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Search Results: 1 - 10 of 751075 matches for " Carlos A. M. Fraga "
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A utiliza??o do safrol, principal componente químico do óleo de sassafráz, na síntese de substancias bioativas na cascata do ácido araquid?nico: antiinflamatórios, analgésicos e anti-trombóticos
Barreiro, Eliezer J.;Fraga, Carlos A.M.;
Química Nova , 1999, DOI: 10.1590/S0100-40421999000500019
Abstract: in this paper we describe the results of a research effort developed in laboratório de avalia??o e síntese de substancias bioativas (lassbio, ufrj) in the utilization of brazilian abundant natural product, safrole (1), the principal chemical constituent of sassafras oil (ocotea pretiosa), as an attractive synthon to access different chemical class of bioactive compounds, as prostaglandins analogues, non-steroidal antiinflammatory agents and antithrombotic compounds.
A utiliza o do safrol, principal componente químico do óleo de sassafráz, na síntese de substancias bioativas na cascata do ácido araquid nico: antiinflamatórios, analgésicos e anti-trombóticos
Barreiro Eliezer J.,Fraga Carlos A.M.
Química Nova , 1999,
Abstract: In this paper we describe the results of a research effort developed in Laboratório de Avalia o e Síntese de Substancias Bioativas (LASSBio, UFRJ) in the utilization of Brazilian abundant natural product, safrole (1), the principal chemical constituent of Sassafras oil (Ocotea pretiosa), as an attractive synthon to access different chemical class of bioactive compounds, as prostaglandins analogues, non-steroidal antiinflammatory agents and antithrombotic compounds.
A química medicinal de N-acilidrazonas: novos compostos-protótipos de fármacos analgésicos, antiinflamatórios e anti-trombóticos
Barreiro, Eliezer J.;Fraga, Carlos A. M.;Miranda, Ana L. P.;Rodrigues, Carlos R.;
Química Nova , 2002, DOI: 10.1590/S0100-40422002000100022
Abstract: in this article are described new bioactive n-acylhydrazone (nah) derivatives, structurally designed as optimization of aryl hydrazones precursors planned by molecular hybridization of two 5-lipoxigenase inhibitors, e.g. cbs-1108 and bw-755c. the analgesic, antiedematogenic and anti-platelet aggregating profile of several isosteric compounds was investigated by using classic pharmacological assays in vivo and ex-vivo, allowing to identify new potent peripheric analgesic lead, a new anti-inflammatory and an antithrombotic agent. during this study was discovered dozen of active nah compounds clarifying the structure-activity relationship for this series of nah derivatives, indicating the pharmacophore character of the n-acylhydrazone functionality.
A química medicinal de N-acilidrazonas: novos compostos-protótipos de fármacos analgésicos, antiinflamatórios e anti-trombóticos
Barreiro Eliezer J.,Fraga Carlos A. M.,Miranda Ana L. P.,Rodrigues Carlos R.
Química Nova , 2002,
Abstract: In this article are described new bioactive N-acylhydrazone (NAH) derivatives, structurally designed as optimization of aryl hydrazones precursors planned by molecular hybridization of two 5-lipoxigenase inhibitors, e.g. CBS-1108 and BW-755c. The analgesic, antiedematogenic and anti-platelet aggregating profile of several isosteric compounds was investigated by using classic pharmacological assays in vivo and ex-vivo, allowing to identify new potent peripheric analgesic lead, a new anti-inflammatory and an antithrombotic agent. During this study was discovered dozen of active NAH compounds clarifying the structure-activity relationship for this series of NAH derivatives, indicating the pharmacophore character of the N-acylhydrazone functionality.
(2E)-N′-[(E)-4-Chlorobenzylidene]-3-phenylprop-2-enohydrazide monohydrate
Samir A. Carvalho,Edson F. da Silva,Carlos A. M. Fraga,Solange M. S. V. Wardell
Acta Crystallographica Section E , 2010, DOI: 10.1107/s160053681003388x
Abstract: The conformation about each of the imine and ethene bonds in the title hydrazide hydrate, C16H13ClN2O·H2O, is E. The hydrazide molecule is approximately planar (r.m.s. deviation of the 20 non-H atoms = 0.172 ). The most significant twist occurs about the ethene bond [C—C=C—C = 164.1 (5)°] and the dihedral angle formed between the benzene rings is 5.3 (2)°]. In the crystal, the presence of N—H...Ow and O—H...Oc (× 2; w = water and c = carbonyl) hydrogen bonds leads to a supramolecular array in the bc plane.
(2E)-N′-[(E)-Benzylidene]-3-phenylprop-2-enohydrazide from synchrotron radiation
Samir A. Carvalho,Edson F. da Silva,Carlos A. M. Fraga,Solange M. S. V. Wardell
Acta Crystallographica Section E , 2012, DOI: 10.1107/s1600536812028504
Abstract: In the title compound, C16H14N2O, the dihedral angle between the phenyl rings is 25.48 (12)°. An E conformation is found for each of the imine [1.269 (3) ] and ethylene [1.313 (3) ] bonds. In the crystal, molecules are linked by N—H...O hydrogen bonds, leading to zigzag chains along [010]. Supramolecular layers in the ab plane are formed, whereby the chains are linked by C—H...N and C—H...π interactions.
(2E)-N′-[(E)-2-Hydroxybenzylidene]-3-phenylprop-2-enohydrazide
Samir A. Carvalho,Edson F. da Silva,Carlos A. M. Fraga,Solange M. S. V. Wardell
Acta Crystallographica Section E , 2012, DOI: 10.1107/s1600536812028516
Abstract: In the non-planar title compound, C16H14N2O2, the dihedral angle between the phenyl rings is 16.67 (8)°. An E conformation is found for each of the imine [1.286 (2) ] and ethylene [1.335 (2) ] bonds. The amide O and H atoms are anti, and an intramolecular hydroxy O—H...N hydrogen bond is noted. The formation of N—H...O(hydroxy) hydrogen bonds in the crystal packing leads to helical chains along the b axis. Supramolecular layers in the ab plane are formed as the chains are linked by C—H...O interactions.
1-Methyl-7-(4-nitrophenyl)-3-phenylpyrazolo[3,4-b]pyrrolo[3,4-d]pyridine-6,8(3H,7H)-dione
Jose R. Sabino,Cecília M. A. Oliveira,Carlos A. M. Fraga,Eliezer J. Barreiro
Acta Crystallographica Section E , 2008, DOI: 10.1107/s1600536808037240
Abstract: In the title compound, C21H13N5O4, the dihedral angles formed between the planes of the phenyl and nitrophenyl rings and that of the heterotricyclic plane are 41.29 (7) and 61.35 (6)°, respectively. In the crystal, weak C—H...O interactions help to establish the packing.
Agentes dopaminérgicos e o tratamento da disfun??o erétil
Neves, Gilda;Rates, Stela M. K.;Fraga, Carlos A. M.;Barreiro, Eliezer J.;
Química Nova , 2004, DOI: 10.1590/S0100-40422004000600020
Abstract: the understanding of the scientific basis of the erectile function expanded rapidly the range of therapies for treating erectile dysfunction in recent years. this article reviews the role of dopamine on the erection mechanisms and its importance for new pro-erectile drug design. the ability of dopaminergic agents to elicit penile erection has been described since 1975 and successively confirmed by numerous studies. the development of apomorphine sl (dopaminergic non selective agonist) to enhance erectile function represents a new pharmacological approach to the management of erectile dysfunction using cns drugs. the search for selective d4 dopaminergic agents is being explored by some research groups and pharmaceutical companies.
Agentes dopaminérgicos e o tratamento da disfun o erétil
Neves Gilda,Rates Stela M. K.,Fraga Carlos A. M.,Barreiro Eliezer J.
Química Nova , 2004,
Abstract: The understanding of the scientific basis of the erectile function expanded rapidly the range of therapies for treating erectile dysfunction in recent years. This article reviews the role of dopamine on the erection mechanisms and its importance for new pro-erectile drug design. The ability of dopaminergic agents to elicit penile erection has been described since 1975 and successively confirmed by numerous studies. The development of apomorphine SL (dopaminergic non selective agonist) to enhance erectile function represents a new pharmacological approach to the management of erectile dysfunction using CNS drugs. The search for selective D4 dopaminergic agents is being explored by some research groups and pharmaceutical companies.
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