Miranda, Andréa Martiniano, Renato José Sassi, Marcos Antonio Gaspar
Social Networking (SN) , 2019, DOI: 10.4236/sn.2019.81005
Abstract: The Web development has drastically changed the human interaction and communication, leading to an exponential growth of data generated by users in various digital media. This mass of data provides opportunities for understanding people’s opinions about products, services, processes, events, political movements, and organizational strategies. In this context, it becomes important for companies to be able to assess customer satisfaction about their products or services. One of the ways to evaluate customer sentiment is the use of Sentiment Analysis, also known as Opinion Mining. This research aims to compare the efficiency of an automatic classifier based on dictionary with the classification by human jurors in a set of comments made by customers in Portuguese language. The data consist of opinions of service users of one of the largest Brazilian online employment agencies. The performance evaluation of the classification models was done using Kappa index and a Confusion Matrix. As the main finding, it is noteworthy that the agreement between the classifier and the human jurors came to moderate, with better performance for the dictionary-based classifier. This result was considered satisfactory, considering that the Sentiment Analysis in Portuguese language is a complex task and demands more research and development.
Determination of anaerobic threshold in rats using the lactate minimum test
Voltarelli, F.A.;Gobatto, C.A.;Mello, M.A.R. de;
Brazilian Journal of Medical and Biological Research , 2002, DOI: 10.1590/S0100-879X2002001100018
Abstract: the break point of the curve of blood lactate vs exercise load has been called anaerobic threshold (at) and is considered to be an important indicator of endurance exercise capacity in human subjects. there are few studies of at determination in animals. we describe a protocol for at determination by the "lactate minimum test" in rats during swimming exercise. the test is based on the premise that during an incremental exercise test, and after a bout of maximal exercise, blood lactate decreases to a minimum and then increases again. this minimum value indicates the intensity of the at. adult male (90 days) wistar rats adapted to swimming for 2 weeks were used. the initial state of lactic acidosis was obtained by making the animals jump into the water and swim while carrying a load equivalent to 50% of body weight for 6 min (30-s exercise interrupted by a 30-s rest). after a 9-min rest, blood was collected and the incremental swimming test was started. the test consisted of swimming while supporting loads of 4.5, 5.0, 5.5, 6.0 and 7.0% of body weight. each exercise load lasted 5 min and was followed by a 30-s rest during which blood samples were taken. the blood lactate minimum was determined from a zero-gradient tangent to a spline function fitting the blood lactate vs workload curve. at was estimated to be 4.95 ± 0.10% of body weight while interpolated blood lactate was 7.17 ± 0.16 mmol/l. these results suggest the application of at determination in animal studies concerning metabolism during exercise.
Determination of anaerobic threshold in rats using the lactate minimum test
Voltarelli F.A.,Gobatto C.A.,Mello M.A.R. de
Brazilian Journal of Medical and Biological Research , 2002,
Abstract: The break point of the curve of blood lactate vs exercise load has been called anaerobic threshold (AT) and is considered to be an important indicator of endurance exercise capacity in human subjects. There are few studies of AT determination in animals. We describe a protocol for AT determination by the "lactate minimum test" in rats during swimming exercise. The test is based on the premise that during an incremental exercise test, and after a bout of maximal exercise, blood lactate decreases to a minimum and then increases again. This minimum value indicates the intensity of the AT. Adult male (90 days) Wistar rats adapted to swimming for 2 weeks were used. The initial state of lactic acidosis was obtained by making the animals jump into the water and swim while carrying a load equivalent to 50% of body weight for 6 min (30-s exercise interrupted by a 30-s rest). After a 9-min rest, blood was collected and the incremental swimming test was started. The test consisted of swimming while supporting loads of 4.5, 5.0, 5.5, 6.0 and 7.0% of body weight. Each exercise load lasted 5 min and was followed by a 30-s rest during which blood samples were taken. The blood lactate minimum was determined from a zero-gradient tangent to a spline function fitting the blood lactate vs workload curve. AT was estimated to be 4.95 ± 0.10% of body weight while interpolated blood lactate was 7.17 ± 0.16 mmol/l. These results suggest the application of AT determination in animal studies concerning metabolism during exercise.
The use of stem cells for the treatment of autoimmune diseases
Rosa, S.B.;Voltarelli, J.C.;Chies, J.A.B.;Pranke, P.;
Brazilian Journal of Medical and Biological Research , 2007, DOI: 10.1590/S0100-879X2006005000166
Abstract: autoimmune diseases constitute a heterogeneous group of conditions commonly treated with anti-inflammatory, immunosuppressant and immunomodulating drugs, with satisfactory results in most cases. nevertheless, some patients become resistant to conventional therapy. the use of high doses of drugs in such cases results in the need for bone marrow reconstitution, a situation which has stimulated research into the use of hematopoietic stem cells in autoimmune disease therapy. stem cell transplantation in such diseases aims to destroy the self-reacting immune cells and produce a new functional immune system, as well as substitute cells for tissue damaged in the course of the disease. significant results, such as the reestablishment of tolerance and a decrease in the recurrence of autoimmune disease, have been reported following stem cell transplantation in patients with autoimmune disease in brazil and throughout the world. these results suggest that stem cell transplantation has the potential to become an important therapeutic approach to the treatment of various autoimmune diseases including rheumatoid arthritis, juvenile idiopathic arthritis, systemic lupus erythematosus, multiple sclerosis, systemic sclerosis, crohn's disease, autoimmune blood cytopenias, and type i diabetes mellitus.
Lymphocyte subpopulations and neutrophil function in chronic human Chagas' disease
Voltarelli, J. C.;Donadi, E. A.;Carvalho, I. F.;Falc?o, R. P.;
Revista do Instituto de Medicina Tropical de S?o Paulo , 1990, DOI: 10.1590/S0036-46651990000400002
Abstract: the absolute numbers of total leukocytes, lymphocytes, t cells, helper/inducer, suppressor/cytotoxic and b cells were decreased in the peripheral blood of patients with chronic chagas' disease. since antilymphocyte antibodies were present only in a minority of patients they probably cannot account for the abnormalities in lymphocyte subsets. patient neutrophils stimulated with endotoxin-treated autologous plasma showed depressed chemotactic activity and this seems to be an intrinsic cellular defect rather than plasma inhibition. random migration of neutrophils was normal. reduction of nitroblue tetrazolium by endotoxin- stimulated neutrophils was also decreased. these findings further document the presence of immunosuppression in human chagas' disease. they may be relevant to autoimmunity, defense against microorganisms and against tumor cells at least in a subset of patients with more severe abnormalities.
Association of Alport's syndrome with HLA-DR2 antigen in a group of unrelated patients
Donadi E.A.,Voltarelli J.C.,Paula-Santos C.M.,Kimachi T.
Brazilian Journal of Medical and Biological Research , 1998,
Abstract: A few family studies have evaluated HLA antigens in Alport's syndrome; however, there are no large population studies. In the present report, we studied 40 unrelated white patients with Alport's syndrome seen at the Unit of Renal Transplantation, Faculty of Medicine of Ribeir o Preto, S o Paulo, Brazil. HLA-A, -B, -DR and -DQ antigens were typed using a complement-dependent microlymphocytotoxicity assay. A control white population (N = 403) from the same geographical area was also typed for HLA antigens. Although the frequencies of HLA-A and -B antigens of patients were not statistically different from controls, the frequency of HLA-DR2 antigen observed in patients (65%) was significantly increased in relation to controls (26%; P<0.001). The relative risk and etiologic fraction for HLA-DR2 antigen were 5.2 and 0.525, respectively. Although few immunological abnormalities have been shown in Alport's syndrome, in this report we emphasize the association of HLA molecules and Alport's syndrome. Besides the well-known inherited molecular defects encoded by type IV collagen genes in Alport's syndrome, the major histocompatibility alleles may be in linkage disequilibrium with these defective collagen genes
DECH cr?nica: fator preditivo para rinossinusite no transplante de medula óssea
Ortiz, Erica;Sakano, Eulalia;Souza, Carmino Antonio De;Vigorito, Afonso;Eid, Katia A. B.;
Revista Brasileira de Otorrinolaringologia , 2006, DOI: 10.1590/S0034-72992006000300006
Abstract: introduction: bone marrow transplantation (bmt) is a treatment option for hematological diseases and immunodeficiency. it is frequently used today. bmt predisposes patients to upper airway infections and its complications, such as rhinosinusitis (rs). chemotherapy, radiotherapy, viral infections, antibiotic therapy, graft versus host disease (gvhd) are rhinosinusitis predisposing conditions. aim: to investigate rs frequence in this population and its relationship to gvhd; to try and establish the best treatment for rs in these patients. method: ent evaluation of two groups. one group with 35 patients (gi) and another with 24 patients (gii), before and after bmt. they were treated with antibiotics, maxillary sinus punction or endoscopic sinusectomy. results: none of them had rs before bmt. 42.8% from gi had rs and 34% had gvhd; in the gii, 58% had rs and 25% had gvhd. 49% from both groups had rs and 30.5% had gvhd. there was significantly more rs in chronic gvhd patients. surgery was used to treat rs in chronic gvhd patients who underwent bmt. conclusion: rs frequence was 49%; gvhd is a predisposing condition to rs; sinusectomy may be necessary to control rs in gvhd patients.
Applications of flow cytometry to hematopoietic stem cell transplantation
Voltarelli, Júlio C;
Memórias do Instituto Oswaldo Cruz , 2000, DOI: 10.1590/S0074-02762000000300018
Abstract: applications of flow cytometry to clinical and experimental hematopoietic stem cell transplantation (hsct) are discussed in this review covering the following topics: diagnosis and classification of lymphohematologic disorders, quantitation of hematopoietic progenitors in the graft, lymphohematopoietic reconstitution following hsct and animal models of human hsct. at the end, the utilization of flow cytometry in clinical hsct by brazilian transplant centers is briefly reviewed.
Hematopoietic stem cell transplantation for autoimmune diseases in Brazil: current status and future prospectives
Voltarelli, Júlio C.;
Revista Brasileira de Hematologia e Hemoterapia , 2002, DOI: 10.1590/S1516-84842002000300007
Abstract: in this paper, we discuss the launching of a cooperative protocol of hematopoietic stem cell transplantation for autoimmune diseases in brazil. we present specific conditions of the country's health system which would affect the trial, preliminary results of the first nine patients transplanted under the protocol (4 systemic lupus, 3 multiple sclerosis, one systemic sclerosis and one overlapping lupus + systemic sclerosis) and future prospectives of organizing phase iii randomized trials to answer specific scientific questions pending in the field.
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