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Establishing Normative Values for the Barnett Balance Assessment-Sit (BBA-SIT)  [PDF]
Lela Rasegan, Holly Klein, Paige Bell, Brandon Bishop, Ellen Herlache-Pretzer
Open Journal of Therapy and Rehabilitation (OJTR) , 2018, DOI: 10.4236/ojtr.2018.62005
Abstract: The purpose of this descriptive study was to collect quantitative, normative data for the Barnett Balance Assessment-Sitting (BBA-SIT), a newly-developed dynamic sitting balance assessment tool based on the Barnett Balance Assessment (BBA). The BBA-SIT was administered to a total of 180 participants (30 people in each of the following age categories: 18 - 29, 30 - 39, 40 - 49, 50 - 59, 60 - 69, and 70+) who did not have any current balance deficits. A review of normative data collected indicated no variation in the total assessment scores within and between groups. Future research on the BBA-SIT is needed with balance-impaired populations to determine if the BBA-SIT is sensitive enough to identify subtle differences in dynamic sitting balance in individuals with various levels of balance impairment.
Denosumab Chemotherapy for Recurrent Giant-Cell Tumor of Bone: A Case Report of Neoadjuvant Use Enabling Complete Surgical Resection
Amit Agarwal,Brandon T. Larsen,Lawrence D. Buadu,Jack Dunn,Russell Crawford,Jonathan Daniel,Maria C. Bishop
Case Reports in Oncological Medicine , 2013, DOI: 10.1155/2013/496351
Abstract: Giant-cell tumor of the bone (GCTB) is a rare neoplasm that affects young adults. The tumor is generally benign but sometimes can be locally aggressive. There are no standardized approaches to the treatment of GCTB. Recently, the RANKL inhibitor denosumab has shown activity in this tumor type. We present the case of a young female who presented with locally advanced disease and was successfully managed with the neoadjuvant use of denosumab allowing for surgical resection of the tumor that was previously deemed unresectable. Following surgery, the patient is being managed with continued use of denosumab as ‘maintenance,’ and she continues to be free of disease. Our case highlights a novel approach for the management of locally advanced and aggressive giant cell tumor of the bone. 1. Introduction Giant-cell tumor of bone (GCTB) is a relatively rare neoplasm that affects young adults [1, 2]. It is a benign but locally aggressive skeletal neoplasm that causes significant bone destruction and has a predilection for the epiphyseal/metaphyseal region of long bones and the spine [2, 3]. Despite the generally benign nature of the disease, GCTBs can have highly variable and unpredictable behavior. Although there are no randomized clinical trials to assess treatment, patients are treated with surgery, radiotherapy, and occasionally systemic therapy [3]. Histologically, GCTB is characterized by abundant osteoclast-like giant cells and their precursors that express receptor activator of nuclear factor kappa-B ligand (RANKL) which is a key mediator of osteoclast activation [4–7]. RANKL signaling has been shown to have an important role in the pathogenesis of giant-cell tumors. Denosumab, a novel monoclonal antibody directed against RANKL that is currently FDA-approved for treatment of osteoporosis, has also been found to be active in GCTB and is now in clinical trials as a novel treatment for this tumor [6, 8]. We present a case of a recurrent GCTB that was initially unresectable but displayed a marked response to combination radiation and denosumab treatment, eventually enabling complete resection. 2. Clinical Presentation A 27-year-old woman presented with complaints of back pain in 2007 while living in Japan. Initial imaging revealed a T6 vertebral mass, and biopsy confirmed a diagnosis of GCTB. She underwent resection of the tumor with spinal stabilization. The patient was then lost to followup. In January 2010, she presented again with a 10.3?cm paraspinal mass in the T6 area on surveillance magnetic resonance imaging (MRI). This mass pushed the upper portion of
PheMaDB: A solution for storage, retrieval, and analysis of high throughput phenotype data
Wenling E Chang, Keri Sarver, Brandon W Higgs, Timothy D Read, Nichole ME Nolan, Carol E Chapman, Kimberly A Bishop-Lilly, Shanmuga Sozhamannan
BMC Bioinformatics , 2011, DOI: 10.1186/1471-2105-12-109
Abstract: PheMaDB allows the user to quickly identify records of interest for data analysis by filtering with a hierarchical ordering of Project, Strain, Phenotype, Replicate, and Temperature. PheMaDB then provides various statistical analysis options to identify specific growth pattern characteristics of the experimental strains, such as: outlier analysis, negative controls analysis (signal/background calibration), bar plots, pearson's correlation matrix, growth curve profile search, k-means clustering, and a heat map plot. This web-based database management system allows for both easy data sharing among multiple users and robust tools to phenotype organisms of interest.PheMaDB is an open source system standardized for OmniLog? PM data. PheMaDB could facilitate the banking and sharing of phenotype data. The source code is available for download at http://phemadb.sourceforge.net webcite.High-throughput phenotype analysis, running multiple viral, bacterial, or eukaryotic strains through miniaturized assays, has long been used in the biotechnology industry and is becoming increasingly important in academic research as laboratory automation costs continue to decrease. With the advent of next generation genome sequencing instruments [1], allowing even small laboratories to sequence potentially hundreds of bacterial strains and viruses per year, very rapid functional profiling of a great number of samples becomes increasingly important.One popular approach for high-throughput phenotype analysis is the OmniLog? platform (Biolog Inc, Heyward, CA), an instrument designed primarily for metabolic and antibiotic resistance assays of bacterial and eukaryotic strains in 96-well microtiter plates. The instrument makes use of specially designed 'phenotype microarray' (PM) plate assays. For a standard bacterial metabolite assay, 20 plates 20 plates (1,920 wells) are used. In each well there is a different substrate (metabolite, antibiotic, etc) as well as a dye. Bacteria are deposited in eac
A Study of Social Engineering in Online Frauds  [PDF]
Brandon Atkins, Wilson Huang
Open Journal of Social Sciences (JSS) , 2013, DOI: 10.4236/jss.2013.13004
Social engineering is a psychological exploitation which scammers use to skillfully manipulate human weaknesses and carry out emotional attacks on innocent people. This study examined the contents of 100 phishing e-mails and 100 advance-fee-scam e-mails, and evaluated the persuasion techniques exploited by social engineers for their illegal gains. The analyses showed that alert and account verification were the two primary triggers used to raise the attention of phishing e-mail recipients. These phishing e-mails were typically followed by a threatening tone via urgency. In advance-fee e-mails, timing is a lesser concern; potential monetary gain is the main trigger. Business proposals and large unclaimed funds were the two most common incentives used to lure victims. The study revealed that social engineers use statements in positive and negative manners in combination with authoritative and urgent persuasions to influence innocent people on their decisions to respond. Since it is highly unlikely that online fraud will ever be completely eliminated, the most important strategy that can be directed to combat social engineering attacks is to educate the public on potential threats from perpetrators.
Surgical Flap and Graft Reconstruction Workshop for Dermatology Residents  [PDF]
Brandon Goodwin, Richard Wagner
Journal of Cosmetics, Dermatological Sciences and Applications (JCDSA) , 2015, DOI: 10.4236/jcdsa.2015.52011
Abstract: Background: Traditional models for teaching surgical principles focus primarily on the apprenticeship theory; however there has been a trend in surgical education to certifying competency in a simulation environment prior to working with patients. Many surgical models emphasize learning the technical and manual dexterity skills necessary to be a surgeon, yet few focus on obtaining the theoretical and abstract skills needed for planning complex cutaneous surgical repairs with flaps and grafts. We developed and evaluated a novel surgical flaps and grafts workshop for residents through the Department of Dermatology. Methods: Participants received a 60 minute PowerPoint lecture focusing on the basic principles of cutaneous repair with flaps and grafts, with examples and explanation of each of the four main types of flaps and grafts. The participants then received nine photocopies of Mohs micrographic surgery defects with instructions to design three repairs, focusing on functional and aesthetic outcome. Hypothetical and actual repair designs were then discussed in an open forum format. Anonymous surveys administered to 11 dermatology residents assessed their knowledge level, confidence level, and likelihood of using flaps and grafts pre- and post-workshop using Likert scales. Overall experience was also assessed. A paired sample Wilcoxon Signed Rank Test was used for analysis, since the data was non-parametrically distributed. Results: There was a statistically significant increase in confidence performing flaps post workshop (p = 0.0469). There was also an increase in knowledge of flaps and grafts, confidence in planning flaps and grafts, and confidence in performing grafts post workshop, but these findings did not reach statistical significance. The workshop had no effect on expected future use of flaps and grafts. Conclusions: The surgical workshop is a novel simulation teaching tool for learning basic principles and design of flaps and grafts in cutaneous surgery.
Plant-to-plant horizontal gene transfer
CL Bishop
Genome Biology , 2003, DOI: 10.1186/gb-spotlight-20030710-01
Abstract: Bergthorsson et al. surveyed the mitochondrial gene content of a number of angiosperms and found distribution anomalies. Phylogenetic analysis of two mitochondrial ribosomal protein genes - rps2 and rps11 - resulted in the identification of four cases of plant-to-plant HGT, suggesting that the frequency of HGT is significant. The authors also suggest that previous placements of the atp1 gene should be reclassed as an HGT event. Expression analysis of Sanguinaria indicated that the rps11 RNA is probably functional and that the atp1 gene of Amborella is transcribed and edited. Using molecular-clock - based divergence times, the age of each transfer was also estimated."These results establish for the first time that conventional genes are subject to evolutionarily frequent HGT during plant evolution and provide the first unambiguous evidence that plants can donate DNA horizontally to other plants. This is also the best evidence that eukaryotic genomes regularly acquire genes by means of horizontal events that are relatively recent, datable and definable as to donor and recipient," conclude the authors.
“Modern Supramolecular Gold Chemistry”, edited Antonio Laguna
Peter Bishop
Gold Bulletin , 2009, DOI: 10.1007/BF03214912
Publications of B.J. van der Walt 1960-2010
S. Bishop
Koers : Bulletin for Christian Scholarship , 2010, DOI: 10.4102/koers.v75i1.82
Abstract: At the Ferdinand Postma Library of the Potchefstroom Campus of the North-West University an electronic list (both chronological and alphabetical according to titles) of B.J. van der Walt’s publications from 1960 to 2000 is available. (To access the list, go to http://www4-win2.p.nwu.ac.za/dbtw-wpd/textbases/puk-eeu.htm and type in the author’s name: Van der Walt BJ) The website of Mr. Steve Bishop (www.allofliferedeemed.co.uk/ vanderwalt.htm) provides an annotated bibliography of all Van der Walt’s publications in English, as well as a list of the publications of the Institute for Reformational Studies. (E-mail: stevebishop.uk@gmail.com)
Pre-service teacher discourses: Authoring selves through multimodal compositions
John Bishop
Digital Culture & Education , 2009,
Abstract: This article explores the use of digital and multimodal compositions among preservice elementary education students in a university language and literacy methods course. Furthermore, this piece argues for the inclusion of multimodal representation in our literacy courses given the changes in our digital landscape and the ever-increasing multimodality of our representational and communicational means online. This research aligns with a burgeoning collection of literature, namely New Literacies (Knobel & Lankshear, 2007) and multimodality (Kress & van Leeuwen, 2001). In addition, this research merges with ‘traditional’ print-based literacy pedagogies that argue for models of teacher learning that foreground opportunities to ‘do’ digital composition in order to more effectively prepare students for 21st century literacy skills in epistemologically diverse digital environments. A combination of discourse and multimodal analysis provides a means to couple both linguistic and semiotic data to examine how multimodal design functions in the construction of teacher identities and how the flexibility of these identities in turn work to prepare new teachers for successful transitions into public school cultures. In other words, how might the practice of multimedia production, and reflection on those processes, foster a deeper self-awareness during a time when students are moving from university settings into public schools? This article argues that multimodal text design is dialogic and purposeful with regards to constructions of teacher identities and highlights two ‘Digital Literacy Projects,’ multimodal video compositions designed and produced by preservice teachers with video editing software. The two DLPs contrast the potential for authors to stabilize and/or improvise formations of identity, both which create opportunities to engage in praxis that merge university experiences with public school responsibilities.
Graines souterraines ? Le sexo-générique dans une oeuvre (auto)-censurée d’Anne Hébert : Les Songes en équilibre
Neil Bishop
Voix Plurielles , 2010,
Abstract: Les songes en équilibre d'Anne Hébert
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