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Search Results: 1 - 10 of 76747 matches for " Bomin Chen "
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Two Important Features of the 156 Deadliest Tropical Cyclones (1851-1996) in the North Atlantic  [PDF]
Bomin Chen, Jiqing Tan, Huiyi Fan
Atmospheric and Climate Sciences (ACS) , 2019, DOI: 10.4236/acs.2019.91005
Abstract: Damages and deaths due to a tropical cyclone (TC) can easily occur at three places belong to a TC: the small ring area (SRA) of maximum sustaining wind around TC eye, the large ring area (LRA) of the rotating wind field around SRA and the skin air belt (SKAB) around LRA. However, weather forecasters only use the intensity of the SRA of a TC as the proxy to gauge the whole TC intensity, which led to many “non-major” TCs proved to be “deadly” TCs. This is called as “over-generalization problem” (OGP). Here we introduce a new way to measure the intensity of a TC. After investigating 156 deadly TCs in North Atlantic, we found an important feature: 83.3% of the top 156 deadliest TCs usually made landfalls along “five major tracks”. Furthermore, we found that the new intensity of those “deadliest” TCs kept almost unchanged with the increasing of time intervals at earlier stage from the genesis points, whereas the new intensity of those “safe” TCs increased in a line with much steeper slope. Using these two features, weather forecasters can have two more options to identify those “non-major” and “deadly” TCs by SSHS in future.
The “Ocean Stabilization Machine” May Represent a Primary Factor Underlying the Effect of “Global Warming on Climate Change”  [PDF]
Yanjun Mao, Jiqing Tan, Bomin Chen, Huiyi Fan
Atmospheric and Climate Sciences (ACS) , 2019, DOI: 10.4236/acs.2019.91009
Abstract: Contemporary references to global warming pertain to the dramatic increase in monthly global land surface temperature (GLST) anomalies since 1976. In this paper, we argue that recent global warming is primarily a result of natural causes; we have established three steps that support this viewpoint. The first is to identify periodic functions that perfectly match all of the monthly anomaly data for GLST; the second is to identify monthly sea surface temperature (SST) anomalies that are located within different ocean basin domains and highly correlated with the monthly GLST anomalies; and the third is to determine whether the dramatically increasing (or dramatically decreasing) K-line diagram signals that coincide with GLST anomalies occurred in El Niño years (or La Niña years). We have identified 15,295 periodic functions that perfectly fit the monthly GLST anomalies from 1880 to 2013 and show that the monthly SST anomalies in six domains in different oceans are highly correlated with the monthly GLST anomalies. In addition, most of the annual dramatically increasing GLST anomalies occur in El Niño years; and most of the annual dramatically decreasing GLST anomalies occur in La Niña years. These findings indicate that the “ocean stabilization machine” might represent a primary factor underlying the effect of “global warming on climate change”.
Numerical Tests for Predicting the Precipitation and Vortices over the Tibetan Plateau in Summer

Chen Bomin,Qian Zhengan,

大气科学 , 1995,
Abstract: This paper first analyzes the differences of the wind and relative humidity fields of FGGE level-IIIb data set for the period from June to July 1979 over the Tibetan Plateau from the truth and reveals the necessity to revise the data set over the west of the Plateau.Then,the initial wind and relative humidity fields in a regional model is corrected,parts of its physical processes modified,and its horizontal resolution inereased.Six predicting experiments are designed.A set of 24-h forecasts of two Plateau vortex/shear line precipitation cases are carried out.The results show that:the precipitation forecast over the Plateau can be clearly improved by modifying thd initial field and model Physics.The now field can also be improved to some extent.This shows that the above modification schemes are feasible.However,the nesting scheme of the model over the Plateau remains to be modified.The next efforts should focus on improving the forecast skill for the Plateau vortex now field.
陈伯民 Chen Bomin,钱正安 Qian Zhengan
大气科学 , 1995, DOI: 10.3878/j.issn.1006-9895.1995.01.07
Abstract: 本文首先分析了1979年6—7月的FGGEIIIb级资料风场和相对湿度场在青藏高原地区的偏差,指出在高原西部应予以订正。然后利用一有限区域模式,通过综合订正初始风场和相对湿度场,改进模式部分物理过程,并提高其水平分辨率,共设计了6组预报试验,对该年的两例高原低涡切变线降水过程进行了24小时预报。结果表明,利用改进了的初始场和部分物理过程,可明显改善高原地区的降水预报,并在一定程度上改善了流场的预报,即上述改进方案是可行的;但在高原地区嵌套预报方案尚待修改,还应继续努力提高模式对高原低涡流场的预报能力。
Systematic Errors of Zonal-Mean Flow in Dynamical Monthly Prediction and Its Improvement

CHEN Bomin,JI Liren,YANG Peicai,ZHANG Daomin,
CHEN Bomin
,JI Liren,YANG Peicai,ZHANG Daomin

大气科学进展 , 2003,
Abstract: An analysis of a large number of cases of 500 hPa height monthly prediction shows that systematicerrors exist in the zonal mean components which account for a large portion of the total forecast errors, andsuch errors are commonly seen in other prediction models. To overcome the difficulties of the numericalmodel, the authors attempt a "hybrid" approach to improving the dynamical extended-range (monthly)prediction. The monthly pentad-mean nonlinear dynamical regional prediction model of the zonal-meangeopotential height (wave number 0) based on a large amount of data is constituted by employing thereconstruction of phase-space theory and the spatio-temporal series predictive method. The dynamicalprediction of the numerical model is then combined with that of the nonlinear model, i.e., the pentad-mean zonal-mean height produced by the nonlinear model is transformed to its counterpart in the numericalmodel by nudging during the time integration. The forecast experiment results show that the above hybridapproach not only reduces the systematic error in zonal mean height by the numerical model, but alsomakes an improvement in the non-axisymmetric components due to the wave-flow interaction.
RNA Interference Targeting Slug Increases Cholangiocarcinoma Cell Sensitivity to Cisplatin via Upregulating PUMA
Kejun Zhang,Dong Chen,Xingang Wang,Shaoyan Zhang,Jigang Wang,Yuan Gao,Bomin Yan
International Journal of Molecular Sciences , 2011, DOI: 10.3390/ijms12010385
Abstract: Slug is an E-cadherin repressor and a suppressor of PUMA (p53 upregulated modulator of apoptosis) and it has recently been demonstrated that Slug plays an important role in controlling apoptosis. In this study, we examined whether Slug’s ability to silence expression suppresses the growth of cholangiocarcinoma cells and/or sensitizes cholangiocarcinoma cells to chemotherapeutic agents through induction of apoptosis. We targeted the Slug gene using siRNA (Slug siRNA) via full Slug cDNA plasmid (Slug cDNA) transfection of cholangiocarcinoma cells. Slug siRNA, cisplatin, or Slug siRNA in combination with cisplatin, were used to treat cholangiocarcinoma cells in vitro. Western blot was used to detect the expression of Slug, PUMA, and E-cadherin protein. TUNEL, Annexin V Staining, and cell cycle analysis were used to detect apoptosis. A nude mice subcutaneous xenograft model of QBC939 cells was used to assess the effect of Slug silencing and/or cisplatin on tumor growth. Immunohistochemical staining was used to analyze the expression of Slug and PUMA. TUNEL was used to detect apoptosis in?vivo. The results showed that PUMA and E-cadherin expression in cholangiocarcinoma cells is Slug dependent. We demonstrated that Slug silencing and cisplatin both promote apoptosis by upregulation of PUMA, not by upregulation of E-cadherin. Slug silencing significantly sensitized cholangiocarcinoma cells to cisplatin through upregulation of PUMA. Finally, we showed that Slug silencing suppressed the growth of QBC939 xenograft tumors and sensitized the tumor cells to cisplatin through PUMA upregulation and induction of apoptosis. Our findings indicate that Slug is an important modulator of the therapeutic response of cholangiocarcinoma cells and is potentially useful as a sensitizer in cholangiocarcinoma therapy. One of the mechanisms is the regulation of PUMA by Slug.
Antisense Oligonucleotide Against Clusterin Regulates Human Hepatocellular Carcinoma Invasion Through Transcriptional Regulation of Matrix Metalloproteinase-2 and E-Cadherin
Dong Chen,Yan Wang,Kejun Zhang,Xuelong Jiao,Bomin Yan,Jun Liang
International Journal of Molecular Sciences , 2012, DOI: 10.3390/ijms130810594
Abstract: Secreted clusterin (sCLU) has been shown to be overexpressed in metastatic hepatocellular carcinoma (HCC) tissue, and its overexpression in HCC cells increases cell migration and the formation of liver metastatic tumor nodules in vivo. In this study, we tested the hypothesis that sCLU plays a role in the invasiveness of human HCC and may be associated with its metastatic spread. HCCLM3, a human hepatocellular carcinoma cell line, was transiently transfected with an antisense oligonucleotide (ASO) against sCLU (OGX-011). HepG2 liver hepatocellular cells were transiently transfected with the pc.DNA3.1-sCLU plasmid to overexpress sCLU, and subsequently evaluated for effects on invasion and the expression of molecules involved in invasion. We observed that suppression of the sCLU gene significantly reduced the invasive capability of the highly invasive HCCLM3 cells, and vice versa in the low invasive HepG2 cell line. The results revealed that knockdown of sCLU by OGX-011 resulted in a significant increase in the expression of E-cadherin and a decrease in matrix metalloproteinase-2 ( MMP-2) gene transcription. Overexpression of sCLU by transfection with pc.DNA3.1-sCLU significantly decreased the expression of E-cadherin and increased MMP-2 gene transcription. These data were further verified by reverse transcription-PCR and Western blot analysis. A significant reduction in MMP-2 expression and an increase in E-cadherin expression in sCLU-knockdown HCCLM3 cells were observed, as well as a significant increase in MMP-2 expression and a decrease in E-cadherin expression in HepG2 cells overexpressing sCLU. These data indicate a role for sCLU in augmenting MMP-2 transcription and decreasing E-cadherin expression. Our data show the involvement of sCLU in human HCC invasion, and demonstrate that silencing sCLU gene expression inhibits the invasion of human HCC cells by inhibiting MMP-2 expression and promoting E-cadherin expression. Thus, OGX-011 could be an effective therapeutic agent for HCC.
An approach to improving the dynamical extended-range(monthly) prediction
An approach to improving the dynamical extended—range(monthly) prediction

Chen Bomin,Ji Liren,Yang Peicai,ZHANG Daomin,WANG Geli,

科学通报(英文版) , 2003,
Abstract: Focusing on common and significant forecast errorsthe zonal mean errors in the numerical prediction model, this report proposes an approach to improving the dynamical extended-range (monthly) prediction. Firstly, the monthly pentad-mean nonlinear dynamical regional predic-tion model of the zonal-mean height based on a large num-ber of historical data is constituted by employing the recon-struction phase space theory and the spatio-temporal series predictive method. The zonal height thus produced is trans-formed to its counterpart in the numerical model and fur-ther used to revise the numerical model prediction during the integration process. In this way, the two different kinds of prediction are combined. The forecasting experimenal results show that the above hybrid approach not only re-duces the systematical error of the numerical model, but also improves the forecast of the non-axisymmetric components due to the wave-flow interaction.
Correction: Liang, J., et al. Antisense Oligonucleotide Against Clusterin Regulates Human Hepatocellular Carcinoma Invasion Through Transcriptional Regulation of Matrix Metalloproteinase-2 and E-Cadherin. Int. J. Mol. Sci. 2012, 13, 10594-10607
Dong Chen,Yan Wang,Kejun Zhang,Xuelong Jiao,Bomin Yan,Jun Liang
International Journal of Molecular Sciences , 2013, DOI: 10.3390/ijms14036516
Abstract: The original version of the paper reports that “ OGX-011 is a second generation 21-mer oligonucleotide with a 20-O-(2-methoxy)-ethyl modification, generously provided by OncoGenex Technologies (OncoGenex, Vancouver, Canada)” [1] (p. 10602). OGX-011 was not provided by OncoGenex Technologies directly. Therefore, we would like to correct the wording to: “OGX-011 was obtained without the benefit of an agreement with OncoGenex, or The University British Columbia, or any other party”. The authors would like to apologize for any inconvenience this may have caused to the readers of this journal.
陈伯民 Chen Bomin,钱正安 Qian Zhengan,张立盛 Zhang Lisheng
大气科学 , 1996, DOI: 10.3878/j.issn.1006-9895.1996.04.14
Abstract: 本文利用一有限区域数值预报模式和综合订正后的1979年6~8月FGGEIIIb级资料,选择该年雨季中三例包含形成和(或)发展阶段的较典型的青藏高原低涡过程,设计了控制性试验和降低高原地形、无地面感热和潜热通量、无凝结潜热、减小温度递减率、增大气柱斜压性、无摩擦影响的十余组试验方案,进行了24h或48h数值模拟。最后提出了青藏高原低涡发生发展的概念模式。简单地讲,青藏高原低涡可看作是一种强烈依赖于青藏高原地形,同时又受层结稳定度、地面热通量和凝结潜热控制的局地性低压涡旋。
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