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Search Results: 1 - 10 of 40239 matches for " Bong Jun Cho "
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A case of colon perforation due to enteropathy-associated T-cell lymphoma
Jun Bong Kim,Seong Hwan Kim,Young Kwan Cho,Sang Bong Ahn
World Journal of Gastroenterology , 2013, DOI: 10.3748/wjg.v19.i11.1841
Abstract: Enteropathy-associated T-cell lymphoma (EATL) is an extremely rare disease, which is often related to gluten-sensitive enteropathy. It is an uncommon intestinal lymphoma with very poor prognosis and high mortality rate. In the absence of specific symptoms or radiological findings, it is difficult to diagnose early. Major complications of EATL have been known as intestinal perforation or obstruction, and only 5 cases of EATL are reported in South Korea. In this study, we report a case of 71-year-old male with symptoms of diarrhea, which later it progressed into cancer perforation of the colon. The initial colonoscopic findings were normal and computed tomography scan demonstrated a segmental wall thickening of the distal ascending colon with nonspecific multiple small lymphnodes, along the ileocolic vessels, but no signs of mass or obstruction. The histologic findings of resected specimen confirmed EATL type II. Patient expired two weeks after the operation. Therefore, we emphasize the need of random biopsy in the presence of normal mucosa appearance on colonoscopy for the early diagnosis of EATL.
Tumor budding as a risk factor of lymph node metastasis in submucosal invasive T1 colorectal carcinoma: a retrospective study
Bong-Hyeon Kye, Ji-Han Jung, Hyung-Jin Kim, Se-Goo Kang, Hyeon-Min Cho, Jun-Gi Kim
BMC Surgery , 2012, DOI: 10.1186/1471-2482-12-16
Abstract: In total, 55 patients revealing submucosal invasive colorectal carcinoma on pathology who underwent curative radical resection at the Department of Surgery, St. Vincent’s Hospital, The Catholic University of Korea from January 2007 to September 2010 were evaluated retrospectively. Tumor size, depth of submucosal invasion, histologic grade, lymphovascular invasion, tumor budding, and microacinar structure were reviewed by a single pathologist. Student t-test for continuous variables and Chi-square test for categorical variables were used for comparing the clinicopathological features between two groups (whether lymph node involvement existed or not). Continuous variables are expressed as the mean?±?standard error while statistical significance is accepted at P?<?0.05.The mean age of 55 patients (34 males and 21 females) was 61.2?±?9.6?years (range, 43–83). Histologically, eight (14.5%) patients had metastatic lymph node. In the univariate analysis, tumor budding (P?=?0.047) was the only factor that was significantly associated with lymph node metastasis. Also, the tumor budding had a sensitivity of 83.3%, a specificity of 60.5%, and a negative predictive value of 0.958 for lymph node metastasis in submucosal invasive T1 colorectal cancer.The tumor budding seems to have a high sensitivity (83.3%), acceptable specificity (60.5%), and a high negative predictive value (0.958). A close examination of pathologic finding including tumor budding should be performed in order to manage early CRC properly.An increase in colorectal cancer (CRC) screening and progress in techniques has resulted greater frequency of detection of T1 stage CRC. With recent advances in endoscopic techniques and improved endoscopes, T1 stage CRC and adenomatous polyps are often resected by endoscopes, regardless of their size or location [1-3]. Local treatments such as endoscopic resection and local excision are considered adequate management for early stage CRC without lymph node metastasis. A comple
The effect of laparoscopic surgery in stage II and III right-sided colon cancer: a retrospective study
Bong-Hyeon Kye, Jun-Gi Kim, Hyeon-Min Cho, Jung-Hwan Lee, Hyung-Jin Kim, Young-Jin Suh, Chung-Soo Chun
World Journal of Surgical Oncology , 2012, DOI: 10.1186/1477-7819-10-89
Abstract: From April 1986 to December 2006, 200 patients who underwent elective surgery with stage II and III right-sided colon cancer were analyzed. The period for group I referred back to the time when laparoscopic approach had not yet been introduced. The period for group II was designated as the time when first laparoscopic approach for right colectomy was carried out until we overcame its learning curve. The period for group III was the period after overcoming this learning curve.When groups I and II, and groups II and III were compared, overall survival (OS) did not differ significantly whereas disease-free survival (DFS) in groups I and III were statistically higher than in group II (P?=?0.042 and P?=?0.050). In group III, laparoscopic surgery had a tendency to provide better long-term OS ( P?=?0.2036) and DFS ( P?=?0.2356) than open surgery. Also, the incidence of local recurrence in group III (2.6%) was significantly lower than that in groups II (7.4%) and I (12.1%) ( P?=?0.013).Institutions should standardize their techniques and then provide fellowship training for newcomers of laparoscopic colon cancer surgery. This technique once mastered will become the gold standard approach to colon surgery as it is both safe and feasible considering the oncological and technical aspects.
EGb761, a Ginkgo Biloba Extract, Is Effective Against Atherosclerosis In Vitro, and in a Rat Model of Type 2 Diabetes
Soo Lim, Ji Won Yoon, Seon Mee Kang, Sung Hee Choi, Bong Jun Cho, Min Kim, Ho Seon Park, Hyun Ju Cho, Hayley Shin, Young-Bum Kim, Hyo Soo Kim, Hak Chul Jang, Kyong Soo Park
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0020301
Abstract: Background EGb761, a standardized Ginkgo biloba extract, has antioxidant and antiplatelet aggregation and thus might protect against atherosclerosis. However, molecular and functional properties of EGb761 and its major subcomponents have not been well characterized. We investigated the effect of EGb761 and its major subcomponents (bilobalide, kaemferol, and quercetin) on preventing atherosclerosis in vitro, and in a rat model of type 2 diabetes. Methods and Results EGb761 (100 and 200 mg/kg) or normal saline (control) were administered to Otsuka Long-Evans Tokushima Fatty rats, an obese insulin-resistant rat model, for 6 weeks (from 3 weeks before to 3 weeks after carotid artery injury). Immunohistochemical staining was performed to investigate cell proliferation and apoptosis in the injured arteries. Cell migration, caspase-3 activity and DNA fragmentation, monocyte adhesion, and ICAM-1/VCAM-1 levels were explored in vitro. Treatment with EGb761 dose-dependently reduced intima-media ratio, proliferation of vascular smooth muscle cells (VSMCs) and induced greater apoptosis than the controls. Proliferation and migration of VSMCs in vitro were also decreased by the treatment of EGb761. Glucose homeostasis and circulating adiponectin levels were improved, and plasma hsCRP concentrations were decreased in the treatment groups. Caspase-3 activity and DNA fragmentation increased while monocyte adhesion and ICAM-1/VCAM-1 levels decreased significantly. Among subcomponents of EGb761, kaemferol and quercetin reduced VSMC migration and increased caspase activity. Conclusions EGb761 has a protective role in the development of atherosclerosis and is a potential therapeutic agent for preventing atherosclerosis.
Phase separations in graded-indium content InGaN/GaN multiple quantum wells and its function to high quantum efficiency

Guo Hongying,Sun Yuanping,Yong-Hoon Cho,Eun-Kyung Suh,Hai-Joon Lee,Rak-Jun Choi,Yoon-Bong Hahn,
,孙元平,Yong-Hoon Cho,Eun-Kyung Suh,Hai-Joon Lee,Rak-Jun Choi,Yoon-Bong Hahn

半导体学报 , 2012,
Abstract: Phase separations have been studied for graded-indium content InxGa1-xN/GaN multiple quantum wells (MQWs) with different indium contents by means of photoluminescence (PL), cathodeluminescence (CL) and time-resolved PL (TRPL) techniques. Besides the main emission peaks, all samples show another 2 peaks at the high and low energy parts of the main peaks in PL when excited at 10 K. CL images show a clear contrast for 3 samples, which indicates an increasing phase separation with increasing indium content. TRPL spectra at 15 K of the main emissions show an increasing delay of rising time with indium content, which means a carrier transferring from low indium content structures to high indium content structures.
Effect of a Dipeptidyl Peptidase-IV Inhibitor, Des-Fluoro-Sitagliptin, on Neointimal Formation after Balloon Injury in Rats
Soo Lim, Sung Hee Choi, Hayley Shin, Bong Jun Cho, Ho Seon Park, Byung Yong Ahn, Seon Mee Kang, Ji Won Yoon, Hak Chul Jang, Young-Bum Kim, Kyong Soo Park
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0035007
Abstract: Background Recently, it has been suggested that enhancement of incretin effect improves cardiac function. We investigated the effect of a DPP-IV inhibitor, des-fluoro-sitagliptin, in reducing occurrence of restenosis in carotid artery in response to balloon injury and the related mechanisms. Methods and Findings Otsuka Long-Evans Tokushima Fatty rats were grouped into four: control (normal saline) and sitagliptin 100, 250 and 500 mg/kg per day (n = 10 per group). Sitagliptin or normal saline were given orally from 1 week before to 2 weeks after carotid injury. After 3 weeks of treatment, sitagliptin treatment caused a significant and dose-dependent reduction in intima-media ratio (IMR) in obese diabetic rats. This effect was accompanied by improved glucose homeostasis, decreased circulating levels of high-sensitivity C-reactive protein (hsCRP) and increased adiponectin level. Moreover, decreased IMR was correlated significantly with reduced hsCRP, tumor necrosis factor-α and monocyte chemoattractant protein-1 levels and plasminogen activator inhibitor-1 activity. In vitro evidence with vascular smooth muscle cells (VSMCs) demonstrated that proliferation and migration were decreased significantly after sitagliptin treatment. In addition, sitagliptin increased caspase-3 activity and decreased monocyte adhesion and NFκB activation in VSMCs. Conclusions Sitagliptin has protective properties against restenosis after carotid injury and therapeutic implications for treating macrovascular complications of diabetes.
Antioxidant Activity and Anti-Adipogenic Effects of Wild Herbs Mainly Cultivated in Korea
Young-Jun Lee,Dan-Bi Kim,Jong Seok Lee,Ju-Hyun Cho,Bong Kyun Kim,Hyeon-Son Choi,Boo-Yong Lee,Ok-Hwan Lee
Molecules , 2013, DOI: 10.3390/molecules181012937
Abstract: Wild herbs, which are edible plants that grow in mountainous areas, have diverse biological effects such as anti-obesity and anti-cancer activities. The aim of this study was to evaluate the total phenolic and flavonoid contents as well as the antioxidant activity of methanol extracts of Aster scaber, Ligularia fischeri, Kalopanax pictus, Codonopsis lanceolata, and Cirsium setidens and to assess their effects on lipid accumulation and reactive oxygen species (ROS) production during adipogenesis of 3T3-L1 cells. The results revealed that among the five studied wild herb extracts, Ligularia fischeri showed the highest total phenolic contents (215.8 ± 14.2 mg GAE/g) and Aster scaber showed the highest total flavonoid content (103.9 ± 3.4 mg RE/g). Furthermore, Aster scaber and Ligularia fischeri extracts showed higher antioxidant activity than the other wild herbs. Regarding anti-adipogenic activity, the Cirsium setidens extract significantly inhibited lipid accumulation (~80%) and ROS production (~50%) during adipogenesis of 3T3-L1 cells compared with control cells. These results suggest that wild herbs could be used for the development of functional foods as well as health promoting and pharmaceutical agents.
Absolute frequency measurement of 1S0 (F = 1/2) - 3P0 (F = 1/2) transition of 171Yb atoms in a one-dimensional optical lattice at KRISS
Chang Yong Park,Dai-Hyuk Yu,Won-Kyu Lee,Sang Eon Park,Eok Bong Kim,Sun Kyung Lee,Jun Woo Cho,Tai Hyun Yoon,Jongchul Mun,Sung Jong Park,Taeg Yong Kwon,Sang-Bum Lee
Physics , 2011,
Abstract: We measured the absolute frequency of the optical clock transition 1S0 (F = 1/2) - 3P0 (F = 1/2) of 171Yb atoms confined in a one-dimensional optical lattice and it was determined to be 518 295 836 590 863.5(8.1) Hz. The frequency was measured against Terrestrial Time (TT; the SI second on the geoid) by using an optical frequency comb of which the frequency was phase-locked to an H-maser as a flywheel oscillator traceable to TT. The magic wavelength was also measured as 394 798.48(79) GHz. The results are in good agreement with two previous measurements of other institutes within the specified uncertainty of this work.
Predicting the Interactome of Xanthomonas oryzae pathovar oryzae for target selection and DB service
Jeong-Gu Kim, Daeui Park, Byoung-Chul Kim, Seong-Woong Cho, Yeong Kim, Young-Jin Park, Hee Cho, Hyunseok Park, Ki-Bong Kim, Kyong-Oh Yoon, Soo-Jun Park, Byoung-Moo Lee, Jong Bhak
BMC Bioinformatics , 2008, DOI: 10.1186/1471-2105-9-41
Abstract: A PPI network in Xoo proteome was predicted by bioinformatics algorithms: PSIMAP, PEIMAP, and iPfam. We present the resultant species specific interaction network and host-pathogen interaction, XooNET. It is a comprehensive predicted initial PPI data for Xoo. XooNET can be used by experimentalists to pick up protein targets for blocking pathological interactions. XooNET uses most of the major types of PPI algorithms. They are: 1) Protein Structural Interactome MAP (PSIMAP), a method using structural domain of SCOP, 2) Protein Experimental Interactome MAP (PEIMAP), a common method using public resources of experimental protein interaction information such as HPRD, BIND, DIP, MINT, IntAct, and BioGrid, and 3) Domain-domain interactions, a method using Pfam domains such as iPfam. Additionally, XooNET provides information on network properties of the Xoo interactome.XooNET is an open and free public database server for protein interaction information for Xoo. It contains 4,538 proteins and 26,932 possible interactions consisting of 18,503 (PSIMAP), 3,118 (PEIMAP), and 8,938 (iPfam) pairs. In addition, XooNET provides 3,407 possible interaction pairs between two sets of proteins; 141 Xoo proteins that are predicted as membrane proteins and rice proteomes. The resultant interacting partners of a query protein can be easily retrieved by users as well as the interaction networks in graphical web interfaces. XooNET is freely available from http://bioportal.kobic.kr/XooNET/ webcite.Proteins constitute 50 percent or more of the dry weight of living organisms. They have the most diverse biological roles. They function by interacting with other molecules including proteins themselves. Usually, protein-protein interactions are the key mechanisms of normal and pathological functions of living cells. Recently, genomic-scale identification of PPI in model organisms such as Saccharomyces cerevisiae [1-3] and Escherichia coli [4] have been reported to map the network protein-protein i
F-Actin-Dependent Regulation of NESH Dynamics in Rat Hippocampal Neurons
Jeomil Bae, Bong Hwan Sung, In Ha Cho, Woo Keun Song
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0034514
Abstract: Synaptic plasticity is an important feature of neurons essential for learning and memory. Postsynaptic organization and composition are dynamically remodeled in response to diverse synaptic inputs during synaptic plasticity. During this process, the dynamics and localization of postsynaptic proteins are also precisely regulated. NESH/Abi-3 is a member of the Abl interactor (Abi) protein family. Overexpression of NESH is associated with reduced cell motility and tumor metastasis. Strong evidence of a close relationship between NESH and the actin cytoskeleton has been documented. Although earlier studies have shown that NESH is prominently expressed in the brain, its function and characteristics are yet to be established. Data from the present investigation suggest that synaptic localization of NESH in hippocampal neurons is regulated in an F-actin-dependent manner. The dynamic fraction of NESH in the dendritic spine was analyzed using FRAP (fluorescence recovery after photobleaching). Interestingly, F-actin stabilization and disruption significantly affected the mobile fraction of NESH, possibly through altered interactions of NESH with the F-actin. In addition, NESH was synaptically targeted from the dendritic shaft to spine after induction of chemical LTP (long-term potentiation) and the translocation was dependent on F-actin. Our data collectively support the significance of the F-actin cytoskeleton in synaptic targeting of NESH as well as its dynamics.
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