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Search Results: 1 - 10 of 29770 matches for " Carah Santos "
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Cinryze as the first approved C1 inhibitor in the USA for the treatment of hereditary angioedema: approval, efficacy and safety
Michael Lunn, Carah Santos, Timothy Craig
Journal of Blood Medicine , 2010, DOI: http://dx.doi.org/10.2147/JBM.S9576
Abstract: ryze as the first approved C1 inhibitor in the USA for the treatment of hereditary angioedema: approval, efficacy and safety Review (3069) Total Article Views Authors: Michael Lunn, Carah Santos, Timothy Craig Published Date August 2010 Volume 2010:1 Pages 163 - 170 DOI: http://dx.doi.org/10.2147/JBM.S9576 Michael Lunn1, Carah Santos2, Timothy Craig1 1Penn State Hershey Section of Allergy, Asthma and Immunology, Hershey, PA USA; 2Stanford University Department of Pediatrics, Palo Alto, CA USA Abstract: Hereditary angioedema (HAE) is a clinical disorder characterized by a deficiency of C1 esterase inhibitor (C1-INH). HAE has traditionally been divided into two subtypes. Unique among the inherited deficiencies of the complement system, HAE Types I and II are inherited as an autosomal dominant disorder. The generation of an HAE attack is caused by the depletion and/or consumption of C1-inhibitor manifested as subcutaneous or submucosal edema of the upper airway, face, extremities, or gastrointestinal tract. Attacks can be severe and potentially life-threatening, particularly with laryngeal involvement. Despite the availability of C1-INH for the treatment of HAE since the 1980s in Europe and other countries, HAE treatment in the United States was limited to androgen therapy. The human plasma-derived C1 esterase -inhibitor (CinryzeTM), distributed by Lev Pharmaceuticals, was approved in October 2008 for the -prevention of HAE attacks based on the results of a phase III clinical trial. This review aims to describe the history of C1-INH replacement in HAE as well as the pharmacology, efficacy and safety of C1-INH, concentrating on Cinryze as the first approved chronic replacement treatment for the prophylaxis of HAE attacks.
The use of airborne laser scanning to develop a pixel-based stratification for a verified carbon offset project
Jordan Golinkoff, Mark Hanus, Jennifer Carah
Carbon Balance and Management , 2011, DOI: 10.1186/1750-0680-6-9
Abstract: This paper presents a pixel-based forest stratification method that uses both ALS and optical remote sensing data to optimally partition the variability across an ~10,000 ha forest ownership in Mendocino County, CA, USA. This new stratification approach improved the accuracy of the forest inventory, reduced the cost of field-based inventory, and provides a powerful tool for future management planning. This approach also details a method of determining the optimum pixel size to best partition a forest.The use of ALS and optical remote sensing data can help reduce the cost of field inventory and can help to locate areas that need the most intensive inventory effort. This pixel-based stratification method may provide a cost-effective approach to reducing inventory costs over larger areas when the remote sensing data acquisition costs can be kept low on a per acre basis.The world's forests are a critical sink of carbon dioxide [1]. It is estimated that forest degradation or destruction results in 6 to 17% of total anthropogenic CO2 emissions annually [2]. Because of the importance of forest ecosystems in adapting to and mitigating climate change, there are now many policy initiatives to preserve and restore forest ecosystems for a climate benefit [3,4]. Despite years of discussion however, policies to reduce emissions from terrestrial ecosystems have generally not been adopted. An exception to this is California's cap and trade system that will incorporate carbon offsets starting in 2012 (barring a legal challenge) - see [5].In part due to the dearth of climate change policies, a vibrant voluntary carbon offset market has sprung up centered around a suite of different carbon project standards [6-9], and managing forests for carbon offsets can provide an important income stream for landowners willing to undertake the costs and requirements of these standards. These standards all have slightly different requirements regarding how to quantify the amount of carbon offsets g
Adaptive Behaviour on the Portuguese Curricula: A Comparison between Children and Adolescents with and without Intellectual Disability  [PDF]
Sofia Santos
Creative Education (CE) , 2014, DOI: 10.4236/ce.2014.57059

The main objective of this study was to assess and compare the adaptive behaviour level of children and adolescents with and without intellectual disability trying to understand how the differences in this area could be influenced by contents and curricula. The sample was composed by 589 children and adolescents with and without intellectual disabilities (both ages 6 to 16, randomly selected from special and regular schools, respectively). The Portuguese version of Adaptive Behaviour Scale was used and administered through an interview, to a proxy who knew the individual being evaluated. Controlling for age, gender, diagnosis, and living area we found that there were statistical significant differences between both groups on most of adaptive behaviour domains in all variables. One of the conclusions is that curricula in special and regular schools differ a lot on contents and in participation activities within the community and that might be one of the causes of the non-skills acquisition by the children and adolescents with intellectual disabilities.

A Matrix Approach to the Socioeconomic Activity of a Country  [PDF]
Susana Santos
Theoretical Economics Letters (TEL) , 2018, DOI: 10.4236/tel.2018.85075
Abstract: A Social Accounting Matrix (SAM) is presented as a tool to study the socioeconomic activity of a country. This activity involves the monetary or nominal flows that are measured by the National Accounts, as well as production (organized in factors, industries and goods and services) and institutions (organized in households, general government, non-financial and financial corporations, non-profit institutions serving households, and rest of the world). In order to contribute to the definition of a methodology that can improve the knowledge of the different aspects of this activity, the potentialities of a SAM for its reading and interpreting are explored, as well as for carrying out experiments regarding its functioning. Through a SAM-based approach, how to construct more or less complex networks of linkages of the above mentioned flows is shown, from which structural features can be evidenced and the associated multiplier effects studied. Following an application to Portugal, it is shown that a numerical version of a SAM, enables an empirical description of the origin, use, and distribution of income, whereas, an algebraic version of a SAM allows one to carry out, for example, a deeper study of the multiplier effects associated with the institutional distribution of income. The crucial role of the factors of production accounts is identified in this study, namely when they establish the link between the generation and the distribution and use of income. In this process, the important role the complementary details that the Input-Output Matrix (IOM) can add is also identified. Thus, being the generation of income, the result of the output of goods and services and the associated costs, on the one hand, an industry by industry IOM can add details regarding domestic and imported intermediate consumption by and between industries and, on the other hand, a product by product IOM can add details regarding the domestic and imported intermediate consumption of goods and services.
Review: The Molecular Basis of Resistance in Mycobaterium tuberculosis  [PDF]
Lorena Cristina Santos
Open Journal of Medical Microbiology (OJMM) , 2012, DOI: 10.4236/ojmm.2012.21004
Abstract: Tuberculosis is a serious global public health problem and its high prevalence is strongly associated with the increase of drug resistance. This steady increase in the frequency of M. tuberculosis strains resistant to one or more agents commonly used to treat tuberculosis has drawn worldwide attention to understanding the molecular basis of resistance in M. tuberculosis. TB resistance is a great concern in the antibiotic resistance pandemic due to the high risk of death, as patients can remain infected for months or years and also because of the difficulty of the treatment. A molecular understanding of the series of events that render M. tuberculosis multi-drug resistant is very important in order to find a fast and appropriated diagnosis as well as a new target for new drugs.
The Higher Education System in Argentina. Networks, Genealogies and Conflicts  [PDF]
Santos Sharpe Andrés
Creative Education (CE) , 2015, DOI: 10.4236/ce.2015.618200
Abstract: The present manuscript aims to identify the genealogies, understood in a Foucaultian perspective, which leads to the actual Higher Education System in Argentina, by distinguishing how series of events are organized, distributed, organized in terms of institutional relations, signifying chains in the social amalgam and educational networks. This analysis will allow understanding the hierarchical relationships between higher education institutions and how the differences on cultural and curricular traditions and history also motivate (though not impose) the differences on the students and on policies. Finally, it is as well an accurate description of the Higher Education System in Argentina with a strong emphasis on universities.
Electron-Domain Wall Interaction with a Ferromagnetic Spherical Domain Wall  [PDF]
Leonardo dos Santos Lima
Journal of Modern Physics (JMP) , 2016, DOI: 10.4236/jmp.2016.713148
Abstract: The interaction between an electron with a three-dimensional domain wall was investigated using the Born’s expansion of the S scattering matrix. We obtain an influence of the scattering of the electron with the ferromagnetic domain wall in the spin wave function of the electron with the aim to generate the knowledge about the state of the electron spin after the scattering. It relates to the recent problem of generation of the spin polarized electric current. We also obtain the contribution of the electron-wall domain interaction on the electric conductivity \"\", through the wall domain, where we have obtained a peak of resonance in the conductivity for one value of \"\" .
O ensino de recrea o: repensando algumas práticas
Edmilson Santos dos Santos
Movimento , 2001,
Abstract: Thispaper aims at analyzing the topics by which the books which suggest practical activities in recreation justify certain procedures and authorize certain academic practices as valid. To reach this result 22 books dealing with child recreation were analyzed. The strategies used by experimental literature to build truth on the discipline of Recreation are subjected to the separation between theory and practice, the backing up of the child's heteronomy and the simplification of reality.
SEEMANN, J rn (Org.). A Aventura Cartográfica: Perspectivas, Pesquisas e Reflex es sobre a Cartografia Humana. Fortaleza, Express o Gráfica, 2005/2006, 224 p.
Clézio Santos Santos
Revista Sociedade & Natureza , 2008,
An Empirical Model for Dinitrogen Gas Emission from Inland Waters  [PDF]
Elizabeth Sikar, Marco Aurelio dos Santos, Ednaldo Oliveira dos Santos
Atmospheric and Climate Sciences (ACS) , 2019, DOI: 10.4236/acs.2019.91001
Abstract: The motivation to calculate this empirical model resulted from often observing—at the time disconcerting—excess dinitrogen gas (N2 concentration > background concentration) in bubble-gas emission samples, collected primarily for the purpose of carbon budget research, from Brazilian rivers and reservoirs sampled during roughly 100 field surveys lasting 4 days each on average and executed between years 2000 and 2012. We model the (serendipitously) measured dinitrogen gas above environmental concentration (N2aec) escaping in bubbles from Brazilian rivers as a function of dissolved nitrogen (N) in water. To this model, we mathematically add a pre-existing model of diffusively emitted denitrified dinitrogen (also as a function of dissolved N) from streams in the United States of America (USA). The resulting model predicts denitrified dinitrogen water-air emission from inland waters in the USA, China and Germany.
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