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Search Results: 1 - 10 of 210340 matches for " Caio P. Fernandes "
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HLB value, an important parameter for the development of essential oil phytopharmaceuticals
Caio P. Fernandes,Manuela P. Mascarenhas,Fiorella M. Zibetti,Barbara G. Lima
Revista Brasileira de Farmacognosia , 2012, DOI: 10.1590/s0102-695x2012005000127
Abstract: Essential oils are used primarily as natural preservatives, flavourants and fragrances in cosmetic products. Several pharmacopeias possess monographs of plants which are good sources of essential oils, such as Brazilian Pharmacopeia, including Illicium verum Hook. f., Schisandraceae and Rosmarinus offi cinalis. Since determination of Hydrophile-Lipophile Balance (HLB) value of essential oils appears as a critical step for development of emulsions and other semi-solid formulations, evaluation of required HLB values for I. verum and R. offi cinalis essential oils is the aim of this study. They were obtained by hydrodistillation and several emulsions were prepared by changing emulsifiers. The couple sorbitan oleate/polysorbate 20 provided best emulsions and was used at different ratios, at a total blend concentration of 5% w/w. The lowest mean droplet diameters for R. offi cinalis and I. verum emulsions were obtained at HLB 16.5 (97.12 nm) and 16.7 (246.6 nm), respectively. Moreover, emulsions with R. offi cinalis were finer and presented some bluish reflection, characteristic of nanoemulsions. The lowest turbidity value for R. offi cinalis emulsion was also obtained at HLB 16.5 (0.33). Thus, the present study describes for the first time HLB values for R. offi cinalis (16.5) and I. verum (16.7) essential oils, contributing to their physicochemical characterization and technology development of phytopharmaceuticals.
HLB value, an important parameter for the development of essential oil phytopharmaceuticals
Caio P. Fernandes,Manuela P. Mascarenhas,Fiorella M. Zibetti,Barbara G. Lima
Revista Brasileira de Farmacognosia , 2013,
Abstract: Essential oils are used primarily as natural preservatives, flavourants and fragrances in cosmetic products. Several pharmacopeias possess monographs of plants which are good sources of essential oils, such as Brazilian Pharmacopeia, including Illicium verum Hook. f., Schisandraceae and Rosmarinus offi cinalis. Since determination of Hydrophile-Lipophile Balance (HLB) value of essential oils appears as a critical step for development of emulsions and other semi-solid formulations, evaluation of required HLB values for I. verum and R. offi cinalis essential oils is the aim of this study. They were obtained by hydrodistillation and several emulsions were prepared by changing emulsifiers. The couple sorbitan oleate/polysorbate 20 provided best emulsions and was used at different ratios, at a total blend concentration of 5% w/w. The lowest mean droplet diameters for R. offi cinalis and I. verum emulsions were obtained at HLB 16.5 (97.12 nm) and 16.7 (246.6 nm), respectively. Moreover, emulsions with R. offi cinalis were finer and presented some bluish reflection, characteristic of nanoemulsions. The lowest turbidity value for R. offi cinalis emulsion was also obtained at HLB 16.5 (0.33). Thus, the present study describes for the first time HLB values for R. offi cinalis (16.5) and I. verum (16.7) essential oils, contributing to their physicochemical characterization and technology development of phytopharmaceuticals.
Antiproliferative activity of Eremanthus crotonoides extracts and centratherin demonstrated in brain tumor cell lines
Jonathas F. R. Lobo,Elaine S. Castro,Dayana R. Gouvea,Caio P. Fernandes
Revista Brasileira de Farmacognosia , 2012,
Abstract: The genus Eremanthus is recognized by the predominance of sesquiterpene lactones from the furanoheliangolide type, a class of substances extensively tested against cancer cell lines. Thus, the species E. crotonoides (DC.) Sch. Bip., Asteraceae, obtained on "restinga" vegetation was evaluated against U251 and U87-MG glioma cell lines using the MTT colorimetric assay. Dichloromethane fraction was cytotoxic to both glioblastoma multiforme cell lines. We then conducted UPLC-PDA-ESI-MS/MS analysis of the dichloromethane fraction, which allowed the identification of the sesquiterpene lactones centratherin and goyazensolide. The isolation of centratherin was performed using chromatographic techniques and the identification of this substance was confirmed according to NMR data. Cytotoxic activity of centratherin alone was also evaluated against both U251 and U87-MG cells, which showed IC50 values comparable with those obtained for the commercial anticancer drug doxorubicin. All the tested samples showed cytotoxic activity against glioblastoma multiforme cells which suggests that E. crotonoides extracts may be important sources of antiproliferative substances and that the centratherin may serve as prototype for developing new antiglioblastoma drugs.
Application of Hartree-Fock Method for Modeling of Bioactive Molecules Using SAR and QSPR  [PDF]
Cleydson B. R. Santos, Cleison C. Lobato, Francinaldo S. Braga, Sílvia S. S. Morais, Cesar F. Santos, Caio P. Fernandes, Davi S. B. Brasil, Lorane I. S. Hage-Melim, Williams J. C. Macêdo, José C. T. Carvalho
Computational Molecular Bioscience (CMB) , 2014, DOI: 10.4236/cmb.2014.41001
Abstract:
The central importance of quantum chemistry is to obtain solutions of the Schr?dinger equation for the accurate determination of the properties of atomic and molecular systems that occurred from the calculation of wave functions accurate for many diatomic and polyatomic molecules, using Self Consistent Field method (SCF). The application of quantum chemical methods in the study and planning of bioactive compounds has become a common practice nowadays. From the point of view of planning it is important to note, when it comes to the use of molecular modeling, a collective term that refers to methods and theoretical modeling and computational techniques to mimic the behavior of molecules, not intend to reach a bioactive molecule simply through the use of computer programs. The choice of method for energy minimization depends on factors related to the size of the molecule, parameters of availability, stored data and computational resources. Molecular models generated by the computer are the result of mathematical equations that estimate the positions and properties of the electrons and nuclei, the calculations exploit experimentally, the characteristics of a structure, providing a new perspective on the molecule. In this work we show that studies of Highest Occupied Molecular Orbital Energy (HOMO), Low Unoccupied Molecular Orbital Energy (LUMO) and Map of molecular electrostatic potential (MEP) using Hatree-Fock method with different basis sets (HF/3-21G*, HF/3-21G**, HF/6-31G, HF/6-31G*, HF/6-31G** and HF/6-311G), that are of great importance in modern chemistry, biochemistry, molecular biology, and other fields of knowledge of health sciences. In order to obtain a significant correlation, it is essential that the descriptors are used appropriately. Thus, the quantum chemical calculations are an attractive source of new molecular descriptors that can, in principle, express all the geometrical and electronic properties of molecules and their interactions with biological receptor.
Daily anticipatory rhythms of behavior and body temperature in response to glucose availability in rats
Breno T.S. Carneiro,Diego A. C. Fernandes,Caio F. P. Medeiros,Nathália L. Diniz
Psychology & Neuroscience , 2012,
Abstract: When food is available recurrently at a particular time of day, several species increase their locomotion in the hours that precede food delivery, a phenomenon called food anticipatory activity (FAA). In mammals, many studies have shown that FAA is driven by a food-entrained circadian oscillator (FEO) that is distinct from the light-entrained pacemaker in the suprachiasmatic nucleus of the hypothalamus. Few studies have investigated the effect of sugar ingestion on food anticipatory rhythms and the FEO. We aimed to extend the understanding of the role of glucose on the emergence of food anticipatory rhythms by investigating whether glucose ingestion is sufficient to produce daily food anticipation, reflected by motor activity and core body temperature rhythms. Under a 12 h/12 h light/dark cycle, chow-deprived rats had glucose solution available between Zeitgeber Time (ZT) 6 and ZT 9 for 10 days (glucose restriction group), whereas control animals had chow available within the same time window (chow restriction group). Animals in both groups exhibited anticipatory motor activity and body temperature around the fourth day of the scheduled food restriction. Glucose-fed rats ingested ~15 kcal on the days immediately before FAA emergence and reached an intake of ~20 kcal/day, whereas chow-fed rats ingested ~40 kcal/day. The glucose restriction group exhibited a pattern of food anticipation (activity and temperature) that was extremely similar to that observed in the chow restriction group. We conclude that glucose ingestion is a sufficient temporal cue to produce recurrent food anticipation, reflected by activity and temperature rhythms, in rats.
Rhinoscleroma and nasal non-Hodgkin lymphoma
Oliveira, Henrique Fernandes de,Carvalho, Ada Simone P. Alencar,Argollo, Núbia Cardoso Santana,Neves, Caio Athayde
International Archives of Otorhinolaryngology , 2009,
Abstract: Introduction: Rhinoscleroma, a rare nasal granulomatous disease, is caused by Klebsiella rhinoscleromatis. The nose is the primary occurrence region. Nasal non-Hodgkin lymphoma is a rare cancer, and could be of T or B type. The rhinoscleroma and the nasal non-Hodgkin lymphoma present with nasal obstruction as the main symptom, and are part of the nasal granulomatosis differential diagnosis. Objective: To report the association of rhinoscleroma and non-Hodgkin lymphoma in the same patient, by remarking the importance of the nasal granulomatosis' differential diagnosis. Case Report: A forty-nine year old female patient that appeared with a one-month progressive nasal obstruction. Rhinoscopy showed papillomatous feature lesion in left middle meatus. The immunohistochemical analysis confirmed rhinoscleroma. The patient was duly treated with total remission of the lesion. Ten months after, she returned with the same symptoms, but the histologic study confirmed non-Hodgkin lymphoma. Final Comments: Both pathologies may cause more severe nasal symptoms and complications. The early diagnostic enables the choice for the right treatment and contributes for the prognosis. The immunohistochemical study was essential for the diagnostic differentiation.
Rinoscleroma e linfoma n o-Hodgkin nasal
Oliveira, Henrique Fernandes de,Carvalho, Ada Simone P. Alencar,Argollo, Núbia Cardoso Santana,Neves, Caio Athayde
Arquivos Internacionais de Otorrinolaringologia , 2009,
Abstract: Introdu o: O rinoscleroma é uma doen a nasal granulomatosa rara, causada pela bactéria klebsiella rhinoscleromatis. O nariz representa a regi o primária de ocorrência. O linfoma n o-Hodgkin nasal é uma rara neoplasia maligna, podendo ser do tipo T ou B. O rinoscleroma e o linfoma nasal n o-Hodgkin apresentam como principal sintoma a obstru o nasal, e fazem parte do diagnóstico diferencial das granulomatoses nasais. Objetivo: Relatar a associa o de rinoscleroma e linfoma n o-Hodgkin nasal em um mesmo paciente, destacando a importancia do diagnóstico diferencial das granulomatoses nasais. Relato do Caso: Paciente do sexo feminino, 49 anos, atendida com obstru o nasal progressiva há um mês. A rinoscopia evidenciava les o aspecto papilomatoso em meato médio esquerdo. A imunohistoquímica confirmou rinoscleroma. A paciente foi corretamente tratada com remiss o total da les o. Dez meses após retornou com mesmos sintomas, mas histologia confirmou linfoma n o-Hodgkin. Comentários Finais: Ambas as patologias podem causar sintomas nasais graves e complica es. O diagnóstico precoce possibilita a institui o do tratamento adequado e favorece o prognóstico. O estudo imunohistoquímico foi fundamental para a diferencia o diagnóstica.
Fatores de risco na cirurgia das dissec??es da aorta ascendente e arco aórtico
Moreira, Luiz Felipe P;Stolf, Noedir A. G;Vianna, Caio B;Pêgo-Fernandes, Paulo M;Barreto, Ant?nio C. Pereira;Verginelli, Geraldo;Jatene, Adib D;
Revista Brasileira de Cirurgia Cardiovascular , 1987, DOI: 10.1590/S0102-76381987000200007
Abstract: the surgical experience in the treatment of 72 patients with proximal aortic dissections was analized to identify the determinants of high operative risk. thirty-seven patients were operated upon in the acute stage and the dissection was restrict to ascending aorta in 9. the most common surgical procedure was the interposition of dacron graft in the ascending aorta associated to obliteration of false lumen. the aortic arch was approached only in 5 patients. the overall operative mortality was 27.7% and patients with acute dissections had mortality rate of 43.5%. there was a direct relationship between the causes of death and preoperative complications in 45% of these cases. the following factors were considered predictors of high operative risk: previous neurologic compromise, cardiac tamponade, persistent shock, acute myocardial ischemia and renal dysfunction. involvement of innominate or carotid arteries by dissection, presence of intimal tear in aortic arch, mesenteric ischemia and only in the acute cases, moderate or severe aortic valve incompetence were also correlated with a higher operative mortality. in conclusion, the operative risk of the treatment of proximal aortic dissection has a relationship with preoperative clinical condition. better results in the acute stage could be improved by early diagnosis and adequate medical therapy during investigation period.
Physicochemical Properties of Pyrolysis Bio-Oil from Sugarcane Straw and Sugarcane in Natura  [PDF]
Josilaine A. C. Durange, Margareth R. L. Santos, Marcelo M. Pereira, Luiz A. P. Fernandes Jr., Marcio N. Souza, Anderson N. Mendes, Liena M. Mesa, Caio G. Sánchez, Elisabete M. S. Sanchez, Juan M. M. Pérez, Nakédia M. F. Carvalho
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2013, DOI: 10.4236/jbnb.2013.42A002
Abstract:

Under the renewable energy context, sugarcane biomass pyrolysis has been growing as a convenient route to produce bio-oil, which can be set into the chemical industry and refineries as building blocks or combustion fuel. In this work sugarcane straw was submitted to direct pyrolysis in a fluidized bed pilot plant at 500°C, in presence of air. Sugarcane in natura was also pyrolysed as a model for comparison, in order to determine the viability of processing different sources of raw biomass. The physicochemical characterization of the biomass precursors as well as of the bio-oils was also carried out, which points both biomass feedstocks as suitable for bio-oil production in terms of viscosity, surface tension, density and acidity. The bio-oil obtained from sugarcane in natura presented higher carbon and hydrogen content as well as lower oxygen content. On the other hand, the metal content is higher in the bio-oil obtained from sugarcane straw, in special the iron and potassium contents were 807 ppm and 123 ppm against 27 ppm and 1 ppm in the bio-oil from sugarcane in natura. Aliphatic and aromatic compounds as well as carbohydrates scaffolds were identified as the main components of the bio-oil. GC-MS analyses showed aromatic products from lignine fragmentation and free sugars and sugar derivatives.

Differential cellular FGF-2 upregulation in the rat facial nucleus following axotomy, functional electrical stimulation and corticosterone: a possible therapeutic target to Bell's palsy
Karen F Coracini, Caio J Fernandes, Almir F Barbarini, César M Silva, Rodrigo T Scabello, Gabriela P Oliveira, Gerson Chadi
Journal of Brachial Plexus and Peripheral Nerve Injury , 2010, DOI: 10.1186/1749-7221-5-16
Abstract: Adult rats received unilateral facial nerve crush, transection with amputation of nerve branches, or sham operation. Other group of unlesioned rats received a daily functional electrical stimulation in the levator labii superioris muscle (1 mA, 30 Hz, square wave) or systemic corticosterone (10 mgkg-1). Animals were sacrificed seven days later.Crush and transection lesions promoted no changes in the number of neurons but increased the neurofilament in the neuronal neuropil of axotomized facial nuclei. Axotomy also elevated the number of GFAP astrocytes (143% after crush; 277% after transection) and nuclear FGF-2 (57% after transection) in astrocytes (confirmed by two-color immunoperoxidase) in the ipsilateral facial nucleus. Image analysis reveled that a seven days functional electrical stimulation or corticosterone led to elevations of FGF-2 in the cytoplasm of neurons and in the nucleus of reactive astrocytes, respectively, without astrocytic reaction.FGF-2 may exert paracrine/autocrine trophic actions in the facial nucleus and may be relevant as a therapeutic target to Bell's palsy.It is important the knowledge on the molecules involved in the trophic mechanisms of motoneurons in order to develop therapeutic targets to peripheral nerve disorders which are the case of facial nerve in the Bell's palsy. The disease usually does not last long and undergoes spontaneous recovery in many cases but sometimes therapeutic interventions are necessary to reduce the symptoms or when amelioration is not achieved.In the disorder, the compromised facial nerve swells up and presses against its trajectory inside the temporal bone, being squashed and functionally/anatomically impaired [1]. Around one in five people will suffer long lasting symptoms. In patients presenting incomplete facial palsy and probably bearing only functional impairments, the prognosis for recovery is very good and treatment may be unnecessary. On the other hand, patients presenting complete paralysis, marked
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