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Search Results: 1 - 10 of 927022 matches for " C.A.M.;de Bruin "
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Restless leg syndrome, sleep quality and fatigue in multiple sclerosis patients
Moreira, N.C.V.;Damasceno, R.S.;Medeiros, C.A.M.;de Bruin, P.F.C.;Teixeira, C.A.C.;Horta, W.G.;de Bruin, V.M.S.;
Brazilian Journal of Medical and Biological Research , 2008, DOI: 10.1590/S0100-879X2008001000017
Abstract: we have tested the hypothesis that restless leg syndrome (rls) is related to quality of sleep, fatigue and clinical disability in multiple sclerosis (ms). the diagnosis of rls used the four minimum criteria defined by the international restless legs syndrome study group. fatigue was assessed by the fatigue severity scale (fss >27), quality of sleep by the pittsburgh sleep quality index (psqi >6), excessive daytime sleepiness by the epworth sleepiness scale (ess >10) and clinical disability by the expanded disability status scale (edss). forty-four patients (32 women) aged 14 to 64 years (43 ± 14) with disease from 0.4 to 23 years (6.7 ± 5.9) were evaluated. thirty-five were classified as relapsing-remitting, 5 as primary progressive and 4 as secondary progressive. edss varied from 0 to 8.0 (3.6 ± 2.0). rls was detected in 12 cases (27%). patients with rls presented greater disability (p = 0.01), poorer sleep (p = 0.02) and greater levels of fatigue (p = 0.03). impaired sleep was present in 23 (52%) and excessive daytime sleepiness in 3 cases (6.8%). fatigue was present in 32 subjects (73%) and was associated with clinical disability (p = 0.000) and sleep quality (p = 0.002). age, gender, disease duration, ms pattern, excessive daytime sleepiness and the presence of upper motor neuron signs were not associated with the presence of rls. fatigue was best explained by clinical disability and poor sleep quality. awareness of rls among health care professionals may contribute to improvement in ms management.
Teoria algébrica de processos da medida em sistemas quanticos
Melo, C.A.M. de;Pimentel, B.M.;Ramirez, J.A.;
Revista Brasileira de Ensino de Física , 2011, DOI: 10.1590/S1806-11172011000300006
Abstract: here we deal in a pedagogical way with an approach to construct an algebraic structure for the quantum mechanical measurement processes from the concept of measurement symbol. such concept was conceived by julian s. schwinger and constitutes a fundamental piece in his variational formalism and its several applications.
Study of the embryofeto-toxicity of Crown-of-Thorns (Euphorbia milii) latex, a natural molluscicide
Souza C.A.M.,de-Carvalho R.R.,Kuriyama S.N.,Araujo I.B.
Brazilian Journal of Medical and Biological Research , 1997,
Abstract: The crude latex of Crown-of-Thorns (Euphorbia milii var. hislopii) is a potent plant molluscicide and a promising alternative to the synthetic molluscicides used in schistosomiasis control. The present study was undertaken to investigate the embryofeto-toxic potential of E. milii latex. The study is part of a comprehensive safety evaluation of this plant molluscicide. Lyophilized latex (0, 125, 250 and 500 mg/kg body weight) in corn oil was given by gavage to Wistar rats (N = 100) from days 6 to 15 of pregnancy and cesarean sections were performed on day 21 of pregnancy. The numbers of implantation sites, living and dead fetuses, resorptions and corpora lutea were recorded. Fetuses were weighed, examined for external malformations, and fixed for visceral examination, or cleared and stained with Alizarin red S for skeleton evaluation. A reduction of body weight minus uterine weight at term indicated that E. milii latex was maternally toxic over the dose range tested. No latex-induced embryolethality was noted at the lowest dose (125 mg/kg) but the resorption rate was markedly increased at 250 mg/kg (62.5%) and 500 mg/kg (93.4%). A higher frequency of fetuses showing signs of delayed ossification (control: 17.4%; 125 mg/kg: 27.4% and 250 mg/kg: 62.8%; P<0.05 vs control) indicated that fetal growth was retarded at doses 3 125 mg latex/kg body weight. No increase in the proportion of fetuses with skeletal anomalies was observed at the lowest dose but the incidence of minor skeletal malformations was higher at 250 mg/kg body weight (control: 13.7%; 125 mg/kg: 14.8%; 250 mg/kg: 45.7%; P<0.05 vs control). Since a higher frequency of minor malformations was noted only at very high doses of latex which are embryolethal and maternally toxic, it is reasonable to conclude that this plant molluscicide poses no teratogenic hazard or, at least, that this possibility is of a considerably low order of magnitude
Study of the effects of -myrcene on rat fertility and general reproductive performance
Paumgartten F.J.R.,De-Carvalho R.R.,Souza C.A.M.,Madi K.
Brazilian Journal of Medical and Biological Research , 1998,
Abstract: -Myrcene (MYR) is a monoterpene found in the oils of a variety of aromatic plants including lemongrass, verbena, hop, bay, and others. MYR and essential oils containing this terpenoid compound are used in cosmetics, household products, and as flavoring food additives. This study was undertaken to investigate the effects of MYR on fertility and general reproductive performance in the rat. MYR (0, 100, 300 and 500 mg/kg) in peanut oil was given by gavage to male Wistar rats (15 per dose group) for 91 days prior to mating and during the mating period, as well as to females (45 per dose group) continuously for 21 days before mating, during mating and pregnancy, and throughout the period of lactation up to postnatal day 21. On day 21 of pregnancy one-third of the females of each group were submitted to cesarean section. Resorption, implantation, as well as dead and live fetuses were counted. All fetuses were examined for external malformations, weighed, and cleared and stained with Alizarin Red S for skeleton evaluation. The remaining dams were allowed to give birth to their offspring. The progeny was examined at birth and subsequently up to postnatal day 21. Mortality, weight gain and physical signs of postnatal development were evaluated. Except for an increase in liver and kidney weights, no other sign of toxicity was noted in male and female rats exposed to MYR. MYR did not affect the mating index (proportion of females impregnated by males) or the pregnancy index (ratio of pregnant to sperm-positive females). No sign of maternal toxicity and no increase in externally visible malformations were observed at any dose level. Only at the highest dose tested (500 mg/kg) did MYR induce an increase in the resorption rate and a higher frequency of fetal skeleton anomalies. No adverse effect of MYR on postnatal weight gain was noted but days of appearance of primary coat, incisor eruption and eye opening were slightly delayed in the exposed offspring. On the basis of the data presented in this paper the no-observed-adverse-effect level (NOAEL) for toxic effects on fertility and general reproductive performance can be set at 300 mg of -myrcene/kg body weight by the oral route.
Stroke service in the Netherlands: an exploratory study on effectiveness, patient satisfaction and utilisation of healthcare
H. Rosendal,C.A.M. Wolters,G.H.M.I. Beusmans,L.P. de Witte
International Journal of Integrated Care , 2002,
Abstract: Objective: To assess whether shared care for stroke patients results in better patient outcome, higher patient satisfaction and different use of healthcare services. Design: Prospective, comparative cohort study. Setting: Two regions in the Netherlands with different healthcare models for stroke patients: a shared care model (stroke service) and a usual care setting. Patients: Stroke patients with a survival rate of more than six months, who initially were admitted to the Stroke Service of the University Hospital Maastricht (experimental group) in the second half of 1997 and to a middle sized hospital in the western part of the Netherlands between March 1997 and March 1999 (control group). Main outcome measures: Functional health status according to the SIP-68, EuroQol, Barthel Index and Rankin Scale, patient satisfaction and use of healthcare services. Results: In total 103 patients were included in this study: 58 in the experimental group and 45 in the control group. Six months after stroke, 64% of the surviving patients in the experimental group had returned home, compared to 42% in the control group (p<0.05). This difference could not be explained by differences in health status, which was comparable at that time. Patients in the shared care model scored higher on patient satisfaction, whereas patients in the usual care group received a higher volume of home care. Conclusions: The Stroke Service Maastricht resulted in a higher number of patients who returned home after stroke, but not in a better health status. Since patients in the usual care group received a higher volume of healthcare in the period of rehabilitation, the Stroke Service Maastricht might be more efficient.
Study of the effects of ?-myrcene on rat fertility and general reproductive performance
Paumgartten, F.J.R.;De-Carvalho, R.R.;Souza, C.A.M.;Madi, K.;Chahoud, I.;
Brazilian Journal of Medical and Biological Research , 1998, DOI: 10.1590/S0100-879X1998000700012
Abstract: ?-myrcene (myr) is a monoterpene found in the oils of a variety of aromatic plants including lemongrass, verbena, hop, bay, and others. myr and essential oils containing this terpenoid compound are used in cosmetics, household products, and as flavoring food additives. this study was undertaken to investigate the effects of myr on fertility and general reproductive performance in the rat. myr (0, 100, 300 and 500 mg/kg) in peanut oil was given by gavage to male wistar rats (15 per dose group) for 91 days prior to mating and during the mating period, as well as to females (45 per dose group) continuously for 21 days before mating, during mating and pregnancy, and throughout the period of lactation up to postnatal day 21. on day 21 of pregnancy one-third of the females of each group were submitted to cesarean section. resorption, implantation, as well as dead and live fetuses were counted. all fetuses were examined for external malformations, weighed, and cleared and stained with alizarin red s for skeleton evaluation. the remaining dams were allowed to give birth to their offspring. the progeny was examined at birth and subsequently up to postnatal day 21. mortality, weight gain and physical signs of postnatal development were evaluated. except for an increase in liver and kidney weights, no other sign of toxicity was noted in male and female rats exposed to myr. myr did not affect the mating index (proportion of females impregnated by males) or the pregnancy index (ratio of pregnant to sperm-positive females). no sign of maternal toxicity and no increase in externally visible malformations were observed at any dose level. only at the highest dose tested (500 mg/kg) did myr induce an increase in the resorption rate and a higher frequency of fetal skeleton anomalies. no adverse effect of myr on postnatal weight gain was noted but days of appearance of primary coat, incisor eruption and eye opening were slightly delayed in the exposed offspring. on the basis of the dat
Cyrioctea (Araneae, Zodariidae) in Africa: temperate Gondwanaland relict, recent radiation, or both?
Rudy C.A.M. Jocqué
European Journal of Taxonomy , 2013, DOI: 10.5852/ejt.2013.47
Abstract: Two new species of the zodariid genus Cyrioctea Simon, 1889 are described: C. sawadee sp. nov. and C. lotzi sp. nov., both only known from males. The genus now contains seven Afrotropical species and this abundance is discussed in the context of its basal situation in the family and its apparent temperate Gondwanaland distribution, which implies a much greater age of the Zodariidae than presently accepted. Unlike most taxa with a temperate Gondwana distribution, Cyrioctea boasts a high number of species with small distribution areas. This points in the direction of a recent radiation initiated after a long period of stasis.
Study of the embryofeto-toxicity of Crown-of-Thorns (Euphorbia milii) latex, a natural molluscicide
Souza, C.A.M.;de-Carvalho, R.R.;Kuriyama, S.N.;Araujo, I.B.;Rodrigues, R.P.;Vollmer, R.S.;E.N., Alves;Paumgartten, F.J.R.;
Brazilian Journal of Medical and Biological Research , 1997, DOI: 10.1590/S0100-879X1997001100011
Abstract: the crude latex of crown-of-thorns (euphorbia milii var. hislopii) is a potent plant molluscicide and a promising alternative to the synthetic molluscicides used in schistosomiasis control. the present study was undertaken to investigate the embryofeto-toxic potential of e. milii latex. the study is part of a comprehensive safety evaluation of this plant molluscicide. lyophilized latex (0, 125, 250 and 500 mg/kg body weight) in corn oil was given by gavage to wistar rats (n = 100) from days 6 to 15 of pregnancy and cesarean sections were performed on day 21 of pregnancy. the numbers of implantation sites, living and dead fetuses, resorptions and corpora lutea were recorded. fetuses were weighed, examined for external malformations, and fixed for visceral examination, or cleared and stained with alizarin red s for skeleton evaluation. a reduction of body weight minus uterine weight at term indicated that e. milii latex was maternally toxic over the dose range tested. no latex-induced embryolethality was noted at the lowest dose (125 mg/kg) but the resorption rate was markedly increased at 250 mg/kg (62.5%) and 500 mg/kg (93.4%). a higher frequency of fetuses showing signs of delayed ossification (control: 17.4%; 125 mg/kg: 27.4% and 250 mg/kg: 62.8%; p<0.05 vs control) indicated that fetal growth was retarded at doses $mvd$:face("symbol") 3 125 mg latex/kg body weight. no increase in the proportion of fetuses with skeletal anomalies was observed at the lowest dose but the incidence of minor skeletal malformations was higher at 250 mg/kg body weight (control: 13.7%; 125 mg/kg: 14.8%; 250 mg/kg: 45.7%; p<0.05 vs control). since a higher frequency of minor malformations was noted only at very high doses of latex which are embryolethal and maternally toxic, it is reasonable to conclude that this plant molluscicide poses no teratogenic hazard or, at least, that this possibility is of a considerably low order of magnitude
Simultaneous optimization of dynamic bioprocesses
Riascos, C.A.M.;Pinto, J.M.;
Brazilian Journal of Chemical Engineering , 2002, DOI: 10.1590/S0104-66322002000400014
Abstract: it is known that the optimal control may introduce significant economical benefits into production processes, thus being an important and challenging research area with practical relevance. the modeling and optimization of biotechnological processes has been object of research and their related results have generated improvements in operating conditions and strategies, however, the inherent features of dynamical bioprocesses prevent the application of conventional optimization algorithms, hence making necessary the development of tailored methods and strategies. the objective of this work is to develop mathematical programming strategies for simultaneous optimization of dynamic systems and evaluate their computational performance. simultaneous optimization with orthogonal collocation is applied to a simplified model for biosynthesis of penicillin from glucose, which was studied by cuthrell and biegler (1989). the results show that discretization of differential equations systems (dae) by orthogonal collocation in finite elements efficiently transforms dynamic optimization problems into nonlinear programming (nlp) problems, enabling to solve complex problems with several control variables and minimizing the approximation error.
Substancias isoladas das folhas de Bauhinia microstachya (Raddi) Macbr. (Caesalpiniaceae)
Bianco, E.M.;Santos, C.A.M;
Revista Brasileira de Farmacognosia , 2003, DOI: 10.1590/S0102-695X2003000200005
Abstract: it is reported the isolation of three compounds from leaves of bauhinia microstachya (raddi) macbr., caesalpiniaceae, including two new constituents in this species, vitexin and the hydrocarbon hexatriacontane. their structures were established by extensive 1d and 2d 1h nmr and ms spectral studies.
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