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Optimization of Contrast Material Dose for Abdominal Multi-Detector Row CT: Predicting Patient Lean Body Weight by Using Preliminary Transverse CT Images  [PDF]
Antonino Guerrisi, Daniele Marin, Huiman Barnhart, Lisa Ho, Thomas L. Toth, Carlo Catalano, Rendon C. Nelson
Advances in Computed Tomography (ACT) , 2014, DOI: 10.4236/act.2014.31001

Estimated LBW could be used to determine the contrast material dose and rate during MDCT. The aim of this study is to test the accuracy of a technique for estimation of lean body weight (LBW) from a single multi-detector row computed tomographic (MDCT) abdominal image, using a bioelectrical body composition analyzer scale as the reference standard. CT images of 21 patients with previously measured LBW (mLBW) were processed using computer-assisted, vendor-specific software (Advantage Windows 4.2; GE Healthcare, Inc). For each transverse image, a fat-fraction was automatically measured as the number of fat pixels (-200 to -50 HU) divided by the total number of pixels having an attenuation value ≥-200 HU. Estimated LBW (eLBW) of five single contiguous sections was calculated in each of three abdominal regions (upper abdomen, mid abdomen and pelvis) by multiplying TBW by (1 – fat-fraction). Bland-Altman plot with limits of agreement was used to assess agreement between mLBW and eLBW. The mean mLBW for all patients was 56 kg (range, 39 - 75 kg). Mean differences and limits of agreement between mLBW and eLBW measurements for the upper abdomen, mid abdomen and pelvis reported were -8.9 kg (-25.6 kg, +7.5 kg), -10.6 kg (-27.7 kg, +6.4 kg), and +0.5 kg (-12.8 kg, +13.8 kg) respectively. eLBW deriving directly from a transverse CT image of the pelvis can accurately predict mLBW.

Myocardial infarction with normal coronary arteries: a case report and review of the literature
Luigi Iuliano, Fausta Micheletta, Alessandro Napoli, Carlo Catalano
Journal of Medical Case Reports , 2009, DOI: 10.1186/1752-1947-3-24
Abstract: We describe here a case of a 49-year-old woman with a history of prior myocardial infarction who continued to be asymptomatic after a 10-year follow-up, in the absence of a high-risk profile for adverse outcomes. She was studied with multi-slice coronary computed tomography and whole-body angiography, which showed normal coronary and extra-coronary arteries.This case report raises two important issues. First, the possible role of multi-slice computed tomography/coronary angiography in the risk- and prognosis assessment of patients with known or suspected coronary artery disease. Second, the important role played by long-term pharmacological therapy in patients with prior myocardial infarction and normal coronary arteries.Myocardial infarction (MI) with normal coronary arteries is a medical condition, which has been described in the literature for more than 30 years but is still a challenge in medical practice because of the lack of evidence-based medical data on its prognosis and on secondary prevention. The prevalence of MI with normal coronary arteries has always been considered low, varying between 1% and 12%. However, it actually involves a considerable number of patients, calling for more clinical trials which specifically study this sub-population of patients affected by coronary heart disease (CHD) [1-3].We report a case of a young female patient with a previous clinically diagnosed MI, who was asymptomatic in standard care therapy for a 10-year follow-up and has been shown to have normal coronary arteries by coronary multi-slice computed tomography (MSCT) and whole-body angiography.A 49-year-old woman was referred to our department for a cardiological follow-up visit. She had a medical history of hypertension and previous MI, with no history of diabetes mellitus, hypercholesterolemia or premature coronary artery disease in her family. She did not smoke, take recreational drugs and was not on oestrogen replacement therapy.Ten years earlier, she had an inferio
T1-weighted dual-echo MRI for fat quantification in pediatric nonalcoholic fatty liver disease
Lucia Pacifico,Michele Di Martino,Carlo Catalano,Valeria Panebianco
World Journal of Gastroenterology , 2011, DOI: 10.3748/wjg.v17.i25.3012
Abstract: AIM: To determine in obese children with nonalcoholic fatty liver disease (NAFLD) the accuracy of magnetic resonance imaging (MRI) in assessing liver fat concentration. METHODS: A case-control study was performed. Cases were 25 obese children with biopsy-proven NAFLD. Controls were 25 obese children matched for age and gender, without NAFLD at ultrasonography and with normal levels of aminotransferases and insulin. Hepatic fat fraction (HFF) by MRI was obtained using a modification of the Dixon method. RESULTS: HFF ranged from 2% to 44% [mean, 19.0% (95% CI, 15.1-27.4)] in children with NAFLD, while in the controls this value ranged from 0.08% to 4.69% [2.0% (1.3-2.5), P < 0.0001]. HFF was highly correlated with histological steatosis (r = 0.883, P < 0.0001) in the NAFLD children. According to the histological grade of steatosis, the mean HFF was 8.7% (95% CI, 6.0-11.6) for mild, 21.6% (15.3-27.0) for moderate, and 39.7% (34.4-45.0) for severe fatty liver infiltration. With a cutoff of 4.85%, HFF had a sensitivity of 95.8% for the diagnosis of histological steatosis ≥ 5%. All control children had HFF lower than 4.85%; thus, the specificity was 100%. After 12 mo, children with weight loss displayed a significant decrease in HFF. CONCLUSION: MRI is an accurate methodology for liver fat quantification in pediatric NAFLD.
Atherosclerotic renal artery stenosis: one year outcome of total and separate kidney function following stenting
Giorgio Coen, Eleonora Moscaritolo, Carlo Catalano, Raffaella Lavini, Italo Nofroni, Giuseppe Ronga, Daniela Sardella, Alvaro Zaccaria, Rosario Cianci
BMC Nephrology , 2004, DOI: 10.1186/1471-2369-5-15
Abstract: In this study, 27 patients with unilateral RAS were subjected to stenting and followed for a period of one year, while 19 patients were observed while on medical treatment only. The group of 27 patients, 67.33 ± 6.8 years of age, creatinine of 2.15 ± 0.9 mg/dl, following stenting, were followed at intervals with biochemical tests, renal scintigraphy and doppler ultrasonography. The control group (70.0 ± 6.1 years, creatinine 1.99 ± 0.7 mg/dl) was also followed for one year.One year after stenting mean creatinine clearance (Ccr) increased from 36.07 ± 17.2 to 40.4 ± 21.6 ml/min (NS). Arterial BP, decreased after 1,3,6, and 12 months (p < 0.05). The number of antihypertensive drugs also decreased (p < 0.05). A significant increase in proteinuria was also observed. In the control group both Ccr, BP and proteinuria did not show significant changes. Based on renal scintigraphy and Ccr at subsequent times, it was possibile to evaluate the timecourse of renal function in both kidneys of the stented patients. In the stented kidneys Ccr increased significantly. On the controlateral kidney a decrease of renal function (p < 0.05) was observed. Resistance index appeared to be a risk factor of the functional outcome.Stenting of RAS due to atherosclerosis is followed by stabilization or improvement of Ccr, mainly at the stented kidney, while contralateral renal function showed a decrease.Renal artery stenosis due to atherosclerotic changes of the renal arteries has become a serious concern as a cause of hypertension and renal ischemia, resulting frequently in end-stage renal failure [1,2]. Several epidemiologic studies have shown the elevated prevalence of ischemic nephropathy, with special regard to atherosclerotic renal artery stenosis, in elderly patients [3,4]. Instead of the classical surgical approach, percutaneous balloon angioplasty or endovascular stenting have recently become accepted procedures in the attempt to revascularize the stenotic kidney and prevent chronic ren
Right ventricular cardiovascular magnetic resonance imaging: normal anatomy and spectrum of pathological findings
Nicola Galea,Iacopo Carbone,David Cannata,Giuseppe Cannavale,Bettina Conti,Roberto Galea,Andrea Frustaci,Carlo Catalano,Marco Francone
Insights into Imaging , 2013, DOI: 10.1007/s13244-013-0222-3
Abstract: The use of CMR increases detection of RV disease as infarction or arrhythmogenic cardiomyopathy.
Molecular Insights into the Local Anesthetic Receptor within Voltage-Gated Sodium Channels Using Hydroxylated Analogs of Mexiletine
Jean-Fran?ois Desaphy,Maria Maddalena Dinardo,Alessia Catalano,Alessia Carocci,Giovanni Lentini,Carlo Franchini,Diana Conte Camerino
Frontiers in Pharmacology , 2012, DOI: 10.3389/fphar.2012.00017
Abstract: We previously showed that the β-adrenoceptor modulators, clenbuterol and propranolol, directly blocked voltage-gated sodium channels, whereas salbutamol and nadolol did not (Desaphy et al., 2003), suggesting the presence of two hydroxyl groups on the aromatic moiety of the drugs as a molecular requisite for impeding sodium channel block. To verify such an hypothesis, we synthesized five new mexiletine analogs by adding one or two hydroxyl groups to the aryloxy moiety of the sodium channel blocker and tested these compounds on hNav1.4 channels expressed in HEK293 cells. Concentration–response relationships were constructed using 25-ms-long depolarizing pulses at ?30 mV applied from an holding potential of ?120 mV at 0.1 Hz (tonic block) and 10 Hz (use-dependent block) stimulation frequencies. The half-maximum inhibitory concentrations (IC50) were linearly correlated to drug lipophilicity: the less lipophilic the drug, minor was the block. The same compounds were also tested on F1586C and Y1593C hNav1.4 channel mutants, to gain further information on the molecular interactions of mexiletine with its receptor within the sodium channel pore. In particular, replacement of Phe1586 and Tyr1593 by non-aromatic cysteine residues may help in the understanding of the role of π–π or π–cation interactions in mexiletine binding. Alteration of tonic block suggests that the aryloxy moiety of mexiletine may interact either directly or indirectly with Phe1586 in the closed sodium channel to produce low-affinity binding block, and that this interaction depends on the electrostatic potential of the drug aromatic tail. Alteration of use-dependent block suggests that addition of hydroxyl groups to the aryloxy moiety may modify high-affinity binding of the drug amine terminal to Phe1586 through cooperativity between the two pharmacophores, this effect being mainly related to drug lipophilicity. Mutation of Tyr1593 further impaired such cooperativity. In conclusion, these results confirm our former hypothesis by showing that the presence of hydroxyl groups to the aryloxy moiety of mexiletine greatly reduced sodium channel block, and provide molecular insights into the intimate interaction of local anesthetics with their receptor.
Dal servizio di principi e granduchi alla ricerca storica. Pietro Domenico Bartoloni da Empoli e le Istorie de’ duchi e re di Boemia Dal servizio di principi e granduchi alla ricerca storica. Pietro Domenico Bartoloni da Empoli e le Istorie de’ duchi e re di Boemia
Alessandro Catalano
Studi Slavistici , 2012,
The political economy of Turkey-EU customs union after the treaty of Lisbon: A Reappraisal
Arianna Catalano
Interdisciplinary Political Studies , 2011,
Abstract: This article analyses the European Union’s (EU) trade policy highlighting the gradual shift towards a more penetrating EU Free Trade Agreements (FTAs) policy and institutional changes brought about by the Treaty of Lisbon and their impact on trade policy’s functioning. Emphasizing Turkey’s changing trade patterns and stressing the growing salience of non-EU trade partners, the article opens up a debate on the rationale of current Customs Union. The analysis brings to the understanding of the on-going cases of trade deflection negatively affecting Turkish economy and the drawbacks arisen from the EU’s changing FTA policy. Finally, the political and technical aspects of Turkey’s accession process are discussed to shed further light on the current and future meaning behind today’s Customs Union.
To Safeguard and to Make the Most of the Rural Environment by Means of a “Sustainable Agro-Environmental Systems” Study
Maurizia Catalano
Italian Journal of Agronomy , 2010, DOI: 10.4081/ija.2010.295
Abstract: An upheaval of the economy in all parts of the world has recently taken place and has hit all the productive sectors including the agricultural one which is in a very critical state also in fertile areas and not only in poor and marginal ones where a gradual abandon of the land had already taken place years before. Since 1988, the European Union has paid particular attention to this problem, by trying to incentivate an intergrated rural development thinking of a prospective of intersectorial growth with the aim of achieving ways of sustainable agriculture which would lead to valid solutions both for ecology and for the economy. Today, however, even the agricultural productions thought to be rich, provide smaller and smaller incomes to the point that farmers are obliged to ask themselves at the end of the cultivation if it is worthwhile gathering the products or not. The abandon of the countryside could extend to fertile areas which would bring about a serious degeneration and environmental harm. A historian of our times Hobsbawm poses this very important question: “What will happen when extensive areas of the rural landscapes will no longer be needed, for an agriculture outdated and inefficient which it had created for long periods? It was the old agriculture which preserved the landscape. Without it what will happen?… replying that we are no longer defending nature, but a nature which is the outcome of an agricultural cultivation manmade”. It is fundamental in these times to study sustainable agro-environmental systems which can create positive economical moves in order to increase traditional incomes to include the classical agricultural ones. The right use of all environmental and anthropical resources organized in a system is the way to transform the poverty of a lot of marginal areas of Apulia, of other Mediterranean countries and in the world into richness because it is this togetherness of resources, activity and initiative in an economical and organized synergy which can, lacking industrial and commercial possibilities and a remunerative agriculture, give way to environmental, economical and social benefits with positive outcomes on the economy and the employment. In relation to the importance of the environmental issues the Department for the Science of Vegetable Productions of the Faculty of Agriculture of the University of Bari “Aldo Moro” which has carried out in time studies regarding the Territorial agronomy and the Ecology of the rural environment has, in 2008, set up a project called “T’ESSERE” written and scientifically co-ordinated by
Persistence of the Sciatic Artery: A Case Report of a Combined (Complete and Incomplete) Type Causing Leg Ischemia
Beatrice Cavallo Marincola,Alessandro Napoli,Michele Anzidei,Eugenio Marotta,Fabrizio Boni,Gaia Cartocci,Luca Bertaccini,Vincenzo Noce,Maria Antonietta Pacilé,Carlo Catalano
Case Reports in Vascular Medicine , 2012, DOI: 10.1155/2012/196798
Abstract: Persistent sciatic artery is a very uncommon embryologic vascular variant, with a prevalence of 0.05% based on angiographic studies. Two different types of this anomaly can occur, complete or incomplete, on the basis of the relationship between sciatic artery and femoral artery. Although many of these patients are asymptomatic, it may represent a threat to the viability of the lower extremity because of atherosclerotic degeneration resulting in aneurysmal dilatation, occlusive thrombosis, or embolic phenomena with distal complication. We present a case of a 64-year-old man with combined, complete and incomplete, type of persistent sciatic artery causing ischemic ulcer of the first toe.
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