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Search Results: 1 - 10 of 26097 matches for " Byung Yong Ahn "
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Statistical Optimization of Ultraviolet Irradiate Conditions for Vitamin D2 Synthesis in Oyster Mushrooms (Pleurotus ostreatus) Using Response Surface Methodology
Wei-Jie Wu, Byung-Yong Ahn
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0095359
Abstract: Response surface methodology (RSM) was used to determine the optimum vitamin D2 synthesis conditions in oyster mushrooms (Pleurotus ostreatus). Ultraviolet B (UV-B) was selected as the most efficient irradiation source for the preliminary experiment, in addition to the levels of three independent variables, which included ambient temperature (25–45°C), exposure time (40–120 min), and irradiation intensity (0.6–1.2 W/m2). The statistical analysis indicated that, for the range which was studied, irradiation intensity was the most critical factor that affected vitamin D2 synthesis in oyster mushrooms. Under optimal conditions (ambient temperature of 28.16°C, UV-B intensity of 1.14 W/m2, and exposure time of 94.28 min), the experimental vitamin D2 content of 239.67 μg/g (dry weight) was in very good agreement with the predicted value of 245.49 μg/g, which verified the practicability of this strategy. Compared to fresh mushrooms, the lyophilized mushroom powder can synthesize remarkably higher level of vitamin D2 (498.10 μg/g) within much shorter UV-B exposure time (10 min), and thus should receive attention from the food processing industry.
The Consumption of Low Animal Food with Low n-6/n-3 Ratio Reduce LDL Cholesterol in Humans
Park Byung-Sung,Ryu Chae-Min,Ahn Yong-Sik,Park Sang-Oh
Research Journal of Medical Sciences , 2012, DOI: 10.3923/rjmsci.2012.107.112
Abstract: The purpose of this study was to examine the effect on lowering LDL-C in a adult human by applying low animal foods with a lower n-6/n-3 ratio. It was found that the n-6/n-3 ratio was significantly lowered in the low Hanwoo beef, the low pork, the low chicken, the low egg and the low milk to 4:1 or below, compared with commercial animal foods (p<0.05). Oleic acid was significantly increased in the low Hanwoo beef, the low chicken, the low egg and the low milk by 11.49, 8.16, 11.25, 2.69 and 24.12%, respectively, compared with commercial animal foods (p<0.05). Compared with the common Hanwoo beef and the low Hanwoo beef, the imported beef showed that the n-6/n-3 ratio was higher by 8.70 and 15.46 times, respectively while oleic acid was significantly decreased by 5.61 and 17.75%, respectively (p<0.05). When commercial animal foods were taken, the blood LDL-C level related with an increase or a decrease of cholesterol was not changed only in the common egg but it was significantly increased in the imported beef, the common Hanwoo beef, the common pork, the common chicken and the common milk by 27,02, 7.85, 25.81, 5.77 and 8.97%, respectively (p<0.05). When low animal foods with lower n-6/n-3 ratio were taken, it was significantly decreased in the low Hanwoo beef, the low pork, the low chicken and the low milk by 22.05, 22.89, 27.55, 12.38 and 14.78%, respectively compared with the imported beef and commercial animal foods (p<0.05).
Income-related health inequalities across regions in Korea
Eunju Hong, Byung Ahn
International Journal for Equity in Health , 2011, DOI: 10.1186/1475-9276-10-41
Abstract: We considered a total of 45,233 subjects (≥ 19 years) drawn from the four waves of the Korean National Health and Nutrition Examination Survey (KNHANES). We considered true health as a latent variable following a lognormal distribution. We obtained ill-health scores by matching self-rated health (SRH) to its distribution and used the Gini Coefficient (GC) and an income-related ill-health Concentration Index (CI) to examine inequalities in income and health, respectively.The GC estimates were 0.3763 and 0.0657 for overall and spatial inequalities, respectively. The overall CI was -0.1309, and the spatial CI was -0.0473. The spatial GC and CI estimates were smaller than their counterparts, indicating substantial inequalities in income (from 0.3199 in Daejeon to 0.4233 Chungnam) and income-related health inequalities (from -0.1596 in Jeju and -0.0844 in Ulsan) within regions.The results indicate a positive relationship between the GC and the average ill-health and a negative relationship between the CI and the average ill-health. Those regions with a low level of health tended to show an unequal distribution of income and health. In addition, there was a negative relationship between the GC and the CI, that is, the larger the income inequalities, the larger the health inequalities were. The GC was negatively related to the average regional income, indicating that an increase in a region's average income reduced income inequalities in the region. On the other hand, the CI showed a positive relationship, indicating that an increase in a region's average income reduced health inequalities in the region.The results suggest that reducing health inequalities across regions require a more equitable distribution of income and a higher level of average income and that the higher the region's average income, the smaller its health inequalities are.Socioeconomic inequalities have represented one of the most controversial issues in Korea, mainly because Korea has achieved consider
The role of adjuvant pelvic radiotherapy in rectal cancer with synchronous liver metastasis: a retrospective study
Jun Kim, Yong Kim, Nam-Kyu Kim, Byung-Soh Min, Sang Shin, Joong Ahn, Woong Koom, Jinsil Seong, Ki Keum
Radiation Oncology , 2010, DOI: 10.1186/1748-717x-5-75
Abstract: Among rectal cancer patients who received total mesorectal excision (TME) between 1997 and 2006 at Yonsei University Health System, eighty-nine patients diagnosed with synchronous liver metastasis were reviewed. Twenty-seven patients received adjuvant pelvic RT (group S + R), and sixty-two patients were managed without RT (group S). Thirty-six patients (58%) in group S and twenty patients (74%) in group S+R received local treatment for liver metastasis. Failure patterns and survival outcomes were analyzed.Pelvic failure was observed in twenty-five patients; twenty-one patients in group S (34%), and four patients in group S+R (15%) (p = 0.066). The two-year pelvic failure-free survival rates (PFFS) of group S and group S+R were 64.8% and 80.8% (p = 0.028), respectively, and the two-year overall survival rates (OS) were 49.1% and 70.4% (p = 0.116), respectively. In a subgroup analysis of fifty-six patients who received local treatment for liver metastasis, the two-year PFFS were 64.9% and 82.9% (p = 0.05), respectively; the two-year OS were 74.1% and 80.0% (p = 0.616) in group S (n = 36) and group S+R (n = 20), respectively.Adjuvant pelvic RT significantly reduced the pelvic failure rate but its influence on overall survival was unclear. Rectal cancer patients with synchronous liver metastasis may benefit from adjuvant pelvic RT through an increased pelvic control rate and improved quality of life.According to the data on cancer incidence between 2003 and 2005 from the Korea Central Cancer Registry, colorectal cancer (CRC) is the fourth most common cancer in men (37.9%) after cancers of the stomach (66.0%), lung (48.5%), and liver (44.9%). According to the same data set, colorectal cancer is the fourth most common cancer in Korean women (28.0%) after breast (37.3%), thyroid (36.2%), and stomach (34.1%) cancers. When the annual incidence of CRCs in 2005 was compared to that in 1999, there was an increase of 150% in men and 135% in women; CRC was shown to be one of the
Therapeutic Effects of Atobeauty Cream in Atopic Dermatitis Model Mice Induced with DNCB
Park Byung-Sung,Park Sang-Oh,Ahn Yong-Sik,Ryu Chae-Min,Noh Ho-Yeol,Noh Ga-Yeong
Research Journal of Medical Sciences , 2012, DOI: 10.3923/rjmsci.2012.71.76
Abstract: This study has been performed to assess the anti-atopic efficiency in DNCB induced BALB/c to examine a therapeutic effect of Atobeauty cream which was provided by NJY Life Science Co., Ltd. on atopic dermatitis. Such BALB/c mice were provided by NJY Life Science Co., Ltd. The randomized complete block design was done by dividing 20 male mice with BALB/c into two groups of which the one group had 10 mice receiving no treatment as a control group and the other group had 10 mice receiving treatment with Atobeauty cream as a treatment group. When Atobeauty cream was applied to the mouse with severe atopic dermatitis 2 times a day for 6 days, it could be observed that its skin recovered to normal condition with the skin surface being clean and smooth without any horny tissue. It was found that each level of IgE and histamine in blood was significantly decreased by 57.80 and 59.41%, respectively in the Atobeauty cream treatment group (here in after, the treatment group), compared with the DNCB induced atopy control group (here in after, the control group (p<0.05). It was also identified that a mouse with atopic dermatitis to which Atobeauty cream was applied, recovered on the order of a normal mouse as its epidermis got to be softly formed with its surface thickness being even and its connective tissue got to be formed more uniformly.
Atrophic Gastritis: A Related Factor for Osteoporosis in Elderly Women
Hye Won Kim, Yang-Hyun Kim, Kyungdo Han, Ga Eun Nam, Gwang Seon Kim, Byoung-Duck Han, Anna Lee, Ji Yong Ahn, Byung Joon Ko
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0101852
Abstract: Purpose Osteoporosis poses a great threat to the aging society. Hypochlorhydric or achlorhydric conditions are risk factors for osteoporosis. Atrophic gastritis also decreases gastric acid production; however, the role of atrophic gastritis as a related factor for osteoporosis is unclear. We investigated the relationship between atrophic gastritis and osteoporosis in postmenopausal women over 60 years of age. Subjects and Methods A total of 401 postmenopausal women were included in this cross-sectional study, which was conducted during their medical check-ups. Bone mineral densitometry was measured using a dual energy X-ray absorptiometry. Atrophic gastritis was defined endoscopically if gastric mucosa in the antrum and the body were found to be atrophied and thinned and submucosal vessels could be well visualized. Results The proportion of people with atrophic gastritis was higher in the osteoporotic group than in the group without osteoporosis. A linear relationship was observed in the proportion of atrophic gastritis according to the categories of normal, osteopenia, and osteoporosis at the lumbar spine (p for trend = 0.039) and femur (p for trend = 0.001). A multiple logistic regression analysis revealed that the presence of atrophic gastritis was associated with an increased odds of osteoporosis after adjusting for age, body mass index, triglyceride, high-density lipoprotein cholesterol, alcohol consumption, and smoking status (odds ratio 1.89, 95% confidence interval 1.15–3.11). Conclusions Atrophic gastritis is associated with an increased likelihood of osteoporosis in Korean elderly women.
The effects of EMLA cream on pain responses of preschoolers  [PDF]
Se Na Ahn, Joohyun Lee, Hae Won Kim, Sook Bin Im, Byung Sun Cho, Hye Young Ahn
Open Journal of Nursing (OJN) , 2013, DOI: 10.4236/ojn.2013.38A001
Abstract:

The aim of present study was to assess the effects of a eutectic mixture of topical anesthetics (EMLA cream) on pain responses of preschoolers during venipuncture. The pain responses were reported by children, nurses, and the children’s mothers. The pre- and post-test-designed study, which included a non-equivalent control group, was carried out in a pediatric unit at E University Hospital in South Korea. Pain responses during venipuncture were measured by the self-reporting of the children using the Face Pain Rating Scale (FPRS), the Procedure Behavior Checklist by nurses (PBCL), the Visual Analog Scale (VAS) by mothers, in addition to measurements of the children’s pulse rate and level of oxygen saturation. EMLA cream was effective in decreasing the pain responses of the children as assessed by FPRS, PBCL, and VAS scores. However, pulse rate and level of oxygen saturation of the children during venipuncture were not significantly different between the two groups. EMLA cream could be a useful option for reducing pain in preschool children during invasive procedures.

Effect of a Dipeptidyl Peptidase-IV Inhibitor, Des-Fluoro-Sitagliptin, on Neointimal Formation after Balloon Injury in Rats
Soo Lim, Sung Hee Choi, Hayley Shin, Bong Jun Cho, Ho Seon Park, Byung Yong Ahn, Seon Mee Kang, Ji Won Yoon, Hak Chul Jang, Young-Bum Kim, Kyong Soo Park
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0035007
Abstract: Background Recently, it has been suggested that enhancement of incretin effect improves cardiac function. We investigated the effect of a DPP-IV inhibitor, des-fluoro-sitagliptin, in reducing occurrence of restenosis in carotid artery in response to balloon injury and the related mechanisms. Methods and Findings Otsuka Long-Evans Tokushima Fatty rats were grouped into four: control (normal saline) and sitagliptin 100, 250 and 500 mg/kg per day (n = 10 per group). Sitagliptin or normal saline were given orally from 1 week before to 2 weeks after carotid injury. After 3 weeks of treatment, sitagliptin treatment caused a significant and dose-dependent reduction in intima-media ratio (IMR) in obese diabetic rats. This effect was accompanied by improved glucose homeostasis, decreased circulating levels of high-sensitivity C-reactive protein (hsCRP) and increased adiponectin level. Moreover, decreased IMR was correlated significantly with reduced hsCRP, tumor necrosis factor-α and monocyte chemoattractant protein-1 levels and plasminogen activator inhibitor-1 activity. In vitro evidence with vascular smooth muscle cells (VSMCs) demonstrated that proliferation and migration were decreased significantly after sitagliptin treatment. In addition, sitagliptin increased caspase-3 activity and decreased monocyte adhesion and NFκB activation in VSMCs. Conclusions Sitagliptin has protective properties against restenosis after carotid injury and therapeutic implications for treating macrovascular complications of diabetes.
Simple, Rapid and Cost-Effective Method for High Quality Nucleic Acids Extraction from Different Strains of Botryococcus braunii
Byung-Hyuk Kim, Rishiram Ramanan, Dae-Hyun Cho, Gang-Guk Choi, Hyun-Joon La, Chi-Yong Ahn, Hee-Mock Oh, Hee-Sik Kim
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0037770
Abstract: This study deals with an effective nucleic acids extraction method from various strains of Botryococcus braunii which possesses an extensive extracellular matrix. A method combining freeze/thaw and bead-beating with heterogeneous diameter of silica/zirconia beads was optimized to isolate DNA and RNA from microalgae, especially from B. braunii. Eukaryotic Microalgal Nucleic Acids Extraction (EMNE) method developed in this study showed at least 300 times higher DNA yield in all strains of B. braunii with high integrity and 50 times reduced working volume compared to commercially available DNA extraction kits. High quality RNA was also extracted using this method and more than two times the yield compared to existing methods. Real-time experiments confirmed the quality and quantity of the input DNA and RNA extracted using EMNE method. The method was also applied to other eukaryotic microalgae, such as diatoms, Chlamydomonas sp., Chlorella sp., and Scenedesmus sp. resulting in higher efficiencies. Cost-effectiveness analysis of DNA extraction by various methods revealed that EMNE method was superior to commercial kits and other reported methods by >15%. This method would immensely contribute to area of microalgal genomics.
Comparative analysis of pepper and tomato reveals euchromatin expansion of pepper genome caused by differential accumulation of Ty3/Gypsy-like elements
Minkyu Park, SungHwan Jo, Jin-Kyung Kwon, Jongsun Park, Jong Hwa Ahn, Seungill Kim, Yong-Hwan Lee, Tae-Jin Yang, Cheol-Goo Hur, Byoung-Cheorl Kang, Byung-Dong Kim, Doil Choi
BMC Genomics , 2011, DOI: 10.1186/1471-2164-12-85
Abstract: For sequence-level analysis, we generated 35.6 Mb of pepper genomic sequences from euchromatin enriched 1,245 pepper BAC clones. The comparative analysis of orthologous gene-rich regions between both species revealed insertion of transposons exclusively in the pepper sequences, maintaining the gene order and content. The most common type of the transposon found was the LTR retrotransposon. Phylogenetic comparison of the LTR retrotransposons revealed that two groups of Ty3/Gypsy-like elements (Tat and Athila) were overly accumulated in the pepper genome. The FISH analysis of the pepper Tat elements showed a random distribution in heterochromatic and euchromatic regions, whereas the tomato Tat elements showed heterochromatin-preferential accumulation.Compared to tomato pepper euchromatin doubled its size by differential accumulation of a specific group of Ty3/Gypsy-like elements. Our results could provide an insight on the mechanism of genome evolution in the Solanaceae family.The Solanaceae is an unusually divergent family consisting of approximately 90 genera and 3,000-4,000 species [1]. Members of the Solanaceae have evolved into extremely divergent forms, ranging from trees to annual herbs, and they occupy diverse habitats ranging from deserts to aquatic areas [1]. Such hyper-diversity in one family makes it useful to study plant adaptation and diversification. Despite this diversity, all Solanaceous species evolved during the last 40 million years [2]. Furthermore, almost all members share the same chromosome number (x = 12) [2].To date, diversity within the Solanaceae has been studied by comparative genome analyses using common genetic markers. As a result, we know that the Solanaceae genomes have undergone relatively small numbers of chromosomal rearrangements (e.g., about 5 rearrangements between potato and tomato and about 30 rearrangements between pepper and tomato), maintaining well-conserved gene content and order [3-8]. The conservation of the Solanaceae
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