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Search Results: 1 - 10 of 20560 matches for " Byoung Gwon Kim "
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Cognitive Profiles and Subtypes of Patients with Mild Cognitive Impairment: Data from a Clinical Follow-Up Study  [PDF]
Kyung Won Park, Eun-Joo Kim, Hwan Joo, Sung-Man Jeon, Seong-Ho Choi, Jay C. Kwon, Byoung Gwon Kim, Jae Woo Kim
International Journal of Clinical Medicine (IJCM) , 2012, DOI: 10.4236/ijcm.2012.35068
Abstract: Background: Mild cognitive impairment (MCI) is a heterogeneous condition with a variety of clinical outcomes, the presence of which correlates with risk of Alzheimer’s disease as well as pre-clinical stages of other dementia subtypes. The aims of this study were to assess the specific patterns of cognitive profiles and to identify changes from baseline to 24 weeks in patients with MCI using detailed neuropsychological testing. Methods: We consecutively recruited 120 MCI patients at baseline according to the Petersen’s clinical diagnostic criteria, who were admitted to the Dementia and Memory Clinics. We analyzed patients who fulfilled both inclusion and exclusion criteria for MCI and classified them into four subtypes according to deficits in major cognitive domains; amnestic MCI single domain (aMCI-s), amnestic multiple domain MCI (aMCI-m), non-amnestic single domain MCI (naMCI-s) and non-amnestic multiple domain MCI (naMCI-m). Four groups of MCI were evaluated by a detailed neuropsychological battery test. Results: 83 patients with MCI at the 24-week follow-up were classified into four subtypes. The most frequent subtype was amnestic multi-domain MCI, with the frequency of MCI subtypes as follows: aMCI-s (n = 21, 25.3%), aMCI-m (n = 53, 63.9%), naMCI-s (n = 5, 6.0%) and naMCI-m (n = 4, 4.8%). In the major cognitive items of the SNSB-D, there were significant changes between the initial and follow-up tests in the domains of language, memory and the fron-tal/executive function (p < 0.05), except for attention, in all MCI patient subtypes. At 24-weeks follow-up, the conversion rate to Alzheimer’s disease was 2.4% (n = 2) from a subtype of amnestic multi-domain MCI. Conclusions: Our study revealed the most frequent subtype of MCI to be multiple domain amnestic MCI, with this subtype having a higher tendency of conversion to Alzheimer’s disease.
p73 G4C14 to A4T14 polymorphism is associated with colorectal cancer risk and survival
Kyung-Eun Lee, Young-Seoub Hong, Byoung-Gwon Kim, Na-Young Kim, Kyoung-Mu Lee, Jong-Young Kwak, Mee-Sook Roh
World Journal of Gastroenterology , 2010,
Abstract: AIM: To analyze the association between the p73 G4C14-to-A4T14 polymorphism (a.k.a., the GC/AT variation) and colorectal cancer risk and survival in the Korean population, and to evaluate the relationships between p73 polymorphism and the p73 protein expression or clinicopathological characteristics of colorectal cancer.METHODS: Three hundred and eighty-three histologically confirmed cases and 469 healthy controls, recruited at one teaching hospital in Pusan, Korea from 2001 and 2007, were genotyped for p73 G4C14-to-A4T14 by PCR with confronting two-pair primers (PCR-CTPP) and the expression profile of p73 in cancer tissues (n = 383) was analyzed by immunohistochemistry.RESULTS: Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by unconditional logistic regression model adjusted for age and gender. Compared with the GC/GC genotypes, the GC/AT and AT/AT genotypes were significantly associated with colorectal cancer risk (GC/AT vs GC/GC: OR = 1.46, 95% CI: 1.10-1.94; AT/AT vs GC/GC: 1.72, 0.98-3.03; Ptrend = 0.01). When stratified by age and gender, the association was restricted to those less than 60 years of age (GC/AT or AT/AT vs GC/GC: 2.22, 1.39-3.55) and male (GC/AT or AT/AT vs GC/GC: 1.91, 1.31-2.77). The expression of p73 was associated with invasion depth (P = 0.003) and advanced Duke’s stage (P = 0.06) of colorectal cancer. The patients with the GC/GC genotype were associated with worse survival compared with those with the other genotypes (P = 0.02). However, no significant relationship was observed between the p73 G4C14-to-A4T14 polymorphism and p73 protein expression in cancer tissues.CONCLUSION: Our results suggest that the p73 GC/AT polymorphism is associated with an increased colorectal cancer risk and survival in the Korean population.
Self-Assembled Core-Shell Poly(ethylene glycol)-POSS Nanocarriers for Drug Delivery  [PDF]
Byoung-Suhk Kim, Kyu-Oh Kim, Ick-Soo Kim
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2011, DOI: 10.4236/jbnb.2011.23025
Abstract: In this work, novel nanostructured core-shell poly(ethylene glycol) (PEG)-polyhedral oligosilsesquioxane (POSS) nanoparticles were used to encapsulate insulin as new drug delivery carriers. The morphologies, particle size and ζ potential of the pure nanostructured core-shell PEG-POSS and the corresponding insulin-loaded PEG-POSS nanoparticles were investigated by transmission electron microscopy (TEM) and laser diffraction particle sizer. TEM analysis demonstrated that pure and insulin-loaded self-assembled PEG-POSS nanoparticles were of spherical shape with core-shell nanostructure, and were well-dispersed and uniform in size distribution. Insulin release test showed that insulin was well-protected inside PEG-POSS nanoparticles at gastric pH for 2hrs, and was released at intestinal pH (pH 6-7) where the absorption and activation of the drug are necessary. We therefore believe that such nanostructured PEG-POSS nanoparticles could be useful as a potential carrier for insulin drug delivery systems.
Cells Attachment Property of PVA Hydrogel Nanofibers Incorporating Hyaluronic Acid for Tissue Engineering  [PDF]
Kyu-Oh Kim, Yaeko Akada, Wei Kai, Byoung-Suhk Kim, Ick-Soo Kim
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2011, DOI: 10.4236/jbnb.2011.24044
Abstract: In this work, we report the fabrication and cell affinity studies of the poly(vinyl alcohol) (PVA)/hyaluronic acid (HA) cross-linked nanofibers via electrospinning and post cross-linking. FT-IR and TGA analysis demonstrate that HA is not influenced by acid environment such as HCl vapor during cross-linking, and well incorporated into PVA nanofibers. Swelling behavior and cell adhesion of the PVA/HA hydrogel nanofibers are investigated and compared with pure PVA hydrogel nanofibers. It is expected that the nanofibrous PVA/HA hydrogel fibers could be a promising scaffold for cell culture and tissue engineering applications.
Enhanced stability of nano-emulsified paclitaxel  [PDF]
Ju Young Lee, Da Yeon Kim, Gyeong Hae Kim, Kkot Nim Kang, Byoung Hyun Min, Bong Lee, Jae Ho Kim, Moon Suk Kim
Journal of Biomedical Science and Engineering (JBiSE) , 2011, DOI: 10.4236/jbise.2011.45044
Abstract: The main goal of this work was to develop an optimal self-microemulsifying paclitaxel prepared with PLGA and solubilizer such as tetraglycol, Cremophor ELP, and Labrasol. The prepared PTx-loaded SMES showed the size of the range of 80–130 nm by dy-namic light scattering and a spherical shape by atomic force microscopy. In experiment of storage stability in deionized water (DW) or blood condition, PTx-loaded SMES showed good stability in DW and comparable stability in blood condition at 37oC for 7 days. In addition, PTx-loaded SMES showed a sig-nificant inhibitory effect on B16F10 melanoma proli-feration. In conclusion, we confirmed that the for-mulations tried in this study could be used as admin-istration form for animal trials of PTx.
Integral transforms, convolution products, and first variations
Bong Jin Kim,Byoung Soo Kim,David Skoug
International Journal of Mathematics and Mathematical Sciences , 2004, DOI: 10.1155/s0161171204305260
Abstract: We establish the various relationships that exist among the integral transform ℱα,βF, the convolution product (F∗G)α, and the first variation δF for a class of functionals defined on K[0,T], the space of complex-valued continuous functions on [0,T] which vanish at zero.
Fabrication and Biocompatibility of Electrospun Silk?Biocomposites
Kai Wei,Byoung-Suhk Kim,Ick-Soo Kim
Membranes , 2011, DOI: 10.3390/membranes1040275
Abstract: Silk fibroin has attracted great interest in tissue engineering because of its outstanding biocompatibility, biodegradability and minimal inflammatory reaction. In this study, two kinds of biocomposites based on regenerated silk fibroin are fabricated by electrospinning and post-treatment processes, respectively. Firstly, regenerated silk fibroin/tetramethoxysilane (TMOS) hybrid nanofibers with high hydrophilicity are prepared, which is superior for fibroblast attachment. The electrospinning process causes adjacent fibers to ‘weld’ at contact points, which can be proved by scanning electron microscope (SEM). The water contact angle of silk/tetramethoxysilane (TMOS) composites shows a sharper decrease than pure regenerated silk fibroin nanofiber, which has a great effect on the early stage of cell attachment behavior. Secondly, a novel tissue engineering scaffold material based on electrospun silk fibroin/nano-hydroxyapatite (nHA) biocomposites is prepared by means of an effective calcium and phosphate (Ca–P) alternate soaking method. nHA is successfully produced on regenerated silk fibroin nanofiber within several min without any pre-treatments. The osteoblastic activities of this novel nanofibrous biocomposites are also investigated by employing osteoblastic-like MC3T3-E1 cell line. The cell functionality such as alkaline phosphatase (ALP) activity is ameliorated on mineralized silk nanofibers. All these results indicate that this silk/nHA biocomposite scaffold material may be a promising biomaterial for bone tissue engineering.
Determination of Viscoelastic Property in Polyethylene Crystallization Using a Quartz Crystal Resonator
Yong Kweon Suh,Byoung Chul Kim,Young Han Kim
Sensors , 2009, DOI: 10.3390/s91209544
Abstract: A new generalized relationship between the viscoelastic properties of an overlayer placed on the electrode interface of a quartz crystal resonator and its resonant characteristic is developed from the mechanics of the quartz movement. The relationship is used to estimate the viscoelastic properties from the experimentally measured resonant characteristic. It is utilized in the estimation of viscosity and elastic shear modulus of a polyethylene overlayer during its crystallization. The measurements are compared with the viscosity and elastic shear modulus of a polyethylene melt measured using a rheometer. It is found that the development of this study is useful in the determination of viscoelastic property of polymer materials by measuring the resonant frequency and conductance of the polymer overlayer placed on the resonator electrode.
Emission filter design to detect poultry skin tumors using fluorescence hyperspectral imaging
Taemin,Kim; Byoung-Kwan,Cho; Moon,Kim;
Revista Colombiana de Ciencias Pecuarias , 2010,
Abstract: this paper presents an optimal emission filter of the fluorescence imaging system to detect skin tumors on poultry carcasses. the secure production of disease-free meat is crucial in the mass production environment. the fluorescence spectra have been gaining the practical use in many areas because the fluorescence response is very sensitive in detecting trace elements. the spectral features of the specimen are embedded across broad spectral bands and have been analyzed in various methods. we apply the linear discriminant analysis to determine the emission filter of fluorescence imaging system. it provides the optimal attenuation of emission wavelengths in terms of discriminant power. the attenuation values prioritize wavelengths to select significant spectral bands. with the optimal filter, skin tumor parts of chicken carcasses are enhanced saliently in resultant fluorescence images.
Emission filter design to detect poultry skin tumors using fluorescence hyperspectral imaging Dise o del filtro de emisión para detectar tumores cutáneos en canales de aves usando imagenes de fluorescencia hiperespectral Desenho de um filtro de emiss o para detectar tumores cutaneos em carca as de aves usando imagens de fluorescência hiperespectral
Kim Taemin,Cho Byoung-Kwan,Kim Moon
Revista Colombiana de Ciencias Pecuarias , 2010,
Abstract: This paper presents an optimal emission filter of the fluorescence imaging system to detect skin tumors on poultry carcasses. The secure production of disease-free meat is crucial in the mass production environment. The fluorescence spectra have been gaining the practical use in many areas because the fluorescence response is very sensitive in detecting trace elements. The spectral features of the specimen are embedded across broad spectral bands and have been analyzed in various methods. We apply the linear discriminant analysis to determine the emission filter of fluorescence imaging system. It provides the optimal attenuation of emission wavelengths in terms of discriminant power. The attenuation values prioritize wavelengths to select significant spectral bands. With the optimal filter, skin tumor parts of chicken carcasses are enhanced saliently in resultant fluorescence images. La producción de carne libre de enfermedades es crucial en producción pecuaria intensiva. Los espectros de fluorescencia se han estado usando en forma práctica en muchas áreas, ya que la respuesta de fluorescencia es muy sensible para detectar elementos traza. Este artículo presenta un óptimo filtro de emisión para el sistema de imágenes de fluorescencia utilizado para detectar tumores cutáneos en canales de pollo. Las características espectrales de la muestra --insertas en bandas espectrales amplias- se han analizado por varias metodologías. En este artículo aplicamos el análisis lineal discriminante para determinar el filtro de emisión del sistema de imágenes por fluorescencia, mediante el cual se obtiene la atenuación optima de las ondas de emisión en términos de poder discriminante. Los valores de atenuación priorizan las longitudes de onda para seleccionar las bandas espectrales más significativas. Gracias a la utilización de este filtro optimizado, los tumores cutáneos existentes en la canal de pollo son magnificados, de modo que se alcanzan a diferenciar perfectamente en las imágenes de fluorescencia resultantes. A produ o de carne livre de doen as é crucial em produ o pecuária intensiva. Os espectros de fluorescência temse estado utilizando em forma prática em muitas áreas, já que a resposta da fluorescência é muito sensível para detectar elementos tra a. Este artículo apresenta um óptimo filtro de emiss o para o sistema de imagens de fluorescência utilizado para detectar tumores cutaneos em carca as de frangos. As características espectrais da amostra, insertas em bandas espectrais amplas s o utilizadas por varias metodologias. Neste artículo aplicamos a análises
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