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Search Results: 1 - 10 of 778 matches for " Bioactive constituents. "
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Production of Natural Coagulant from Moringa Oleifera Seed for Application in Treatment of Low Turbidity Water  [PDF]
Eman N. Ali, Suleyman A. Muyibi, Hamzah M. Salleh, Md Zahangir Alam, Mohd Ramlan M. Salleh
Journal of Water Resource and Protection (JWARP) , 2010, DOI: 10.4236/jwarp.2010.23030
Abstract: This study focused on developing an efficient and cost effective processing technique for Moringa oleifera seeds to produce natural coagulant for use in drinking water treatment. The produced natural coagulant can be used as an alternative to aluminum sulphate and other coagulants and used worldwide for water treatment. This study investigates processing Moringa oleifera seeds to concentrate the bio-active constituents which have coagulation activity. Moringa oleifera seeds were processed for oil extraction using electro thermal soxhlet. Isolation and purification of bio-active constituents using chromatography technique were used to determine the molecular weight of the bio-active constituents. The molecular weight of bio-active constitu-ents found to be in a low molecular weight range of between 1000 – 6500 Dalton. The proposed method to isolate and purify the bio-active constituents was the cross flow filtration method, which produced the natu-ral coagulant with very simple technique (oil extraction; salt extraction; and microfiltration through 0.45 µm). The turbidity removal was up to 96.23 % using 0.4 mg/L of processed Moringa oleifera seeds to treat low initial turbidity river water between 34-36 Nephelometric Turbidity Units (NTU) without any additives. The microfiltration method is considered to be a practical method which needs no chemicals to be added com-pared to other researchers proposed methods. The natural coagulant produced was used with low dosages to get high turbidity removal which considered to be a breakthrough in this study and recommended to be scaled up for industry level. The product is commercially valuable at the same time it is minimizing the cost of water treatment.
Pharmacological Characterization and Beneficial Uses of Punica granatum
Nakuleshwar Dut Jasuja,Richa Saxena,Subhash Chandra,Richa Sharma
Asian Journal of Plant Sciences , 2012,
Abstract: Punica granatum L. commonly known as Pomegranate belongs to the Family Punicaceae. Pomegranate has been known to be a reservoir of secondary metabolites which are being exploited as source of bioactive substance for various pharmacological purposes. Many researchers have focused their interest to investigate the bioactive compounds of Punica granatum for human health. In order to facilitate the further investigation and exploit the said plant, this study summarized herein the research achievements on some of the phytochemical and pharmacological properties of Punica granatum. The different types of phytochemicals have been identified from various parts of the pomegranate tree and from pomegranate juice, leaves, flower, fruits and seeds. The constituents of this plant were thoroughly reviewed discussed based on literatures.
Kavitha Sama,Rajeshwari Sivaraj,Hasna Abdul Salam,Rajiv. P
International Research Journal of Pharmacy , 2013,
Abstract: Medicinal plants are of great importance to the health of individuals and communities in general. Plants contain some chemical substances that produce definite physiological actions in and on the human body. The main aim of the present study was to evaluate the pharmacognostical properties and screen the bioactive constituents of Asystasia gangetica. Phytochemical screening of different extracts of the plant flower was carried out. The ethanol extract showed presence of maximum bioactive compounds including phenols, flavonoids, alkaloids, glycosides, tannins, terpenoids and saponins compared to other extracts. The yield and colour of the extracts varied with solvents and fluorescence analysis of powder was treated with various chemicals according to standard procedure. The results suggested that the plant flower possesses phytochemical constituents which are helpful to develop natural drugs to treat various diseases.
Isolation and HPLC-HRMS analysis of anti-tumor constituents from mycelia of a strain of Hirsutella sp.

HE Ya-Qiong,HU Feng-Lin,WANG Li,LI Chun-Ru,FAN Mei-Zhen,LI Zeng-Zhi,

微生物学报 , 2008,
Abstract: During a screening of fungal strains with anti-tumor activity against CHO cells, a strain named RCEF0851 of Hirsutella sp. whose extract exhibited significant bioactivity was found. Extraction tests with different solvents revealed that acetylacelate was the best solvent for obtaining the extraction with active components. The extract can be best purified by using RP column Synergi Hydro. Bioactive guided isolations resulted in obtaining a pure active compound Hh-1. The inhibition rate of the compound against CHO cells reached 83.61% at the concentration of 40μg/mL. HPLC-HRMS analysis revealed that the possible molecular formula of the active compound was C30H22O10 which was isolated from entomogenous fungi for the first time.
Srinivasa U,Amrutia Jay N,Katharotiya Reena,Moses Semuel Rajan
International Research Journal of Pharmacy , 2011,
Abstract: Petroleum ether, chloroform, methanol and aqueous extracts of leaves of Moringa oleifera were screened for various bioactive constituents like glycosides, carbohydrates, tannins, flavonoids, triterpenoids and alkaloids. The chloroform and methanol extracts were evaluated for anthelmintic activity on adult Indian earthworms Pheritima postuma using Piperazine citrate and Rajah Pravartani Vati (Ayurvedic preparation) as a reference standards. The results obtained indicated that the chloroform extract was more potent compared to other extracts.
Isolation and HPLC-HRMS analysis of anti-tumor constituents from mycelia of a strain of Hirsutella sp.

HE Ya-Qiong,HU Feng-Lin,WANG Li,LI Chun-Ru,FAN Mei-Zhen,LI Zeng-Zhi,

菌物学报 , 2008,
Abstract: 在一次多菌株的生物活性测定中,发现一株被毛孢菌株RCEF0851菌丝体提取物具有较强的抗肿瘤CHO细胞的活性.本研究用不同溶剂对活性组分进行了提取试验,发现乙酸乙酯能最大程度地提取出该活性成分.分离试验表明该提取物较适于用反相柱Synergi Hydro进行分离.活性指导下的分离得到一活性组分的纯品Hh-1.该组分在40μg/mL时对CHO细胞的抑制率达到83.61%.高分辨质谱分析表明该活性化合物的可能分子式是C30H22O10.该分子为首次从虫生真菌中发现.
Monoterpene constituents of the brown alga Dictyopteris divaricata Okam.

徐秀丽,印丽媛,宋福行,范 晓,石建功
海洋科学 , 2012,
Abstract: 为了研究中国沿海海藻中的活性化学成分, 利用正相硅胶柱色谱、Sephadex LH-20 柱色谱、反相HPLC 及重结晶等手段, 从采自青岛的褐藻叉开网翼藻(Dictyopteris divaricata Okam.)中首次分离得到了6 个单萜类化合物, 经红外波谱(IR), 质谱(MS)及核磁共振波谱(1H NMR、13C NMR)等现代波谱技术鉴定为loliolide (1), isololiolide (2), 3β-hydroxy-5α,6α-epoxy-7-megastigmen-9-one (3), dehydrovomifoliol(4), (3R)-4-(2R,4S)-2-hydroxy-2,6,6-trimethylcyclohexylidene]-3-buten-2-oneiol (5), (3R)-4-(2R,4S)-4-acetoxy-2-hydroxy-2,6,6-trimethylcyclohexylidene]-3-buten-2-one (6)。并通过MTT 法对所得化合物进行细胞毒活性筛选, 通过比色法进行乙酰胆碱酯酶抑制活性筛选。
Bioactive Constituents from Twigs and Leaves of Kopsia hainanensis

YANG Yong,MEI Wen-li,ZUO Wen-jian,ZENG Yan-bo,LI Xiao-na,DAI Hao-fu,

热带亚热带植物学报 , 2012,
Abstract: 从海南蕊木(Kopsia hainanensis Tsiang)枝叶的乙醇提取物中分离得到7个化合物,通过波谱分析(NMR、MS、IR等),鉴定其结构分别为:蕊木宁(1)、土波台文碱(2)、二氢脱氢二松柏基醇(3)、 β-香树脂醇(4)、熊果酸(5)、 2α,3β-二羟基熊果酸(6)和 β-谷甾醇(7)。其中化合物3~7为首次从该植物中分离得到。用滤纸片琼脂扩散法检测表明,化合物1~3和5对耐甲氧西林金黄色葡萄球菌(MRSA)生长有抑制作用;化合物2对金黄色葡萄球菌生长有抑制作用;化合物5对慢性髓原白血病细胞(K562)、人胃癌细胞(SGC-7901)和人肝癌细胞(SMMC-7721)增殖均具有细胞毒活性。
Multivariate Geostatistical Model for Groundwater Constituents in Texas  [PDF]
Faye Anderson
International Journal of Geosciences (IJG) , 2014, DOI: 10.4236/ijg.2014.513132
Abstract: Although many studies have explored the quality of Texas groundwater, very few have investigated the concurrent distributions of more than one pollutant, which provides insight on the temporal and spatial behavior of constituents within and between aquifers. The purpose of this research is to study the multivariate spatial patterns of seven health-related Texas groundwater constituents, which are calcium (Ca), chloride (Cl), nitrate (NO3), sodium (Na), magnesium (Mg), sulfate (SO4), and potassium (K). Data is extracted from Texas Water Development Board’s database including nine years: 2000 through 2008. A multivariate geostatistical model was developed to examine the interactions between the constituents. The model had seven dependent variables—one for each of the constituents, and five independent variables: altitude, latitude, longitude, major aquifer and water level. Exploratory analyses show that the data has no temporal patterns, but hold spatial patterns as well as intrinsic correlation. The intrinsic correlation allowed for the use of a Kronecker form for the covariance matrix. The model was validated with a split-sample. Estimates of iteratively re-weighted generalized least squares converged after four iterations. Matern covariance function estimates are zero nugget, practical range is 44 miles, 0.8340 variance and kappa was fixed at 2. To show that our assumptions are reasonable and the choice of the model is appropriate, we perform residual validation and universal kriging. Moreover, prediction maps for the seven constituents are estimated from new locations data. The results point to an alarmingly increasing levels of these constituents’ concentrations, which calls for more intensive monitoring and groundwater management.
Osteogenesis of MC3T3 Preosteoblasts on 3D Bioactive Peptide Modified Nano-Macroporous Bioactive Glass Scaffolds  [PDF]
Colin Przybylowski, Mohamed Ammar, Courtney LeBlon, Sabrina S. Jedlicka
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2015, DOI: 10.4236/jbnb.2015.63015
Abstract: Biointerface design that targets osteogenesis is a growing area of research with significant implications in biomedicine. Materials known to either support or stimulate osteogenesis are composed of a biomimetic ceramic material, such as bioactive glass. Bioactive glass is osteoproductive, and the potential for osteoproductivity can be enhanced by the addition of proteins or other additives designed to alter functionality. In addition, soluble growth factors are often added to osteogenic culture on bioactive glasses, further intensifying the effects of the material. In this paper, synthetic peptide combinations, covalently bound to a three-dimensional bioactive glass network, are used to mimic the effects of the whole fibronectin and bone morphogenetic proteins (BMP) 2 and 9. Peptide-silanes possessing critical binding sequences from each of these proteins are synthesized and used to decorate the surface of three-dimensional (3D) nano-macroporous bioactive glass. MC3T3 preosteoblast cells are then assessed for differentiation on the materials in the absence of soluble differentiation cues. MC3T3 preosteoblasts undergo enhanced differentiation on the peptide-silane samples over the standard nano-macroporous bioactive glass, and the differentiation capacity of the cells exposes only to peptide-silane surfaces approaches that of cells grown in chemical differentiation induction media.
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