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Search Results: 1 - 10 of 21677 matches for " Byung Il Kim "
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Comparative Study of Imaging Characteristics of I-125 Imaging Using the Siemens Inveon Scanner and Siemens Symbia TruePoint  [PDF]
Young Jun Kim, Ilhan Lim, A Ram Yu, Byung Il Kim, Chang Woon Choi, Sang Moo Lim, Jin Su Kim
Journal of Biomedical Science and Engineering (JBiSE) , 2015, DOI: 10.4236/jbise.2015.810064
Abstract: Objective: Although Iodine-125 (125I) has been widely used for in vitro studies because of its relatively long half-life (60.1 days), 125I imaging is limited because of its low energy (27 - 35 keV), even in an animal-dedicated system. In this study, imaging characteristics of 125I were assessed using a small animal-dedicated imaging system and clinical scanner. Methods: Using the Siemens Inveon and Siemens Symbia TruePoint systems, imaging characteristics such as resolution, sensitivity, and image quality were compared. Mouse high resolution (MHR-0.5), mouse general purpose (MGP-1.0), and mouse high sensitivity (MHS-2.0) collimators were used for the Inveon scanner, and low energy high-resolution (LEHR) and low energy all-purpose (LEAP) collimators were used for the Symbia TruePoint. For animal imaging, 16.8 MBq of 125I was administered to BALB/c mice intravenously, and the planar image and single-photon emission computed tomography (SPECT) were obtained using both scanners. Results: The resolution of 125I for the Inveon scanner was 3.98 mm full width at half maximum (FWHM) at a 30-mm distance with the MHR-0.5 collimator, and the value of Symbia scanner was 8.72 mm FWHM at a 30-mm distance with the LEHR collimator. The sensitivity of 125I for the Inveon scanner was 21.87 cps/MBq, and the value for the clinical scanner was 30.55 cps/MBq. The planar images of mice were successfully obtained at the level of evaluating specific binding in both scanners. Conclusion: 125I small animal imaging can be achieved with a clinical scanner. This result may enhance the utilization of 125I small animal imaging using a clinical scanner.
A DO- and pH-Based Early Warning System of Nitrification Inhibition for Biological Nitrogen Removal Processes
Seil Hong,Il Choi,Byung Jin Lim,Hyunook Kim
Sensors , 2012, DOI: 10.3390/s121216334
Abstract: In Korea, more than 80% of municipal wastewater treatment plants (WWTPs) with capacities of 500 m3·d?1 or more are capable of removing nitrogen from wastewater through biological nitrification and denitrification processes. Normally, these biological processes show excellent performance, but if a toxic chemical is present in the influent to a WWTP, the biological processes (especially, the nitrification process) may be affected and fail to function normally; nitrifying bacteria are known very vulnerable to toxic substances. Then, the toxic compound as well as the nitrogen in wastewater may be discharged into a receiving water body without any proper treatment. Moreover, it may take significant time for the process to return back its normal state. In this study, a DO- and pH-based strategy to identify potential nitrification inhibition was developed to detect early the inflow of toxic compounds to a biological nitrogen removal process. This strategy utilizes significant changes observed in the oxygen uptake rate and the pH profiles of the mixed liquor when the activity of nitrifying bacteria is inhibited. Using the strategy, the toxicity from test wastewater with 2.5 mg·L?1 Hg2+, 0.5 mg·L?1 allythiourea, or 0.25 mg·L?1 chloroform could be successfully detected.
Kaons in Dense Half-Skyrmion Matter
Byung-Yoon Park,Joon-Il Kim,Mannque Rho
Physics , 2009, DOI: 10.1103/PhysRevC.81.035203
Abstract: Dense hadronic matter at low temperature is expected to be in crystal and at high density make a transition to a {\em chirally restored but color-confined} state which is a novel phase hitherto unexplored. This phase transition is predicted in both skyrmion matter in 4D and instanton matter in 5D, the former in the form of half-skyrmions and the latter in the form of half-instantons or dyons. We predict that when $K^-$'s are embedded in this half-skyrmion or half-instanton (dyonic) matter which may be reached not far above the normal density, there arises an enhanced attraction from the soft dilaton field figuring for the trace anomaly of QCD and the Wess-Zumino term. This attraction may have relevance for a possible strong binding of anti-kaons in dense nuclear matter and for kaon condensation in neutron-star matter. Such kaon property in the half-skyrmion phase is highly non-perturbarive and may not be accessible by low-order chiral perturbation theory. Relevance of the half-skyrmion or dyonic matter to compact stars is discussed.
Should anticoagulants be administered for portal vein thrombosis associated with acute pancreatitis?
Won-Seok Park,Hyeong-Il Kim,Byung-Jun Jeon,Seong-Hun Kim
World Journal of Gastroenterology , 2012, DOI: 10.3748/wjg.v18.i42.6168
Abstract: Venous complications in patients with acute pancreatitis typically occur as a form of splenic, portal, or superior mesenteric vein thrombosis and have been detected more frequently in recent reports. Although a well-organized protocol for the treatment of venous thrombosis has not been established, anticoagulation therapy is commonly recommended. A 73-year-old man was diagnosed with acute progressive portal vein thrombosis associated with acute pancreatitis. After one month of anticoagulation therapy, the patient developed severe hematemesis. With endoscopy and an abdominal computed tomography scan, hemorrhages in the pancreatic pseudocyst, which was ruptured into the duodenal bulb, were confirmed. After conservative treatment, the patient was stabilized. While the rupture of a pseudocyst into the surrounding viscera is a well-known phenomenon, spontaneous rupture into the duodenum is rare. Moreover, no reports of upper gastrointestinal bleeding caused by pseudocyst rupture in patients under anticoagulation therapy for venous thrombosis associated with acute pancreatitis have been published. Herein, we report a unique case of massive upper gastrointestinal bleeding due to pancreatic pseudocyst rupture into the duodenum, which developed during anticoagulation therapy for portal vein thrombosis associated with acute pancreatitis.
Surgical palliation of unresectable pancreatic head cancer in elderly patients
Sang Il Hwang, Hyung Ook Kim, Byung Ho Son, Chang Hak Yoo, Hungdai Kim, Jun Ho Shin
World Journal of Gastroenterology , 2009,
Abstract: AIM: To determine if surgical biliary bypass would provide improved quality of residual life and safe palliation in elderly patients with unresectable pancreatic head cancer.METHODS: Nineteen patients, 65 years of age or older, were managed with surgical biliary bypass (Group A). These patients were compared with 19 patients under 65 years of age who were managed with surgical biliary bypass (Group B). In addition, the results for group A were compared with those obtained from 17 patients, 65 years of age or older (Group C), who received percutaneous transhepatic biliary drainage to evaluate the quality of residual life.RESULTS: Five patients (26.0%) in Group A had complications, including one intraabdominal abscess, one pulmonary atelectasis, and three wound infections. One death (5.3%) occurred on postoperative day 3. With respect to morbidity, mortality, and postoperative hospitalization, no statistically significant difference was noted between Groups A and B. The number of readmissions and the rate of recurrent jaundice were lower in Group A than in Group C, to a statistically significant degree (P = 0.019, P = 0.029, respectively). The median hospital-free survival period and the median overall survival were also significantly longer in Group A (P = 0.001 and P < 0.001, respectively).CONCLUSION: Surgical palliation does not increase the morbidity or mortality rates, but it does increase the survival rate and improve the quality of life in elderly patients with unresectable pancreatic head cancer.
15-deoxy-Δ12,14-prostaglandin J2 Down-Regulates Activin-Induced Activin Receptor, Smad, and Cytokines Expression via Suppression of NF-κB and MAPK Signaling in HepG2 Cells
Seung-Won Park,Chunghee Cho,Byung-Nam Cho,Youngchul Kim,Tae Won Goo,Young Il Kim
PPAR Research , 2013, DOI: 10.1155/2013/751261
Abstract: 15-Deoxy- -prostaglandin J2 (15d-PGJ2) and activin are implicated in the control of apoptosis, cell proliferation, and inflammation in cells. We examined both the mechanism by which 15d-PGJ2 regulates the transcription of activin-induced activin receptors (ActR) and Smads in HepG2 cells and the involvement of the nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) pathways in this regulation. Activin A (25?ng/mL) inhibited HepG2 cell proliferation, whereas 15d-PGJ2 (2?μM and 5?μM) had no effect. Activin A and 15d-PGJ2 showed different regulatory effects on ActR and Smad expression, NF-κB p65 activity and MEK/ERK phosphorylation, whereas they both decreased IL-6 production and increased IL-8 production. When co-stimulated with 15d-PGJ2 and activin, 15d-PGJ2 inhibited the activin-induced increases in ActR and Smad expression, and decreased activin-induced IL-6 production. However, it increased activin-induced IL-8 production. In addition, 15d-PGJ2 inhibited activin-induced NF-κB p65 activity and activin-induced MEK/ERK phosphorylation. These results suggest that 15d-PGJ2 suppresses activin-induced ActR and Smad expression, down-regulates IL-6 production, and up-regulates IL-8 production via suppression of NF-κB and MAPK signaling pathway in HepG2 cells. Regulation of ActR and Smad transcript expression and cytokine production involves NF-κB and the MAPK pathway via interaction with 15d-PGJ2/activin/Smad signaling. 1. Introduction Activins are either heterodimers or homodimers of inhibin β subunits (βAβA, βBβB, or βAβB) [1]. The biological activities of activins are mediated by receptor complexes that consist of 2 different activin serine/threonine kinase receptors (ActR), type I (ActR I) and type II (ActR II) [2]. Smad2 and Smad3 proteins are phosphorylated by specific activated type I serine/threonine kinase receptors. Formation of dimeric complexes leads to phosphorylation of Smad2 and Smad3, subsequent complex formation with Smad4, and regulation of activin-responsive genes [3, 4]. Smad7 functions as an inhibitor of transforming growth factor-β (TGF-β) family signaling, including activin signaling [5, 6]. Activin-responsive genes have been implicated in the control of homeostasis, development, proliferation, apoptosis, differentiation, and inflammation in diverse cellular systems [2]. 15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) is a derivative of prostaglandin D2 and is a natural ligand of peroxisome proliferator-activated receptor-gamma (PPARγ), which is a transcriptional nuclear receptor [7, 8]. 15d-PGJ2 has a broad spectrum of
Visfatin Induces Sickness Responses in the Brain
Byong Seo Park,Sung Ho Jin,Joong Jean Park,Jeong Woo Park,Il Seong Namgoong,Young Il Kim,Byung Ju Lee,Jae Geun Kim
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0015981
Abstract: Visfatin, also known as nicotiamide phosphoribosyltransferase or pre-B cell colony enhancing factor, is a pro-inflammatory cytokine whose serum level is increased in sepsis and cancer as well as in obesity. Here we report a pro-inflammatory role of visfatin in the brain, to mediate sickness responses including anorexia, hyperthermia and hypoactivity.
Metabolic syndrome is associated with erosive esophagitis
Jung Ho Park, Dong IL Park, Hong Joo Kim, Yong Kyun Cho, Chong IL Sohn, Woo Kyu Jeon, Byung Ik Kim
World Journal of Gastroenterology , 2008,
Abstract: AIM: To clarify whether insulin resistance and metabolic syndrome are risk factors for erosive esophagitis.METHODS: A case-control study was performed using the database of the Kangbuk Samsung Hospital Medical Screening Center.RESULTS: A total of 1679 cases of erosive esophagitis and 3358 randomly selected controls were included. Metabolic syndrome was diagnosed in 21% of the cases and 12% of the controls (P < 0.001). Multiple logistic regressions confirmed the association between erosive esophagitis and metabolic syndrome (Odds ratio, 1.25; 95% CI, 1.04-1.49). Among the components of metabolic syndrome, increased waist circumference, elevated serum triglyceride levels and hypertension were significant risk factors for erosive esophagitis (all P < 0.01). Furthermore, increased insulin resistance (Odds ratio, 0.91; 95% CI, 0.85-0.98) and fatty liver, as diagnosed by ultrasonography (Odds ratio, 1.39; 95% CI, 1.20-1.60), were also related to erosive esophagitis even after adjustment for a series of confounding factors.CONCLUSION: Metabolic syndrome and increased insulin resistance are associated with an increased risk of developing erosive esophagitis.
Topological Structure of Dense Hadronic Matter
Byung-Yoon Park,Hee-Jung Lee,Vicente Vento,Joon-Il Kim,Dong-Pil Min,Mannque Rho
Physics , 2004,
Abstract: We present a summary of work done on dense hadronic matter, based on the Skyrme model, which provides a unified approach to high density, valid in the large $N_c$ limit. In our picture, dense hadronic matter is described by the {\em classical} soliton configuration with minimum energy for the given baryon number density. By incorporating the meson fluctuations on such ground state we obtain an effective Lagrangian for meson dynamics in a dense medium. Our starting point has been the Skyrme model defined in terms of pions, thereafter we have extended and improved the model by incorporating other degrees of freedom such as dilaton, kaons and vector mesons.
Unified Approach to Dense Matter
Byung-Yoon Park,Hee-Jung Lee,Vicente Vento,Joon-Il Kim,Dong-Pil Min,Mannque Rho
Physics , 2004, DOI: 10.1016/j.nuclphysbps.2004.12.040
Abstract: We apply the Skyrme model to dense hadronic matter, which provides a unified approach to high density, valid in the large Nc limit. In our picture, dense hadronic matter is described by the classical soliton configuration with minimum energy for the given baryon number density. By incorporating the meson fluctuations on such ground state we obtain an effective Lagrangian for meson dynamics in a dense medium. Our starting point has been the Skyrme model defined in terms of pions, thereafter we have extended and improved the model by incorporating other degrees of freedom such as dilaton, kaons and vector mesons.
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