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Search Results: 1 - 10 of 42567 matches for " Bochu Xu "
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Study on Characteristics of the Wheelchair-User Combination  [PDF]
Zerui Xiang, Jinyi Zhi, Shiyu Dong, Bochu Xu
Journal of Biosciences and Medicines (JBM) , 2016, DOI: 10.4236/jbm.2016.46002
Abstract:
To summarize the characteristics of wheelchair-user combination, this paper studied wheelchairs, wheelchair users, nursing staffs and interaction relationship between them. Firstly, the findings of some research on wheelchairs and wheelchair users were investigated, and the studies in four aspects of wheelchairs and their accessories, wheelchair users, wheelchairs and wheelchair users (man-machine system), and skills training for the performance of wheelchair were reviewed. Then “wheelchair-user combination” was put forward based on the relationship between wheelchairs and wheelchair users in real life, and the “wheelchair-user combination” was divided into “WUs-Ws system” and “WUs-Ws-NSs system” according to whether the nursing staffs were needed. Finally, this paper analytically studied the characteristics of wheelchair users, characteristics in use of wheelchair and characteristics of nursing staffs, as well as put forward the characteristics of the wheelchair-user combination.
地铁客室乘坐设备人机功能尺寸设计
Man-Machine Functional Dimension Design of Riding Equipment in Subway Passenger Compartments

魏峰, 徐伯初, 支锦亦, 董石羽
WEI Feng
, XU Bochu, ZHI Jinyi, DONG Shiyu

- , 2018, DOI: 10.3969/j.issn.0258-2724.2018.04.027
Abstract: 为探讨乘客身材特征对地铁客室中乘坐设备功能尺寸设计的影响,运用人机工程学以人为中心的实验和相关分析法展开研究.围绕人的生理结构、心理尺度和乘坐设备的功能属性等因素,结合压力分布实验、虚拟仿真技术和主观评价分析,对人与地铁座椅和扶手之间的功能尺寸配置关系进行了测试与分析.研究结果表明:座椅腰靠纵向外凸圆弧的曲率半径为186 mm、座垫横向内凹圆弧的曲率半径为785 mm时更贴近人体坐姿的生理曲度和满足乘坐的舒适性要求;扶手的吊环高度设置在1 710 mm、横杆高度设置在1 860 mm时能够分别保障不同身材的乘客的使用需求,并能满足适用性、安全性和通行性之间的平衡.
:A human-centred experiment and ergonomic correlation-analysis approach was adopted to investigate the impact of passenger body size on the functional dimension design of riding equipment in subway passenger compartments. Subsequently, the relationship between the functional dimension configuration among passengers, subway seats, and handrails was tested and analysed based on human physiological structure, psychological endurance, and functional properties of riding equipment. This was achieved by combining a pressure distribution experiment with virtual simulation technology and subsequent subjective evaluation and analysis. Results demonstrate that when the curvature radius of the backrest outer convex arc measures 186 mm while that of the cushion inner concave arc measures 785 mm, seat surface closely matches the physiological curvature of the body-sitting posture, thereby meeting the requirements of riding comfort. Also, when the height of handrail rings and that of cross rods are set as 1 710 mm and 1 860 mm, respectively, handrail height meets usage requirements of passengers having different bodies sizes as well as that of balance between applicability, safety, and accessibility
Biodegradation of Silk Biomaterials
Yang Cao,Bochu Wang
International Journal of Molecular Sciences , 2009, DOI: 10.3390/ijms10041514
Abstract: Silk fibroin from the silkworm, Bombyx mori, has excellent properties such as biocompatibility, biodegradation, non-toxicity, adsorption properties, etc. As a kind of ideal biomaterial, silk fibroin has been widely used since it was first utilized for sutures a long time ago. The degradation behavior of silk biomaterials is obviously important for medical applications. This article will focus on silk-based biomaterials and review the degradation behaviors of silk materials.
南海西北次海盆及其邻区的地热流特征与研究
Characteristics and Research of Heat Flow in the Northwest Sub-Basin and Its Adjacent Areas of the South China Sea

徐行,王先庆,彭登,姚永坚,姚伯初,万志峰
Xu Xing
, Wang Xianqing, Peng Deng, Yao Yongjian, Yao Bochu, Wan Zhifeng

地球科学(中国地质大学学报) , 2018, DOI: 10.3799/dqkx.2017.606
Abstract: 西北次海盆是南海海盆的一个重要构造单元,揭示西北次海盆的地热流特征对于整体认识南海海盆热状态和热结构至关重要.沿着OBS2006-1地震剖面采集的一批实测地热流数据显示,该热流探测剖面横穿南海北部陆坡、西北次海盆、中沙隆起、东部次海盆4个构造单元,结合地震解释剖面等资料对西北次海盆进行地热流特征分析及研究.结果表明:西北次海盆的平均热流密度值为104.5±9.9 mW/m2,与中沙隆起相邻的东部次海盆北部的平均热流密度值为97±2.5 mW/m2,热流密度值的空间变化与地幔埋深起伏相对应,并受地幔热源所控制;通过研究热流异常点,发现水深相近的相邻站位之间的海底表层沉积物温度差异是判别测站受海底地下水热循环影响程度和类型的依据之一;用最新海洋地热流探测成果,结合区域地质与地球物理资料,推测西北次海盆形成演化时代与西南次海盆相近,只是它的生命史比较短暂.
The Northwest sub-basin (NW sub-basin) is an important tectonic unit in the South China Sea. It is of great importance to reveal the geothermal characteristics of the NW sub-basin for the better understanding of thermal and thermal structures of the basins of South China Sea. We have collected a series of measured heat flow data along the OBS2006-1 seismic profile. This heat flow profile crosses four tectonic units, including the northern slope of the South China Sea,the NW sub-basin,the Zhongsha rise and the east sub-basin. With the seismic interpretation profile,this paper analyzes and studies in detail the heat flow characteristics. The results show that the average heat flow value is 104.5±9.9mW/m2 in the NW subbasin,and the average heat flow value in the northern part of the East subbasin is 97±2.5mW/m2,the change trend of the heat flow values is similar to that of the Moho depth,which manifests that the deep thermal state is controlled by the source of mantle heat. By studying the anomalies of heat flow,it is found that the temperature difference between the seabed surface sediments in adjacent sites is one of the basis for judging the degree and type of groundwater thermal cycling. With the latest ocean heat flow detection results,combined with regional geology and geophysical data,it is suggested that the formation of the NW sub-basin is similar to that of the Southwest sub-basin,but with relatively shorter history
Quantum Dots: A Novel Tool to Discovery
Tan Jun,Wang Bochu,Zhu Liancai
Pakistan Journal of Biological Sciences , 2006,
Abstract: Quantum dots, namely semiconductor nanocrystals, have caught great interests of scientists in physics, chemistry, materials science, biology, in particular drug discovery in recent years. In this paper, we mainly review the characteristics of quantum dots, its significance and potential applications to drug discovery. In addition, biocompatibility, bioconjugation and biotoxicity of quantum dots are analyzed and discussed.
Effect of Ginsenosides on Malondialdehyde, Nitric Oxide and Endothelin-1 Production in Vascular Endothelial Cells Suffering from Lipid Peroxidation Injury
Tan Jun,Zhu Liancai,Wang Bochu
International Journal of Pharmacology , 2007,
Abstract: Ginsenosides are the main effective substance in Panax ginseng and have bioactivity to improve cardiovascular function. In this study, effect of ginsenosides on malondialdehyde (MDA), Nitric Oxide (NO) and endothelin-1 (ET-1) production in human vascular endothelial cells strain VEC304 treated with diamide was studied. The treatment of VEC304 with 0.01 μL · L-1 diamide significantly increased MDA production (p<0.01), significantly decreased NO production (p<0.05) and slightly increased ET-1 production in cells, indicating that diamide induced lipid Peroxidation injury for VEC304. While after VEC304 injured by lipid peroxidation were treated with ginsenosides, MDA production and ET-1 production in cells were decreased significantly (p<0.01) by 29.81 and 38.18%, respectively and NO production in cells was increased significantly (p<0.01) by 6.04 times. The results implied that Panax ginseng and ginsenosides work effectively on cardiovascular diseases probably by anti-oxidation and increasing NO production and decreasing ET-1 production in VEC.
Effects of Quercetin on DNA Damage Induced by Copper Ion
Tan Jun,Zhu Liancai,Wang Bochu
International Journal of Pharmacology , 2007,
Abstract: It is well known that DNA damage plays an important role in carcinogenesis. Quercetin, as an antioxidant and free radical-scavenger, is known to protect DNA from damage produced by Reactive Oxygen Species (ROS) such as hydroxyl free radical (·OH), Hydrogen Peroxide (H2O2) and superoxide ion (O2·G). But quercetin has been reported to be carcinogenic too. Based on the contradiction in terms, we study the effect of quercetin on DNA damage in the presence of cupric ion. Present results show that quercetin has opposite effects on DNA damage induced by cupric ion depending on the concentration of cupric ion. At low concentration of cupric ion, quercetin exerted a protective role. While at higher concentration of cupric ion, quercetin promoted DNA cleavage, which was not inhibited by hydroxyl free radical scavenger. Additionally, quercetin diminished slightly the oxidation of CT DNA by cupric ion plus H2O2 in the 2-thiobarbituric acid-reactive substances (TBARS) assay. So, it can be concluded that oxidative stress is not the only reason for DNA damage induced by quercetin plus cupric ion. We further propose a mechanism for explaining the promoting effect that formation of quercetin copper (II) complexes binding to DNA in an intercalation mode may result in hydrolytic cleavage of DNA. The results may imply that in certain pathological situations quercetin may result in DNA damage rather than exert a protective role to bring on carcinogenesis.
Thermo-sensitive Polymers for Controlled-release Drug Delivery Systems
Li Jun,Wang Bochu,Wang Yazhou
International Journal of Pharmacology , 2006,
Abstract: In recent years, thermo-sensitive polymer as a novel carrier for controlled-release drug delivery systems has been widely concerned by researchers. With respect to thermo-sensitive polymer, Researchers study on its properties in controlled-release drug delivery systems, such as biodegradation, biocompatibility, Lower Critical Solution Temperature (LCST), biotoxicity, etc. In this study, we mainly review the characteristics of thermo-sensitive polymer, its present research state and further study tendency.
The Application of Thermosensitive Nanocarriers in Controlled Drug Delivery
Pengyu Shao,Bochu Wang,Yazhou Wang,Jun Li,Yiqiong Zhang
Journal of Nanomaterials , 2011, DOI: 10.1155/2011/389640
Abstract: Thermosensitive nanocarriers as the “smart” drug delivery systems have shown tremendous promise in the field of controlled drug delivery due to their special property. Thermosensitive nanocarriers with long circulation properties can accumulate in the pathological sites by enhanced permeability and retention (EPR) effect or attach targeting ligands to the surface of the nanocarriers, and the drug release rates of these pharmaceutical nanocarriers can be adjusted in response to thermal variability of the environment. In this paper, we first discuss the classification of thermosensitive polymer according to their functional properties in thermosensitive nanocarriers. On the basis of this, our main purposes are focused on reviewing the characteristics of various thermosensitive nanocarriers including the strategies for their functionalization, thermosensitive behavior, or site-specific targeting. Furthermore, the paper discusses the current and future trends of the thermosensitive nanocarriers in controlled drug delivery.
Improved nanoparticles preparation and drug release for liver targeted delivery
Qiao Weili,Wang Bochu,Liu Peng,Yang Lichun
Iranian Journal of Medical Hypotheses & Ideas , 2009,
Abstract: "nTargeted delivery of drugs and proteins to liver can be achieved via asialoglycoprotein receptor, which can recognize and combine the galactose- and N-acetygalatosamine-terminated glycoproteins. Glycosyl is usually conjugated with drugs directly to fabricate prodrugs or with nanoparticles encapsulated drugs via forming covalent bonds, while the covalent bonds may lead to some shortages for drug release. Therefore, we have a hypothesis that we can prepare nanoparticles for efficient targeting by glycosylation using galactosylated poly (L-glutamic acid) (Gal-PLGA) as a carrier to entrap the model drugs in nanoparticles core physically rather than forming covalent drug conjugation. The means of incorporation of drug in nanoparticles may improve drug release to maintain its activity, raise its therapeutic index and diminish the adverse effect. Based on previous researches, it is achievable to obtain nanoparticles that we hypothesize to prepare. Due to their nanometer-size and galactosyl, the nanoparticles may be a potential delivery system for passive and active targeting to liver parenchymal cells for therapy of hepatitis and liver cancer.
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