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Search Results: 1 - 10 of 3470 matches for " Carl Schubert "
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Challenges in Thermal Welding of Aluminium Alloys  [PDF]
Emil Schubert
World Journal of Engineering and Technology (WJET) , 2018, DOI: 10.4236/wjet.2018.62018
Abstract: Modern transport systems have the challenge to integrate more and more functions. This increases the weight of the structures. On the other hand demands and the legal regulations for emissions can only be fulfilled if the weight is reduced. This results in an ongoing increase of the usage of lightweight materials. Due to its low density and high strength Aluminium Alloys are the most used lightweight metals. However, some other physical properties hamper the processing of these alloys. The publication shows ways to overcome these challenges applying appropriate material preparation and handling in combination with specialized welding equipment for Aluminium welding. Application examples demonstrate the state of the art in Aluminium welding.
A Platform for Parameter Unlimited Molecular Geometry Imaging Obviously Enabling Life Saving Measures in ALS  [PDF]
Walter Schubert
Advances in Pure Mathematics (APM) , 2018, DOI: 10.4236/apm.2018.83017
Abstract: This article deals with a molecular geometry imaging platform capable of mapping the spatial protein-colocalisation and anti-colocalisation code of large molecular systems at a time. The platform called molecular unlimited systems imaging cycler (MUSIC) robotics was applied to amyotrophic lateral sclerosis (ALS). The detection of ALS specific cells with a corresponding multimolecular geometry in the blood led to therapeutic depletion of these cells and to recovery of the treated patient, obviously because this therapy interferes with pathogenic invasion of these cells into the central nervous system, where they axotomize motor axons. Large scale geometry MUSIC robotics imaging of up to 4.5 × 10481 power of combinatorial molecular resolution is key to detect these cells and to control depletion therapy for clinical success. These data and new possibilities may argue for clinical application and for a systematic research in the field of molecular geometry of diseases to discover new mathematically defined insight.
No Evidence for “Break-Induced Replication” in a Higher Plant – But Break-Induced Conversion May Occur
Ingo Schubert,Veit Schubert
Frontiers in Plant Science , 2011, DOI: 10.3389/fpls.2011.00008
Abstract: “Break-induced replication” (BIR) is considered as one way to repair DNA double-strand breaks (DSBs). BIR is defined as replication of the proximal break-ends up to the end of the broken chromosome using an undamaged (homologous) double-stranded template and mimicking a non-reciprocal translocation. This phenomenon was detected by genetic experiments in yeast. BIR is assumed to occur also in mammals, but experimental evidence is not yet at hand. We have studied chromosomes of the field bean, Vicia faba L., with respect to the occurrence of BIR after DSB induction during S and G2 phase. Simultaneous incorporation of the base analog ethynyldeoxyuridine (EdU) revealed no chromosomal replication pattern indicative of BIR. Thus, if occurring at all, BIR does not play a major role in DSB repair in higher plants with large chromosome arms. However, the frequency of interstitial asymmetric EdU incorporation within heterochromatic regions, visible on metaphase chromosomes, increased after chromosome breakage during S and G2 phase. Such asymmetric labeling could be interpreted as conservative replication up to the next replicon, circumventing a DSB, and yielding an interstitial conversion-like event.
Feed-Forward Microprocessing and Splicing Activities at a MicroRNA–Containing Intron
Maja M. Janas,Mehdi Khaled,Steffen Schubert,Jacob G. Bernstein,David Golan,Rosa A. Veguilla,David E. Fisher,Noam Shomron,Carmit Levy ? ,Carl D. Novina ?
PLOS Genetics , 2011, DOI: 10.1371/journal.pgen.1002330
Abstract: The majority of mammalian microRNA (miRNA) genes reside within introns of protein-encoding and non-coding genes, yet the mechanisms coordinating primary transcript processing into both mature miRNA and spliced mRNA are poorly understood. Analysis of melanoma invasion suppressor miR-211 expressed from intron 6 of melastatin revealed that microprocessing of miR-211 promotes splicing of the exon 6–exon 7 junction of melastatin by a mechanism requiring the RNase III activity of Drosha. Additionally, mutations in the 5′ splice site (5′SS), but not in the 3′SS, branch point, or polypyrimidine tract of intron 6 reduced miR-211 biogenesis and Drosha recruitment to intron 6, indicating that 5′SS recognition by the spliceosome promotes microprocessing of miR-211. Globally, knockdown of U1 splicing factors reduced intronic miRNA expression. Our data demonstrate novel mutually-cooperative microprocessing and splicing activities at an intronic miRNA locus and suggest that the initiation of spliceosome assembly may promote microprocessing of intronic miRNAs.
Identification of a Potential Susceptibility Locus for Macular Telangiectasia Type 2
Nancy L. Parmalee, Carl Schubert, Maria Figueroa, Alan C. Bird, Tunde Peto, Mark C. Gillies, Paul S. Bernstein, Krzysztof Kiryluk, Joseph D. Terwilliger, Rando Allikmets, for the MacTel Project
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0024268
Abstract: Macular Telangiectasia type 2 (MacTel) is a relatively rare macular disease of adult onset presenting with distortions in the visual field and leading to progressive loss of visual acuity. For the purpose of a gene mapping study, several pedigrees were ascertained with multiple affected family members. Seventeen families with a total of 71 individuals (including 45 affected or possibly affected) were recruited at clinical centers in 7 countries under the auspices of the MacTel Project. The disease inheritance was consistent with autosomal dominant segregation with reduced penetrance. Genome-wide linkage analysis was performed, followed by analysis of recombination breakpoints. Linkage analysis identified a single peak with multi-point LOD score of 3.45 on chromosome 1 at 1q41-42 under a dominant model. Recombination mapping defined a minimal candidate region of 15.6 Mb, from 214.32 (rs1579634; 219.96 cM) to 229.92 Mb (rs7542797; 235.07 cM), encompassing the 1q41-42 linkage peak. Sanger sequencing of the top 14 positional candidates genes under the linkage peak revealed no causal variants in these pedigrees.
Polymyositis, Topological Proteomics Technology and Paradigm for Cell Invasion Dynamics
Walter Schubert
Computational and Mathematical Methods in Medicine , 2002, DOI: 10.1080/10273660290015224
Abstract: Polymyositis is an inflammatory myopathy characterized by muscle invasion of T-cells penetrating the basal lamina and displacing the plasma membrane of normal muscle fibers. This investigation presents a technology for the direct mapping of protein networks involved in T-cell invasion in situ. Simultaneous localization of 17 adhesive cell surface receptors reveals 18 different combinatorial expression patterns (CEP), which are unique for the T-cell invasion process in muscle tissue. Each invasion step can be assigned to specific CEP on the surface of individual T-cells. This indicates, that the T-cell invasion is enciphered combinatorially in the T-cells' adhesive cell surface proteome fraction. Given 217 possible combinations, the T-cell appears to have at its disposal a highly non-random restricted repertoire to specify migratory pathways at the cell surface. These higher-level order functions in the cellular proteome cannot be detected by large-scale protein profiling techniques from tissue homogenates. High-throughput whole cell mapping machines working on structurally intact tissues, as shown here, will allow to measure how cells of different origin (immune cells, tumor cells) combine cell surface receptors to encipher specificity and selectivity for interactions.
QED in the worldline representation
Schubert, Christian
High Energy Physics - Phenomenology , 2007, DOI: 10.1063/1.2751955
Abstract: Simultaneously with inventing the modern relativistic formalism of quantum electrodynamics, Feynman presented also a first-quantized representation of QED in terms of worldline path integrals. Although this alternative formulation has been studied over the years by many authors, only during the last fifteen years it has acquired some popularity as a computational tool. I will shortly review here three very different techniques which have been developed during the last few years for the evaluation of worldline path integrals, namely (i) the ``string-inspired formalism'', based on the use of worldline Green functions, (ii) the numerical ``worldline Monte Carlo formalism'', and (iii) the semiclassical ``worldline instanton'' approach.
Die Entstehung eines politischen Mythos in Athen. Von der Tyrannis zur Demokratie
Charlotte Schubert
Behemoth : a Journal on Civilisation , 2010,
Abstract: The choice of the heroes Harmodius and Aristogeiton as the symbol of a founding myth – unencumbered by previous conflicts after the victory of Salamis in the Persian wars – represents the belief of the Athenians that tyranny was finally defeated. The Athenians declared Harmodius and Aristeigeiton as founders and ascribed them the merit of having introduced the new political order rather than Cleisthenes, the reformer, who had introduced it and who was, together with the Spartan king Cleomenes, largely responsible for the overthrow of tyranny some years before the Persian wars. After Salamis this phase was completed, the new founding fathers Harmodius and Aristogeiton were successfully established and with them the conflicts of previous decades were covered over, or in the strict sense of the word, rendered invisible – in the truest sense this is then one of the most spectacular examples of counterfactual history.
Portfolio Optimization with Target-Shortfall-Probability Vector
Leo Schubert
Economic Analysis Working Papers , 2002,
Abstract: Traditional portfolio optimization uses the standard deviation of the returns as a measure of risk. In recent years, the Target-Shortfall-Probability (TSP) was discussed as an alternative measure. From the utility-theoretical point of view, the TSP is not perfect. Furthermore it is criticized due to the insufficient description of the risk. The advantages of the TSP are the usage independent of the distribution and the intuitive understanding by the investor. The use of a TSP-vector reduces an utility-theoretical disadvantage of a single TSP and offers an sufficient description of risk. The developed Mean-TSP-vector model is a mixed-integer linear program. The CPU-Time of the program to get a solution demonstrates that the model is suitable for practical applications. A test of the performance shows, that the average return of the model when used in bear markets is equal to the results of the traditional portfolio optimization but - due to skewness - in bullish markets can achieve better returns.
Rese a de "Teoría de la acción comunicativa: complementos y estudios previos" de Jürgen Habermans
Claudio Schubert
Stomatos , 2006,
Abstract:
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