The plants of the genus Melodinus (Apocynaceae) are widely distributed, and have long been used in folk medicine for the treatment of various ailments such as meningitis in children and rheumatic heart diseases, hernia, infantile malnutrition, dyspepsia and testitis. Over 100 alkaloids together with flavonoids, lignans, steroids, terpenoids and coumarins have been identified in the genus, and many of these have been evaluated for biological activity. This review presents comprehensive information on the chemistry and pharmacology of the genus together with the traditional uses of many of its plants. In addition, this review discusses the structure-activity relationship of different compounds as well as recent developments and the scope for future research in this aspect.
high-performance liquid chromatographic method was applied to the determination
of stachydrine hydrochloride concentration in TJF granule (Chinese name:
Tiao-Jing-Fang), using a mobile phase of methanol-acetonitrile (50:50, v/v) by the Agilent
Kromasi NH2 column (250 mm × 4.6 mm, 5 μm, S/N: 22N25110). Detection wavelength was 201
nm. The result revealed good linearity of stachydrine hydrochloride and was
obtained within the range of 0.20 - 1.98 μg/mL (R = 0.9995). The average recovery was 97.01%; the relative standard deviation (RSD) was 0.19%. To the best of our knowledge,
this is the first report dedicated to the determination of stachydrine
hydrochloride by the evaporative light scattering detector-high-performance
liquid chromatographic (ELSD-HPLC) method.