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Search Results: 1 - 10 of 15695 matches for " Biotin-D "
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Appraisal of Techniques, Investigation and Analysis of Vitamin (B7) Biotin  [PDF]
Safila Naveed, Fatima Qamar, Syeda Sarah Abbas, Syed Hameez Jawed, Wajiha Raza, Mahera Khan, Bushra Iqbal
Open Access Library Journal (OALib Journal) , 2015, DOI: 10.4236/oalib.1101894
Abstract: Biotin is also called vitamin B7, vitamin B8 or vitamin H. Biotin is a water soluble compound and is colorless in appearance. Overall eight different types of biotin exist but only Biotin-D occurs naturally with its complete vitamin activity. It is mainly synthesized by mold, algae, bacteria, yeast and some plant species. There are different methods used to find the vitamins in nutrients and samples. This article is composed of the comprehensive review of the competitive techniques and various methods for the assay of biotin. High-pressure liquid chromatographic (HPLC), microbiological analysis and HPLC producer are adopted for the determination of biotin. An optimal analytical condition of biotin determination was performed by the HPCL method. The statistical parameters of the HPLC methods were compared and reviewed with other determination.
Scientific Opinion on the substantiation of a health claim related to a combination of thiamin, riboflavin, niacin, pantothenic acid, pyridoxine, D-biotin and pumpkin seed oil and maintenance of normal hair pursuant to Article 13(5) of Regulation (EC) No 1924/2006
EFSA Panel on Dietetic Products, Nutrition and Allergies
EFSA Journal , 2012, DOI: 10.2903/j.efsa.2012.2807
Abstract: Following two applications from Nutrilinks Sarl, submitted pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Belgium, the Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scientific substantiation of a health claim related to a combination of thiamin, riboflavin, niacin, pantothenic acid, pyridoxine, D-biotin and pumpkin seed oil (Cucurbita pepo L.) and maintenance of normal hair. The Panel considers that the specified combination is sufficiently characterised. The claimed effects are “contributes to reduce hair loss” and “increases the number of hair”. The target population proposed by the applicant is healthy adults in the general population. The Panel considers that maintenance of normal hair is a beneficial physiological effect. The applicant identified one publication as being pertinent to the health claim. This study did not use the food which is the subject of the claim. No conclusions can be drawn from this study for the scientific substantiation of the claim. The Panel concludes that a cause and effect relationship has not been established between the consumption of a combination of thiamin, riboflavin, niacin, pantothenic acid, pyridoxine, D-biotin and pumpkin seed oil (Cucurbita pepo L.) and maintenance of normal hair.
Differential effect of biotin on carboxylase activity and mice skeletal muscle metabolism  [PDF]
Marco Antonio Parra Montes de Oca, Gabriel Gutiérrez-Ospina, Pablo Hofmann Salcedo, Alma Lilia Fuentes-Farías, Esperanza Meléndez-Herrera, Margarita Gómez-Chavarín, Armida Báez-Salda?a
Advances in Bioscience and Biotechnology (ABB) , 2013, DOI: 10.4236/abb.2013.47A2006
Abstract: In mammalian skeletal muscle there are four carboxylases involved in several biochemical processes like gluconeogenesis, tricarboxylic acid cycle anaplerosis, metabolism of fatty acids and metabolism of various amino acids. It has been shown that biotin deficiency reduces body weight at the expense of muscular mass. When necessary, the liver uses skeletal muscle protein to provide glucose and amino acids to organs in need of such compounds. In this paper we analyzed carboxylase specific activities in hind limb skeletal muscle of 3 weeks old BALB/c male mice, at 0, 1, 4, 7, and 14 days of a specific diet with different biotin concentrations. Biotin was used at 0.0, 1.8 or 98.2 mg per kg of food; and was referred to as biotin deficient, sufficient and supplemented, respectively. Water and food supply and consumption by the three groups of mice were the same. Therefore, the observed effects were directly related to biotin ingestion. The body weight of biotin supplemented mice was the same as the body weight of mice in the biotin sufficient group, while biotin deficiency caused body weight reduction after 7 days of biotin depletion. We found that the total protein concentration in the vastus lateralis muscle is associated with the biotin content in the diet. After 7 days, the muscle total protein content was lower in mice of the biotin deficient group while it was higher in the mice from the biotin supplemented group (P < 0.001). Of the four analyzed enzymes, only pyruvate carboxylase specific activity was reduced in both cases: by consuming the supplemented diet and by the lack of this vitamin. Our data show that PC and muscle metabolism are differentially altered by both, biotin excess and biotin deficiency. The mechanisms of these effects are currently under investigation.
Effects of a rumen protected B vitamin blend substituted for biotin upon milk production and component yield in lactating dairy cows  [PDF]
Essi Evans, David T. Mair
Open Journal of Animal Sciences (OJAS) , 2013, DOI: 10.4236/ojas.2013.32014
Abstract:

Results from 4 switchback field trials involving 608 cows were combined to assess the effects of a protected B vitamin blend (BVB) vs 10 mg of unprotected biotin upon milk yield (kg), fat %, protein %, fat yield (kg) and protein yield (kg) in primiparous and multiparous cows. Trials consisted of 3 DHIA periods executed in the order control-test-control. Cows from 45 to 300 days in milk (DIM) at the start of the experiment that were available for all 3 periods were included in the analysis. No diet changes other than the substitution of 3 grams/cow/day of the BVB for 10 mg of biotin during the test period occurred. Results from the two control periods were compared to results obtained during the test period by individual cow using a paired T test. Results for all cows showed that the provision of the BVB resulted in increased (P < 0.05) milk, fat percentage (%), protein %, fat yield and protein yield. Analysis by age revealed that milk production and milk protein yield were only improved in mature cows. Milk production had a negative effect upon the magnitude of the increase in milk components. The change in milk yield was greatest in early lactation and declined with DIM. Protein % and fat % increased with DIM in mature cows, but not in first lactation cows. Differences in fat yields between test and control feeding periods did not change with DIM, but the improvement in protein yield in mature cows declined with DIM. These results indicate that the BVB provided economically important advantages throughout lactation beyond those witnessed with biotin, but expected results would vary with cow age and stage of lactation.

Synthesis of Biotinylated Galiellalactone Analogues  [PDF]
Zilma Escobar, Martin Johansson, Anders Bjartell, Rebecka Hellsten, Olov Sterner
International Journal of Organic Chemistry (IJOC) , 2014, DOI: 10.4236/ijoc.2014.44026
Abstract: Two biotinylated derivatives of the fungal metabolite galiellalactone (1) were synthesized in order to facilitate the investigation of the molecular mechanism of action of the galiellalactonoids. Galiellalactone is a STAT3-signaling inhibitor that inhibits growth in vitro as well as in vivo of prostate cancer cells expressing activated STAT3. To provide a suitable point of attachment for biotin, the 8-hydroxymethyl derivative (3) and its 7-phenyl analogue 4 were synthesized by a modified tandem Pd-catalysed carbonylation and intramolecular vinyl allene Diels-Alder procedure previously developed. The two primary alcohols obtained, 3 and 4, were coupled to biotin as the 6-aminohexanoic acid amide, activated as the acid chloride, yielding the derivatives 5 and 6.
Determination of biotin content in beet molasses by Lactobacillus plantarum
Lon?ar Eva S.,Do?enovi? Irena S.,Markov Sini?a L.,Malba?a Radomir V.
Acta Periodica Technologica , 2005, DOI: 10.2298/apt0536215l
Abstract: D-biotin content in beet molasses was determined by microbiological method using Lactobacillus plantarum, based on the comparison of the growth of this microorganism in molasses solutions with those in standard solutions of biotin. Incubation of the microorganism was performed on original Vitamin Biotin Testbouillon and laboratory prepared liquid culture medias. The amount of "real" biotin in molasses is low. The results depend upon the sample and volume of molasses solutions. Biotin contents obtained on both liquid media are close.
Efecto de la biotina sobre la expresión genética y el metabolismo
Vilches-Flores, Alonso;Fernández-Mejía, Cristina;
Revista de investigación clínica , 2005,
Abstract: during the last few decades, an increasing number of vitamin-mediated effects has been discovered at the level of gene expression in addition to their well-known roles as substrates and cofactors; the best recognized examples are the lipophilic vitamins a and d. although little is known about water-soluble vitamins as genetic modulators, there are increasing examples of their effect on gene expression. biotin is a hydro soluble vitamin that acts as a prosthetic group of carboxylases. besides its role as carboxylase cofactor, biotin affects several systemic functions such as development, immunity and metabolism. in recent years, significant progress has been made in the identification of genes that are affected by biotin at the transcriptional and post-transcriptional levels as well as in the elucidation of mechanisms that mediate the effects of biotin on the gene expression. these studies bring new insights into biotin mediated gene expression and will lead to a better under-standing of biotin roles in the metabolism and in systemic functions.
Efeitos da suplementa??o de alto nível de cobre e de biotina na dieta de suínos de 8 a 20 kg
Menten, J.F.M.;Ku, P.K.;Miller, E.R.;
Scientia Agricola , 1992, DOI: 10.1590/S0103-90161992000400022
Abstract: two trials were carried out to investigate the need for supplemental biotin in the diet of weanling pigs when high dietary copper is used as growth promoter. wheat - soybean meal based feeds, containing marginal levels of biotin (.10 ppm) were supplemented or not with .4 ppm biotin (bio) and 250 ppm copper (cop). the diets were fed to 168 piglets weaned at 4 weeks of age with an average weight of 7.8 kg. the trials were conducted for 5 weeks. in trial 1 there was a bio x cop interaction (p < .05) for weight gain; bio resulted in a 10% improvement in gain in absence of cop, but not when cop was present; cop resulted in a 16% improvement in absence of bio and no improvement when bio was present. there was also a main effect of cop on feed efficiency (p < .05), resulting in a 7% improvement. a similar tendency was observed in trial 2, but the differences were not significant (p > .05). the combination of supplemental bio and cop did not result in further improvement in performance compared to the individual supplementation.
Enhanced Succinic Acid Production from Sake Lees Hydrolysate by Dilute Sulfuric Acid Pretreatment and Biotin Supplementation  [PDF]
Ke-Quan Chen, Han Zhang, Ye-Lian Miao, Min Jiang, Jie-Yu Chen
Journal of Sustainable Bioenergy Systems (JSBS) , 2012, DOI: 10.4236/jsbs.2012.22003
Abstract: Succinic acid is valued as a potential starting point for the production of chemicals of the C4 family or in the prepara-tion of biodegradable polymers. For sustainable development in this era of petroleum shortage, production of succinic acid by microbial fermentation of renewable feedstock has attracted great interest. In this study, pretreatment with sulfuric acid and biotin supplementation were used to enhance succinic acid production by Actinobacillus succinogenes 130Z from sake lees, a byproduct of Japanese rice wine. Pretreatment with sulfuric acid resulted in little change of glucose, total nitrogen and succinic acid content in the sake lees hydrolysate but had a positive effect on succinic acid fermentation, which caused a 25.0% increase in succinic acid yield in batch fermentation. Biotin supplementation was used to further enhance the fermentability of sake lees hydrolysate. As a result, a 30 h batch fermentation of 0.5% sulfuric acid pretreated sake lees hydrolysate with 0.2 mg/L biotin gave a succinic acid yield of 0.59 g/g from 61.6 g/L of glucose, with a productivity of 1.21 g/(L?h). A 22.9% increase in succinic acid yield and a 101.7% increase in succinic acid productivity were obtained compared with untreated sake lees hydrolysate.
Effects of a rumen protected B vitamin blend upon milk production and component yield in lactating dairy cows  [PDF]
Essi Evans, David T. Mair
Open Journal of Animal Sciences (OJAS) , 2013, DOI: 10.4236/ojas.2013.31011
Abstract:

Results from 12 switchback field trials involving 1216 cows were combined to assess the effects of a protected B vitamin blend (BVB) upon milk yield (kg), fat percentage (%), protein %, fat yield (kg) and protein yield (kg) in primiparous and multiparous cows. Trials consisted of 3 test periods executed in the order control-test-control. No diet changes other than the inclusion of 3 grams/cow/ day of the BVB during the test period occurred. Means from the two control periods were compared to results obtained during the test period using a paired T test. Cows include in the analysis were between 45 and 300 days in milk (DIM) at the start of the experiment and were continuously available for all periods. The provision of the BVB resulted in increased (P < 0.05) milk, fat %, protein %, fat yield and protein yield. Regression models showed that the amount of milk produced had no effect upon the magnitude of the increase in milk components. The increase in milk was greatest in early lactation and declined with DIM. Protein and fat % increased with DIM in mature cows, but not in first lactation cows. Differences in fat yields between test and control feeding periods did not change with DIM, but the improvement in protein yield in mature cows declined with DIM. These results indicate that the BVB provided economically important advantages throughout lactation, but expected results would vary with cow age and stage of lactation.

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