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Therapeutic Effects of Curcumin on Alzheimer’s Disease  [PDF]
Edward C. Yao, Lei Xue
Advances in Alzheimer's Disease (AAD) , 2014, DOI: 10.4236/aad.2014.34014
Abstract: As the number of patients with Alzheimer’s disease (AD) continues to rise throughout the twenty- first century, scientists are increasingly looking for remedies, although the cause and pathology of the disease remain uncertain. Among treatments for AD, there is a renewed interest in curcumin as a potential medication. Studies of the substance have found a large amount of consumption associated benefits, including anti-inflammatory and antioxidant effects. Its wide healing properties make it increasingly interesting to scientists, with potential uses in the treatment of cancers, arthritis, various cardiovascular diseases, and neurodegenerative diseases. More recently, curcumin has been shown to have multipotent effects against various symptoms of AD. Among other things, curcumin has been able to ameliorate toxicity of beta-amyloid species, a key part of AD nuerodegeneration, in vivo and in vitro, and has been able to inhibit multiple parts along suspected AD pathology. The goal of this review is to summarize the research done on curcumin with respect to its applicability as a treatment for AD and AD related pathology.
The Genus Melodinus (Apocynaceae): Chemical and Pharmacological Perspectives  [PDF]
Yao Lu, T. J. Khoo, C. Wiart
Pharmacology & Pharmacy (PP) , 2014, DOI: 10.4236/pp.2014.55064
Abstract:

The plants of the genus Melodinus (Apocynaceae) are widely distributed, and have long been used in folk medicine for the treatment of various ailments such as meningitis in children and rheumatic heart diseases, hernia, infantile malnutrition, dyspepsia and testitis. Over 100 alkaloids together with flavonoids, lignans, steroids, terpenoids and coumarins have been identified in the genus, and many of these have been evaluated for biological activity. This review presents comprehensive information on the chemistry and pharmacology of the genus together with the traditional uses of many of its plants. In addition, this review discusses the structure-activity relationship of different compounds as well as recent developments and the scope for future research in this aspect.

Ill-posedness of the incompressible Navier-Stokes equations in $\dot{F}^{-1,q}_{\infty}({R}^3)$
C. Deng,X. Yao
Mathematics , 2013,
Abstract: In this paper, authors show the ill-posedness of 3D incompressible Navier-Stokes equations in the critical Triebel-Lizorkin spaces $ \dot{F}^{-1,q}_{\infty} (\mathbb{R}^3) $ for any $ q>2 $ in the sense that arbitrarily small initial data of $ \dot{F}^{-1,q}_{\infty}(\mathbb{R}^3) $ can lead the corresponding solution to become arbitrarily large after an arbitrarily short time. In view of the well-posedness of 3D-incompressible Navier-Stokes equations in $ BMO^{-1} $ (i.e. the Triebel-Lizorkin space $ \dot{F}^{-1,2}_{\infty}(\mathbb{R}^3) $) by Koch and Tataru, our work completes a dichotomy of well-posedness and ill-posedness in the Triebel-Lizorkin space framework depending on $ q=2 $ or $ q>2 $.
NQP_{C} = co-C_{=}P
Tomoyuki Yamakami,Andrew C. Yao
Computer Science , 1998,
Abstract: Adleman, DeMarrais, and Huang introduced the nondeterministic quantum polynomial-time complexity class NQP as an analogue of NP. Fortnow and Rogers implicitly showed that, when the amplitudes are rational numbers, NQP is contained in the complement of C_{=}P. Fenner, Green, Homer, and Pruim improved this result by showing that, when the amplitudes are arbitrary algebraic numbers, NQP coincides with co-C_{=}P. In this paper we prove that, even when the amplitudes are arbitrary complex numbers, NQP still remains identical to co-C_{=}P. As an immediate corollary, BQP differs from NQP when the amplitudes are unrestricted.
A New Family of Practical Non-Malleable Diffie-Hellman Protocols
Andrew C. Yao,Yunlei Zhao
Computer Science , 2011,
Abstract: Cryptography algorithm standards play a key role both to the practice of information security and to cryptography theory research. Among them, the MQV and HMQV protocols ((H)MQV, in short) are a family of (implicitly authenticated) Diffie-Hellman key-exchange (DHKE) protocols that are widely standardized and deployed. In this work, from some new perspectives and approaches and under some new design rationales and insights, we develop a new family of practical implicitly authenticated DHKE protocols, which enjoy notable performance among security, privacy, efficiency and easy deployment. We make detailed comparisons between our new DHKE protocols and (H)MQV, showing that the newly developed protocols outperform HMQV in most aspects. Along the way, guided by our new design rationales, we also identify a new vulnerability (H)MQV, which brings some new perspectives (e.g., computational fairness) to the literature.
Capacity Worth of Energy Storage System in Renewable Power Generation Plant  [PDF]
Jinbin Li, Yao Yao
Engineering (ENG) , 2013, DOI: 10.4236/eng.2013.59B001
Abstract: With the advance in renewable generation technologies, the cost of renewable energy becomes increasingly competitive when compared to fossil fuel-based generation resources. It is economically beneficial to integrate large amounts of renewable capacity in power systems. Unlike traditional generation facilities, however, using renewable resources for generation presents technical challenges in producing continuous power. In this report, an Energy Storage System (ESS) is integrated to smooth the variations in renewable power production and ensure the output power more controllable. Since it requires capital investment for the storage devices, it is important to obtain reasonable estimate of the storage capacities. This project is therefore formulated as an optimization problem in determining the two dominating factors of the capital cost for the ESS: the power capacity and the energy capacity. The objective is to make the renewable power more reliable and simultaneously maximize the economic benefits that can be obtained from the scheme. To make the results more convincing, analyses in this report start with wind generation, for wind has greater variability and unpredictability than other renewable sources. Selection of ESS type is narrowed down to battery energy storage system (BESS) in the scheme. However, the methods presented here are suitable for any type of energy storage methods and are also useful for intermittent renewable energy resources other than wind.
Research of Quality Standards for Stachydrine Hydrochloride in Chinese Medicine TJF Granule  [PDF]
Yao Lu, Wei Yu, Pingniang Shen, T. J. Khoo, C. Wiart
Pharmacology & Pharmacy (PP) , 2013, DOI: 10.4236/pp.2013.43040
Abstract:

A high-performance liquid chromatographic method was applied to the determination of stachydrine hydrochloride concentration in TJF granule (Chinese name: Tiao-Jing-Fang), using a mobile phase of methanol-acetonitrile (50:50, v/v) by the Agilent Kromasi NH2 column (250 mm × 4.6 mm, 5 μm, S/N: 22N25110). Detection wavelength was 201 nm. The result revealed good linearity of stachydrine hydrochloride and was obtained within the range of 0.20 - 1.98 μg/mL (R = 0.9995). The average recovery was 97.01%; the relative standard deviation (RSD) was 0.19%. To the best of our knowledge, this is the first report dedicated to the determination of stachydrine hydrochloride by the evaporative light scattering detector-high-performance liquid chromatographic (ELSD-HPLC) method.

Erratum
Aninwene G II , Yao C, Webster TJ
International Journal of Nanomedicine , 2012, DOI: http://dx.doi.org/10.2147/IJN.S31596
Abstract: Erratum Erratum (2344) Total Article Views Authors: Aninwene G II , Yao C, Webster TJ Published Date March 2012 Volume 2012:7 Pages 1573 - 1574 DOI: http://dx.doi.org/10.2147/IJN.S31596 Received: 08 March 2012 Accepted: Published: 22 March 2012 Aninwene II GE, Yao C, Webster TJ. Enhanced osteoblast adhesion to drug-coated anodized nanotubular titanium surfaces. Int J Nanomedicine. 2008;3(2):257–264. There is a mistake in the Drug coating section of the Materials and methods. In the paper it is written as follows: “For simple physical adsorption, 120 μL of either penicillin/streptomycin (Hyclone, Logan, UT, USA; 5 μg/mL) or dexamethasone (Sigma, St. Louis, MO, USA; 5 μg/mL) solutions were placed onto each unanodized or anodized titanium for 3 days at room temperature.” But the text should be written as: “For simple physical adsorption, 120 μL of either penicillin/streptomycin (Hyclone, Logan, UT, USA; 6.25 mg penicillin and 10 mg streptomycin per mL) or dexamethasone (Sigma, St. Louis, MO, USA; 5 mg/mL) solutions were placed onto each unanodized or anodized titanium for 3 days at room temperature.” Read the original article Post to: Cannotea Citeulike Del.icio.us Facebook LinkedIn Twitter Other articles by Dr Thomas J Webster Mechanisms of greater cardiomyocytes functions on conductive nanoengineered composites for cardiovascular applications. [Corrigendum] Anodized 20 nm diameter nanotubular titanium for improved bladder stent applications Anodizing color coded anodized Ti6Al4V medical devices for increasing bone cell functions Antimicrobial applications of nanotechnology: methods and literature Bactericidal effect of iron oxide nanoparticles on Staphylococcus aureus Biomimetic helical rosette nanotubes and nanocrystalline hydroxyapatite coatings on titanium for improving orthopedic implants Carbon nanotubes impregnated with subventricular zone neural progenitor cells promotes recovery from stroke Comparison study of ferrofluid and powder iron oxide nanoparticle permeability across the blood–brain barrier Cytotoxicity of selenium nanoparticles in rat dermal fibroblasts Decreased Staphylococcus aureus biofilm formation on nanomodified endotracheal tubes: a dynamic airway model Decreased astroglial cell adhesion and proliferation on zinc oxide nanoparticle polyurethane composites Decreased cervical cancer cell adhesion on nanotubular titanium for the treatment of cervical cancer Decreased lung carcinoma cell density on select polymer nanometer surface features for lung replacement therapies Differential effects of nanoselenium doping on healthy and cancerous osteoblasts in coculture on titanium Enhanced endothelial cell density on NiTi surfaces with sub-micron to nanometer roughness Enhanced endothelial cell functions on rosette nanotube-coated titanium vascular stents Enhanced osteoblast adhesion on nanostructured selenium compacts for anti-cancer orthopedic applications Enhanced osteoblast adhesion to drug-coated anodized nanotubular titanium s
Application of Vertical Cluster Analysis Method to the Analysis of Time Dependent Biological Data Sets
Sathees B.C. Chandra,Yao Wang
Journal of Applied Sciences , 2007,
Abstract: The purpose of this study is to apply vertical cluster analysis method to interpret and analyze habituation of the leg movement response, to different odors, in fruit flies. In most cases cluster analysis methods are used to analyze data sets, which can be classified into categories. We define this type of method as horizontal cluster analysis method. In this study, instead of dividing the data into categories, we divide the data based on different periods of time. We define this method as a vertical cluster analysis method. Here we apply vertical cluster analysis method to evaluate the habituation of leg movement responses of fruit fly, Drosophila melanogaster. The vertical cluster analyses helped us to identify hidden features of fruit fly behavior.
Optical Forces Between Coupled Plasmonic Nano-particles near Metal Surfaces and Negative Index Material Waveguides
C. Van Vlack,P. Yao,S. Hughes
Physics , 2011, DOI: 10.1103/PhysRevB.83.245404
Abstract: We present a study of light-induced forces between two coupled plasmonic nano-particles above various slab geometries including a metallic half-space and a 280-nm thick negative index material (NIM) slab waveguide. We investigate optical forces by non-perturbatively calculating the scattered electric field via a Green function technique which includes the particle interactions to all orders. For excitation frequencies near the surface plasmon polariton and slow-light waveguide modes of the metal and NIM, respectively, we find rich light-induced forces and significant dynamical back-action effects. Optical quenching is found to be important in both metal and NIM planar geometries, which reduces the spatial range of the achievable inter-particle forces. However, reducing the loss in the NIM allows radiation to propagate through the slow-light modes more efficiently, thus causing the light-induced forces to be more pronounced between the two particles. To highlight the underlying mechanisms by which the particles couple, we connect our Green function calculations to various familiar quantities in quantum optics.
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