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Search Results: 1 - 10 of 450088 matches for " César Júnior; "
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Espectroscopia de Ressonancia Magnética Nuclear de 13C no estudo de rotas biossintéticas de produtos naturais
Macedo Júnior, Fernando César de;
Química Nova , 2007, DOI: 10.1590/S0100-40422007000100023
Abstract: during the last five decades, as a result of an interaction between natural product chemistry, synthetic organic chemistry, molecular biology and spectroscopy, scientists reached an extraordinary level of comprehension about the natural processes by which living organisms build up complex molecules. in this context, 13c nuclear magnetic resonance spectroscopy, allied with isotopic labeling, played a determinant role. nowadays, the widespread use of modern nmr techniques allows an even more detailed picture of the biochemical steps by accurate manipulation of the atomic nuclei. this article focuses on the development of such techniques and their impact on biosynthetic studies.
Crohn's Disease: current state of biological therapy
Santos Júnior, Júlio César Monteiro;
Journal of Coloproctology (Rio de Janeiro) , 2011, DOI: 10.1590/S2237-93632011000400017
Abstract: the inflammatory bowel diseases (ibd) are defined as nonspecific chronic intestinal inflammations with possible systemic involvement. ibd have unknown etiology. the inflammatory process is complex and heterogeneous, both as to the characterization of the disease that affects the digestive tract, without an intelligible pattern of revelation and balance, and in its different systemic damages when including the extensive and severe extraintestinal symptoms. aparently, the natural history of the disease is irregular in relation to the offending agent system and the attacked system, both in the intestinal and extraintestinal teguments. isolated aspects showing irregularity in this balance gives us the notion that ibd, especially crohn's disease, can be caused by the stimulation of an immune response caused by damaging agents (intestinal bacteria), but mediated by inadequate genetic factors, whose expressions determine different individual susceptibilities. these observations have been shown in genetic studies that emphasize the importance of pathological interaction between host and bacteria subsidized by a genomic region that contains genes producing proteins (nod2 - nucleotide-binding oligomerization domain containing 2) participating in an enhanced defense response by the tissue. increased numbers and the activation of these cells in the intestinal mucosa elevate local levels of tumor necrosis factor α (tnf-α), interleukin-1β, interferon-γ, and cytokines of the interleukin-23-th17 pathway. so, it can be assumed that the susceptibility, which is a result of genetic alterations, is connected to an exaggerated response in the pro-inflammatory phase because of a dysfunction in the intestinal immune system. the identification of tumor necrosis factor (tnf-α) as the active element in the pro-inflammatory inadequate response gave rise to the heightened production of biological substances that could block tnf-α, at different levels, opening a large field of view to new treat
Evolu??o do acesso a servi?os de saneamento básico no Brasil (1970 a 2004)
Saiani, Carlos César Santejo;Toneto Júnior, Rudinei;
Economia e Sociedade , 2010, DOI: 10.1590/S0104-06182010000100004
Abstract: the aim of the article is to analyze the evolution of the coverage of basic sanitation services in brazil since the beginning of the 1970s until 2004, taking into account some regional, municipal, and domiciliary variables: (i) geographic region; (ii) population and city size; (iii) urbanization rate; (iv) domicile location (rural or urban areas) and (v) monthly domiciliary income. this analysis allowed to evaluate: (i) whether the characteristics of domiciliary access deficit are recent or were already taking place in 1970 and (ii) whether there is a convergence of domiciliary access rates, i.e., if in the analyzed categories, the difference between the best and the worse rates of access are decreasing. besides, it was possible to inquire which type of public policy carried away for the sector has generated investments that succeeded to reach the poorest localities.
Propostas de melhorias em um método de avalia??o de sistemas de gest?o de seguran?a e saúde no trabalho
Saurin, Tarcisio Abreu;Carim Júnior, Guido César;
Produ??o , 2011, DOI: 10.1590/S0103-65132010005000038
Abstract: this article presents proposals for improvements of a method for assessing health and safety management systems. this method has resilience engineering (re) as its underlying philosophy and it was originally devised and tested in a case study of a manufacturing plant. four changes were proposed in comparison with the original version of the method: (a) guidelines for assessing the use of re principles more systematically; (b) guidelines for developing an action plan as a result of the assessment; (c) re-organization of the data collection tools in order to make it easier for use by inexperienced auditors; and (d) procedures for facilitating the assignment of scores to the items assessed. the impact of these changes is illustrated by means of a case study in which the method was applied in a company that distributes electrical energy. the changes in the method were not made as a result of the particularities of the company involved in the case study, which is an indication of possible application of the method in other sectors, beyond manufacturing.
Propostas de melhorias em um método de avalia o de sistemas de gest o de seguran a e saúde no trabalho Proposals of improvements to a method for assessing health and safety management systems
Tarcisio Abreu Saurin,Guido César Carim Júnior
Produ??o , 2011,
Abstract: Este artigo apresenta propostas de melhorias em um método de avalia o de sistemas de gest o da seguran a e saúde no trabalho, o qual tem a engenharia de resiliência (ER) como filosofia e foi originalmente aplicado em um estudo de caso em uma metalúrgica. Quatro modifica es foram propostas em rela o à vers o original: (a ) diretrizes para que a avalia o do atendimento aos princípios da ER seja realizada de modo sistemático; (b) diretrizes para elaborar um plano de a o resultante da avalia o; (c) reorganiza o dos instrumentos de coleta de dados, para facilitar sua aplica o por usuários com pouca experiência no método; e (d) procedimentos para facilitar a atribui o de pontua es aos itens avaliados. A implanta o dessas propostas é ilustrada por meio de um estudo de caso de aplica o do método em uma distribuidora de energia elétrica. As modifica es propostas n o foram consequência das particularidades do estudo de caso, o que é um indicativo da viabilidade de aplica o do método em outros setores, além da indústria da manufatura. This article presents proposals for improvements of a method for assessing health and safety management systems. This method has resilience engineering (RE) as its underlying philosophy and it was originally devised and tested in a case study of a manufacturing plant. Four changes were proposed in comparison with the original version of the method: (a) guidelines for assessing the use of RE principles more systematically; (b) guidelines for developing an action plan as a result of the assessment; (c) re-organization of the data collection tools in order to make it easier for use by inexperienced auditors; and (d) procedures for facilitating the assignment of scores to the items assessed. The impact of these changes is illustrated by means of a case study in which the method was applied in a company that distributes electrical energy. The changes in the method were not made as a result of the particularities of the company involved in the case study, which is an indication of possible application of the method in other sectors, beyond manufacturing.
SISTEMAS DE CULTIVO EM MILHO (ZEA MAYS L.) E SEUS EFEITOS RESIDUAIS NAS CARACTERíSTICAS FíSICAS DO SOLO E NA PRODU O DE GR OS1
MACIEL JúNIOR, Vinícius,CORSINI, Paulo César
Nucleus , 2004,
Abstract: The objetive of this study was to evaluate the residual effect on four cultivation systemskept under tilled system compared to those under conventional system in the 7 th and 8 th agricultural years.The experiment was carried out during the agricultural years of 96/97 and 97/98 in dark red latosol ofmedium texture at the experimental area of Faculdade de Ciências Agrárias e Veterinárias – UniversidadeEstadual Paulista, located in Jaboticabal, State of S o Paulo, Brazil. The soil density, porosity and waterretention were evaluated in soil samples collected in the row and the inter- row of the culture in three differentdepths and periods durind the culture cycle. In general, no significant differences were found in any of thetreatments. The corn final production was evaluated and no significant differences were found in thetreatments. This study concluded that the corn cultivation systems did not affect the density and the final cornyield, atthough significant differences on the porosity and water retention were found in the treatments.O presente trabalho objetivou avaliar o efeito residual, no 7o e 8 o anos, de quatro sistemas decultivo, mantidos sob plantio direto, comparados ao sistema de cultivo convencional. O experimento foidesenvolvido nos anos agrícolas 96/97 e 97/98, em um latossolo vermelho escuro, textura média, na FazendaExperimental da Faculdade de Ciências Agrárias e Veterinárias – Universidade Estadual Paulista, emJaboaticabal – SP. A densidade do solo, a porosidade e a reten o de água foram avaliadas no tratamentos, emamostras de solo coletadas na linha se entrelinha, em três profundidades e em três épocas, durante o ciclo dacultura, n o sendo encontradas diferen as significativas entre tratamentos. A produ o final do milho foiavaliada, n o sendo observadas diferen as significativas entre os tratamentos. Neste trabalho, conclui-se queos sistemas de cultivo em milho n o afetaram os valores de densidade e a produ o final do milho, entretanto,apresentaram diferen as a porosidade total, e a curva de reten o de água para os tratamentos.
Modelamento da perda de qualidade de sementes de soja, em fun??o das condi??es iniciais e da atmosfera no armazenamento
Afonso Júnior, Paulo César;Corrêa, Paulo César;Queiroz, Daniel Mar?al de;
Revista Brasileira de Engenharia Agrícola e Ambiental , 2000, DOI: 10.1590/S1415-43662000000300016
Abstract: in order to predict the germination potencial of soybean seeds of the santa rosa variety during storage, an experiment was conducted, the seeds with initial moisture content of 0.333 (dry basis) were dried under an air temperature of 30 oc and relative humidity of 40% until the moisture content of 0.111; 0.176 and 0.250 (dry basis) were reached. the seeds were conditioned in paper bags and maintained under different storage temperatures (5, 10, 20 and 30 °c). the seed viability was evaluated just after drying and every 10 days, during 60 days, applying the standard germination test. in general, for the majority of the tests, the temperature and the moisture content affected the seed germination during the storage period. however, for the storage temperatures of 5 and 10 °c the seeds maintained the viability at satisfactory levels, independently of the moisture content of the product. the experimental results of germination were evaluated by adjusting the data to the exponential and probit mathematical models. the results obtained in this work lead to the conclusion that the temperature and the moisture content of the stored soybean seeds affect their germination and that the exponential model better fits the experimental data.
Characterization and Evaluation of Bond Strength of Dental Polymer Systems Modified with Hydroxyapatite Nanoparticles  [PDF]
Vitor César Dumont, Rafael Menezes Silva, Luiz Edmundo Almeida-Júnior, Juan Pedro Bretas Roa, Adriana Maria Botelho, Maria Helena Santos
Journal of Materials Science and Chemical Engineering (MSCE) , 2013, DOI: 10.4236/msce.2013.17003
Abstract: The study modifies an adhesive system with hydroxyapatite nanoparticles as load, characterizing it and evaluate the effectiveness of its bond to dental structure. The middle thirds of healthy premolar tooth crowns were obtained, and each crown was sectioned vertically, resulting in two sections. The sections were divided into ten groups (n = 15), in which resin composite restorations were simulated: (G1E and G1D) conventional adhesive system (SAC); (G2E and G2D) SAC modified with HAP; (G3E and G3D) Primer modified with HAP; (G4E and G4D) monocomponent adhesive system; (G5E and G5D) self-etching adhesive system. The specimens were submitted to the microshear test and characterization technique. There was statistically significant difference (Kruskal-Wallis) between the groups (p < 0.01). G3 presented the highest bond strength to enamel (64.40 MPa, ±7.36) and dentin (39.59 MPa, ±21.46). The majority of specimens were found adhesive fractures. Bond strength to enamel and dentin of the primer modified with HAP of SAC showed higher values.
PREVAL NCIA DE SOBREPESO EM UM GRUPO DE IDOSOS DE ARARAQUARA-SP
RITA DE C??SSIA PEREIRA SILVA,RODOLPHO TELAROLLI J??NIOR,THAIS BORGES C?‰SAR
Alimentos e Nutri??o , 2009,
Abstract: O perfil alimentar e antropom trico de 61 idosos foi avaliado neste estudo visando obter um diagn 3stico da adequa § £o nutricional de um grupo de idosos, homens e mulheres, com idade m dia de 71 ±7 anos. O perfil s 3cio-econ ′mico mostrou predomin ¢ncia de baixa renda associada com escolaridade prec ria. Os inqu ritos alimentares mostraram que as mulheres apresentavam uma ingest £o alimentar reduzida em gl -cides (233,7 ± 63,4g/d) e elevada em l -pides (69,0 ±14,3g/d), prote -nas (78,8 ±16,3g/d) e energia (8,48 ±1,39MJ/d). Os homens apresentaram ingest £o elevada de prote -nas (92,1 ±13,9g/d) e l -pides (76,7 ±11,6g/d) e adequada em gl -cides (242,6 ±79,9 g/d) e energia (8,4 ±1,4MJ/d). Os resultados obtidos indicaram ingest £o desbalanceada de macronutrientes na dieta dos idosos e de energia na dieta das mulheres. PALAVRAS-CHAVE: Idosos; ingest £o alimentar; perfil nutricional; adequa § £o nutricional.
Fístula arteriovenosa coronário- pulmonar: tratamento cirúrgico
CéSAR Cláudio Albernaz,ARAKAKI Nilo,BARBOSA Carlos Idelmar C.,FERREIRA JúNIOR Wilson
Revista Brasileira de Cirurgia Cardiovascular , 1997,
Abstract: Fístulas arteriovenosas coronárias pertencem a um grupo de les es cardíacas de difícil diagnóstico, por n o apresentarem sintomas; quando suspeitadas de ocasionar o quadro clínico de um paciente, ou descobertas em exame de rotina, devem ser pesquisadas para o tratamento adequado. é relatado o caso de homem de 65 anos de idade, com história de precordialgia súbita, evoluindo para IAM de parede inferior, cuja investiga o revelou a presen a de fístulas de artérias coronárias direita e esquerda para tronco pulmonar. Após tratamento clínico seguido da opera o, demonstrou resultados satisfatórios.
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