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Search Results: 1 - 10 of 71113 matches for " Carlos Roberto;Spadella "
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Efeitos da ligadura do ducto pancreático e da sec??o ductal com livre drenagem de secre??es para o perit?nio sobre as fun??es endócrina e exócrina do pancreas: estudo clínico e laboratorial em coelhos
Kuczynski, Lauro Bogodar;Spadella, César Tadeu;Padovanni, Carlos Roberto;
Acta Cirurgica Brasileira , 2004, DOI: 10.1590/S0102-86502004000300008
Abstract: after pancreatic ressections due to chronic pancreatitis the remnant pancreas can lead to new outbreaks of pancreatitis in variable degrees of severity. after the resections by tumors or pancreatitis, the most common complications are the pancreatic fistulas with their resultant morbidity and mortality. in the pancreas transplantation the bowel or bladder drainage of the exocrine part of the graft, beyond the technical peculiarities of the execution, is not exempt of several complications. in order to avoid or reduce such consequences and trying to simplify the surgical technique, there have been used other approaches for the treatment of the pancreatic stump/graft: free drainage of the secretions with the duct left open, ductal ligature and duct occlusion with polymers. purpose: the proposal of our investigation was to study the clinical and laboratorial effects of the ductal ligature and the ductal left open in the endocrine and exocrine compounds of the rabbit pancreas. methods: one hundred and fifty operations were performed, divided in 3 groups: laparotomy/control (n=50), opened group (n=50) and ligated (n=50). the moments of observation were pre-operative, day 0 (operation's day) and post-operative (observation and sacrifice): 7 days, 14 days, 28 days, 90 days and 180 days. the parameters analysed were: general clinic state, activity and controls of body weight, water intake, food intake and measurements of blood and urinary glucose, serum-amylase and plasma insulin levels. results: all the groups had a similar clinical evolution: progressive body weight gain, water and food intake, as well as in good health conditions. conclusions: except for a significant serum-amylase elevation in the first 24-48 hours for the two ductal interference groups, there were no other blood glucose and insulin and urine-glucose variations in the 3 groups, in all observation moments.
Efeitos da ligadura do ducto pancreático e da sec o ductal com livre drenagem de secre es para o perit nio sobre as fun es endócrina e exócrina do pancreas: estudo clínico e laboratorial em coelhos
Kuczynski Lauro Bogodar,Spadella César Tadeu,Padovanni Carlos Roberto
Acta Cirurgica Brasileira , 2004,
Abstract: As ressec es pancreáticas seguidas de anastomoses acompanham-se de altas taxas de morbidade, que incluem: surtos de pancreatite e, principalmente, fístulas digestivas. Nos transplantes pancreáticos a drenagem da parte exócrina do enxerto para o intestino ou para a bexiga, além das peculiaridades técnicas, também n o é isenta de diversas complica es. Visando evitar ou atenuar tais conseqüências e simplificar a técnica cirúrgica, têm sido usadas outras abordagens para o tratamento ductal do coto/enxerto pancreático, tais como: drenagem livre de secre es para o perit nio, com o ducto pancreático aberto, ligadura ductal e oclus o do ducto com polímeros sintéticos. OBJETIVO: O presente estudo visa avaliar clínica e laboratorialmente as fun es endócrina e exócrina do pancreas de coelhos com o ducto aberto e ligado. MéTODOS: Foram realizadas 150 opera es, divididas em 3 grupos: N - manipula o/controle (n=50), A - grupo aberto (n=50), e L - ligado (n=50). Os momentos de observa o foram pré-operatório, dia 0 (dia da opera o) e pós-operatório (observa o e sacrifício): 7 dias, 14 dias, 28 dias, 90 dias e 180 dias. Os parametros analisados foram: estado geral, atividade, controles do peso corporal, ingest o hídrica, ingest o alimentar e dosagens da amilase sangüínea, glicemia, glicose urinária e insulina plasmática. RESULTADOS: Todos os grupos tiveram evolu o clínica similar, com bom estado geral, ganho ponderal progressivo e valores normais da ingest o hídrica e ingest o alimentar. Exceto uma significativa eleva o da amilase sangüínea nas primeiras 24-48h para os 2 grupos com interferência ductal, n o houve qualquer altera o dos níveis basais da glicemia, glicosúria e insulinemia entre os 3 grupos experimentais, em todos os momentos de observa o. CONCLUS O: à exce o da amilase sangüínea, cujos níveis basais foram significativamente elevados no 1o e 2o dias de pós-operatório, as duas modalidades técnicas de abordagem da secre o exócrina do pancreas, utilizadas em coelhos, n o determinaram quaisquer altera es clínicas, bem como dos níveis basais de glicose sangüínea, glicose urinária e insulina plasmática, durante 6 meses de seguimento.
Estudo comparativo entre cinco diferentes tratamentos sobre as altera??es clínicas e laboratoriais do rato diabético induzido pela aloxana
Spadella, César Tadeu;Macedo, Célia Sperandéo;Machado, José Lúcio Martins;Schellini, Silvana Artioli;Padovanni, Carlos Roberto;
Acta Cirurgica Brasileira , 2005, DOI: 10.1590/S0102-86502005000100008
Abstract: purpose: the long-term effects of five different treatments of diabetes were evaluated in alloxan-induced diabetic rats. methods: seven experimental groups, with 50 rats each (gn normal control; gd untreated diabetic control; gi, ga, gia treated groups with insulin, acarbose, and insulin plus acarbose, respectively; gtil, gtpd treated groups with islet of langerhans and pancreas transplantation) were studied. clinical (body weight, water intake, food intake and urine output) and laboratory (blood and urinary glucose, and plasma insulin) parameters were analyzed at the beginning of the study, and after 1, 3, 6, 9 and 12 months of follow-up. results: mortality was observed in all groups, except gn, during 12 months (gd= 50%; gi= 20%; ga= 26%; gia= 18%; gtil= 4%; gtpd= 20%). rats from the gd, gi, and gia groups died due to metabolic or hydrossaline disbalance, and/or pneumonia, diarrhoea, and cachexy. all deaths observed in gtil and gtpd groups were in decorrence of technical failure at the immediate postoperative, until 72h. animals from the gi, ga and gia had significative improving of the clinical and laboratory parameters (p < 0,05) observed in diabetic rats, being the efficacy of theses treatments equal. however, rats from the gtil and gtpd groups had better control of these parameters than gi, ga, and gia groups. transplanted rats had complete restoration, at the normal levels, of all analyzed variables (p<0,01). conclusions: conventional treatments with insulin, acarbose, and insulin plus acarbose improved the severe diabetic state of the alloxan-diabetic rats, but pancreas and islet transplantation have a better performance for treatment of diabetes.
Caracteriza??o de um modelo experimental de Diabetes Mellitus, induzido pela aloxana em ratos: estudo clínico e laboratorial
Lerco, Mauro Masson;Spadella, César Tadeu;Machado, José Lúcio Martins;Schellini, Silvana Artioli;Padovani, Carlos Roberto;
Acta Cirurgica Brasileira , 2003, DOI: 10.1590/S0102-86502003000200010
Abstract: purpose: this work aimed to determine the clinical and laboratory alterations of rat with diabetes mellitus using alloxan endovenously. methods: the animals were randomly assigned to two experimental groups: normal control group (g1) with 25 healty animals and diabetic group (g2) with 25 severe diabetic animals. they were evaluated in 5 moments (1, 3, 6, 9 and 12 months) during which the following parameters were studied: clinical evolution (body weight, water intake, food intake, and diuresis) and biochemical exams (fast glycemia, urinary glucose, glucosuria, ketonury, total cholesterol, hdl cholesterol, triglycerides and lipids). results: alloxan 2% injection intravenously in the rat was followed by 39% death rate and also caused severe diabetes in 39% of the animals. diabetes was characterized by progressive body weight loss, significative water intake, food intake and diuresis with blood glucose levels above 300 mg/dl, glucosuria 3+ and eventually ketonury. diabetes doesn`t change profile a long-term of cholesterol and lipids levels. conclusion: our studies showed that alloxan causes clinical and laboratory alterations in the rat, what is typical of severe diabetes. they allow the long-term studies of diabetic.
Role of metabolic control on diabetic nephropathy
Macedo, Célia Sperandéo;Capelletti, Sonia Maria;Mercadante, Maria Cecília Salgado;Padovani, Carlos Roberto;Spadella, César Tadeu;
Acta Cirurgica Brasileira , 2002, DOI: 10.1590/S0102-86502002000600003
Abstract: objective: the aim of this investigation was studying the influence of glucose metabolic control on diabetic nephropathy. the authors observed the effect of acarbose, insulin, and both drugs on the metabolic control and development of mesangial enlargement of kidney glomeruli in alloxan-diabetic rats. methods: five groups of wistar rats were used: normal rats (n), non-treated alloxan-diabetic rats (d), alloxan-diabetic rats treated with acarbose (ad), alloxan-diabetic rats treated with insulin (id), and alloxan-diabetic rats treated with insulin plus acarbose (iad). the following parameters were evaluated: body weight; water and food intake; diuresis; blood and urine glucose levels; and the kidney lesions: mesangial enlargement and tubule cell vacuolization. renal lesions were analysed using a semi-quantitative score 1, 3, 6, 9, and 12 months after diabetes induction. results: diabetic rats showed a marked increase of glycemia, urinary glucose levels, diuresis, water and food intake, and weight loss, while the treated diabetic rats showed significant decreased levels of these parameters. the most satisfactory metabolic control was that of diabetic rats treated with acarbose + insulin. there was a significant mesangial enlargement in diabetic rats compared to normal rats from the third up to the 12th month after diabetes induction, with a significant difference between the animals treated with acarbose + insulin and non-treated diabetic rats. a difference between the animals treated with acarbose or insulin alone and non-treated diabetics rats was not seen. conclusions: the authors discuss the results stressing the role of diabetic metabolic control in the prevention of diabetic nephropathy.
Considerations for Erythema Nodosum Leprosum, with Emphasis on Its Oral Manifestations  [PDF]
Antonio Carlos Vinhas, Roberto Meyer Nascimento
Advances in Infectious Diseases (AID) , 2013, DOI: 10.4236/aid.2013.31004

Leprosy is an infectious disease caused by Mycobacterium leprae, transmitted from person to person through contact among susceptible untreated patients. It presents a broad clinical spectrum which is related to the host’s ability to mount a specific immune response. The lesions caused by the proliferation of Mycobacterium leprae (M. leprae) were significantly reduced in recent years with the early detection of new cases. Because they are less evident and/or study, maxillofacial injuries and the oral mucosa may reveal important details about the transmissibility and immunopathogenesis of leprosy. This article was based on a literature to verify an interrelation between oral manifestations in virchowian patients and immuno-pathological factors. Association between the infection of oral mucosa and some pathological findings as well as the participation of the local immune response in protection against the disease are research topics still not fully exploited.

Progression of nephropathy after islet of langerhans transplantation in alloxan-induced diabetic rats
Spadella, César Tadeu;Mercadante, Maria Cecília Salgado;Breim, Luiz Carlos;Macedo, Célia Sperandéo de;Bacchi, Carlos Eduardo;Macedo, Arthur Roquete de;
Acta Cirurgica Brasileira , 1997, DOI: 10.1590/S0102-86501997000100003
Abstract: we studied the effects of islet of langerhans transplantation (it) on the kidney lesions of rats with alloxan-induced diabetes. forty-five inbred male lewis rats were randomly assigned to 3 experimental groups: group gl included 15 non-diabetic control rats (nc), group git included 15 alloxan-induced diabetic rats (dc), and group iii included 15 alloxan-induced diabetic rats that received pancreatic islet transplantation prepared by nonenzymatic method from normal donor lewis rats and injected into the portal vein (it). each group was further divided into 3 subgroups of 5 rats which were sacrificed at 1, 3, and 6 months of follow-up, respectively. clinical and laboratorial parameters were recorded in the mentioned periods in the 3 experimental groups. for histology, the kidneys of all rats of each subgroup were studied and 50 glomeruli and 50 tubules of each kidney were analyzed using light microscopy by two different investigators in a double blind study. the results showed progressive glomerular basement membrane thickening (gbmt), mesangial enlargement (me), and bowman's capsule thickening (bct) in the 3 experimental groups throughout the follow-up. these alterations were significantly more severe in dc rats at 6 months when compared to nc rats (p < 0.01). however, the degree of gbmt, me, and bct observed in dc rats was not statistically different from it rats at 1, 3, and 6 months. in addition, armanni-ebstein lesions of the tubules (ae) and tubular lumen protein (pro) observed in dc rats were also observed in it rats all over the study. these lesions were never present in nc rats. we conclude that it did not prevent progression of kidney lesions in alloxan-induced diabetic rats within 6 months after transplantation.
PPRA/PCMSO: auditoria, inspe??o do trabalho e controle social
Miranda, Carlos Roberto;Dias, Carlos Roberto;
Cadernos de Saúde Pública , 2004, DOI: 10.1590/S0102-311X2004000100039
Abstract: the authors analyzed environmental risk prevention programs and occupational health monitoring programs implemented by 30 companies from various industrial sectors, each with more than 100 employees, in salvador, bahia, brazil. observed inconsistencies were studied according to occupational risk, considering the different stages of development in the programs. the study suggested low technical quality in these programs, revealing the need to increase the range of government inspection and to stimulate worker and trade union participation in such programs. the development and improvement of inspection procedures, instruments, and protocols were also considered fundamentally important for health and safety in the workplace.
PPRA/PCMSO: auditoria, inspe o do trabalho e controle social
Miranda Carlos Roberto,Dias Carlos Roberto
Cadernos de Saúde Pública , 2004,
Abstract: Os autores analisaram Programas de Preven o de Riscos Ambientais (PPRA) e Programas de Controle Médico de Saúde Ocupacional (PCMSO) implementados por 30 empresas, de diferentes ramos econ micos, com mais de cem empregados, em atividade em Salvador, Bahia. As inconsistências verificadas foram estudadas segundo os riscos ocupacionais, levando-se em conta as diversas etapas de desenvolvimento dos programas. Os Autores constataram a baixa qualidade técnica desses programas e apontam a evidente necessidade de ampliar a cobertura da fiscaliza o estatal, assim como de estimular a participa o dos trabalhadores e dos seus representantes no desenvolvimento dos programas PPRA e PCMSO. Consideram, ainda, de fundamental importancia o desenvolvimento e o aprimoramento de condutas, procedimentos e instrumentos de inspe o na área de seguran a e saúde no trabalho.
Leiomiossarcoma de retroperit?nio: relato de caso
Minossi, José Guilherme;Mendes, Elson Felix;Spadella, César Tadeu;Gon?alves Júnior, írio;Anefalos, Alexandre;Trindade, José Carlos Souza;
Acta Cirurgica Brasileira , 2000, DOI: 10.1590/S0102-86502000000100006
Abstract: one case of retroperitoneal leiomyosarcoma is related, probably from the inferior vena cava wall. several ultrasonics and abdominal tomography showed contradictories results which delayed surgical treatment. it was emphasized the need of a early diagnosis of the tumor by imaging and needle biopsy. when possible the complete excision of the tumor or partial resections followed by complimentary treatment.
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