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Search Results: 1 - 10 of 5226 matches for " Carla Tortorella "
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O fundamento ético da política em Gramsci
Tortorella, Aldo;
Lua Nova: Revista de Cultura e Política , 1998, DOI: 10.1590/S0102-64451998000100006
Abstract: history shows a constant division between the governing and the governed. how to put the question of going beyond this without abandoning the solid soil of history, and how to maintain the reference to history without losing sight of universal ethical imperatives, including the idea of a political direction oriented towards the end of this division? the author examines the way gramsci frames and meets these questions.
Low Serum Urate Levels Are Associated to Female Gender in Multiple Sclerosis Patients
Stefano Zoccolella, Carla Tortorella, Pietro Iaffaldano, Vita Direnzo, Mariangela D’Onghia, Elena Luciannatelli, Damiano Paolicelli, Paolo Livrea, Maria Trojano
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0040608
Abstract: Background Urate is a natural antioxidant and may prevent CNS tissue damage and the clinical manifestations of experimental autoimmune encephalitis. Results from clinical studies are conflicting and the contribution of urate to the pathogenesis of Multiple Sclerosis (MS) remains uncertain. Objective To evaluate serum urate levels in MS patients and their relationships with clinical, demographic and MRI variables. Methods Levels of non-fasting serum uric acid and creatinine were determined by an automated enzymatic assay and glomerular filtration rate was assessed in 245 MS patients, in 252 age/sex-matched neurological controls (NC) and in 59 Healthy controls (HC). Results Median serum urate levels did not differ between MS patients (3.8 mg/dL), HC (4.0 mg/dl) and NC (4.0 mg/dL). Serum urate levels were lower in females than in males in all groups (p = <0.0001). In female-MS, serum urate levels (3.2 mg/dL) were lower compared to those in female HC (3.8; p = 0.01) and NC (3.5 mg/dL; p = 0.02), whereas in male-MS they(4.8 mg/dL) did not differ from those in male HC (4.5 mg/dl) and NC (4.8 mg/dL). Urate concentrations trended to be lower in Clinically isolated syndromes suggestive of MS (3.7 mg/dL) and in relapsing MS (3.7 mg/dL), compared to patients with progressive MS (4.4 mg/dL; p = 0.06), and in patients with an annual relapse rate (ARR) >2 (3.3 mg/dL) than in those with an ARR ≤2: 3.9 mg/dL; p = 0.05). Significant lower serum urate levels were found in females than in males in all clinical MS subtypes (p<0.01), separately evaluated. Female sex (beta: ?0.53; p<0.00001) was the most significant determinant of serum urate concentrations in MS patients on multivariate regression analysis. Conclusions Our findings suggest that low urate levels could be of significance in predominantly inflammatory phases of MS even at the early stage and mainly in females.
Aquaporin-4 Autoantibodies in Neuromyelitis Optica: AQP4 Isoform-Dependent Sensitivity and Specificity
Francesco Pisani, Angelo Sparaneo, Carla Tortorella, Maddalena Ruggieri, Maria Trojano, Maria Grazia Mola, Grazia Paola Nicchia, Antonio Frigeri, Maria Svelto
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0079185
Abstract: Neuromyelitis Optica (NMO) is an autoimmune demyelinating disease, characterized by the presence of autoantibody (NMO-IgG) to Aquaporin-4 (AQP4). NMO-IgG identification supports NMO diagnosis and several diagnostic tests have been developed, but their sensitivity is too variable, and some assay show low sensitivity. This impairs correct diagnosis of NMO. By cell based assay (CBA) we here evaluate the efficacy of different strategies to express AQP4 in mammalian cells in terms of: a) AQP4 translation initiation signals; b) AQP4 isoforms (M1 and M23) and fluorescent tag position; c) NMO serum concentration and AQP4 degradation. Our results demonstrate that when using AQP4-M1, the nucleotide in position ?3 of the AUG greatly affects the AQP4-M1/M23 protein ratio, NMO-IgG binding, and consequently test sensitivity. Test sensitivity was highest with M23 expressing cells (97.5%) and only 27.5% with AQP4-M1. The fluorescent tag added to the N-terminus of AQP4-M23 considerably affected the NMO-IgG binding, and test sensitivity, due to disruption of AQP4 suprastructures. Furthermore, sera used at high concentration resulted in AQP4 degradation which affected test sensitivity. To further evaluate the reliability of the M23 based CBA test, samples of one NMO patient collected during about 2 years clinical follow-up were tested. The results of serum titer correlated with disease activity and treatment response. In conclusion, we provide a molecular explanation for the contrasting CBA test data reported and suggest the use of M23 with a C-terminus fluorescent tag as the proper test for NMO diagnosis.
Influence of Interferon beta treatment on quality of life in multiple sclerosis patients
Isabella Simone, Antonia Ceccarelli, Carla Tortorella, Alessandra Bellacosa, Fabio Pellegrini, Immacolata Plasmati, Maria De Caro, Mariangela Lopez, Francesco Girolamo, Paolo Livrea
Health and Quality of Life Outcomes , 2006, DOI: 10.1186/1477-7525-4-96
Abstract: Seventy-seven disease modifying treatment (DMT) free and 41 IFN-β treated MS patients were evaluated. QoL, assessed by MSQoL-54, was related to IFN-β treatment and to clinical and demographic parameters at baseline and after two years. Multivariate hierarchical linear model for repeated measurements was used.Treated patients showed a younger age, a lower disease duration and a higher relapse rate in the two years preceding study entry. At inclusion time treated and untreated patients did not differ in relapse rate, expanded disability status scale (EDSS), fatigue, depression, physical and mental QoL. IFN-β did not influence QoL at inclusion time, but when QoL was evaluated after two years, treatment negatively affected mental QoL. Depression and fatigue negatively influenced physical and mental QoL both at baseline and after two years. EDSS correlated with a poor physical QoL only at baseline.IFN-β had a negative impact on QoL over the time in MS patients, influencing mainly mental QoL. The impairment of QoL in MS was strongly associated with increasing fatigue and depression, whereas clinical disability had a minor unfavourable role.In the last years increasing interest focused on QoL instrument as a broader measure of the burden of MS. Recent studies reported that QoL assessment may provide unique information often underestimated by the EDSS [1-3], which remains to date the primary clinical outcome measure for MS related disability [4]. Several factors may influence the QoL in MS patients. Previous studies showed varying results on the relationship between neurological disability and impaired QoL, suggesting only a partial contribute of disability on QoL. On the contrary fatigue and depression are highly associated to a poor QoL [5-11].Although the QoL instrument is recommended as an outcome measure of therapeutic choices and treatment effectiveness, its use is still limited in the routine clinical approaches [12]. Patient's perspectives derived from lifelong trea
Decision-Making in Multiple Sclerosis Consultations in Italy: Third Observer and Patient Assessments
Erika Pietrolongo, Andrea Giordano, Monica Kleinefeld, Paolo Confalonieri, Alessandra Lugaresi, Carla Tortorella, Maura Pugliatti, Davide Radice, Claudia Goss, Christoph Heesen, Alessandra Solari, the AutoMS group
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0060721
Abstract: Objective To assess decision-making in multiple sclerosis (MS) from third observer and patient perspectives. Method Audio recordings of first-ever consultations with a participating physician (88 outpatients, 10 physicians) at four tertiary MS care clinics in Italy, were rated by a third observer using the Observing Patient Involvement in Shared Decision Making (OPTION) and by patients using the Perceived Involvement in Care Scale (PICS). Results Mean patient age was 37.5, 66% were women, 72% had MS, and 28% had possible MS or other disease. Mean PICS subscale scores (range 0 poor, 100 best possible) were 71.9 (SD 24.3) for "physician facilitation" (PICS-F); 74.6 (SD 22.9) for "patient information exchange" (PICS-I); and only 22.5 (SD 16.2) for "patient decision making" (PICS-DM). Mean OPTION total score (0 poor, 100 best possible) was 29.6 (SD 10.3). Poorest OPTION scores were found for items assessing “preferred patient approach to receiving information” and “preferred patient level of involvement.” Highest scores were for “clinician drawing attention to identified problem”, “indicating need for decision making,” and “need to review the decision.” Consultation time, woman physician, patient-physician gender concordance and PICS-F were associated with higher OPTION total score; older physician and second opinion consultation were associated with lower OPTION score. Conclusions In line with findings in other settings, our third observer findings indicated limited patient involvement abilities of MS physicians during first consultations. Patient perceptions of physician skills were better than third observers’, although they correlated. Consultations with women physicians, and younger physicians, were associated with higher third observer and patient-based scores. Our findings reveal a need to empower Italian MS physicians with better communication and shared decision-making skills, and show in particular that attention to MS patient preferences for reception of information and involvement in health decisions, need to be improved.
Planejamento sistemático de layout com apoio de análise de decis?o multicritério
Tortorella, Guilherme L.;Fogliatto, Flávio S.;
Produ??o , 2008, DOI: 10.1590/S0103-65132008000300015
Abstract: the proper use of physical space in a factory is an important operational factor since it establishes its primary organization as well as the material and information flow patterns, with long run impacts. in order to systematize an adequate plant layout, methods for macro-space planning such as slp (systematic layout planning) have been proposed to support the development of layout alternatives. however, due to the generation of sub-optimal solutions with different pros and cons, the process of determining the best layout alternative becomes critical to assure the company's efficiency and flexibility, when facing different market scenarios. in this paper we propose the use of multicriteria decision support tools in conjunction with slp. the multicriteria analysis proposed is illustrated in a case study from the automotive industry. the company analyzed is expanding its physical area to house new machines and optimize material flows. nine different macro-layout alternatives were generated and the best overall alternative was evaluated in relation to seven criteria using ahp (analytic hierarchy process).
Jacobi structures up to homotopy
Andrew James Bruce,Alfonso G. Tortorella
Mathematics , 2015,
Abstract: We present the notion of a homotopy Kirillov structure on the sections of an even line bundle over a supermanifold. When the line bundle is trivial we shall speak of a homotopy Jacobi structure. These structures are understood furnishing the module of sections with an $L_{\infty}$-algebra. We are then led to higher Kirillov algebroids as higher generalisations of Jacobi algebroids. Furthermore, we show how to associate an $L_{\infty}$-algebroid and a homotopy BV-algebra with every homotopy Kirillov manifold.
Significando a morte, através de redes sociais, em um contexto de vulnerabilidade social: um estudo com crian?as pré-escolares, seus pais e professores
Jucá, Vládia Jamile dos Santos;Silva, Ana Carla Nunes da;Passos, Cecília Mello;Castro, Gabriela Alves de;Melo, Geisa Bastos;Tortorella, Isabele;Sena, Isael de Jesus;Souza, Juliana da Arcela de;Oliveira, Laís;Lima, Poliane;Sampaio, Renata Oliveira;Reis, Samara dos;
Psicologia & Sociedade , 2007, DOI: 10.1590/S0102-71822007000200016
Abstract: this paper is the result of a research carried out in 2004, in a poor area of the city of salvador. the objective was to understand the process of the meaning of death to a group of socially vulnerable preschool children. the study focused on the children's social network of parents and other educators in order to understand how these relationships gave a social basis to the construction of death meanings. in the social context of investigation, the children were frequently exposed to deaths caused by drug related conflicts. the research was carried out as an exploratory study, in a day care center with twelve children, nine of their caretakers and four teachers. the instruments were adapted to each group. as a result of this study, we observed that the parents had a hard time approaching the subject of violence and death with the children, although they lived in a context of violence and death. nevertheless, these children would bring to school, through play and talk, their experiences of violence and death in their community.
Evaluation of Benzamide Derivatives as New Influenza A Nucleoprotein Inhibitors  [PDF]
Jinxi Liao, Huimin Cheng, Junting Wan, Panyu Chen, Yingjun Li, Ke Ding, Micky D. Tortorella, Zhengchao Tu, Yanmei Zhang
Open Journal of Medicinal Chemistry (OJMC) , 2016, DOI: 10.4236/ojmc.2016.63004
Abstract: Virus nucleoprotein (NP) is an emerging target for drug development for Influenza. We designed benzamide derivatives as new inhibitors of NP that demonstrate good potency in blocking influenza A. Screening revealed that compound 39 was the most potent molecule in the series, exhibiting IC50 values of 0.46 and 0.27 μM in blocking the replication of H3N2 (A/HK/8/68) and (A/WSN/33) influenza A viral strains. The observed inhibition of viral replication correlated well with cytopathic protection. Furthermore, based on computational analysis and fluorescence microscopy, it was determined that compound 39 inhibited nuclear accumulation by targeting influenza A viral nucleoproteins. Finally, the rodent pharmacokinetic profile of compound 32 displayed half-life of greater than 4 hours and bioavailability greater than 20%, suggesting this class of molecules had drug-like properties.
Progresso científico em reprodu??o na primeira década do século XXI
Neves, Jairo Pereira;Miranda, Karina Leite;Tortorella, Rodrigo Dorneles;
Revista Brasileira de Zootecnia , 2010, DOI: 10.1590/S1516-35982010001300046
Abstract: the aim of the review is to show the major scientific advances achieved in the animal reproduction area and how they can affect the productive and reproductive performance of cattle in brazil. the knowledge about the mechanisms involved in the reproductive physiology control, in endocrine, cellular and molecular level allowed the development of reproductive biotechnologies. among these the tai has been used in large scale, with some advantages such as the multiplication of genetically superior animals, increasing on birth rate in addition to being an effective tool for adjusting the breeding season especially in beef cattle. other biotechnologies such as et, ivep, cloning and transgenesis are also fundamental in the development of basic science, medicine and animal preservation researches. the main nutritional, reproductive and health management factors that affect the dairy cattle productivity are also presented. however, research incentive is essential to improve these biotechnologies, to continue helping the development of national livestock.
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