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sRAGE in diabetic and non-diabetic critically ill patients: effects of intensive insulin therapy
Yaseen M Arabi, Mohammed Dehbi, Asgar H Rishu, Engin Baturcam, Salim H Kahoul, Riette J Brits, Brintha Naidu, Abderrezak Bouchama
Critical Care , 2011, DOI: 10.1186/cc10420
Abstract: A predesigned analysis was conducted of prospectively collected samples from 76 hyperglycemic critically ill patients (33 type-2 diabetes, 43 non-diabetes) aged ≥18 years with blood glucose of > 6.1 mmol/L enrolled in a randomized controlled trial comparing intensive insulin therapy with conventional insulin therapy. sRAGE and its ligand HMGB-1 together with IL-6, and soluble thrombomodulin (as markers of inflammation and endothelial cell injury, respectively) were evaluated in ICU, at Days 1, 3, 5 and 7. Plasma samples from 18 healthy subjects were used as controls.Both diabetic and non-diabetic hyperglycemic patients showed increased plasma sRAGE, HMGB-1 and soluble thrombomodulin levels at the time of admission to ICU. Plasma IL-6 concentration was only increased in non-diabetic patients. Plasma levels of sRAGE were higher in diabetic compared with non-diabetic patients. Intensive insulin therapy resulted in a significant decrease of sRAGE and thrombomodulin at Day 7, in diabetic but not in non-diabetic patients. Circulating sRAGE levels correlated positively with IL-6 and soluble thrombomodulin levels and inversely with HMGB-1. Multivariate regression analysis demonstrated that sRAGE remains independently correlated with HMGB-1 only in diabetic patients. Neither sRAGE nor any inflammatory markers are associated with mortality.These findings support the hypothesis that sRAGE release, time-course and response to intensive insulin therapy differ between hyperglycemic diabetic and non-diabetic critically ill patients. Whether this difference underlies the dissimilarity in clinical outcome of hyperglycemia in these two conditions warrants further studies.Hyperglycemia represents an important independent risk factor for morbidity and mortality in critically ill patients admitted to ICU [1,2]. Accordingly, the benefit of strict control of blood sugar with intensive insulin therapy (IIT) versus conventional insulin therapy (CIT) has been greatly debated with some studie
Review on Maize Based Intercropping
Thayamini H. Seran,I. Brintha
Journal of Agronomy , 2010,
Abstract: World population is growing exponentially and it has to fulfill their food requirements. An attractive strategy for increasing productivity and labour utilization per unit area of available land is to intensify land use. Intercropping is advanced agro technique of cultivating two or more crops in the same space at the same time have been practiced in past decades and achieved the goal of agriculture. It increases in productivity per unit of land via better utilization of resources, minimizes the risks, reduces weed competition and stabilizes the yield. Several factors influence the intercropping such as maturity of crop, selection of compatible crop, planting density, time of planting as well as socio economic status of farmers and the region. In intercropping, land is effectively utilized and Land Equivalent Ratio (LER) is used to measure the productivity of land. Several findings show the advantages of intercropping by using LER. Cereal-legume intercropping is commonly practiced in world wide. Maize has reorganized as a component crop in most intercropping. In this study, the work carried out by various researches in maize based intercropping are discussed. This work would be useful to the researchers who involves in this field.
Hypercoagulability in Liver Transplant Recipients: Does Portal Vein Thrombosis Predict Post-Operative Thrombotic Complications?  [PDF]
Brintha K. Enestvedt, C. Kristian Enestvedt, Brian Diggs, Susan L. Orloff
Open Journal of Organ Transplant Surgery (OJOTS) , 2011, DOI: 10.4236/ojots.2011.11001
Abstract: Background: Cirrhotic patients have higher rates of hypercoagulable disorders. We hypothesized that orthotopic liver transplant (OLT) recipients with pre-operative portal vein thrombosis (PVT) have more post-operative thrombotic events than those without PVT. Aims: To compare rates of post-op thrombotic events and outcomes between those with and without pre-op PVT. Methods: All OLT recipients between 1/02-4/09 were retrospectively reviewed. Outcome measures included survival, deep venous thrombosis, pulmonary embolism, hepatic artery thrombosis, and recurrent PVT. Minimum follow up was 6 months. Results: In 363 OLTs performed, mean recipient age was 53.1 yrs (±9.2); 268 patients were male. Mean MELD at transplant was 22.1 (±6.2). The prevalence of pre-op PVT was 11.2% (41/350). There was no difference in the % of post-op thrombotic events between those with and without PVT (p = 0.77). MELD, recipient and donor age, and gender were similar in both groups. Mean survival in those with pre-op PVT was 85.2 months vs. 78.7 in those without PVT (p = 0.19). Conclusions: The rate of post-op thrombotic events was equivalent in OLT recipients with and without pre-op PVT. The presence of PVT did not adversely impact patient survival and should not be a contraindication to OLT.
Impact of Different Carbohydrates and Their Concentrations on in Vitro Regeneration of Solanum viarum (Dunal)—An Important Anticancer Medicinal Plant  [PDF]
Manikyam Doraiswamy Naidu Mahadev, Chandra Sekhar Panathula, ChallagundlaVaradarajulu Naidu
American Journal of Plant Sciences (AJPS) , 2014, DOI: 10.4236/ajps.2014.51026

In this present study, the effect of various carbon sources such as sucrose, glucose, fructose and maltose was investigated on in vitro shoot regeneration of Solanum viarum using axillary bud explants. The frequency, growth and multiplication rate were highly influenced by the type and concentration of carbon source used. Among the different concentrations (1%-6%) of carbohydrates studied, the maximum number of shoots (22.6 ± 0.50) and shoot length (5.92 ± 0.13 cm) was obtained on MS medium supplemented with 4% (w/v) fructose. The least number of shoots (1.5 ± 0.32) was obtained on 6% maltose and the least shoot length (1.2 ± 0.23) was observed on 6% glucose. Among the four types of carbon sources that were employed in the present study, fructose at 4%

The Stimulatory Effects of the Antimicrobial Agents Bavistin, Cefotaxime and Kanamycin on In Vitro Plant Regeneration of Centella asiatica (L.)—An Important Antijaundice Medicinal Plant  [PDF]
Chandra Sekhar Panathula, Manikyam Doraiswamy Naidu Mahadev, Challagundla Varadarajulu Naidu
American Journal of Plant Sciences (AJPS) , 2014, DOI: 10.4236/ajps.2014.53038

Antimicrobial agents such as bavistin, cefotaxime and kanamycin were evaluated for their effects on the rapid shoot regeneration from nodal explants of Centella asiatica (L.). Filter sterilized bavistin (250 mg/L) was augmented alone and in combination with cytokinins such as BAP and TDZ into the media to trace the effect on regeneration. On this basis, the potential use of bavistin (150 mg/L) along with BAP (2.0 mg/L) was evaluated which showed the maximum shoot number (6.6) and shoot length (4.4 cm) respectively. Cefotaxime at the concentration of 100 μM/L was found to be effective to obtain the maximum shoot number formation (5.8) with the regeneration frequency (90%). Kanamycin at the concentration of 80 μM/L induced maximum shoot regeneration (5.12). Kanamycin at 100 μM/L or at higher concentrations reduced the shoot regeneration. The best rooting response was noticed when in vitro regenerated microshoots were transferred to the rooting medim which was supplemented with IBA (2.0

Influence of Ethylene Inhibitor Silver Nitrate on Direct Shoot Regeneration from in Vitro Raised Shoot Tip Explants of Sphaeranthus indicus Linn.—An Important Antijaundice Medicinal Plant  [PDF]
K. Harathi, C. V. Naidu
American Journal of Plant Sciences (AJPS) , 2016, DOI: 10.4236/ajps.2016.73046
Abstract: In the present investigation, an attempt has been made to study the influence of ethylene inhibitor silver nitrate on direct shoot regeneration in Sphaeranthus indicus, an important antijaundice medicinal plant, by using in vitro raised shoot tip explants. The effect of various concentrations of kinetin, BAP (0.5 - 3.0 mg/l), and NAA (0.1 - 0.5 mg/l) along with AgNO3 (0.1 - 1.0 mg/l) was studied. Among the combinations tested MS medium augmented with kinetin (1.0 mg/l), NAA (0.1 mg/l) and AgNO3 (0.4 mg/l) was found to be optimum for production of multiple shoots (34.3 ± 0.36). Addition of AgNO3 to the media not only increases shoot number in all the concentrations tested but also shoot length. AgNO3 at the concentration of 0.4 mg/l produced 35% more number of multiple shoots when compared to multiple shoots (10.8 ± 0.12) produced in control. In the present study by the addition of ethylene inhibitor silver nitrate and growth regulators, more number of multiple shoots (three folds) and shoot length was observed compared to control. These in vitro raised shoots were transferred to the rooting medium containing different concentrations of auxins such as NAA and IAA along with AgNO3 (0.1 - 0.6 mg/l). Better rooting response (21.6) was observed on NAA (2.0 mg/l) and AgNO3 (0.4 mg/l) containing media. The healthy rooted plantlets were transferred to polybags containing soil and vermiculate in 1:1 ratio for hardening. Finally the hardened plants were transferred to field environment for utmost survivability.
Determination of Azacitidine by Spectrophotometric Method  [PDF]
B. Ramachandra, N. Venkatasubba Naidu
Open Journal of Medicinal Chemistry (OJMC) , 2018, DOI: 10.4236/ojmc.2018.82002
Abstract: Simple, selective and sensitive spectrophotometric method has been developed for the determination of Azacitidine in pharmaceutical formulations and blood with MBTH (3-methyl-2-benzothiazolone hydrazone hydrochloride) reagent, at PH-4.0 which is extractable at 620 nm. Beer’s law is obeying in the concentration ranges 10 - 35 μg·ml-1 for formulations and 4 - 24 μg·ml-1 for blood sample. %R.S.D was found to be 0.0240%, 0.0610 and Recovery 99.82% 99.24% respectively. The method was completely validated and proven to be rugged. The interferences of the other ingredients and excipients were not observed. The repeatability and the performance of the proven method were conventional by point and interior proposition and through recovery studies.
Common eye emergencies
K Naidu
Continuing Medical Education , 2007,
Evaluating the rural health placements of the Rural Support Network at the Faculty of Health Sciences, University of Cape Town
CS Naidu
South African Family Practice , 2012,
Abstract: Objectives: The Rural Support Network (RSN) is an undergraduate student society that aims to raise awareness among the student body of the plight of rural health in South Africa, and organises individual and group placements in rural hospitals during vacations. This research aimed to evaluate these placements from the students’ perspectives. Design: In-depth, face-to-face interviews were conducted with 10 students and nine placement-reflective reports were reviewed. The data were analysed and coded for key themes using a constant, comparative grounded theory approach. Setting: Faculty of Health Sciences (FHS) at the University of Cape Town. Subjects: Students who had been on RSN placements in 2010. Results: Students reported that the experience exceeded their expectations of learning new skills and observing and performing procedures. They gained significant insights into rural health care and were inspired to contribute to rural health in future. Their experiences helped them to gain confidence and an appreciation of the psycho-social aspects of patient care. The importance of community empowerment and of connecting and building relationships with communities was also emphasised. Challenges pertained to conflict within groups, incidents of unprofessional health care and being unable to help as much as they would have liked. Conclusion: The study highlights the impact that positive experiences of rural health may have on health science students’ interest in, passion for, and commitment to practising in underserved rural areas. Students’ key recommendations for the FHS included the development of a rural programme within the undergraduate curriculum. Better group composition and improved planning and co-ordination of placements by the RSN were also recommended.
A Comparison of Qualitative and Quantitative Methods of Detecting Earnings Management: Evidence from two Fijian Private and two Fijian State-owned Entities
Dharmendra Naidu
Australasian Accounting Business and Finance Journal , 2013,
Abstract: This paper compares the performance-matched discretionary accrual model (quantitative)and the Mulford and Comiskey (2002) qualitative measure to compute earnings management in two state-owned and two private entities for 1998 to 2009. The results provide evidence that the two measures are unable to provide similar results for theexistence of earnings management. The difference in the results between the two methods is attributed to the different ontological and epistemological views and the primary focus of the respective models. The results do not imply superiority of any model.
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