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Search Results: 1 - 10 of 462866 matches for " Brain A. Shaw "
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Circular and Faceted Monopile Installation Fatigue Damage  [PDF]
Giorge Koulin, Ian Sewell, Brain A. Shaw
Engineering (ENG) , 2016, DOI: 10.4236/eng.2016.84020
Abstract: There are currently no models predicting localised stressing induced in monopole foundations resulting from pile driving installation. A scaled down test was conducted for both circular and faceted monopile, during which monopile stressing was measured. From the stress data gathered fatigue damage was estimated. Fatigue damage of the faceted geometry is significantly larger than that of the circular geometry. It is shown that in the worst case the fatigue damage incurred is still negligible compared to the full service life of the foundation. Suggestions for future developments are made, such developments can be helpful in providing greater understanding of the occasional cases where fatigue damage resulting from pile driving is not negligible and has perhaps resulted in failure.
Early Exposure to Environmental Toxin Contributes to Neuronal Vulnerability and Axonal Pathology in a Model of Familial ALS  [PDF]
Grace Lee, Christopher A. Shaw
Neuroscience & Medicine (NM) , 2012, DOI: 10.4236/nm.2012.34050
Abstract: Adult onset amyotrophic lateral sclerosis (ALS) arises due to progressive and irreversible functional deficits to the central nervous system, specifically the loss of motor neurons. Sporadic ALS causality is not well understood, but is almost certainly of multifactorial origin involving a combination of genetic and environmental factors. The discovery of endemic ALS in the native Chamorro population of Guam during the 1950s and the co-occurrence of Parkinsonism and dementia in some patients led to searches for environmental toxins that could be responsible. In the present paper, we report that an environmental neurotoxin enhances mutant superoxide dismutase (SOD)-induced spinal motor neuron death and pathology and induces motor axon abnormalities. These results cumulatively confirm earlier findings that exposure to an environmental toxin is sufficient to produce the disease phenotype and indicate a role for gene-environment interaction in some forms of the disease.
A. Shaw
Scientia Militaria : South African Journal of Military Studies , 2012, DOI: 10.5787/10-1-714
Abstract: In multi-ethnic military forces, problems can be expected to be related to questions of language, attitudes and values, the extent of inter-ethnic mixing and discrimination. It has also emerged that there are no standard solutions to these problems, but that any remedies must be based on accurate knowledge of ethnic differences, and should normally include programmes of education to promote understanding of these differences.
Dose-modified lenalidomide induces sustained hematological response in patients with intermediate to high risk myelodysplasia
Alhossain A. Khalafallah,Bernadene Fernandopulle,Terry Brain
Mediterranean Journal of Hematology and Infectious Diseases , 2010, DOI: 10.4084/mjhid.2011.
Abstract: No Abstract Available
An Assessment of Trends of Monthly Contributions to Seasonal Rainfall in South-Eastern Zimbabwe  [PDF]
Brain Mapurisa, David Chikodzi
American Journal of Climate Change (AJCC) , 2014, DOI: 10.4236/ajcc.2014.31005

Trends in the proportional contribution to the seasonal rainfall of each month were analyzed for the meteorological stations of Buffalo Range, Masvingo Airport and Zaka in South-Eastern Zimbabwe. Results found indicate the existence of some trends for all the stations and months. However, when subjected to a Mann-Kendel trend analysis, all the trends were found to be statistically not significant for all instances except for the month of October at the Zaka station. This month showed a significant trend of increasing proportional rainfall.

Magnetic Barkhausen Noise Profile Analysis: Effect of Excitation Field Strength and Detection Coil Sensitivity in Case Carburized Steel  [PDF]
Mohamed Mehemed Blaow, Brian A. Shaw
Materials Sciences and Applications (MSA) , 2014, DOI: 10.4236/msa.2014.55030

The sensitivity of magnetic Barkhausen noise (MBN) profile to changes in the excitation field strength and the number of turns of the detection coil was investigated in inhomogeneous material. Generally, the 0.5 mm case depth EN 36 steel specimen shows a double peak profile indicative of inhomogeneity through the detected depth the magnetized landscape. Various excitation field amplitudes were applied to the specimen and the induced MBN emission was analyzed for each magnetizing current. Excitation field at the lowest level induced an MBN emission of two peaks of equivalent heights. The first peak occurs at lower field than the second peak in the magnetization period. As the excitation field increased, the height of both peaks increased but the second peak increased in a higher rate than that of the first peak. Beyond certain excitation level, both peaks began to saturate and no increase in the MBN intensity was observed with increased excitation field strength. However, peak position and the number of Barkhausen events, indicated linearly as a function of the applied field strength. The experiment also establishes that the number of turns in the detection coil is important parameter which controls the height of the first peak. Low field peak height increases as the number of turn of the detection coil increases. The results indicate that the potential difference applied to the electromagnet and the sensitivity of the detection coil, determine the MBN profile characteristics.

Quality of Pharmaceutical Print Advertising in South Africa - Assessment of Reproductive Health Advertisements 2001-2005
A Shaw, A Gray
South African Family Practice , 2009,
Abstract: Background: Pharmaceutical advertising, in a variety of forms, has been shown to influence prescribing behaviour. Regulatory systems have therefore been concerned with the quality of advertising and compliance with either imposed or self-regulatory codes of practice. Although the South African Medicines Act provides for an enforceable code of practice, the draft version published in 2004 has yet to be put into effect. This study aimed to assess the quality of pharmaceutical advertisements for reproductive health products, published in South African medical publications over the period 2001 to 2005. Compliance with the draft code of practice was considered, as well as the usefulness of the code itself. Methods: Half-page and larger print advertisements for reproductive health medicines were sought from two South African peer-reviewed and four non-peer-reviewed medical publications. Advertisements published in three consecutive months in 2001 to 2005 were selected. This period represented the period prior to legislation being developed and the period during which the code of practice was developed and published for comment. Details from each advertisement were captured independently by two reviewers using a pre-determined, pre-tested 60-question questionnaire. Differences were resolved by consensus. The questionnaire was pre-tested and adapted before being applied. Questions sought to identify characteristics of the advertisement that were indicative of quality relating to claims and evidence used in support of the claims, as well as adherence to the draft code of practice. The number of claims made in each advertisement was identified, and for each claim the evidence provided in the form of references was assessed. Results: A total of 136 reproductive health product advertisements were retrieved from 105 medical publications. Only 63 advertisements were unique. On average each medical publication selected contained 1.3 reproductive health product advertisements. All but three advertisements were for registered orthodox medicines. A total of 191 ‘claims’ could be discerned in advertisements placed in medical publications (average 3.0 ‘claims’ per advertisement). Only 7/103 (6.8%) references cited in unique advertisements in medical publications could be retrieved in abstract form from Medline, and only 1/7 (14.3%) of these references could be retrieved in free full-text format. In total, 14/103 (13.6%) of the references cited in advertisements placed in medical publications were listed as “data on file”. Compliance with the relevant general regulation was easier to judge, and seen more often, than was the case in respect of the more subjective elements included in the draft code of practice. Conclusions: The quality of advertisements for reproductive health products placed in medical publications appears to fall short of at least some of the requirements of both existing and draft regulatory instruments. This may potentially have deleterious conseq
?Es posible la integración residencial en las ciudades chilenas?: Disposición de los grupos medios y altos a la integración con grupos de extracción popular
Sabatini,Francisco; Rasse,Alejandra; Mora,a; Brain,Isabel;
EURE (Santiago) , 2012, DOI: 10.4067/S0250-71612012000300008
Abstract: with relative independence of their social level, age or sex, the residents of the chilean cities of santiago, antofagasta and temuco show a significant disposition to residential integration with people of different social conditions. however, this positive evaluation of integration is confronted by concrete obstacles and fears (like the possible damage to the value of their properties or to the education of their children) that make the materialization of less segregated neighborhoods harder, on the one hand, and "classist" attitudes and conducts, on the other. in practical terms, this ambivalent urban culture, together with a relative assymetry of residential segregation are the main dimensions in the latin american context. these, together with a mixture of indifference and tolerance towards the "other", which are characteristic of modern cities, give cultural viability to future policies for the reduction of segregation.
Journal of the Chilean Chemical Society , 2008, DOI: 10.4067/S0717-97072008000400010
Abstract: in this work an hplc stability-indicating method was developed and applied to study the hydrolytic behavior of pravastatin in different phs and temperatures. from the system suitability test, the selected chromatographic conditions were a c-18 column, acetonitrile-30 mmol l-1 phosphate buffer solution ph 2 (28:72) as mobile phase, 40°c temperature column, a flux of 1 ml/min and 239 nm as wavelength detection. the developed method exhibited an adequate repeatability and reproducibility (cv 0.11% and 0.49%, respectively) and a recovery higher than 98%. furthermore, the detection and quantitation limits were 3.4x10-7mol l-1 and 3.7xl0-6mol l-1. the kinetic degradation of pravastatin fits to a pseudo-first order kinetic. the degradation was ph-dependent: alkaline ph < acid ph and the generation of degradation products was dependent of the media tested (one product in alkaline medium and 4 products in acid medium). activation energy, kinetic rate constants at different temperatures, t1/2 and t90 values are also reported.
Effects of Dietary Fats on Blood Cholesterol and Other Measures Related to Chd Risk in Male and Female Laboratory Mice
Tahia A. Maimanee,Paul F. Brain,Maria Andrade
Pakistan Journal of Biological Sciences , 1999,
Abstract: Juvenile and adult male and female Swiss mice were fed one of four specially-formulated, pelleted diets containing respectively 8 per cent saturated vegetable fat, 8 per cent soya oil, 8 per cent olive oil and 2 per cent soya oil (with identities hidden from the experimenter) or a local commercial rodent food. It was intended to assess their impact on some blood indices linked to risk of coronary heart disease (CHD). Subjects were individually housed and their blood concentrations of cholesterol, high-density lipoprotein cholesterol (HDLC) and triglycerides were assessed. Clearly, these non-isocaloric diets differed in palatability, producing complex effects on growth as well as physiological measures. Many indices were influenced by age, sex, and the duration of dietary exposure. Interactions between factors were common but it appeared that males showed the greater increase in risk factors in response to some diets.
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