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Search Results: 1 - 10 of 1899 matches for " Bishajit Sarkar "
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Molecular Docking and Pharmacological Property Analysis of Phytochemicals from Clitoria ternatea as Potent Inhibitors of Cell Cycle Checkpoint Proteins in the Cyclin/CDK Pathway in Cancer Cells  [PDF]
Asad Ullah, Nazmul Islam Prottoy, Yusha Araf, Sohana Hossain, Bishajit Sarkar, Ananna Saha
Computational Molecular Bioscience (CMB) , 2019, DOI: 10.4236/cmb.2019.93007
Abstract: Cancer comprises a group of diseases which are involved in the aberrant growth of the cells causing disruption of normal body function. Due to the lack of proper sophisticated treatments this nasty disease leads to the death of most of the patients affected with it. Moreover, treatments like chemotherapy involve other post-treatment complications which make them unfavorable for extended use. Medicinal plants possess many phytochemicals of great therapeutic value and many of them are effective in killing cancer cells. These compounds working by variety of mechanisms and in most of the cases exhibit their anticancer potentiality by inhibiting many proteins involved in cell growth and division. Molecular docking is a computational approach which facilitates the finding of the best molecule from a group which may bind with the highest affinity with the intended target by providing a virtual biological system. This process works on the basis of specific algorithm and involves scoring function to rank the molecules that fit with the target. This study has been designed to investigate the potentiality of four phytochemicals from Clitoria ternateaKaempferol, Myricetin, P-Hydroxycinnamic acid and Quercetin as inhibitors of two cell cycle checkpoint proteins—Cyclin Dependent Kinase-2 (CDK-2) and Cyclin Dependent Kinase-6 (CDK-6) in Cyclin/CDK pathway. Quercetin and Myricetin docked with higher affinity with CDK-2 and CDK-6 respectively. Drug likeness property analysis and ADME/T test impose computational approach to investigate physicochemical and pharmacological properties of candidate drug molecules. P-Hydroxycinnamic acid performed well in both drug likeness property analysis and ADME/T than Quercetin and Myricetin. So, P-Hydroxycinnamic acid is the best finding of this experiment.
Thrombolytic Activity, Drug Likeness Property and ADME/T Analysis of Isolated Phytochemicals from Ginger (Zingiber officinale) Using In Silico Approaches  [PDF]
Sohana Hossain, Bishajit Sarkar, Md. Nazmul Islam Prottoy, Yusha Araf, Masuma Afrin Taniya, Md. Asad Ullah
Modern Research in Inflammation (MRI) , 2019, DOI: 10.4236/mri.2019.83003
Abstract: This experiment has been carried out to observe the potential thrombolytic activity of naturally occuring phytochemicals in Ginger (Zingiber officinale) and to analyze their drug likeness property and ADME/T profile. Thrombolytic activity of Ginger has already been confirmed in laboratory experiment and this study focuses on the molecular interactions among four phytocompounds (Isovanillin, Gingerol, Beta-sitosterol and 2,6-Dimethyl-2-octene-1,8-diol) found in Ginger and Tissue Plasminogen Activator (tPA). Present experiment is largely based on computer-aided drug design protocol where the strength of interaction is described as binding energy function. Isovanillin exhibited better docking score, and so this compound might have greater thrombolytic activity than others. Moreover, Isovanillin also suggested sound drug likeness property and ADME/T profile which predicts its safeness for consumption in human body. But Beta-sitosterol violated Lipinski’s rule of five and 2, 6-Dimethyl-2-octene-1,8-diol showed the lowest affinity of binding with tPA. However, further in vivo or in vitro study may be required to confirm the thrombolytic activity of Isovanillin.
Computational Assessment and Pharmacological Property Breakdown of Eight Patented and Candidate Drugs against Four Intended Targets in Alzheimer’s Disease  [PDF]
Bishajit Sarkar, Syed Sajidul Islam, Md. Asad Ullah, Sohana Hossain, Md. Nazmul Islam Prottoy, Yusha Araf, Masuma Afrin Taniya
Advances in Bioscience and Biotechnology (ABB) , 2019, DOI: 10.4236/abb.2019.1011030
Abstract:
Alzheimer’s Disease (AD) is the most prevalent age-related dementia. AD can be caused by abnormal processing of amyloid precursor protein (APP) or by oxidative stress or may be due to the actions of kinases or the degeneration and loss of functions of neurons in the brain. Although various treatments have already gained success in the in vitro studies, however, till now not a single satisfactory drug has been proven that can cure this disease permanently till now. In this study, the best possible drug has been determined from a group of drug molecules using methods of molecular docking. Molecular docking is a computational approach which helps to determine the best molecule from a group of molecules which may bind with the highest affinity with the intended target by mimicking the original biological environment in a computer. The tested drug molecules in this experiment are the disease modifying agents, capable of inhibiting a particular protein involving in the AD pathway. Eight drug molecules (ligands)-memantine (-4.075 Kcal/mol), hymenialdisine (-8.079 Kcal/mol), tideglusib (-6.445 Kcal/mol)
Perfect Entanglement Transport in Quantum Spin Chain Systems  [PDF]
Sujit Sarkar
Journal of Quantum Information Science (JQIS) , 2011, DOI: 10.4236/jqis.2011.13014
Abstract: We propose a mechanism for perfect entanglement transport in anti-ferromagnetic (AFM) quantum spin chain systems with modulated exchange coupling and also for the modulation of on-site magnetic field. We use the principle of adiabatic quantum pumping process for entanglement transfer in the spin chain systems. We achieve the perfect entanglement transfer over an arbitrarily long distance and a better entanglement transport for longer AFM spin chain system than for the ferromagnetic one. We explain analytically and physically—why the entanglement hops in alternate sites. We find the condition for blocking of entanglement transport even in the perfect pumping situation. Our analytical solution interconnects quantum many body physics and quantum information science.
Adsorptive Mass Transport of Dye on Rice Husk Ash  [PDF]
Debasish Sarkar, Amitava Bandyopadhyay
Journal of Water Resource and Protection (JWARP) , 2010, DOI: 10.4236/jwarp.2010.25049
Abstract: Experimentations have been carried out to characterize the adsorption of Methylene Blue (MB) and Congo Red (CR) dyes in the aqueous phase onto Rice Husk Ash (RHA). Theoretically analyses are also made for describing the sorption and diffusion processes. The effective pore diffusivities of the dye molecules studied in RHA are determined by a suitable global optimization technique. The depth of penetration, on the other hand, has been estimated for various initial concentrations of dyes. Theoretically predicted concentration pro-files are compared with the experimental values at different initial concentrations of these dyes. Such com-parative studies indicate that the predicted values are in excellent agreement with the experimental values.
Global Climate Change and Emerging Environmental and Strategic Security Issues for South Asia  [PDF]
Amarendra Nath Sarkar
Journal of Environmental Protection (JEP) , 2011, DOI: 10.4236/jep.2011.29135
Abstract: Global climate change-essentially an adverse consequence of global warming, is principally caused by progressive build-up and extensive spread of greenhouse gases (GHGs) across countries, regions or continents because of earth’s rotational movement. The potent sources of GHGs are fossil-fuels and biomass. With the increasing pace of globalization, industrialization and rapid change of life-style the demand and consumption of these feed-stocks to stimulate economic growth is steadily rising-both in the developing and developed economy. In the process, the emissions level is also rising phenomenally; and of late become quite alarming-more in the former than latter case, affecting thereby the environmental quality as also its security concerns globally. This paper highlights the major impacts of global warming and consequential climate change on the environmental quality and overall security aspects-including commercial, strategic and defense angles for the South-Asian region. The paper also discusses some relevant aspects linking the larger question of energy security with environmental security through the approach of sustainable energy development for envisioning a balanced economic development as well as growth perspective for South Asia. The significance of International cooperation in the mitigation and adaptation of climate change impacts with special reference to Asia- Pacific and South Asian region is also discussed at some length in the paper.
Studies on Aluminum-Iron Ore in-Situ Particulate Composite  [PDF]
S. Sarkar, Akhilesh Singh
Open Journal of Composite Materials (OJCM) , 2012, DOI: 10.4236/ojcm.2012.21004
Abstract: Discontinuously reinforced aluminium matrix composites are fast emerging as engineering materials and competing with common metals and alloys. They are gaining significant acceptance because of higher specific strength, specific modulus and good wear resistance as compared to ordinary unreinforced alloys. Reinforcing particles or short fibers normally used are silicon carbide and alumina which are added externally. Recently it has been shown that alumina particles can be produced in-situ by reaction with metallic oxides reduced by aluminium. Alumina particles thus produced are dispersed in the aluminium matrix and the elementary metal gives solid solution strengthening of the matrix. In-situ particulate composites in comparison with conventional cast particulate composites produced by external addition promote cleaner interface, eliminates interface incompatibility of the matrices with the reinforcements, help to achieve greater thermodynamic stability of reinforcement particles in the matrix at elevated temperature and also increase the possibility of developing coherency between the matrix and particles formed in-situ. The morphology and the distribution of particles strongly influence the physical and mechanical properties of composites. In the present investigation, iron ore was added to molten aluminium, aluminium-magnesium and aluminium-silicon alloys by vortex method. The iron oxides present in the iron ore are observed to react with aluminium, magnesium resulting in production of Al2O3, MgO and metallic iron which dissolved in liquid aluminium. The composites thus produced were cast into cast iron die. The mechanical properties of the composites were evaluated. The dry sliding wear behavior of the cast composites was studied at different loads and different sliding velocities using Pin-On-Disk configuration wear testing machine. The worn surfaces and the wear debris were also analyzed using optical microscope and scanning electron microscope.
Evolving Green Aviation Transport System: A Hoilistic Approah to Sustainable Green Market Development  [PDF]
A. N. Sarkar
American Journal of Climate Change (AJCC) , 2012, DOI: 10.4236/ajcc.2012.13014
Abstract: Aviation is one of the fastest growing industries as well as transportation modes in the world. Global aviation contributes about 2% of global greenhouse gas emissions and supports 8% of the world economic activity in terms of GDP. With the phenomenal growth in air trafficking by the national and international airliners the total carbon space available for flying is getting progressively diminished and the consequential emission levels are also becoming alarming over passage of time. The paper describes the concept of evolution of Green Transport system with focus on manufacturing of green aircraft and sustainable green marketing involving green supply chain. This entails introduction of New and innovative technologies, including aircraft designing, improving operational efficiency, air traffic control & monitoring etc; combined with emission mitigation efforts towards sustainable growth of the industry, can make enormous improvements in emission control and reduction in a planned and system-based manner. These integrated approaches are proposed to be used to harmonize the systems and processes that can essentially constitute the suggested framework of the Green Aviation Transport system. The paper, inter alia, discusses various conceptual, strategic, technological and economic and environmental dimensions of the Green Aviation transport system with focus on creating new Green Marketing opportunities for the aviation industry in future.
Artificial Neural Networks for Event Based Rainfall-Runoff Modeling  [PDF]
Archana Sarkar, Rakesh Kumar
Journal of Water Resource and Protection (JWARP) , 2012, DOI: 10.4236/jwarp.2012.410105
Abstract: The Artificial Neural Network (ANN) approach has been successfully used in many hydrological studies especially the rainfall-runoff modeling using continuous data. The present study examines its applicability to model the event-based rainfall-runoff process. A case study has been done for Ajay river basin to develop event-based rainfall-runoff model for the basin to simulate the hourly runoff at Sarath gauging site. The results demonstrate that ANN models are able to provide a good representation of an event-based rainfall-runoff process. The two important parameters, when predicting a flood hydrograph, are the magnitude of the peak discharge and the time to peak discharge. The developed ANN models have been able to predict this information with great accuracy. This shows that ANNs can be very efficient in modeling an event-based rainfall-runoff process for determining the peak discharge and time to the peak discharge very accurately. This is important in water resources design and management applications, where peak discharge and time to peak discharge are important input variables
Consumption Profile of the Socially Excluded People  [PDF]
Maniklal Adhikary, Khokon Sarkar
Modern Economy (ME) , 2012, DOI: 10.4236/me.2012.36098
Abstract: People are excluded when they are not a part of main stream of society in their daily life due to caste, creed, religion and economic condition. This indicates that the socially excluded people are customarily shunned in the zone of employment, community, friends and family. Nobody would deny that many old age people, homeless people, people with aids, people with mental and physical disability, ex-prisoners are said to be at the risk of exclusion. In this paper we have defined excludability in terms of castes, creed, religion, economic conditions and others. We would look into the food security status reflected in consumption profile among those particular categories of people, in terms of their monthly per capita expenditure (MPCE) on both food and non-food items with the help of NSSO 61st round data. Based on goal post index the consumption pattern of the socially excluded people across different states of India has been made evident. We have also tested the Engels law, and it has been found empirically accepted. Contrasted with the situation of other caste people the food security status of the socially excluded people has been found to be placed at all-time low level.
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