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Search Results: 1 - 10 of 5925 matches for " Byeongwook Jeon1 "
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IFNγ-mediated inhibition of cell proliferation through increased PKCδ-induced overexpression of EC-SOD
Yoon-Jae Jeon1, Hyun Yoo1, Byung Hak Kim1, Yun Sang Lee1, Byeongwook Jeon1, Sung-Sub Kim2,* & Tae-Yoon Kim1,*
BMB Reports , 2012,
Abstract: Extracellular superoxide dismutase (EC-SOD) overexpressionmodulates cellular responses such as tumor cell suppression andis induced by IFNγ. Therefore, we examined the role of EC-SODin IFNγ-mediated tumor cell suppression. We observed that thedominant-negative protein kinase C delta (PKCδ) suppressesIFNγ-induced EC-SOD expression in both keratinocytes andmelanoma cells. Our results also showed that PKCδ-induced ECSODexpression was reduced by pretreatment with a PKCspecificinhibitor or a siRNA against PKCδ. PKCδ-induced ECSODexpression suppressed cell proliferations by the up-regulationof p21 and Rb, and the downregulation of cyclin A and D.Finally, we demonstrated that increased expression of EC-SODdrastically suppressed lung melanoma proliferation in an EC-SODtransgenic mouse via p21 expression. In summary, our findingssuggest that IFNγ-induced EC-SOD expression occurs via activationof PKCδ. Therefore, the upregulation of EC-SOD may beeffective for prevention of various cancers, including melanoma,via cell cycle arrest.
X-ray radiation at low doses stimulates differentiation and mineralization of mouse calvarial osteoblasts
Soon-Sun Park1,#, Kyoung-A Kim2,#, Seung-Youp Lee1, Shin-Saeng Lim3, Young-Mi Jeon1 & Jeong-Chae Lee1,3,*
BMB Reports , 2012,
Abstract: Radiotherapy is considered to cause detrimental effects on bonetissue eventually increasing bone loss and fracture risk. However,there is a great controversy on the real effects of irradiation itselfon osteoblasts, and the mechanisms by which irradiation affectsosteoblast differentiation and mineralization are not completelyunderstood. We explored how X-ray radiation influences differentiationand bone-specific gene expression in mouse calvarialosteoblasts. Irradiation at 2 Gy not only increased differentiationand mineralization of the cells, but also upregulated the expressionof alkaline phosphatase, type I collagen, osteopontin,and osteocalcin at early stages of differentiation. However, irradiationat higher doses (>2 Gy) did not stimulate osteoblast differentiation,rather it suppressed DNA synthesis by the cells withouta toxic effect. Additional experiments suggested that transforminggrowth factor-beta 1 and runt-transcription factor 2 play importantroles in irradiation- stimulated bone differentiation by acting asupstream regulators of bone-specific markers.
A Free Market Economy Model for Resource Management in Wireless Sensor Networks  [PDF]
Byeongwook Bae, Junyoung Park, Sunggu Lee
Wireless Sensor Network (WSN) , 2015, DOI: 10.4236/wsn.2015.76007
Abstract: This paper presents a free market economy model that can be used to facilitate fully distributed autonomous control of resources in massive heterogeneous wireless sensor networks (WSNs). In the future, it is expected that WSNs will exist as part of the global Internet of Things (IoT), and different WSNs can work together in a massive network of heterogeneous WSNs in order to solve common problems. Control of valuable processing, sensing and communication resources, determining which nodes will remain awake during specific time periods in order to provide sensing services, and determining which nodes will forward other nodes’ packets are difficult problems that must be dealt with. It is proposed that just as the free market economy model enables the global human society to function reasonably well when individuals simply attempt to trade money and services in order to maximize their individual profits, and a similar model and mechanism should enable a massive network of heterogeneous WSNs to function well in a fully distributed autonomous manner. The main contributions of this paper are the introduction of the free market economy model for use with WSNs, the formal definition of a maximum profit price problem for multihop packet relaying, and the proposal of a distributed genetic algorithm for the solution of the maximum profit price problem. Simulation results show that the proposed distributed solution produces results that are 70% - 80% similar to a pareto optimal solution for this problem.
Meibomian Epithelioma of the Lower Eyelid in a Thoroughbred Horse
Seong-Kyoon Choi1§, Jin-Kyu Park1§, Won Bae Jeon, Kyung-Hyun Lee2 and Gil-Jae Cho*
Pakistan Veterinary Journal , 2013,
Abstract: A 9-year old, castrated male, thoroughbred horse presented for a left lower eyelid mass with ocular signs of mucopurulent discharge, conjunctival hyperemia and ocular discomfort. On physical examination, there was no other abnormality. Surgically, the mass arising from the inner surface of left lower eyelid was excised and examined histopathologically. Microscopically, the eyelid mass exhibited neoplastic basaloid cells forming irregular cell masses of variable size separated by thin fibrous tissues. The basaloid cells showed mildly pleomorphic and undifferentiated appearances with prominent oval nuclei and scant cytoplasm. Poorly differentiated meibocytes were observed occasionally in the periphery regions of the cell masses suggesting the mass of lower eyelid originated from meibomian glands. Based on histopathological observation, the present case was diagnosed as an equine meibomian epithelioma in the lower eyelid. To the author’s knowledge, the present case is the first report of equine meibomian epithelioma in veterinary literatures.
Roles of NADPH oxidase 2 and 4 in endothelial cell survival and death under serum depletion  [PDF]
Hyeona Jeon, Yong Chool Boo
Advances in Biological Chemistry (ABC) , 2014, DOI: 10.4236/abc.2014.41003
Abstract: Oxidative stress and redox-signal pathways are known to be involved in endothelial apoptosis induced by serum depletion. However, the associated mechanism is not well understood and thus, was investigated in the present study focusing on NADPH oxidases (NOX). Serum removal from the culture medium led to an increase in reactive oxygen species (ROS) production and apoptotic death of human umbilical vein endothelial cells. Serum depletion also increased the gene expression of the NOX2 and NOX4 subunits. The selective suppression of NOX4 expression by small interfering RNA (siRNA) attenuated ROS production and cell death due to serum-depletion whereas siRNA for NOX2 increased cell death. Expression of exogenous NOX2 or NOX4 subunit alone had no significant effects on ROS production or cell death. Coexpression of the subunits of the NOX4 complex (NOX4 and p22phox) or the NOX2 complex (NOX2, p22phox, p47phox and p67phox) increased ROS production and cell death under serum-depleted conditions. This study suggests that endothelial cell survival and death are differentially regulated by expression levels of the subunits of NOX2 and NOX4 complexes.
Optimality Modeling in Human Evolutionary Behavioral Science
Jeon, Joonghwan
Journal of Ecology and Field Biology , 2008,
Abstract: Recently, the evolutionary study of human psychology and behavior has undergone rapid growth,diversifying into a few distinct sub-disciplines. One fundamental issue over which researchers in Human BehavioralEcology and Evolutionary Psychology (EP) have different views is the role of formal optimality modelingfor making hypotheses and deriving predictions about human adaptations. The study of EP typically rests oninformal inferences and rarely uses optimality modeling, a strategy which human behavioral ecologists haveseverely criticized. Here I argue that EP researchers have every reason to make extensive use of optimalitymodeling as its research method. I show that optimality modeling can play an integral role in identifying thefunctional organization of human psychological adaptations.
Jet Quenching in Evolving QGP Medium
Sangyong Jeon
Physics , 2009, DOI: 10.1016/j.nuclphysa.2009.10.012
Abstract: A short summary of different approaches to the parton energy loss problem is given. A particular attention is paid to the differences between various models. A possible solution to the problem of distinguishing competing approaches is discussed.
Hydrodynamic Transport Coefficients in Relativistic Scalar Field Theory
Sangyong Jeon
Physics , 1994, DOI: 10.1103/PhysRevD.52.3591
Abstract: Hydrodynamic transport coefficients may be evaluated from first principles in a weakly coupled scalar field theory at arbitrary temperature. In a theory with cubic and quartic interactions, the infinite class of diagrams which contribute to the leading weak coupling behavior are identified and summed. The resulting expression may be reduced to a single linear integral equation, which is shown to be identical to the corresponding result obtained from a linearized Boltzmann equation describing effective thermal excitations with temperature dependent masses and scattering amplitudes. The effective Boltzmann equation is valid even at very high temperature where the thermal lifetime and mean free path are short compared to the Compton wavelength of the fundamental particles. Numerical results for the shear and the bulk viscosities are presented.
Computing Spectral Densities in Finite Temperature Field Theory
Sangyong Jeon
Physics , 1992, DOI: 10.1103/PhysRevD.47.4586
Abstract: Convenient Cutkosky-like diagrammatic rules for computing the spectral densities of arbitrary two-point correlation functions in finite temperature field theory are derived. The approach is based on an explicit analytic continuation of imaginary-time Feynman diagrams and avoids the complications of real-time finite temperature perturbation theory. The application of this method to the perturbative evaluation of transport coefficients is briefly discussed.
Production of $η'$ from Thermal Gluon Fusion
Sangyong Jeon
Physics , 2001, DOI: 10.1103/PhysRevC.65.024903
Abstract: We study the production of $\eta'$ from hadronizing thermal gluons using recently proposed $\eta'-g-g$ effective vertex. The $\eta'$ yield is found to be sensitive to the initial condition. At RHIC and LHC, the enhancement is large enough to be easily detected.
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