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Search Results: 1 - 5 of 5 matches for " Birgita;Chovanec "
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The effect of femoral and popliteal percutaneous transluminal balloon angioplasty on patients' quality of life
Slovacek, Ladislav;Slovackova, Birgita;Chovanec, Vendelin;
Sao Paulo Medical Journal , 2007, DOI: 10.1590/S1516-31802007000400012
Abstract: context and objective: peripheral arterial occlusive disease (paod) is a prevalent atherosclerotic disorder characterized by limb pain on exertion, limb loss and a high mortality rate. because of its chronic nature, it often has a negative impact on patients' quality of life (qol). this study aimed to assess qol among patients with paod that was treated by endovascular intervention using femoral and popliteal percutaneous transluminal balloon angioplasty (ptba). design and setting: this study was local, prospective and longitudinal. it was carried at the second department of internal medicine of charles university hospital in hradec kralove, czech republic. methods: thirty paod patients (20 male and 10 female) were treated by endovascular intervention using femoral and popliteal ptba. the czech version of the international generic european quality of life questionnaire (eq-5d) was applied. results: the statistical evaluation demonstrated that qol presented highly significant statistical dependence on femoral and popliteal ptba (p < 0.0001). conclusion: the results showed that femoral and popliteal ptba had a highly positive effect on the qol of patients with paod.
Graphical Reprezentation of Atomic D-posets
Ferdinand Chovanec,Eva Drobna
Advances in Electrical and Electronic Engineering , 2004,
Abstract: In the present paper is shown a construction of D-posets using of the method of the MV-algebra pasting and their graphical representation by Haase and Greechie diagrams.
Psychosocial, health and demographic characteristics of quality of life among patients with acute myeloid leukemia and malignant lymphoma who underwent autologous hematopoietic stem cell transplantation
Slovacek, Ladislav;Slovackova, Birgita;Jebavy, Ladislav;Macingova, Zuzana;
Sao Paulo Medical Journal , 2007, DOI: 10.1590/S1516-31802007000600012
Abstract: context and objective: this study evaluated the effect of selected psychosocial, health and demographic characteristics of quality of life (qol) among patients treated with autologous hematopoietic stem cell transplantation (hsct). design and setting: this was a retrospective study at charles university hospital, hradec kralove. methods: the czech version of the international generic european quality-of-life questionnaire (eq-5d) was applied to evaluate qol among patients with acute myeloid leukemia (aml) and malignant hodgkin?s and non-hodgkin?s lymphoma (ml). the total number of respondents was 36: 12 with aml (seven males and five females) and 24 with ml (11 males and 13 females). the mean age of aml respondents was 46 years and the mean age of ml respondents was 44.5 years. results: age, smoking status and education level had statistically significant effects on qol among aml respondents (p < 0.05), and age had a statistically significant effect on qol among ml respondents (p < 0.05). the overall qol among aml and ml respondents was generally good: the mean eq-5d score among aml respondents was 71.5% and among ml respondents it was 82.7%. conclusion: the qol among aml and ml respondents treated with autologous hsct was good. however, patients more than 50 years old, smokers and patients with lower education levels presented worse qol. these findings need to be better evaluated in longitudinal studies, using large samples.
Mining of Coal Seams Under the Main Haulage Level
Josef Chovanec , Petr Urban , Ivo Pěg ímek , Vitězslav Ko novsky
GeoScience Engineering , 2011, DOI: 10.2478/v10205-011-0002-6
Abstract: The question of mining under the main haulage level as a way by which in some cases coal reserves can be effectively extracted is still discussed. The paper introduces advantages and disadvantages of this method. It presents examples of the bedding of a seam in a limited depth under level, for example 50 m, when the opening by the under level mining method is obviously more advantageous. Special attention is given to risks of ventilation short circuit which are higher in this method compared to classical opening. The paper also gives a brief economical reflection allowing to determine the efficiency of under level mining.
Components of a Fanconi-Like Pathway Control Pso2-Independent DNA Interstrand Crosslink Repair in Yeast
Thomas A. Ward equal contributor,Zuzana Dudá?ová equal contributor,Sovan Sarkar,Mangesh R. Bhide,Danu?a Vlasáková,Miroslav Chovanec,Peter J. McHugh
PLOS Genetics , 2012, DOI: 10.1371/journal.pgen.1002884
Abstract: Fanconi anemia (FA) is a devastating genetic disease, associated with genomic instability and defects in DNA interstrand cross-link (ICL) repair. The FA repair pathway is not thought to be conserved in budding yeast, and although the yeast Mph1 helicase is a putative homolog of human FANCM, yeast cells disrupted for MPH1 are not sensitive to ICLs. Here, we reveal a key role for Mph1 in ICL repair when the Pso2 exonuclease is inactivated. We find that the yeast FANCM ortholog Mph1 physically and functionally interacts with Mgm101, a protein previously implicated in mitochondrial DNA repair, and the MutSα mismatch repair factor (Msh2-Msh6). Co-disruption of MPH1, MGM101, MSH6, or MSH2 with PSO2 produces a lesion-specific increase in ICL sensitivity, the elevation of ICL-induced chromosomal rearrangements, and persistence of ICL-associated DNA double-strand breaks. We find that Mph1-Mgm101-MutSα directs the ICL-induced recruitment of Exo1 to chromatin, and we propose that Exo1 is an alternative 5′-3′ exonuclease utilised for ICL repair in the absence of Pso2. Moreover, ICL-induced Rad51 chromatin loading is delayed when both Pso2 and components of the Mph1-Mgm101-MutSα and Exo1 pathway are inactivated, demonstrating that the homologous recombination stages of ICL repair are inhibited. Finally, the FANCJ- and FANCP-related factors Chl1 and Slx4, respectively, are also components of the genetic pathway controlled by Mph1-Mgm101-MutSα. Together this suggests that a prototypical FA–related ICL repair pathway operates in budding yeast, which acts redundantly with the pathway controlled by Pso2, and is required for the targeting of Exo1 to chromatin to execute ICL repair.
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