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Search Results: 1 - 10 of 22414 matches for " Bruno Ant?nio Veloso Cerqueira "
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Sickle cell disease: Only one road, but different pathways for inflammation  [PDF]
Wendell Vilas-Boas, Bruno Antnio Veloso Cerqueira, Thassila Nogueira Pitanga, Magda Oliveira Seixas, Joelma Menezes, Cyntia Cajado de Souza, Elisangela Vitória Adorno, Marilda Souza Goncalves
Advances in Bioscience and Biotechnology (ABB) , 2012, DOI: 10.4236/abb.2012.324071
Abstract: Sickle cell disease (SCD) is a genetic disorder characterized by a chronic inflammatory process, and new biomarkers have been studied as promising molecules for understanding the inflammation in its pathophysiology. The hemolysis and the release of molecules associated to the hemoglobin (Hb) catabolism, such as free Hb, iron, and heme, generating a oxidant environment with production of reactive oxygen and nitrogen species. The immune system plays a very important role in the inflammation, with cells secreting pro-inflammatory cytokines and chemokines. There is also a nitric oxide (NO) resistance state, with an impaired NO bioactivity, leading to a vascular dys-function; activation of platelet, leukocytes, erythrocytes, and endothelial cells, with expression of adhesion molecules and its ligands, and several receptors, that altogether participate at inflammatory process. During inflammation, there is an increase of dendritic cells (DCs) expresse toll like receptors (TLR), but the role of DCs and TLR in SCD pathogenesis is unclear. Also, there are molecules contributing for enhance the endothelium dysfunction, such as homocysteine that has been associated with vascular complications in the pathology of other diseases and it may contribute to the vascular complications presented by SCD patients. Circulating microparticules (MPs) levels are augmented in several diseases and have been described in SCD, where cells membrane compounds are associated to cell’s thrombotic and coagulation state, such as tissue factor and phosphatidylserine (PS), which may contribute to endothelial dysfunction. The knowledge of all these biomarkers may contribute to new therapeutic approach discover, improveing SCD patient life quality.
Cytokine profiles in sickle cell anemia: Pathways to be unraveled  [PDF]
Thassila Nogueira Pitanga, Wendell Vilas-Boas, Bruno Antnio Veloso Cerqueira, Magda Oliveira Seixas, Cynara Gomes Barbosa, Elisangela Vitória Adorno, Marilda Souza Goncalves
Advances in Bioscience and Biotechnology (ABB) , 2013, DOI: 10.4236/abb.2013.47A1002
Abstract: Sickle cell anemia (SCA) is a genetically inherited hemolytic disorder characterized by chronic inflammation. Cytokine expression affects the pivotal pathways that contribute to disease pathogenesis, but the mechanisms involved are not well understood. SCA is associated with a proinflammatory state, and an enhanced inflammatory response occurs during vasoocclusive crisis. The immune system thus plays an important role in this inflammatory condition, with several cell types secreting pro-inflammatory cytokines that contribute to the occurrence of common cyclical events in SCA patients, such as hemolysis, vascular occlusion and inflammation. Studies of these cytokines and chemokines in SCA patients have clarified the mechanisms that underlie this disease and highlighted the need for a better understanding of cytokine participation in SCA pathophysiology.
Molecular surveillance of dengue virus in Bahia State, Brazil  [PDF]
Paulo R. S. Melo, Cistina Domingo, Stênio Carvalho Santos, Bruno Antnio Cerqueira, Luis Jesuino Andrade, Juliana Braga Nunes, Isolina A. Ciuffo, Antnio Tenório, Ronald E. Blanton, Mitermayer G. Reis
American Journal of Molecular Biology (AJMB) , 2012, DOI: 10.4236/ajmb.2012.21005
Abstract: Dengue is an important emerging viruses, posing a threat to one-third of the global human population. In 2002, the introduction of DENV-3 in the state of Bahia produced massive epidemic (about 35,000 cases detected) and the first cases of dengue hemorrhagic fever. To understand the nature of the virus circulating at Bahia, E/NS1 sequence was determined for 31 DENV viruses isolated in Bahia during the 2006 and 2007 transmission season, from patients presenting with different degrees of severity. The carboxi-terminal region of the E gene (220 nt) of 31 viruses, isolated from dengue patients with clinical diagnosis of dengue infection were used to determine the genetic variability of dengue 2 (DENV-2) and dengue 3 (DENV-3). Sequence data were used in phylogenetic comparisons with global samples of DENV-2 and DENV-3. DENV-2 sample grouped in the South East Indian genotype, while DENV-3 samples were grouped within Indian genotype. This study is the first report on Bahia isolates during two transmission seasons. Our data confirms reports from other parts of Brazil and different countries showing the DENV-3 (geno-type III) strains circulating in the Americas are closely related, and cluster within the genotype that has been associated with DHF epidemics in different conti-nents.
Optimization of Geometry at Hartree-Fock level Using the Generalized Simulated Annealing  [PDF]
Luiz Augusto Carvalho Malbouisson, Antonio Moreira de Cerqueira Sobrinho, Marco Antnio Chear Nascimento, Miceal Dias de Andrade
Applied Mathematics (AM) , 2012, DOI: 10.4236/am.2012.330212
Abstract: This work presents a procedure to optimize the molecular geometry at the Hartree-Fock level, based on a global opti-mization method—the Generalized Simulated Annealing. The main characteristic of this methodology is that, at least in principle, it enables the mapping of the energy hypersurface as to guarantee the achievement of the absolute minimum. This method does not use expansions of the energy, nor of its derivates, in terms of the conformation variables. Distinctly, it performs a direct optimization of the total Hartree-Fock energy through a stochastic strategy. The algorithm was tested by determining the Hartree-Fock ground state and optimum geometries of the H2, LiH, BH, Li2, CH+, OH?, FH, CO, CH, NH, OH and O2 systems. The convergence of our algorithm is totally independent of the initial point and do not require any previous specification of the orbital occupancies.
Para uma psicobiologia antropológica: aspectos culturais biopsicopatológicos Hacia una psicobiología antropológica: aspectos biopsicopatologicos culturales
Ana Claudia Rodrigues de Cerqueira,Antnio Egídio Nardi
Jornal Brasileiro de Psiquiatria , 2008, DOI: 10.1590/s0047-20852008000200014
Prevalência e fatores associados à obesidade abdominal e ao excesso de peso em adultos maranhenses
Veloso, Helma Jane Ferreira;Silva, Antnio Augusto Moura da;
Revista Brasileira de Epidemiologia , 2010, DOI: 10.1590/S1415-790X2010000300004
Abstract: objective: to determine the prevalence of excess body weight and abdominal obesity and assess the association with socioeconomic, demographic and behavioral factors among adults of maranh?o, brazil. methods: multistage cluster sample investigated through a household survey on 1,005 adults aged 20 to 59 years (393 men and 612 women). anthropometric measures: weight, height and waist circumference (wc) were assessed. abdominal obesity was defined as wc > 80 for women and wc > 94 for men. body mass index (bmi), weight in kilograms divided by the square of height in meters, > 25 kg/m2 was considered excess body weight. the dependent variable was divided into four categories: normal bmi and wc, excess body weight only (ebw), abdominal obesity only (ao) and abdominal obesity with excess body weight (aoebw). multinomial logistic regression was used for statistical analysis and estimates took the complex sampling design into account. results: among men the prevalence of ao was 1.3%, ebw 20.3% and aoebw 27.5%. among women 15.5% presented ao, 1.3% ebw and 42.0% aoebw. there was a significant statistical difference among sexes (p value < 0.001). in the multivariable analysis, among men, schooling > 9 years and living with a partner were factors associated with higher prevalence of ebw. age > 35 years, family income > two minimum wages and living with a partner were associated with higher prevalence of aoebw. among women, age > 35 and living with a partner were factors associated with ao. age > 35 years, living with a partner and schooling < 9 years were associated with a higher prevalence of aoebw. conclusion: the prevalence of ebw was higher among men whereas ao prevailed among women. factors associated with excess body weight, abdominal obesity and both excess body weight and abdominal obesity varied.
Pneumatose intestinal
Veloso, Luiz Fernando;Rodrigues, Marco Antnio Gon?alves;
Revista do Colégio Brasileiro de Cirurgi?es , 2001, DOI: 10.1590/S0100-69912001000500013
Abstract: pneumatosis intestinalis (pi) is the presence of gas-filled cysts within the wall of the gastrointestinal tract (git). it is a clinical and/or radiological sign associated with a wide spectrum of diseases, so that it has a variable clinical significance. probably, its prevalence is increasing. the nature of the diseases causing pi is been modifying in last decades. peptic ulcers were its main cause in the past. nowadays, probably, immunosuppressive conditions and states of increased permeability of the git mucosa (aids, transplanted patients or in chemotherapy, etc) are more common causes. pi can be shown on simple abdominal roentgenograms and computed tomographic scans obtained with lung windows. its diagnosis include definition of the cause in addition to its presence. the treatment should be directed to the cause of the pi, fluctuating from expectant to emergency laparotomy. the present report is a contribution to the limited literature experience in this topic and calls attention to the importance of recognizing pi and its clinical significance in order to define the right conduct.
Dieselization and Road Transport CO2 Emissions: Evidence from Europe  [PDF]
António Cardoso Marques, Bruno Miguel Gon?alves, José Alberto Fuinhas
Low Carbon Economy (LCE) , 2012, DOI: 10.4236/lce.2012.33008
Abstract: Road transport carbon dioxide emissions were analyzed, by focusing on a panel of 14 European countries for the time span 1995-2007. We deal with the existence of contemporaneous correlation by using the Panel Corrected Standard Errors estimator. We extend the empirical literature by controlling the effect of new diesel passenger car registrations and the average power of those vehicles. The price of gasoline and income reduce road transport carbon dioxide emissions, while population density and average power of new diesel passenger cars raises those emissions. We deepen the debate about dieselization, concluding that saving emissions by using diesel tend to be surpassed by the increased kilometers driven.
Comparison of Botox® or Prosigne® and Facial Nerve Blockade as Adjuvant in Chronic Migraine  [PDF]
Gabriela R. Lauretti, Christiane P. Rosa, Antnio Kitayama, Bruno C. P. Lopes
Journal of Biomedical Science and Engineering (JBiSE) , 2014, DOI: 10.4236/jbise.2014.78047
Abstract: Background: The treatments suggested for chronic migraine (CM) include: 1) intramuscular (im) botulinum toxin (BTX) every 12 weeks, and 2) blockade of peripheral nerves of the head. The present study evaluated the efficacy of facial nerve blockade in combination with a single administration of different low BTX. Methods: Forty patients with CM submitted to unilateral facial nerve blockade (supraorbital, supratrochlear and auriculotemporal) were divided into 4 randomized groups in a double-blind manner in order to receiveim, after 7 days: 25 IU Botox® (Botox group), 25 IU Prosigne® (25-Pro group), 33.3 IU Prosigne® (33-Pro group) or saline (control group), with the dose divided for application to 10 sites in the frontal and bilateral temporal regions. Analgesia and adverse effects were evaluated: 1) before blockade of the facial nerves and 2) 4 weeks, 3) 8 weeks and 4) 12 weeks after BTX-A or saline application (HC clinical trial no. 12465). Results: Botox® (25 IU) or Prosigne® (33.3 IU) resulted in at least seven-day intervals between headache attacks associated with 70% reduction in frequency and intensity of crises over 12 weeks (P < 0.05), while the 25 IU dose of Prosigne® resulted in 8 weeks of analgesia. The conversion factor between Botox® and Prosigne® was 1:1.3. Conclusions: Im application of Botox® (25 IU) or Prosigne® (33.3 IU) one week after nerve blockade on the painful side was equally effective for 12 weeks in patients with chronic daily headache, with the conversion factor between Botox® and Prosigne® being 1:1.3.
Tratamento de queimadura de segundo grau superficial em face e pesco o com heparina tópica: estudo comparativo, prospectivo e randomizado Treatment of superficial second degree burn of face and neck with topical heparin: a comparative, prospective and randomized study
Guilherme Gurgel do Amaral Teles,José Antnio Veloso Bastos,Antnio Amary,Luis Antnio Rufatto
Revista Brasileira de Cirurgia Plástica , 2012,
Abstract: INTRODU O: Novas op es terapêuticas para o tratamento de les es térmicas s o constantemente buscadas, especialmente se reduzirem tempo de cicatriza o e dor, sem aumentar as taxas de infec o das queimaduras. Estudos recentes sugerem que o uso tópico de heparina pode alcan ar esses objetivos. Este estudo tem o objetivo de avaliar tempo de epiteliza o, dor e taxa de infec o, comparando o uso de heparina tópica ao uso de colagenase no tratamento de queimadura de segundo grau superficial de face e pesco o. MéTODO: No total, 20 pacientes foram randomizados em dois grupos: grupo tratado com heparina sódica e grupo tratado com colagenase (controle). Os critérios de exclus o foram: história de sangramento, discrasia sanguínea, alergias ao produto, úlcera péptica ativa e queimadura há mais de 24 horas. O teste de Mann-Whitney foi utilizado para avaliar os resultados. A dor foi avaliada pela necessidade do uso de analgésicos opioides. RESULTADOS: A heparina n o foi efetiva em diminuir o tempo de epiteliza o ou o uso de opioides, e a taxa de infec o n o apresentou diferen a estatística entre os grupos. CONCLUS ES: A heparina pode ser usada com seguran a no tratamento de queimadura de segundo grau superficial em face e pesco o, mas seus efeitos benéficos ainda precisam ser comprovados. BACKGROUND: New treatment options for thermal injuries are very desirable, especially if they reduce healing time and pain without increase of infection rates. Recent studies suggest that heparin topical use can achieve those goals. This study has the objective to evaluate healing time, pain and infection rate comparing topical use of heparin and collagenase in the treatment of superficial second degree burns of face and neck. METHODS: Twenty patients were randomized into 2 groups: group treated with topical heparin and group treated with collagenase (control group). The exclusion criteria were: history of bleeding, blood discrasia, allergies to the product, active peptic ulcer and burns with more than 24 hours. Mann-Whitney test was applied to evaluate the results. The pain was measured by the use of opioid analgesics. RESULTS: The heparin was not effective in decrease of healing time nor the use of opioids, and the infection rate didn't present significant difference between the groups. CONCLUSIONS: The heparin can be used safely in treatment of superficial second degree burn of face and neck, but its beneficial effects need to be proven.
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