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Search Results: 1 - 10 of 30493 matches for " Byung Ho Lee "
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Polymyxin B Alleviates Angiotensin II-Induced Stress Fiber Formation and Cellular Hypertrophy  [PDF]
Kwang-Seok Oh, Jeong Hyun Lee, Byung Koo Oh, Jihye Mun, Byung Kil Park, Byung Ho Lee
Pharmacology & Pharmacy (PP) , 2014, DOI: 10.4236/pp.2014.59101

Polymyxin B is widely used antibiotic in the clinic for resistant Gram-negative infections. In addition, polymyxin B-immobilized hemoperfusion cartridge has been used for endotoxin removal therapy in patients with septic shock. The aim of this study was to investigate the anti-fibrotic and anti-cellular hypertrophic effects of polymyxin B, and further to explore its possible mechanism. Polymyxin B (3, 10 μM) significantly inhibited stress fiber formation induced by angiotensin II (Ang II) in rat heart-derived H9c2 cells. Furthermore, polymyxin B (1 - 10 μM) showed a potent inhibitory effect on Ang II-induced cellular hypertrophy in H9c2 cells. Under the mechanism study, the inhibitory activities of polymyxin B against kinases involved in cellular hypertrophy such as AKT1, CAMK, GRK5, GSK3β, MLCK, PKC, PKD2, AMPK, ROCK2, p70S6K, SGK1were evaluated. Polymyxin B possesses a potent G protein related kinase 5 (GKR5) inhibitory activity with IC50 value of 1.1 μM, and has an ATP non-competitive inhibitory mode. Taken together, these results indicate that polymyxin B alleviates Ang II-induced stress fiber formation and cellular hypertrophy, and propose that one mechanism underlying these effects involves inhibition of the GRK5 pathway.

1-Chloromethyl-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-sulfonic acid amide, a derivative of tetrahydroisoquinoline, induces granulocytic differentiation of the human leukemic HL-60 cells via G0/G1 phase arrest  [PDF]
Sung-Min Ju, Hyun-Ock Pae, Won-Sin Kim, Chai-Ho Lee, Byung-Hun Jeon
Health (Health) , 2013, DOI: 10.4236/health.2013.55A001

Tetrahydroisoquinolines are known to have various biological effects, including antitumor activity. This study investigated the effect of 1-chloromethyl-6, 7-dimethoxy-3, 4-dihydro-1H-isoquinoline-2-sulfonic acid amide (CDST), a newly synthesized anticancer agent, on cellular differentiation and proliferation in HL-60 cells. Differentiation and proliferation of HL-60 cells were determined through expression of CD11b and CD14 surface antigens using flow cytometry and nitroblue tetrazolium (NBT) assay, and through analysis of cell cycle using propidium iodide staining, western blot analysis and immunoprecipitation, respectively. CDST induced the differentiation of HL-60, as shown by increased expression of differentiation surface antigen CD11b (but no significant change in CD14 expression) and increased NBT-reducing functional activity. DNA flow cytometry analysis indicated that CDST markedly induced a G0/G1 phase arrest of HL-60 cells. Subsequently, we examined the expre-ssion of G0/G1 phase cell cycle-related proteins, including cyclin-dependent kinases (CDKs), cyclins and cyclin dependent kinase inhibitors (CKIs), during the differentiation of HL-60. The levels of CDK2, CDK6, cyclin E and cyclin A were decreased, whereas steady-state levels of CDK4 and cyclin D1 were unaffected. The expression of the p27Kip1 was markedly increased by CDST, but not p21WAF1/Cip1. Moreover, CDST markedly enhanced the binding of p27Kip1 with CDK2 and CDK6, resulting in the reduced activity of

Distribution of LGR5+ Cells and Associated Implications during the Early Stage of Gastric Tumorigenesis
Bo Gun Jang, Byung Lan Lee, Woo Ho Kim
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0082390
Abstract: Lgr5 was identified as a promising gastrointestinal tract stem cell marker in mice. Lineage tracing indicates that Lgr5+ cells may not only be the cells responsible for the origin of tumors; they may also be the so-called cancer stem cells. In the present study, we investigated the presence of Lgr5+ cells and their biological significance in normal human gastric mucosa and gastric tumors. RNAscope, a newly developed RNA in situ hybridization technique, specifically labeled Lgr5+ cells at the basal glands of the gastric antrum. Notably, the number of Lgr5+ cells was remarkably increased in intestinal metaplasia. In total, 76% of gastric adenomas and 43% of early gastric carcinomas were positive for LGR5. Lgr5+ cells were found more frequently in low-grade tumors with active Wnt signaling and an intestinal gland type, suggesting that LGR5 is likely involved in the very early stages of Wnt-driven tumorigenesis in the stomach. Interestingly, similar to stem cells in normal tissues, Lgr5+ cells were often restricted to the base of the tumor glands, and such Lgr5+ restriction was associated with high levels of intestinal stem cell markers such as EPHB2, OLFM4, and ASCL2. Thus, our findings show that Lgr5+ cells are present at the base of the antral glands in the human stomach and that this cell population significantly expands in intestinal metaplasias. Furthermore, Lgr5+ cells are seen in a large number of gastric tumors ; their frequent basal arrangements and coexpression of ISC markers support the idea that Lgr5+ cells act as stem cells during the early stage of intestinal-type gastric tumorigenesis.
Analysis of High-Resolution QTL Markers Associated with Rice Yields Using Data for Two Consecutive Years in Different Environmental Conditions  [PDF]
Ye-Jin Son, Gyu-Ho Lee, Hyun-Suk Lee, Tri Handoyo, Byung-Wook Yun, Kyung-Min Kim
Natural Science (NS) , 2014, DOI: 10.4236/ns.2014.611080

Previously we reported the identification of seven quantitative trait loci (QTLs) associated with the rice yield measuring five parameters including panicles per plant (PPP), spikelets per panicle (SPP), seed set percentage (SSP), 1000-grain weight (TGW) and yield in 2012. Here we report the analysis of QTLs using the same trait parameters data of the mapping population in 2013 for detecting highly conserved QTL markers. A total of 6 QTLs were identified from chromosomes 1, 7, 8, 10, 11, and 12, which were contrasted with our previous results (chromosomes 1, 2, 4, 5, 6, 8, and 11). In this comparison, three QTLs from chromosome 1, 8, and 11 were only found to be associated with the components of yield over two consecutive years indicating high sensitivity of QTL markers to the environment. Of those three QTLs, SPP-associated marker RM12285 was found to be dominantly expressed by real-time PCR (qPCR). In addition, compared to our previous report the numbers of mapping population and markers were significantly increased for higher resolution markers from 70 to 120, and from 143 to 217, respectively. We also found that the parameter SPP was dominantly correlated with the rice yield. Furthermore, the double haploid (DH) population facilitated to analyze the epistatic effects for yield and yield components in rice. Taken together, combining multiple mapping population data over years possibly enables narrowing down to the highly conserved QTL markers against diverse environmental fluctuation caused by such as drought and high temperature. Thus, these data would be critically exploited to improve for the crop breeding strategy.

Characteristics of Mechanical and Electrical Power Transmission for Small-Scaled Wind Turbine  [PDF]
Kyu-Jin Lee, Hyun-Dai Yang, Sung-Hoon Park, Sung-Do Song, Byung-Sun Kim, Joong-Ho Shin
World Journal of Engineering and Technology (WJET) , 2016, DOI: 10.4236/wjet.2016.43D011
Small-scaled wind turbine is converted to mechanical power of windmill to electric power by generator. However almost all studies seems to have overlooked converting relation of mechanical & electric power. It the reason for was very difficult establishing wind turbine system. In this paper, it is define equation of converting relation of mechanical & electric power. And it is verified by experimental methods. Defined equation will be used in developing electric devices such as inverter and controller in wind turbines. In addition this method can be used in the fields that utilize the rotational power into electrical power through generator.
Simple in situ decompression for idiopathic cubital tunnel syndrome using minimal skin incision
Jeon In-Ho,Mici? Ivan,Lee Byung-Woo,Lee Seong-Man
Medicinski Pregled , 2010, DOI: 10.2298/mpns1010601j
Abstract: Cubital tunnel syndrome is one of the most frequently occurring compression neuropathy in the upper limb next to carpal tunnel syndrome. Recent minimal invasive technique has prompted us to gain clinical experience with simple in situ decompression with minimal skin incision for idiopathic cubital tunnel syndrome. Sixty six consecutive patients with cubital tunnel syndrome were treated using minimal skin incision technique. The mean age of the patients was 49.7 (range: 15-77) years and average follow up period was 23.9 months (range: 12-60 months). The severity of ulnar neuropathy was classified according to the McGowan classification: there were 17 in grade I , 47 in grade II and 2 in grade III. A preoperative nerve conduction study was done by inching method, which revealed motor conduction delay around the medial epicondyle. All operations were carried out in a day surgery unit under local anesthetics. The postoperative outcome was evaluated by Messina classification. The mean duration of the operation was 12 minutes. The technique was highly satisfactorily esthetic for all. Over 80% of the patients were completely satisfied with the procedure taking into consideration their symptoms. Postoperative outcome measures and patient satisfactions (pain, return to normal activities and work, scar and pillar tenderness) were comparable with published series of anterior transposition. The overall satisfactory results were recorded 81% in the patients of McGowan stage I and II. There were 2 cases of hematoma as a postoperative complication. This procedure is comparably effective alternative which involves less surgical trauma, morbidity and rehabilitation time with good surgical outcomes especially in mild and moderate degrees. Minimal skin incision is a simple, safe and effective method to treat patients with idiopathic cubital tunnel syndrome.
Shedding new light on the mystery of wetting on soft solids
Su Ji Park,Byung Mook Weon,Ji San Lee,Junho Lee,Jinkyung Kim,Jung Ho Je
Physics , 2013,
Abstract: One of the most questionable issues in wetting is the vertical force balance that is excluded in Young's law. On soft deformable solids, such as biotic materials and synthetic polymers, the vertical force of liquid leads to a microscopic protrusion of the contact line, i.e. a "wetting ridge". The wetting principle that determines the geometry of the ridge-tip is at the heart of the issues over the past half century. Here, we reveal a universal wetting principle by directly visualizing ridge-tips with high spatio-temporal resolution using x-ray microscopy. We find that the tip-geometry is asymmetric and bent, and invariant during ridge growth or by surface softness. This singular geometry is explained by linking the macroscopic and microscopic contact angles to Young's and Neumann's laws, respectively. Our dual-scale model would be applicable to a general framework in wetting and give new clues to various issues in cell-substrate interaction and elasto-capillary problems.
Photocatalytic decomposition of gaseous formaldehyde using , - and Pt-
Byung-Yong Lee,Sung-Wook Kim,Sung-Chul Lee,Hyun-Ho Lee,Suk-Jin Choung
International Journal of Photoenergy , 2003, DOI: 10.1155/s1110662x03000072
Abstract: In this study, in order to improve the photocatalytic decomposition activities of formaldehyde, TiO2 catalyst modified with SiO2 substitution and metal (Pt, Cu and Fe) impregnation, were tested. In case of TiO2 substituted by SiO2, the optimal catalytic activity was found at the mole ration of 2 : 8. Among the metal impregnated TiO2, the Pt impregnated TiO2 showed the best activity even better than that of P-25 which is widely used in commercial application. However, Cu and Fe impregnated TiO2 showed the reverse effect. In the case of SiO2 substituted TiO2 the observed values of photoluminescence spectroscopy were quite proportional to the photocatalytic activities depending upon the mole ratio of SiO2 to TiO2. However, for the samples of metal impregnated TiO2, the reverse relationships were found. In UV-visible spectra for metal impregated TiO2, the transmittance value was reduced depending upon the loading of metals. The enhanced photocatalytic activity for high metal loading on TiO2 might be associated with the high concentration of excited electron that was monitored through UV-visible spectra.
A spectral approach to compute the mean performance measures of the queue with low-order input
Ho Woo Lee,Jong Min Moon,Jong Keun Park,Byung Kyu Kim
International Journal of Stochastic Analysis , 2003, DOI: 10.1155/s1048953303000273
Abstract: This paper targets engineers and practitioners who want a simple procedure to compute the mean performance measures of the Batch Markovian Arrival process (BMAP/G/1) queueing system when the parameter matrices order is very low. We develop a set of system equations and derive the vector generating function of the queue length. Starting from the generating function, we propose a spectral approach that can be understandable to those who have basic knowledge of M/G/1 queues and eigenvalue algebra.
A Model for Predicting the Effect of Increasing Air Temperature on the Net Photosynthetic Rate of Quercus mongolica Stands
Ihm, Byung-Sun,Jeom-Sook Lee,Jong-Wook Kim,Joon-Ho Kim
Journal of Ecology and Field Biology , 2007,
Abstract: A model was developed to predict the effects of rising air temperature on net photosynthetic rateof Quercus mongolica stands at Mt. Paekcheok-san, Kangwon-do in South Korea. The PFD (Photon flux density)and air temperature were determined from weather data from the research site and the Daegwallyeongmeteorological station and gas exchange or release responses of each tree component were measured. Usingthese data, we simulated the effects of increases in mean annual air temperatures above current conditions onannual CO2 budget of Q. mongolica stands. If mean annual air temperature is increased by 0.5, 1.0, 1.5, 2.0,2.5 or 3.0℃, annual net photosynthetic rate will be increased by 8.8, 12.8, 14.5, 12.6, 9.2 and 1.0 ton CO2 ha-1yr-1, respectively. Simulations indicate that changes in air temperature will have a major impact on gas exchangeand release in Q. mongolica stands, resulting in a net increase in the rate of of carbon fixation by standing crops.
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